Профессиональная учебная практика: I курс : Учебно-методическое пособие для студентов и преподавателей - 2-е изд., испр.

Letter recognition is assumed to involve several levels of analysis, including coarse tuning for category and novelty and more fine tuning for specific features, related to letter orientation. We employed an oddball fast periodic visual stimulation (FPVS) paradigm with magnetoencephalography (Elekta VectorView, 306 sensors) to study neural discrimination responses in the source space. Using contrasts ...

Added: May 24, 2026

Molecular dynamics simulations refine the pathogenicity of ACVRL1 kinase domain variants by quantifying impacts on ATP binding in pulmonary arterial hypertension

Borovikova I., Okhrimenko G., Zamyatin V. et al., Journal of Structural Biology 2026 Vol. 218 No. 2 Article 108315

Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular diagnosis for pulmonary arterial hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). Since aberrant ATP binding disrupts downstream SMAD1/5/8 phosphorylation, we employed molecular dynamics ...

Added: May 20, 2026

uPAR deficiency triggers TGFβ1-mediated fibrotic remodeling in a cardiac perivascular-like microenvironment

Goltseva Y., Tsokolaeva Z., Beloglazova I. et al., Stem Cell Research and Therapy 2026 Vol. 17 No. 1 Article 112

Background Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling. The urokinase plasminogen activator receptor (uPAR), a critical component of the urokinase system, plays a pivotal role in vascular remodeling and fibrosis. While prior evidence indicates that uPAR deficiency leads to microvascular dysfunction and perivascular fibrosis, ...

Added: May 19, 2026

Motor imagery perspective shapes corticospinal excitability with effector-specific effects

Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098

Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...

Added: May 5, 2026

Multimodal EEG, ECG, and video dataset of yoga practitioners during concentration and mind-wandering tasks

Kashevnik A., Glekler E., Artemenko E. et al., Scientific data 2026 Article 7209

We present a multimodal dataset containing electroencephalography (EEG), electrocardiography (ECG), and video recordings from 49 participants. Each participant completed a single session lasting approximately 45 minutes. During each session they performed five tasks: resting state, inward concentration (focusing on the center of the forehead), outward concentration (visual search), and mind-wandering. EEG data were recorded from ...

Added: April 23, 2026

Rapid synthesis of redox-responsive trithiocyanuric acid-based nanocarriers: in vitro multidrug resistance reversal and In vivo safety assessment

Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16

Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...

Added: April 20, 2026

Функциональные признаки листьев и экологические стратегии важны для формирования растительных сообществ субальпийских болот и высокотравья

Гулов Д. М., Елумеева Т. Г., Федоров Н. И. et al., Журнал общей биологии 2024 Т. 85 № 2 С. 83–94

Plant functional traits are important for the formation of plant communities and for the ability of plants to dominate there. The comparison of mean trait values of organisms within community with that for the random samples of the local biota allows estimating the importance of the trait for the formation of the community composition. The ...

Added: April 19, 2026

The partitioning of mobile fractions of chemical elements in the mineral loamy soils during natural regeneration after plowing in Western Russia

Enchilik P. R., G.V.Klink, Semenkov I. N., Science of the Total Environment 2025 Vol. 998 Article 180219

Natural regeneration of forest soils affected by agricultural practices is a common phenomenon in many regions worldwide, particularly in boreal ecosystems. Affecting soil quality, the partitioning of extractable fractions of heavy metals and metalloids (HMMs) is not studied during natural regeneration. The following stages of natural regeneration after plowing have been identified in the Smolenskoye ...

Added: April 19, 2026

Self-face viewing attenuates cardiac modulation of corticospinal excitability

Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807

Introduction: While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception). Methods: In 15 healthy adults, motor-evoked potentials (MEPs) were ...

Added: April 17, 2026

Inactivation of NONO by Auranofin or RNA Interference Triggers Lethal Oxidative Stress in Neuroblastoma Cells

Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544

Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...

Added: April 15, 2026

Discovery of Novel 1,3,5-Triazine Derivative as Potent Anticancer Agent: DNA and HSA Binding, MTT Assay

Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287

This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...

Added: April 15, 2026

Saying “Yes” to NONO: A Therapeutic Target for Neuroblastoma and Beyond

Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228

Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...

Added: April 15, 2026

Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and Clinical Perspectives

Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -

The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...

Added: April 15, 2026

Взаимодействие аффективных и когнитивных компонентов рабочей памяти при удержании эмоционально-окрашенной информации. Нейрокогнитивный анализ

Kochetkova E., Мачинская Р. И., Журнал высшей нервной деятельности им. И.П. Павлова 2025 Т. 75 № 2 С. 170–188

The review provides an analysis of modern cognitive psychological theories of emotions and neural basis of mechanisms standing behind retention of emotional information in working memory. The tendency seen in modern neurocognitive theories is characterized by the rejection of localization for any psychological functions in favor of network models, where higher-order processes are supported by distributed neural networks connecting ...

Added: April 15, 2026

Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and Clinical Perspectives

Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40

Added: April 15, 2026

Retention of Emotional and Socio-Emotional Information in Working Memory: EEG Functional Connectivity Study

Kochetkova E., Machinskaya R., Human Physiology 2025 Vol. 51 No. 6 P. 580–590

Growing evidence suggests the specific systems for emotional information maintenance and processing in working memory, highlighting the role of cognitive domains in emotional awareness. The question of neural basis of social-emotional processing in working memory remains open. We hypothesized that the neural systems supporting working memory for emotional processing may rely on shared ‘core’ networks ...

Added: April 15, 2026

The Complex of Copper (II) and Zoledronic Acid: Relevance to Oxidative Death of Leukemia Cells in the Bone Marrow

Barskaya E. S., Savin A. M., Chernov K. V. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 6 Article 2800

Copper–organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the ...

Added: April 15, 2026

Enhancement of Rotenone Cytotoxicity in the Presence of Bach1 Inhibitors

S. V. Nikulin, Olkhovik D., A.V. Razumovskaya et al., Doklady Biochemistry and Biophysics 2026 Vol. 526 P. 59–64

A novel trend in anticancer therapy is based on the combination of cytotoxic and metabolic drugs. Bach1 is a transcription factor activating glycolysis and increasing proliferation and metastatic potential in cancer cells. The cytotoxic effect was evaluated for a combination of rotenone, an inhibitor of mitochondrial respiration, and two different inhibitors of Bach1 transcription factor ...

Added: April 13, 2026

Unlocking Stress Coping Mechanisms: Implications for Salivary Antioxidant Defense and Trace Element Homeostasis

Portnova G., Proskurnina E., Liaukovich K. et al., Journal of Molecular Neuroscience 2026 Vol. 76 Article 19

This study investigates the relationship between stress coping ability, salivary antioxidant capacity (AOC), and trace element concentrations, focusing on zinc (Zn) and potassium (K). A cohort of 73 participants, divided into groups based on stress coping ability (SCA) (“adaptive”, “intermediate”, and “maladaptive”), underwent cognitive tasks while physiological and behavioral data were collected. Saliva samples were ...

Added: February 2, 2026

Студент - Исследователь - Учитель. Материалы 25-й Межвузовской студенческой научной конференции. Санкт-Петербург, 2024

Гаевская М. А., СПб.: РГПУ им. А.И. Герцена, 2024.

В сборнике представлены прошедшие отбор редакционной коллегии сборника и рецензирование статьи, которые были подготовлены на основе докладов и сообщений участников 25-й Межвузовской студенческой научной конференции «Студент - Исследователь - Учитель», состоявшейся 3-17 апреля 2023 года в Санкт-Петербурге в Российском государственном педагогическом университете им. А.И. Герцена. Материалы отражают результаты изысканий молодых исследователей - студентов бакалавриата, магистратуры ...

Added: October 5, 2025

Студент - Исследователь - Учитель. Материалы 24-й Межвузовской студенческой научной конференции. Санкт-Петербург, 2023

Гаевская М. А., СПб.: РГПУ им. А.И. Герцена, 2023.

Сборник включает статьи, подготовленные на основе докладов и сообщений участников 24-й Межвузовской студенческой научной конференции «Студент - Исследователь - Учитель», состоявшейся 4-15 апреля 2022 года в Санкт-Петербурге в Российском государственном педагогическом университете им. А.И. Герцена. Статьи прошли отбор редакционной коллегии сборника и рецензирование. Содержание материалов сборника отражает результаты изысканий молодых исследователей - студентов бакалавриата, магистратуры ...

Added: October 5, 2025

Биохимия человека. Материалы всероссийской конференция с международным участием

ООО «Е-ното», 2024.

В сборнике представлены материалы конференции «Биохимия человека 2024», посвящённой 100-летию со дня рождения акад. Темирболата Берёзова (17–19 октября, Москва). В сборник вошли отобранные тезисы по 26 научным секциям в области биохимии и смежных дисциплин. Предназначено для исследователей в области биомедицинских наук, преподавателей биохимии и смежных дисциплин в высшей школе, врачей клинической лабораторной диагностики, эндокринологов, онкологов ...

Added: September 9, 2025

Metabolomics and viability of fibroblasts on the influence of the components of the malate dehydrogenase shuttle system in vitro

Kolotyeva N., Limareva L., Remizov V. et al., Сибирское медицинское обозрение 2023 No. 1 P. 46 –50

The aim of the research.The aim is to evaluate the metabolic profile and viability of human dermal fibroblasts under the influence of malate and oxaloacetate in vitro. Material and methods. Fibroblasts grown by the method of primary explants were incubated with solutions of malate and oxaloacetate. After that, the biochemical profile and enzyme activity relative to ...

Added: June 9, 2025

Корреляционные взаимосвязи показателей крови и ротовой жидкости после офисного отбеливания зубов

Магсумова О. А., Ryskina H., Постников М. А. et al., Клиническая стоматология 2022 Т. 25 № 4 С. 88–92

There are interactions between the oral fluid and blood, showing the status of the hematosalivary barrier, which is a kind of non-specific adaptive mechanism. The purpose of this work is to assess the correlation between the biochemical parameters of the oral fluid and blood of patients after the office teeth whitening procedure. This study involved ...

Added: June 9, 2025