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Коррекция Мнестико-интеллектуальных Нарушений В Соматогенной Стадии Острых Отравлений Смесью Психотропных Препаратов
Клиническая медицина. 2012. № 3. С. 63–65.
Шилов В. В., Aleksandrov M., Васильев С. А., Батоцыренов Б. В., Кузнецов О. А.
Ок. Е. Колодеева, Ол. Е. Колодеева, Биотехнология 2025 Т. 41 № 6 С. 64–71
A three-dimensional (3D) matrix consisting of collagen fibers can create culture conditions that are more similar to in vivo tissues than 2D cultures in in vitro culture plates. Macrophages are among the most important innate immune cells. They are extremely plastic, allowing them to respond effectively to pro- and anti-inflammatory signals within their microenvironment. There ...
Added: December 24, 2025
Knyazev E., Timur Kulagin, Antipenko I. et al., Placenta 2026 Vol. 176 P. 1–12
Background. Preeclampsia (PE) complicates 2–8% of pregnancies and involves placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Chemical mimetics like cobalt(II) chloride (CoCl2) and oxyquinoline derivatives model trophoblast hypoxia in vitro, yet their fidelity in recapitulating PE gene profiles remains unclear. Integrating patient tissue analyses with experimental models may reveal common markers and ...
Added: December 22, 2025
Antipenko I., Knyazev E., Timur Kulagin et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1731126
Preeclampsia is a leading cause of maternal and perinatal morbidity associated with systemic lipid metabolism disturbances, yet the underlying molecular mechanisms remain incompletely understood. In this study, we integrated single-cell RNA-seq data from preeclamptic placentas with an in vitro hypoxia model to analyze gene expression changes across distinct trophoblast subpopulations. While all trophoblast lineages exhibited ...
Added: December 2, 2025
Горбатова М. А., В кн.: Актуальные вопросы развития государственности и публичного права: материалы VIII международной научно-практической конференции (Санкт-Петербург, 7 окт. 2022 г.). В 2 т.Т. 1.: СПб.: Санкт-Петербургский институт (филиал) ВГУЮ (РПА Минюста России), 2022. С. 48–54.
В статье рассматриваются признаки состава хищения наркотических средств или психотропных веществ, а также растений, содержащих наркотические средства или психотропные вещества, либо их частей, содержащих наркотические средства или психотропные вещества. Анализ положений уголовного закона и рекомендаций Пленума Верховного Суда РФ приводит автора к выводу о проблемах квалификации данного преступления, связанных с определением предмета хищения, момента его ...
Added: February 10, 2025
Klevtsov K., Наркоконтроль 2024 № 1 С. 29–33
Цель: исследование международно-правовых основ взаимодействия государств в сфере борьбы с незаконным оборотом наркотических средств и психотропных веществ, в том числе с использованием информационно-телекоммуникационных технологий, и определение разграничения между международным процессуальным и полицейским (оперативно-разыскным) сотрудничеством в указанной сфере. Метод исследования: изучение исследуемых вопросов проведено с использованием историко-правового, сравнительно-правового и формально-юридического методов.
Вывод: международно-правовое регулирование сотрудничества государств по ...
Added: October 15, 2024
Vishnyakova P., Gantsova E., Kiseleva V. et al., Placenta 2024 Vol. 145 P. 151–161
Introduction
The role of the TGFβ signaling pathway, an important cascade responsible for the anti-inflammatory polarization of macrophages, in the development of both early- and late-onset preeclampsia (eoPE and loPE), remains poorly understood. In this study, we examined the components of the TGFβ signaling cascade and macrophage markers within placental tissue in normal pregnancy and in ...
Added: December 8, 2023
Raigorodskaya M., Zhiyanov A., Averinskaya D. et al., Клеточные технологии в биологии и медицине 2022 № 1 С. 14–18
Tumor hypoxia is one of the main reasons of progression and metastasis of colorectal cancer. The important molecular mechanism of cell response to hypoxia consists in up- or down-regulation of microRNA expression. In this work we performed microRNA and mRNA sequencing of human colorectal adenocarcinoma HT-29 cell lines treated with two chemical agents mimicking hypoxia: ...
Added: September 21, 2022
Хушпульян Д. М., Nikulin S., Христиченко А. Ю. et al., Вестник Московского университета. Серия 2: Химия 2021 Т. 62 № 3 С. 213–222
The attempts to elucidate the mechanism of hypoxic activation of erythropoietin synthesis let to the
discovery of hypoxia inducible factor (HIF) and its stability regulation via HIF prolyl hydroxylase, iron
and α-ketoglutarate dependent dioxygenase. Enzyme inhibitors mimic the action of hypoxia, however, are
far more specific. Comparative transcriptomic microanalysis of various types on the enzyme inhibitors
with hypoxia at ...
Added: December 20, 2021
Knyazev E., Maltseva D., Raigorodskaya M. et al., Frontiers in Genetics 2021 Vol. 12 Article 791640
Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium. In contrast, pathological hypoxia is a common feature of some chronic disorders, including inflammatory bowel disease (IBD). This work was aimed at studying HIF-associated changes in the intestinal epithelium in IBD. ...
Added: November 11, 2021
Knyazev E. N., Paul S. Yu., Tonevitsky A. G., Doklady Biochemistry and Biophysics 2021 Vol. 499 No. 1 P. 251–256
Choriocarcinoma cells BeWo b30 are used to model human placental trophoblast hypoxia using cobalt (II) chloride and hydroxyquinoline derivative (HD) as chemical inducers of hypoxia-inducible factor (HIF). In this study, it was shown that both substances activate the hypoxic pathway and the epithelial–mesenchymal transition and inhibit the pathways of cell proliferation. However, CoCl2 caused activation of ...
Added: August 26, 2021
Knyazev E. N., Paul S. Yu., Bulletin of Russian State Medical University 2021 No. 2 P. 11–17
In humans, trophoblast hypoxia during placental development can be a cause of serious pregnancy complications, such as preeclampsia and fetal growth restriction. The pathogenesis of these conditions is not fully clear and may be associated with changed expression of some genes and regulatory molecules, including miRNA, in trophoblast cells. The aim of this study was ...
Added: June 18, 2021
Nersisyan S., Galatenko A. V., Chekova M. et al., Frontiers in Genetics 2021 Vol. 12 Article 662468
Hypoxia is an extensively investigated condition due to its contribution to various pathophysiological processes including cancer progression and metastasis formation. MicroRNAs (miRNAs) are well-known post-transcriptional gene expression regulators. However, their contribution to molecular response to hypoxia is highly dependent on cell/tissue types and causes of hypoxia. One of the most important examples is colorectal cancer, ...
Added: May 31, 2021
Nersisyan S., Galatenko A. V., Maltseva D. et al., Вестник Российского государственного медицинского университета 2020 № 6 С. 48–54
Гипоксия возникает в различных патофизиологических процессах, включая прогрессирование опухолевых заболеваний и метастазирование. Один из механизмов молекулярного ответа клеток на гипоксию состоит в рекрутировании специфичных микроРНК, регулирующих экспрессию своих генов-мишеней. Целью работы было оценить изменения экспрессии микроРНК и их генов-мишеней в клеточной линии колоректальной аденокарциномы человека HT-29 в ответ на гипоксию с помощью интегрированного секвенирования микроРНК ...
Added: December 8, 2020
Maltseva D., Шкурников М. Ю., Nersisyan S. et al., Вестник Российского государственного медицинского университета 2020 № 4 С. 62–69
The integrity of the intestinal epithelial cell lining is crucial for the normal intestinal function. As a rule, intestinal inflammation is associated with additional tissue hypoxia, leading to the loss of epithelial monolayer integrity. However, in the absence of visible damage to the epithelium, there still might be a risk of infection driven by changes ...
Added: October 13, 2020
Knyazev E. N., Petrov V. A., Gazizov I. N. et al., Bulletin of Experimental Biology and Medicine 2019 Vol. 166 No. 3 P. 369–372
Natural response to hypoxia critically depends on rapid stabilization of hypoxia-inducible factor (HIF). Under normoxic conditions, HIF-prolyl hydroxylases mark α-subunits of HIF for degradation, while hypoxia results in stabilization of HIF-α. Oxyquinoline derivatives suppress activity of HIF-prolyl hydroxylases leading to HIF activation in the cell. Here we show that 24-h incubation of BeWo b30 choriocarcinoma ...
Added: October 28, 2019
Knyazev E., Zakharova G. S., Astakhova L. A. et al., Bulletin of Experimental Biology and Medicine 2019 Vol. 166 No. 3 P. 321–325
Hypoxia of trophoblast cells is an important regulator of normal development of the placenta. However, some pathological states associated with hypoxia, e.g. preeclampsia, impair the functions of placental cells. Oxyquinoline derivative inhibits HIF-prolyl hydroxylase by stabilizing HIF-1 transcription complex, thus modeling cell response to hypoxia. In human choriocarcinoma cells BeWo b30 (trophoblast model), oxyquinoline increased the expression ...
Added: October 28, 2019
Никитина С. Ю., Семенова В. Г., Сабгайда Т. П. et al., Электронный научный журнал "Социальные аспекты здоровья населения" 2017 Т. 53 № 1 С. 1–7
Проведен анализ смертности в контексте множественных причин. ...
Added: April 27, 2019
Knyazev E., Захарова Г. С., Астахова Л. А. et al., Бюллетень экспериментальной биологии и медицины 2018 Т. 9 № 166 С. 290–295
Hypoxia of trophoblast cells is an important regulating factor in the process of normal placenta development. However, the effect of hypoxia on the placenta in a number of pathological conditions, such as preeclampsia, leads to impaired cellular functions. A oxyquinoline derivative is capable of inhibiting HIF-prolyl hydroxylases, thereby stabilizing the transcription complex of HIF-1 and ...
Added: October 29, 2018