Взаимосвязь изменения экспрессии микроРНК и мРНК в клетках линии НТ-29 в условиях гипоксии

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Взаимосвязь изменения экспрессии микроРНК и мРНК в клетках линии НТ-29 в условиях гипоксии

Вестник Российского государственного медицинского университета. 2020. № 6. С. 48–54.

Nersisyan S., Galatenko A. V., Maltseva D., Ushkarev Y., Tonevitsky A.

Reconstruction of EEG signals using next-generation reservoir computing

Ratnikov F., European Physical Journal: Special Topics 2026 P. 1–10

EEG recordings are often affected by the loss or corruption of individual channels due to electrode detachment, poor scalp contact, or external interference. Such channels must be accurately reconstructed before further analysis. In this study, we investigate Next-Generation Reservoir Computing (NG-RC) as a data-driven approach for reconstructing corrupted EEG channels and compare its performance with ...

Added: August 12, 2026

HPRC2: A human pangenome reference with near-complete coverage of common genetic variation

Lucas J., Hebbar P., Ryabov F. et al., / Series 10.64898/2026.07.21.739710 "10.64898/2026.07.21.739710". 2026.

A pangenome reference overcomes the inherent limitation of any individual reference genome by integrating the variation present in a population. We present the Human Pangenome Reference Consortium’s (HPRC) Release 2 (HPRC2), an openly available, second phase pangenome that is an approximately fivefold expansion in genome number over HPRC Release 1 (HPRC1) and measurable improvement in ...

Added: August 10, 2026

Encyclopedia of Ecology, 3rd Edition

Sandlerskiy R., Elsevier USA, 2026.

Encyclopedia of Ecology, Third Edition, Four Volume Set - with over 300 chapters - once again provides a comprehensive reference work covering the current ideas and practices in ecology. Ecology is the ideal field for studying complex, adaptive, and self-organizing systems and by observing and understanding ecosystems, it provides valuable insights into creating sustainable systems. This knowledge is ...

Added: August 9, 2026

Structure of the Obligate Heterodimer of the IHF Protein in Solution and in the Crystal

Dadinova L., Petoukhov M., Mozhaev A. et al., Crystallography Reports 2026 Vol. 71 P. 52–58

Bacterial chromosomes are tightly packed in the cells due to interactions with specific nucleoid-associated proteins. Among them, the IHF protein draws attention due to its presumed influence on intracellular crystallization processes, leading to bacterial resistance to drugs. The crystal structure of the IHF heterodimer is known only in complex with a short DNA fragment, whereas ...

Added: August 6, 2026

Functional Brain Connectivity and Musical Training: Insights from EEG Phase Synchronization during Music Perception

Radygina A., Kulikova S., Herald of the Russian Academy of Sciences 2025 Vol. 95 No. 6 P. 963–970

Musical training has a significant impact on brain organization, leading to functional and structural adaptations that enhance auditory, visual, motor, and cognitive processes. This study investigates how extensive musical training shapes functional brain connectivity by comparing professional musicians and non-musicians. Using EEG phase-locking value (PLV) analysis, we examined neural synchronization across alpha, beta, and gamma frequency ranges during music ...

Added: August 5, 2026

EEG evidence for reproducible neural states during Buddhist Highest Yoga Tantra meditation

Mikhaylets E. V., Razorenova A. М., Chernyshev V. L. et al., Scientific Reports 2026 Vol. 16 Article 23560

Meditation offers a naturalistic paradigm for studying introspection, yet the neural dynamics of advanced tantric practices remain largely unexplored. Buddhist Highest Yoga Tantra (BHYT) comprises a sequence of eight dissolution stages culminating in the “clear light” state. We recorded EEG during eyes-closed BHYT meditation performed in monasteries and hermitages (51 sessions from 36 male practitioners; ...

Added: July 29, 2026

WSI-GT: Pseudo-Label Guided Graph Transformer for Whole-Slide Histology

Sun Z., Khvostikov A., Krylov A. et al., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8

Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...

Added: July 16, 2026

Phase-1 study of vamotinib (PF-114), a 3rd generation BCR::ABL1 tyrosine kinase-inhibitor, in chronic myeloid leukaemia

Turkina A., Vinogradova O., Lomaia E. et al., Annals of Hematology 2025 Vol. 104 P. 2707–2715

Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...

Added: July 16, 2026

Neural-molecular signatures of insomnia: Insights from signed differential mapping and gene expression analysis

Wang R., He Y., Myachykov A. et al., Neuroimage 2026 Vol. 332 Article 121926

Insomnia disorder (ID) exhibits considerable heterogeneity in neuroimaging findings across studies, and whether functional brain alterations are consistent across resting and task states remains unclear. This study aimed to identify neural dysfunction across states in ID and explore its transcriptomic correlates. ...

Added: July 13, 2026

Особенности потенциала, следующего за частотой, зарегистрированного в ответ на изменения в параметрах звучания речевого сигнала (изолированного слога)

Окнина Л. Б., Подлепич В. В., Sieber I. et al., Физиология человека 2026 Т. 52 № 3 С. 5–15

The aim of this study was to evaluate the frequency following response (FFR) for the analysis of the intact perception of syllables in humans. For this purpose, event-related potentials (ERPs) in response to isolated Russian syllables were recorded and analyzed in 29 healthy persons in two frequency ranges, standard (1-40 Hz) and high frequency (70-150 ...

Added: June 30, 2026

Human Locomotion Monitoring in Space Flight: Retrospective Nonparametric Changepoint Detection Methods

Shestoperov A. I., Ivchenko A., Fomina E. V., Microgravity Science and Technology 2025 Vol. 37 Article 19

The paper is dedicated to the analysis of medico-biological data obtained during locomotor testing of astronauts. Accurate data interpretation plays a crucial role in locomotion system monitoring, prophylaxis of long-duration spaceflight negative effects and thus in the development of an autonomous medical support system for deep space expeditions. During the locomotor testing the astronaut changes ...

Added: June 26, 2026

Эволюция, экология, генетика человека, медицинская паразитология. Практикум.

Ryskina H., Лобаева Т. А., Ануркина А. И., Ваш формат, 2025.

Я Эволюция, экология, генетика человека, медицинская паразитология. Практикум. Аннотация Аннотация к практикуму «Эволюция, экология, генетика человека, медицинская паразитология» Учебное пособие «Эволюция, экология, генетика человека, медицинская паразитология. Практикум» (авторы: Лобаева Т. А., Рыскина Е. А., Ануркина А. И.; издательство «Ваш формат», 2025 год, 194 страницы) предназначено для студентов высших учебных заведений. Цель практикума — обеспечить комплексное освоение ключевых разделов биологии с акцентом на их прикладное значение в медицине. ...

Added: June 23, 2026

Zα and Zβ Localize ADAR1 to Flipons That Modulate Innate Immunity, Alternative Splicing, and Nonsynonymous RNA Editing

Herbert A., Cherednichenko O., Lybrand T. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 6 Article 2422

The double-stranded RNA editing enzyme ADAR1 connects two forms of genetic programming, one based on codons and the other on flipons. ADAR1 recodes codons in pre-mRNA by deaminating adenosine to form inosine, which is translated as guanosine. ADAR1 also plays essential roles in the immune defense against viruses and cancers by recognizing left-handed Z-DNA and ...

Added: June 22, 2026

Embryonic enhancers help transmit positional information to the initiator cores that control Drosophila Abd-B regulatory domains

Kyrchanova O., Kudryashova K., Ibragimov A. et al., Development 2025 Vol. 152 No. 19 Article dev205051

Drosophila homeotic gene Abdominal-B (Abd-B) is controlled throughout development by four infraabdominal (iab) regulatory domains, the active or repressed state of which is determined by initiators that have parasegment-specific enhancer activity at an early stage of embryonic development. For this reason, it has long been assumed that the enhancer activity and initiation function of these elements are synonymous. ...

Added: June 20, 2026

Initiators counteract Polycomb repression and stimulate long-range contacts between enhancers and the Abdominal-B promoter in Drosophila

Kyrchanova O., Ksenia Kudryashova, Dubrovskaya V. et al., Open Biology 2025 Vol. 15 No. 11 Article 250192

The specification of abdominal segments A5 to A9 depends on the expression of Abdominal-B (Abd-B), which is regulated by four infraabdominal domains: iab-5 through iab-8,9. Each iab domain contains an initiation element that determines its active state, along with enhancers responsible for tissue-specific activation of Abd-B. These iab domains function autonomously due to their flanking boundaries, Fab-6, Fab-7 and Fab-8, which both block crosstalk between adjacent iab domains (insulator function) and facilitate long-range ...

Added: June 20, 2026

Construction of Promoter Elements for Strong, Moderate, and Weak Gene Expression in Drosophila melanogaster

Kudryashova K.S., Deriglazova I. O., Osadchiy I. S. et al., Genes 2025 Vol. 16 No. 1 Article 3

Background/Objectives: Transcriptional promoters play an essential role in regulating protein expression. Promoters with weak activity generally lead to low levels of expression, resulting in fewer proteins being produced. At the same time, strong promoters are commonly used in studies using transgenic organisms as model systems. This approach can have various negative consequences for the organism, ...

Added: June 20, 2026

Diverse β-bungarotoxin isoforms manifest different affinities to voltage-gated potassium channels of Kv1.x subfamily

Ksenia Kudryashova, Filippova E., Kryukova E. et al., Archives of Biochemistry and Biophysics 2025 Vol. 769 Article 110437

β-Bungarotoxins (β-BuTx), consisting of covalently bound phospholipase A2 subunit (A-chain), a member of group Ia of secretory phospholipases A2, and non-enzymatic subunit (B-chain) structurally related to Kunitz-type protease inhibitors, block presynaptic neuromuscular transmission via a not completely defined mechanism of action. In vivo physiological studies revealed that the B-chain is targeting voltage-gated potassium channels of not identified subtypes. In our work, six β-BuTx isoforms were ...

Added: June 20, 2026

Benchmarking DNA large language models on quadruplexes

Cherednichenko O., Herbert A., Poptsova M., Computational and Structural Biotechnology Journal 2025 Vol. 27 P. 992–1000

Large language models (LLMs) in genomics have successfully predicted various functional genomic elements. While their performance is typically evaluated using genomic benchmark datasets, it remains unclear which LLM is best suited for specific downstream tasks, particularly for generating whole-genome annotations. Current LLMs in genomics fall into three main categories: transformer-based models, long convolution-based models, and state-space models ...

Added: June 19, 2026

Kolmogorov–Arnold networks for genomic tasks

Cherednichenko O., Poptsova M., Briefings in Bioinformatics 2025 Vol. 26 No. 2 Article bbaf129

Kolmogorov–Arnold networks (KANs) emerged as a promising alternative for multilayer perceptrons (MLPs) in dense fully connected networks. Multiple attempts have been made to integrate KANs into various deep learning architectures in the domains of computer vision and natural language processing. Integrating KANs into deep learning models for genomic tasks has not been explored. Here, we ...

Added: June 19, 2026

Molecular biology of the deadliest cancer – glioblastoma: what do we know?

Aly Ismailov, Spallone A., Belogurov A. et al., Frontiers in Immunology 2025 Vol. 16 Article 1530305

Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal followed by radio- and chemotherapy, the median survival for glioblastoma patients has remained around 18 months for decades. Glioblastoma is distinguished by its highly complex mechanisms of immune evasion ...

Added: June 17, 2026

Artificial intelligence framework for multi-pathology risk assessment from retinal fundus images: deep learning approach to 15-disease screening

Vasilev R., Savchenko A., Blinov P. et al., Frontiers in Medicine 2026 Vol. 13 Article 1778404

Automated disease screening systems face challenges when applied to multi-class medical image analysis, particularly under severe class imbalance inherent in clinical datasets. Retinal fundus imaging enables non-invasive screening for multiple ocular and systemic diseases simultaneously, yet current automated systems typically assess risk for only a single pathology or a limited disease range. We developed a ...

Added: June 16, 2026

Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers

Silina M., Dzhalilova D., Fokichev N. et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1674608

Humans and laboratory animals differ in their resistance to hypoxia, which affects the severity of inflammatory diseases and the rate of tumor progression. Therefore, it is necessary to search for methods for assessing the initial tolerance to oxygen deficiency and the risks of developing acute mountain sickness without direct hypoxia exposure on the organism. The ...

Added: March 24, 2026

Длительное культивирование макрофагов в коллагеновом геле на мембране (Transwell) индуцирует гипоксию

Ок. Е. Колодеева, Ол. Е. Колодеева, Биотехнология 2025 Т. 41 № 6 С. 64–71

A three-dimensional (3D) matrix consisting of collagen fibers can create culture conditions that are more similar to in vivo tissues than 2D cultures in in vitro culture plates. Macrophages are among the most important innate immune cells. They are extremely plastic, allowing them to respond effectively to pro- and anti-inflammatory signals within their microenvironment. There ...

Added: December 24, 2025

scRNA-seq of preeclamptic trophoblasts identifies EBI3, COL17A1, miR-27a-5p, and miR-193b-5p as hypoxia markers: validation of neuradapt as a superior mimetic to cobalt chloride

Knyazev E., Timur Kulagin, Antipenko I. et al., Placenta 2026 Vol. 176 P. 1–12

Background. Preeclampsia (PE) complicates 2–8% of pregnancies and involves placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Chemical mimetics like cobalt(II) chloride (CoCl2) and oxyquinoline derivatives model trophoblast hypoxia in vitro, yet their fidelity in recapitulating PE gene profiles remains unclear. Integrating patient tissue analyses with experimental models may reveal common markers and ...

Added: December 22, 2025