Взаимосвязь изменения экспрессии микроРНК и мРНК в клетках линии НТ-29 в условиях гипоксии

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Взаимосвязь изменения экспрессии микроРНК и мРНК в клетках линии НТ-29 в условиях гипоксии

Вестник Российского государственного медицинского университета. 2020. № 6. С. 48–54.

Nersisyan S., Galatenko A. V., Maltseva D., Ushkarev Y., Tonevitsky A.

Sweet-taste liking is associated with preference for less risky and immediate rewards in economic decision-making

Давидович А. С., Shestakova A., Arzumanyan N. et al., Frontiers in Psychology 2026 Vol. 17 - 2026 P. 1–18

Background: Delay discounting refers to the tendency to choose sooner, smaller rewards over larger, later rewards. Many previous studies link this tendency positively to reward sensitivity, yet the specific mechanisms behind this association remain poorly understood. Reward sensitivity may relate to delay discounting through at least three possible pathways: increased sensitivity to reward size, increased sensitivity ...

Added: May 27, 2026

Novelty, Category and Orientation Tuning for Printed Characters: A Magnetoencephalography Study with Fast Periodic Visual Stimulation

Kochetkova Ekaterina, Kostanian D., Martynova O. et al., Brain Topography 2026 Vol. 39 No. 4 Article 51

Letter recognition is assumed to involve several levels of analysis, including coarse tuning for category and novelty and more fine tuning for specific features, related to letter orientation. We employed an oddball fast periodic visual stimulation (FPVS) paradigm with magnetoencephalography (Elekta VectorView, 306 sensors) to study neural discrimination responses in the source space. Using contrasts ...

Added: May 24, 2026

Overcoming the Curse of Dimensionality with Synolitic AI

Zaikin A., Sviridov I., Sosedka A. et al., Technologies 2026 Vol. 14 No. 2 Article 84

High-dimensional tabular data are common in biomedical and clinical research, yet conventional machine learning methods often struggle in such settings due to data scarcity, feature redundancy, and limited generalization. In this study, we systematically evaluate Synolitic Graph Neural Networks (SGNNs), a framework that transforms high-dimensional samples into sample-specific graphs by training ensembles of low-dimensional pairwise ...

Added: May 23, 2026

Технологии генетического секвенирования как средство профилактики рождения детей с генетическими аномалиями

Plotnikov S., ЯКУБЕНКО Т. В., Ratio et Natura 2024 № 3 (11) Статья 10

The article presents the results of our own research aimed at studying the prospects of using genetic sequencing technologies to identify the risk of having children with genetic abnormalities. ...

Added: May 21, 2026

Molecular dynamics simulations refine the pathogenicity of ACVRL1 kinase domain variants by quantifying impacts on ATP binding in pulmonary arterial hypertension

Borovikova I., Okhrimenko G., Zamyatin V. et al., Journal of Structural Biology 2026 Vol. 218 No. 2 Article 108315

Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular diagnosis for pulmonary arterial hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). Since aberrant ATP binding disrupts downstream SMAD1/5/8 phosphorylation, we employed molecular dynamics ...

Added: May 20, 2026

uPAR deficiency triggers TGFβ1-mediated fibrotic remodeling in a cardiac perivascular-like microenvironment

Goltseva Y., Tsokolaeva Z., Beloglazova I. et al., Stem Cell Research and Therapy 2026 Vol. 17 No. 1 Article 112

Background Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling. The urokinase plasminogen activator receptor (uPAR), a critical component of the urokinase system, plays a pivotal role in vascular remodeling and fibrosis. While prior evidence indicates that uPAR deficiency leads to microvascular dysfunction and perivascular fibrosis, ...

Added: May 19, 2026

Применение методик кортикальной и субкортикальной стимуляции у пациентов с глиальными опухолями различной степени злокачественности доминантного по речи полушария головного мозга в условиях хирургии с пробуждением.

Андрушкевич О. М., Калиновский А. В., Гаврюшин А. В. et al., Нейрохирургия 2026 Т. 28 № 1 С. 33–42

Background. The application of cortical and subcortical stimulation during awake craniotomy mitigates the risk of persistent postoperative speech deficits. However, the functions of some white matter pathways remain inadequately understood, particularly the frontal aslant tract (FAT) of the dominant hemisphere. Aim. To evaluate the efficacy of cortical and subcortical stimulation techniques in the localization of glial tumors near ...

Added: May 18, 2026

Motor imagery perspective shapes corticospinal excitability with effector-specific effects

Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098

Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...

Added: May 5, 2026

Мультимодальные модели в медицинской диагностике как универсальный инструмент

Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29

Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...

Added: May 4, 2026

Баланс в условиях сверхзагруженности: структура и объемы рабочего времени преподавателей медицинских вузов

Garmonova A., Shcheglova D., Камалова Г. Р. et al., Кубанский научный медицинский вестник 2026 Т. 33 № 2 С. 92–110

Introduction. The study analyzes the structure and volume of workload for faculty at Russian medical universities amidst increasing student numbers, rising demands for students' clinical training, scientific output, and continuous professional education. The relevance of the topic stems from the contradiction between official regulatory requirements and the actual excessive workload of medical educators. The aim is to provide ...

Added: April 29, 2026

Multimodal EEG, ECG, and video dataset of yoga practitioners during concentration and mind-wandering tasks

Kashevnik A., Glekler E., Artemenko E. et al., Scientific data 2026 Article 7209

We present a multimodal dataset containing electroencephalography (EEG), electrocardiography (ECG), and video recordings from 49 participants. Each participant completed a single session lasting approximately 45 minutes. During each session they performed five tasks: resting state, inward concentration (focusing on the center of the forehead), outward concentration (visual search), and mind-wandering. EEG data were recorded from ...

Added: April 23, 2026

Machine Learning Approach to Anticancer Activity Prediction of Transition-Metal Complexes Based on a Large-Scale Experimental Database

Krasnov L., Malikov D., Kiseleva M. et al., Journal of Medicinal Chemistry 2026 Vol. 69 No. 8 P. 8838–8851

In this work, we developed a straightforward data-driven approach to predict the cytotoxicity of metal complexes based entirely on their (metal + ligands) composition. To this end, we have manually curated MetalCytoToxDB─a comprehensive experimental database comprising 26,500 IC50 values for 7050 metal complexes against 754 cell lines from 1921 articles. Based on these, machine learning ...

Added: April 23, 2026

Rapid synthesis of redox-responsive trithiocyanuric acid-based nanocarriers: in vitro multidrug resistance reversal and In vivo safety assessment

Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16

Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...

Added: April 20, 2026

Функциональные признаки листьев и экологические стратегии важны для формирования растительных сообществ субальпийских болот и высокотравья

Гулов Д. М., Елумеева Т. Г., Федоров Н. И. et al., Журнал общей биологии 2024 Т. 85 № 2 С. 83–94

Plant functional traits are important for the formation of plant communities and for the ability of plants to dominate there. The comparison of mean trait values of organisms within community with that for the random samples of the local biota allows estimating the importance of the trait for the formation of the community composition. The ...

Added: April 19, 2026

The partitioning of mobile fractions of chemical elements in the mineral loamy soils during natural regeneration after plowing in Western Russia

Enchilik P. R., G.V.Klink, Semenkov I. N., Science of the Total Environment 2025 Vol. 998 Article 180219

Natural regeneration of forest soils affected by agricultural practices is a common phenomenon in many regions worldwide, particularly in boreal ecosystems. Affecting soil quality, the partitioning of extractable fractions of heavy metals and metalloids (HMMs) is not studied during natural regeneration. The following stages of natural regeneration after plowing have been identified in the Smolenskoye ...

Added: April 19, 2026

Self-face viewing attenuates cardiac modulation of corticospinal excitability

Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807

Introduction: While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception). Methods: In 15 healthy adults, motor-evoked potentials (MEPs) were ...

Added: April 17, 2026

Inactivation of NONO by Auranofin or RNA Interference Triggers Lethal Oxidative Stress in Neuroblastoma Cells

Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544

Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...

Added: April 15, 2026

Discovery of Novel 1,3,5-Triazine Derivative as Potent Anticancer Agent: DNA and HSA Binding, MTT Assay

Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287

This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...

Added: April 15, 2026

Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers

Silina M., Dzhalilova D., Fokichev N. et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1674608

Humans and laboratory animals differ in their resistance to hypoxia, which affects the severity of inflammatory diseases and the rate of tumor progression. Therefore, it is necessary to search for methods for assessing the initial tolerance to oxygen deficiency and the risks of developing acute mountain sickness without direct hypoxia exposure on the organism. The ...

Added: March 24, 2026

Длительное культивирование макрофагов в коллагеновом геле на мембране (Transwell) индуцирует гипоксию

Ок. Е. Колодеева, Ол. Е. Колодеева, Биотехнология 2025 Т. 41 № 6 С. 64–71

A three-dimensional (3D) matrix consisting of collagen fibers can create culture conditions that are more similar to in vivo tissues than 2D cultures in in vitro culture plates. Macrophages are among the most important innate immune cells. They are extremely plastic, allowing them to respond effectively to pro- and anti-inflammatory signals within their microenvironment. There ...

Added: December 24, 2025

scRNA-seq of preeclamptic trophoblasts identifies EBI3, COL17A1, miR-27a-5p, and miR-193b-5p as hypoxia markers: validation of neuradapt as a superior mimetic to cobalt chloride

Knyazev E., Timur Kulagin, Antipenko I. et al., Placenta 2026 Vol. 176 P. 1–12

Background. Preeclampsia (PE) complicates 2–8% of pregnancies and involves placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Chemical mimetics like cobalt(II) chloride (CoCl2) and oxyquinoline derivatives model trophoblast hypoxia in vitro, yet their fidelity in recapitulating PE gene profiles remains unclear. Integrating patient tissue analyses with experimental models may reveal common markers and ...

Added: December 22, 2025

Comparative Analysis of Lipid Metabolism in Trophoblast Subpopulations in Preeclampsia and In Vitro Hypoxia Model

Antipenko I., Knyazev E., Timur Kulagin et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1731126

Preeclampsia is a leading cause of maternal and perinatal morbidity associated with systemic lipid metabolism disturbances, yet the underlying molecular mechanisms remain incompletely understood. In this study, we integrated single-cell RNA-seq data from preeclamptic placentas with an in vitro hypoxia model to analyze gene expression changes across distinct trophoblast subpopulations. While all trophoblast lineages exhibited ...

Added: December 2, 2025

Профиль микроРНК у женщин с инсомнией в менопаузе: пилотное исследование

Семенова Н. В., Райгородская М. П., Averinskaya D. et al., Бюллетень экспериментальной биологии и медицины 2025 Т. 180 № 7 С. 114–118

The microRNA profile in the blood plasma of menopausal women with insomnia (according to the Pittsburgh Sleep Quality Index questionnaire) was studied in two stages with 15 participants in each and an interval of 12 months. Both stages involved 12 women, and no transition from one group to another was detected in the second stage ...

Added: September 5, 2025

Influence of Microplastics on Manifestations of Experimental Chronic Colitis

Zolotova N., Silina M., Dzhalilova D. et al., - 2025 Vol. 13 No. 8 Article 701

Environmental pollution with microplastics (MPs) can have a negative impact on human health. Certain findings point to the relationship between MP and the development of inflammatory bowel diseases (IBD). We investigated the effect of MP consumption on the severity of chronic colitis in male C57BL/6 mice. The MP effect was modeled by drinking water consumption ...

Added: August 25, 2025