Knyazev E., Чеботарева О. Е., М. : Издательский дом НИУ ВШЭ, 2023
В пособии кратко изложены теоретические и практические аспекты первичных навыков, необходимых для работы в биологической лаборатории, а также приведены протоколы практических занятий в рамках профессиональной учебной практики (ознакомительной) I курса бакалаврской программы «Клеточная и молекулярная биотехнология» факультета биологии и биотехнологии НИУ ВШЭ.
Учебно-методическое пособие предназначено для студентов и преподавателей факультета биологии и биотехнологии НИУ ВШЭ и ...
Added: March 11, 2024
М. : Издательский дом НИУ ВШЭ, 2023
В пособии кратко изложены теоретические и практические аспекты первичных навыков, необходимых для работы в биологической лаборатории, а также приведены протоколы практических занятий в рамках профессиональной учебной практики (ознакомительной) I курса бакалаврской программы «Клеточная и молекулярная биотехнология» факультета биологии и биотехнологии НИУ ВШЭ.
Учебно-методическое пособие предназначено для студентов и преподавателей факультета биологии и биотехнологии НИУ ВШЭ и ...
Added: February 9, 2024
Корякина М. М., Агранович О. Е., Bermúdez-Margaretto B. et al., IEEE, 2023
The current study aimed to compare differences in the verbal fluency, action/verbal naming and semantic association development of children with variable degree of limb motor disorders vs. healthy controls. The study involved 68 children from 7 to 15 years old; 36 children with Obstetric brachial plexus palsy (OBPL) (N=22) and amyoplasia (N=14) and 32 healthy ...
Added: December 10, 2023
Здоровье всегда являлось весомым капиталом человека, а грамотное распоряжением им всегда приносило ощутимые инвестиции. В современном мире с его темпами, задачами и вызовами у большинства людей все меньше времени остается на сохранение, поддержание и тем более укрепление здоровья. Но на возникающий запрос, формируется решение, продиктованное самим обществом, а именно, его цифровым отражением. Оцифровка общественной и ...
Added: May 15, 2023
Мырсина А. А., Издательская группа "ЗАКОН", 2020
Автором предпринимается попытка критически осмыслить существующие критерии установления правового режима медицинского изделия ex ante и ex post с учетом практики правоприменения. С одной стороны, производитель ex ante (до выхода товара на рынок) самостоятельно решает вопрос о предназначении изделия и его регистрации, а с другой стороны, Росздравнадзор ex post (после выхода товара на рынок) может изменить ...
Added: October 21, 2022
Баранова Е. Е., Брызгалина Е. В., Введенская Е. В. et al., ИНИОН РАН, 2021
В монографии рассматриваются этико-правовые и социально-психологические проблемы развития геномной медицины. Особое внимание уделяется биоэтическим вопросам развития биобанкинга, генетического тестирования, медико-генетического консультирования, а также проблемам социогуманитарного сопровождения развития генетических технологий в нашей стране. Для всех, кто заинтересован в понимании этических, правовых и социальных контекстов развития геномной медицины. ...
Added: January 13, 2022
Chernyaeva D., Taupitz J., Deuring S., Berlin, Heidelberg : Springer, 2020
The book contains 19 national reports and a comparative legal analysis of the legal regulations on the procedure of genome editing on the human germline. It is worked out which shared values the different legal systems connect and which differences exist. On this basis, it is examined whether an international regulation of the topic is ...
Added: April 13, 2019
Meta-analysis is one of the concepts of scientific methodology, and is a frequent but optional component of systematic reviews of empirical research. It joins the results of several scientific studies and tests one or more interrelated scientific hypotheses using quantitative (statistical) methods. This analysis can either use primary data from the original studies or published ...
Added: March 22, 2024
We propose a learning mechanism for intracellular synthetic genetic classifiers based on the selective elimination (curing) of plasmids bearing parts of the classifier circuit. Our focus is on a two-input, two-plasmid classifier scheme designed to solve a simple proof-of-concept learning problem. The problem is formulated in terms of Boolean variables, and the learning process boils ...
Added: March 12, 2024
Bogdanov V., Kim A., Nodel M. et al., International Journal of Molecular Sciences 2021 Vol. 22 No. 9 Article 4736
Development of differential and early (preclinical) diagnostics of Parkinson’s disease (PD) is among the priorities in neuroscience. We searched for changes in the level of catecholamines and α-2-macroglobulin activity in the tear fluid (TF) in PD patients at an early clinical stage. It was shown that TF in patients is characterized by an increased level ...
Added: March 4, 2024
Blokhin V. E., M. V. Ugryumov, Neurochemical Journal 2021 Vol. 15 No. 1 P. 18-23
One of the priorities of neuroscience is the fight against socially relevant neurodegenerative diseases, including Parkinson’s disease (PD). Given the limited possibilities of studying the pathogenesis of this disease, the creation and detailed study of appropriate experimental models is of great importance. Therefore, the purpose of this work was to continue the long-term study of ...
Added: March 4, 2024
Kim A., Pavlova E., Kolacheva A. et al., Biomedicine and Pharmacotherapy 2022 Vol. 150 Article 112944
The fight against neurodegenerative diseases, including Parkinson’s disease (PD), is a global challenge of this century. The effectiveness of current PD therapy is limited, since it is diagnosed many years after the onset, following the death of most nigrostriatal dopaminergic neurons regulating motor function. PD treatment could be greatly improved if it was started at ...
Added: March 4, 2024
Blokhin V., Shupik M., Gutner U. et al., Biomolecules 2022 Vol. 12 No. 1 Article 93
Parkinson’s disease (PD) is a neurodegenerative disease incurable due to late diagnosis and treatment. Therefore, one of the priorities of neurology is to study the mechanisms of PD pathogenesis at the preclinical and early clinical stages. Given the important role of sphingolipids in the pathogenesis of neurodegenerative diseases, we aimed to analyze the gene expression ...
Added: March 4, 2024
Katunina E., Blokhin V., Nodel M. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 3 Article 1842
Parkinson’s disease (PD) is diagnosed many years after its onset, under a significant degradation of the nigrostriatal dopaminergic system, responsible for the regulation of motor function. This explains the low effectiveness of the treatment of patients. Therefore, one of the highest priorities in neurology is the development of the early (preclinical) diagnosis of PD. The ...
Added: March 4, 2024
Blokhin V., Lavrova A., Surkov S. et al., International Journal of Molecular Sciences 2022 Vol. 23 No. 7 Article 3678
This is the first study aiming to develop a method for the long-term visualization of living nigrostriatal dopaminergic neurons using 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine-BODIPY (GBR-BP), the original fluorescent substance, which is a derivative of GBR-12909, a dopamine uptake inhibitor. This method is based on the authors’ hypothesis about the possibility of specifically internalizing into dopaminergic neurons substances with ...
Added: March 4, 2024
Beliakov S., Blokhin V., Surkov S. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 1 Article 733
The low effectiveness of symptomatic pharmacotherapy for Parkinson’s disease (PD), which compensates for dopamine (DA) deficiency under degeneration of nigrostriatal dopaminergic (DAergic) neurons, could apparently be improved with neuroprotective therapy, which slows down neurodegeneration and PD progression. For this, it is necessary to have a DAergic cell line for the development of a PD model ...
Added: March 1, 2024
Kolacheva A., Bannikova A., Pavlova E. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 1 Article 683
The fight against neurodegenerative diseases, including Parkinson’s disease (PD), is among the global challenges of the 21st century. The low efficiency of therapy is due to the late diagnosis and treatment of PD, which take place when there is already significant degradation of the nigrostriatal dopaminergic system, a key link in the regulation of motor ...
Added: March 1, 2024
Kolacheva A., Pavlova E., Bannikova A. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 3 Article 3027
Given the limited access to clinical material for studying the pathogenesis of Parkinson's disease (PD), these studies should be carried out on experimental models. We have recently developed a subchronic model of the progressive development of PD with a gradual transition from the preclinical (asymptomatic) stage to the clinical (symptomatic) one. The aim of this ...
Added: March 1, 2024
It was proven that tumor organoids effectively mirror the phenotypic and genetic traits of the original biomaterial. It was reported that outcomes from drug testing in organoid cultures can accurately represent the clinical response observed in patients. In this study, an organoid culture was derived from biopsy material of prostate cancer (PC). Subsequently, clinical practice ...
Added: March 1, 2024
Sushentsev N., Rundo L., Abrego L. et al., European Radiology 2023 Vol. 33 No. 6 P. 3792-3800
Serial MRI is an essential assessment tool in prostate cancer (PCa) patients enrolled on active surveillance (AS). However, it has only moderate sensitivity for predicting histopathological tumour progression at follow-up, which is in part due to the subjective nature of its clinical reporting and variation among centres and readers. In this study, we used a ...
Added: February 28, 2024
Nené N. R., Ney A., Nazarenko T. et al., Communications Medicine 2023 Vol. 3 No. 1 Article 10
Nene et al. construct machine learning models based on serum protein biomarker data to detect pancreatic ductal adenocarcinoma in a nested case-control study from the UKCTOCS cohort. Their ensemble modelling approach outperforms existing combinations of biomarkers.
BackgroundEarlier detection of pancreatic ductal adenocarcinoma (PDAC) is key to improving patient outcomes, as it is mostly detected at advanced ...
Added: February 28, 2024
Peasley R., Rangel L. A., Casagrandi D. et al., Ultrasound in Obstetrics and Gynecology 2023 Vol. 62 No. 1 P. 106-114
ObjectivesThere is limited prospective evidence to guide the management of late-onset fetal growth restriction (FGR) and its differentiation from small-for-gestational age. The aim of this study was to assess prospectively a novel protocol in which ultrasound criteria were used to classify women with suspected late FGR into two groups: those at low risk, who were ...
Added: February 28, 2024
Yong H. E., Maksym K., Yusoff M. A. et al., Cells 2023 Vol. 12 No. 7 Article 1093
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Altered placental formation and functional capacity are major contributors to FGR pathogenesis. Relating placental structure to function across the placenta in healthy and FGR pregnancies remains largely unexplored but could improve understanding of placental diseases. We investigated integration of these parameters spatially ...
Added: February 28, 2024
Sushentsev N., Abrego L., Colarieti A. et al., EUROPEAN UROLOGY OPEN SCIENCE 2023 Vol. 52 P. 36-39
The global uptake of prostate cancer (PCa) active surveillance (AS) is steadily increasing. While prostate-specific antigen density (PSAD) is an important baseline predictor of PCa progression on AS, there is a scarcity of recommendations on its use in follow-up. In particular, the best way of measuring PSAD is unclear. One approach would be to use ...
Added: February 28, 2024
Gao H., Liu L., Zaikin A. et al., Biochimica et Biophysica Acta - Biomembranes 2023 Vol. 1865 No. 7 Article 184195
Numerous cellular processes are regulated by Ca2+ signals, and the endoplasmic reticulum (ER) membrane's inositol triphosphate receptor (IP3R) is critical for modulating intracellular Ca2+ dynamics. The IP3Rs are seen to be clustered in a variety of cell types. The combination of IP3Rs clustering and IP3Rs-mediated Ca2+-induced Ca2+ release results in the hierarchical organization of the Ca2+ signals, which challenges the numerical ...
Added: February 28, 2024
To date, colorectal cancer (CRC) remains one of the most common malignant neoplasms worldwide with a high mortality rates. In recent decades, progress in the study of the mechanisms underlying drug resistance in CRC confirmed the need to search for new therapeutic approaches. In particular, tumor cells that are resistant to standard therapy and to ...
Added: February 13, 2024
Ignatieva N., Захаркина О. Л., Свиридов А. П., Современные технологии в медицине 2023 Т. 15 № 6 С. 31-39
Цель исследования — оценка эффективности лазерной спайки биологических тканей и материалов для объемного прогрева альбуминового припоя на примере соединения интактного и химически модифицированного хрящей перегородки носа свиньи. Материалы и методы. Материалами для соединения служили двукратно трипсинизированные и обработанные глицериновым альдегидом пластины, изготовленные из хряща перегородки носа свиньи, и интактный хрящ. Для спайки этих материалов в ...
Added: February 6, 2024