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Relationship between the Expression Level of PSMD11 and Other Proteasome Proteins with the Activity of Ricin and Viscumin
Doklady Biochemistry and Biophysics. 2020. Vol. 493. No. 1. P. 198-200.
The role of proteasome proteins and proteins of the ERAD system in the cytotoxicity of type II ribosome-inactivating proteins ricin and viscumin was investigated. For this, the cell line of colorectal adenocarcinoma HT29, as well as the HT29-sh002 line obtained on its basis, were used. On the basis on the proteome analysis of these lines and the estimation of the proportion of inactivated ribosomes, it was shown that the contribution of the proteasome to the degradation of the catalytic subunits of toxins is different. The role of the Cdc37 co-chaperone in maintaining the stability of A subunit of viscumin in the cytoplasm is shown.
Maltseva D., Райгородская М. П., Тихонова О. В. et al., Доклады академии наук. Науки о жизни 2020 Т. 493 С. 373-375
The role of proteasome proteins and proteins of the ERAD system in the cytotoxicity of type II ri- bosome-inactivating proteins ricin and viscumin was investigated. For this, the cell line of colorectal adeno- carcinoma HT29, as well as the HT29-sh002 line obtained on its basis, were used. Based on the proteome analysis of these lines ...
Added: October 14, 2020
Maltseva D. V., Raigorodskaya M. P., Zgoda V. G. et al., Doklady Biochemistry and Biophysics 2020 Vol. 494 No. 1 P. 219-221
In the present study, we assessed the role of annexin 13 membrane-binding protein (ANXA13) in the intracellular transport of vesicles containing type II ribosome-inactivating proteins (RIP-IIs). A modified human intestinal epithelial cell line HT29 was used, in which the expression of ANXA13 was significantly reduced. The cytotoxic effect of ricin and viscumin was evaluated by ...
Added: February 1, 2021
Maltseva D., Райгородская М. П., Згода В. Г. et al., Доклады академии наук. Науки о жизни 2020 Т. 494 С. 444-447
In the present study, we assessed the role of annexin 13 membrane-binding protein (ANXA13) in the intracellular transport of vesicles containing ribosome-inactivating proteins of the second type (RIP-IIs). A modified human intestinal epithelial cell line HT29 was used, in which the expression of ANXA13 was significantly reduced. The cytotoxic effect of ricin and viscumin was evaluated ...
Added: October 14, 2020
Shilova N., Bovin N., Maltseva D. et al., Biochimie 2022 Vol. 202 P. 94-102
Viscumin, a lectin used in anti-cancer therapy, was originally considered as βGal recognizing protein; later, an ability to bind 6'-sialyl N-acetyllactosamine (6'SLN) terminated gangliosides was found. Here we probed viscumin with a printed glycan array (PGA) containing a large number of mammalian sulfated glycans, and found a strong binding to glycans with 6-O-SuGal moiety as lactose, N-acetyllactosamine ...
Added: August 25, 2022
Dosaev K. A., S.Ya. Istomin, Strebkov D. A. et al., Electrochimica Acta 2022 Vol. 428 Article 140923
Using the rotating disk electrode (RDE) and cyclic voltammetry (CV) techniques, we studied electrochemical behavior, including activity in the oxygen reduction reaction (ORR) in an alkaline solution, of different AMn2O4 (A=Mn(II), Mg(II), Li(I) and Cd(II)) oxides with the spinel structure. With the help of postmortem XPScharacterization we demonstrate that the surface of the studied spinels (except for MgMn2O4) undergoes essential modification ...
Added: August 31, 2022
Maltseva D., Raygorodskaya М., Knyazev E. et al., Biochimie 2020 Vol. 174 P. 107-116
The interaction of tumor cells with the extracellular matrix (ECM) may affect the rate of cancer progression and metastasis. One of the major components of ECM are laminins, the heterotrimeric glycoproteins consisting of α-, β-, and γ-chains (αβγ). Laminins interact with their cell surface receptors and, thus, regulate multiple cellular processes. In this work, we ...
Added: June 8, 2020
Koshev N., Butorina A., Skidchenko E. et al., Human Brain Mapping 2021 Vol. 42 No. 15 P. 4844-4856
Abstract In the current article, we present the first solid-state sensor feasible for magnetoencephalography (MEG) that works at room temperature. The sensor is a fluxgate magnetometer based on yttrium-iron garnet films (YIGM). In this feasibility study, we prove the concept of usage of the YIGM in terms of MEG by registering a simple brain induced ...
Added: January 24, 2022
Knyazev E. N., Paul S. Yu., Bulletin of Russian State Medical University 2021 No. 2 P. 11-17
In humans, trophoblast hypoxia during placental development can be a cause of serious pregnancy complications, such as preeclampsia and fetal growth restriction. The pathogenesis of these conditions is not fully clear and may be associated with changed expression of some genes and regulatory molecules, including miRNA, in trophoblast cells. The aim of this study was ...
Added: June 18, 2021
М. : ООО «Макс Пресс», 2020
The XVI international interdisciplinary Congress "Neuroscience for medicine and psychology" continues the cycle of scientific events (High Tatras, Slovakia, 2002 and 2003; Karadag, Crimea, Ukraine, 2002 and 2003; Hurghada, Egypt, 2004, Sudak, Crimea, Ukraine, 2004-2013, Sudak, Crimea, Russia, 2014-2019), which are dedicated to the multi-faceted study of the nervous system and the use of this ...
Added: May 5, 2020
Sabatier P., Beusch C., Maltseva D. et al., Nature Communications 2021 No. 12 Article 6558
Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. To systematically study such transitions, we introduce a method that simultaneously measures protein expression and thermal stability changes in cells and provide the web-based visualization tool ProteoTracker. We apply our ...
Added: November 12, 2021
Butovskaya M., Annals of Human Genetics 2018 Vol. 82 No. 6 P. 407-414
The key regulator in the control of aggressive behavior is dopamine receptors. Association of variants in these genes with aggression has been shown in modern populations. However, these studies have not been conducted in traditional cultures. The aim of our study was to investigate population features in distributions of allele and genotype frequencies of DRD2 rs1800497, DRD4 120 bp Ins, ...
Added: September 20, 2018
Zamotaev I., Белобров В. П., Юдин С. А. et al., Научные ведомости Белгородского государственного университета. Серия: Естественные науки 2018 Т. 42 № 2 С. 172-180
The results of soil studies for the agrolandscapes of the Lgov district, Kursk region are presented. They prove that the most of gray forest soils and chernozems involved in intensive agricultural activities are degrading now. This degradation is manifested by activation of sheet and linear erosion, the decrease in the soil organic carbon content and ...
Added: December 1, 2020
Orlov I. B., В кн. : Человек в российской повседневности. : М. : МГУС, 2001. С. 111-119.
In the article the phenomenon of the hungry years considered in the context of the history of everyday life. In this case we are talking about the so-called "normal exceptions"that is very common in the Russian history of the situation, when in the conditions of emergency social norms and anomalies are reversed. One of the ...
Added: February 25, 2014
S. A. Nersisyan, M. Yu. Shkurnikov, E. N. Knyazev, Doklady Biochemistry and Biophysics 2020 Vol. 493 No. 1 P. 205-207
One of the main complications of pregnancy and causes of maternal and perinatal mortality is preeclampsia. The pathophysiology of preeclampsia is associated with the development of placenta and fetal hypoxia and secretion of a number of effective molecules. The human choriocarcinoma cell line BeWo b30 is often used as a model of the placental barrier. ...
Added: October 13, 2020
Knyazev E., Maltseva D., Raigorodskaya M. et al., Frontiers in Genetics 2021 Vol. 12 Article 791640
Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium. In contrast, pathological hypoxia is a common feature of some chronic disorders, including inflammatory bowel disease (IBD). This work was aimed at studying HIF-associated changes in the intestinal epithelium in IBD. ...
Added: November 11, 2021
Knyazev E., Nersisyan S., Tonevitsky A., Frontiers in Immunology 2021 Vol. 12 Article 636966
Since 2003, the world has been confronted with three new betacoronaviruses that cause human respiratory infections: SARS-CoV, which causes severe acute respiratory syndrome (SARS), MERS-CoV, which causes Middle East respiratory syndrome (MERS), and SARS-CoV-2, which causes Coronavirus Disease 2019 (COVID-19). The mechanisms of coronavirus transmission and dissemination in the human body determine the diagnostic and ...
Added: September 7, 2021
Shkurnikov M. Yu., Nersisyan S. A., Osepyan A. S. et al., Doklady Biochemistry and Biophysics 2020 Vol. 493 No. 1 P. 208-210
Human colorectal adenocarcinoma cell line Caco-2 is often used as a model of healthy intestinal epithelium, in particular, in miRNA studies. The work of the enzymes Drosha and Dicer is an integral part of the process of miRNA formation. Inaccuracies in the work of these enzymes lead to a change in the nucleotide sequences of ...
Added: October 13, 2020
Knyazev E. N., Paul S. Yu., Tonevitsky A. G., Doklady Biochemistry and Biophysics 2021 Vol. 499 No. 1 P. 251-256
Choriocarcinoma cells BeWo b30 are used to model human placental trophoblast hypoxia using cobalt (II) chloride and hydroxyquinoline derivative (HD) as chemical inducers of hypoxia-inducible factor (HIF). In this study, it was shown that both substances activate the hypoxic pathway and the epithelial–mesenchymal transition and inhibit the pathways of cell proliferation. However, CoCl2 caused activation of ...
Added: August 26, 2021
Gureev M.A., Порозов Ю. Б., Journal of Biomolecular Structure and Dynamics 2021 Vol. 40 No. 12 P. 5481-5492
ABSTARCT The development of new anti-influenza drugs remains an active area, and efforts in this direction will likely continue far into the future. In this paper, we present the results of a theoretical study explaining the mechanisms behind the antiviral activity of camphor derivatives. These include camphecene and a number of its analogues. The compounds ...
Added: March 22, 2024
Safonov G., Кокотов Б., Тонков Н. et al., Нефть России 2005 № 5 С. 36-42
Как отразится на системе природопользования принятие Экологического кодекса и введение экологических платежей? Ситуцию анализируют специалисты по охране окружающей среды. ...
Added: July 20, 2016
Shaitan A., Комарова Г. А., Timokhin G. et al., Russian Journal of Genetics 2024 Vol. 60 No. 1 P. 11-31
The COVID-19 pandemic has become a serious challenge for the healthcare system and the econ- omy of many states, and understanding the molecular mechanisms of the pathogenesis of this disease has become a significant challenge for modern science. At the same time, for the first time, a number of high- precision and high-throughput methods for ...
Added: February 14, 2024
Jaaskelainen I., Klucharev V., Panidi K. et al., Frontiers in Human Neuroscience 2020 Vol. 14 P. 253
Narratives, in the form of, e.g., written stories, mouth-to-mouth accounts, audiobooks, fiction movies, and media-feeds, powerfully shape the perception of reality and widely influence human decision-making. In this review, we describe findings from recent neuroimaging studies unraveling how narratives influence the human brain, thus shaping perception, cognition, emotions, and decision-making. It appears that narrative sense-making ...
Added: September 23, 2020
Sergeyev V., Гришуткина Д., Логистика и управление цепями поставок 2007 № 3 С. 10-28
It is shown, that recently among technologies of integration of contractors at supply chains «Vendor managed inventory» concept has been growing in popularity (VMI). Basic definitions within the framework of this concept/technology are analysed. VMI technology is viewed within the confines of development of logistics and supply chain management, and are estimated those benefits, which ...
Added: December 14, 2012
Minin A. A., Voskova A. V., Russian Journal of Developmental Biology 2014 Vol. 45 No. 3 P. 127-133
A series of dates of unfolding of the first leaves and duration of the season of vegetation in the silver birch (Betula pendula Roth. (B. verrucosa Ehrh.)), as well as the duration of flowering of the bird cherry (Padus avium), mountain ash (Sorbus aucuparia), and smallleaved lime (Tilia cordata Mill.) for the period 1970–2010 in ...
Added: October 17, 2014