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Chemical Induction of Trophoblast Hypoxia by Cobalt Chloride Leads to Increased Expression of DDIT3
Doklady Biochemistry and Biophysics. 2021. Vol. 499. No. 1. P. 251–256.
Choriocarcinoma cells BeWo b30 are used to model human placental trophoblast hypoxia using cobalt (II) chloride and hydroxyquinoline derivative (HD) as chemical inducers of hypoxia-inducible factor (HIF). In this study, it was shown that both substances activate the hypoxic pathway and the epithelial–mesenchymal transition and inhibit the pathways of cell proliferation. However, CoCl2 caused activation of the apoptosis pathway, increased the activity of effector caspases 3 and 7, and increased the expression of the unfolded protein response target DDIT3. The mTORC1 pathway was activated upon exposition to CoCl2, while HD suppressed this pathway, as it happens during real trophoblast hypoxia. Thus, effect of CoCl2 on BeWo cells can be a model of severe hypoxia with activation of apoptosis, while HD mimics moderate hypoxia.
Priority areas:
IT and mathematics
Language:
English
Ratnikov F., European Physical Journal: Special Topics 2026 P. 1–10
EEG recordings are often affected by the loss or corruption of individual channels due to electrode detachment, poor scalp contact, or external interference. Such channels must be accurately reconstructed before further analysis. In this study, we investigate Next-Generation Reservoir Computing (NG-RC) as a data-driven approach for reconstructing corrupted EEG channels and compare its performance with ...
Added: August 12, 2026
Lucas J., Hebbar P., Ryabov F. et al., / Series 10.64898/2026.07.21.739710 "10.64898/2026.07.21.739710". 2026.
A pangenome reference overcomes the inherent limitation of any individual reference genome by integrating the variation present in a population. We present the Human Pangenome Reference Consortium’s (HPRC) Release 2 (HPRC2), an openly available, second phase pangenome that is an approximately fivefold expansion in genome number over HPRC Release 1 (HPRC1) and measurable improvement in ...
Added: August 10, 2026
Tsydypova M., Современные проблемы дистанционного зондирования Земли из космоса 2026 Т. 23 № 3 С. 263–275
The article presents a methodology for mapping coniferous forest decline, based on the integration of automated remote sensing data interpretation techniques, vegetation indices, remote sensing data on above-ground biomass (Biomass CCI (Climate Change Initiative)), and materials from ground-based forest pathology surveys using forests of the Khamar-Daban ridge (Republic of Buryatia) as a case study. The ...
Added: August 9, 2026
Sandlerskiy R., Elsevier USA, 2026.
Encyclopedia of Ecology, Third Edition, Four Volume Set - with over 300 chapters - once again provides a comprehensive reference work covering the current ideas and practices in ecology.
Ecology is the ideal field for studying complex, adaptive, and self-organizing systems and by observing and understanding ecosystems, it provides valuable insights into creating sustainable systems. This knowledge is ...
Added: August 9, 2026
Dadinova L., Petoukhov M., Mozhaev A. et al., Crystallography Reports 2026 Vol. 71 P. 52–58
Bacterial chromosomes are tightly packed in the cells due to interactions with specific nucleoid-associated proteins. Among them, the IHF protein draws attention due to its presumed influence on intracellular crystallization processes, leading to bacterial resistance to drugs. The crystal structure of the IHF heterodimer is known only in complex with a short DNA fragment, whereas ...
Added: August 6, 2026
Radygina A., Kulikova S., Herald of the Russian Academy of Sciences 2025 Vol. 95 No. 6 P. 963–970
Musical training has a significant impact on brain organization, leading to functional and structural
adaptations that enhance auditory, visual, motor, and cognitive processes. This study investigates how
extensive musical training shapes functional brain connectivity by comparing professional musicians and
non-musicians. Using EEG phase-locking value (PLV) analysis, we examined neural synchronization across
alpha, beta, and gamma frequency ranges during music ...
Added: August 5, 2026
Ponomarenko A., / Series Computer Science "arxiv.org". 2025.
This paper addresses the challenge of merging hierarchical navigable small world (HNSW) graphs, a critical operation for distributed systems, incremental indexing, and database compaction. We propose three algorithms for this task: Naive Graph Merge (NGM), Intra Graph Traversal Merge (IGTM), and Cross Graph Traversal Merge (CGTM). These algorithms differ in their approach to vertex selection ...
Added: July 30, 2026
Mikhaylets E. V., Razorenova A. М., Chernyshev V. L. et al., Scientific Reports 2026 Vol. 16 Article 23560
Meditation offers a naturalistic paradigm for studying introspection, yet the neural dynamics of advanced tantric practices remain largely unexplored. Buddhist Highest Yoga Tantra (BHYT) comprises a sequence of eight dissolution stages culminating in the “clear light” state. We recorded EEG during eyes-closed BHYT meditation performed in monasteries and hermitages (51 sessions from 36 male practitioners; ...
Added: July 29, 2026
Manivelan S. V., Srinivasan S., Thamilmaran K. et al., Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 2026 Vol. 114 No. 1 Article 014217
This study investigates the dynamical origins and statistical properties of extreme events (EEs) in a diffusively coupled theoretical Brusselator system, extending from pairwise interactions to globally coupled networks. Statistically, the emergence of EEs is characterized by heavy-tailed probability density functions and exponential interevent interval distributions, alongside an analysis of the complementary cumulative distribution function and ...
Added: July 15, 2026
Окнина Л. Б., Подлепич В. В., Sieber I. et al., Физиология человека 2026 Т. 52 № 3 С. 5–15
The aim of this study was to evaluate the frequency following response (FFR) for the analysis of the intact perception of syllables in humans. For this purpose, event-related potentials (ERPs) in response to isolated Russian syllables were recorded and analyzed in 29 healthy persons in two frequency ranges, standard (1-40 Hz) and high frequency (70-150 ...
Added: June 30, 2026
Мелешко Е. В., Афанасенко Т. С., Ш. М. Гаджимирзаев et al., Компьютерные исследования и моделирование 2022 Т. 14 № 6 С. 1255–1268
This work contains a description of the results of modeling the process of maintaining the readiness of a section of the road network under strikes of with specified parameters. A one-dimensional section of road up to 40 km long with a total number of strikes up to 100 during the work of the brigade is ...
Added: June 26, 2026
Piontkovski D., / Series arXiv "math". 2026.
A noncommutative projective variety is defined, following Artin and Zhang, by a graded coherent algebra 𝐴. The category of coherent sheaves is then the quotient qgr(𝐴) of the category of finitely presented graded modules by the subcategory of torsion modules. We consider the categorical and polynomial entropies of the Serre twist, that is, of the ...
Added: June 23, 2026
Piontkovski D., / Series arXiv "math". 2025.
If a symmetric multilinear algebra is weakly nil, then it is Engel. This result may be regarded as an infinite-dimensional analogue of the well-known Jacobian theorem, which states that if a polynomial mapping has a polynomial inverse, then its Jacobian matrix is invertible. This refines a theorem of Gerstenhaber and partially answers a question posed ...
Added: June 23, 2026
Ryskina H., Лобаева Т. А., Ануркина А. И., Ваш формат, 2025.
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Эволюция, экология, генетика человека, медицинская паразитология. Практикум. Аннотация
Аннотация к практикуму «Эволюция, экология, генетика человека, медицинская паразитология»
Учебное пособие «Эволюция, экология, генетика человека, медицинская паразитология. Практикум» (авторы: Лобаева Т. А., Рыскина Е. А., Ануркина А. И.; издательство «Ваш формат», 2025 год, 194 страницы) предназначено для студентов высших учебных заведений. Цель практикума — обеспечить комплексное освоение ключевых разделов биологии с акцентом на их прикладное значение в медицине. ...
Added: June 23, 2026
Herbert A., Cherednichenko O., Lybrand T. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 6 Article 2422
The double-stranded RNA editing enzyme ADAR1 connects two forms of genetic programming, one based on codons and the other on flipons. ADAR1 recodes codons in pre-mRNA by deaminating adenosine to form inosine, which is translated as guanosine. ADAR1 also plays essential roles in the immune defense against viruses and cancers by recognizing left-handed Z-DNA and ...
Added: June 22, 2026
Kyrchanova O., Kudryashova K., Ibragimov A. et al., Development 2025 Vol. 152 No. 19 Article dev205051
Drosophila homeotic gene Abdominal-B (Abd-B) is controlled throughout development by four infraabdominal (iab) regulatory domains, the active or repressed state of which is determined by initiators that have parasegment-specific enhancer activity at an early stage of embryonic development. For this reason, it has long been assumed that the enhancer activity and initiation function of these elements are synonymous. ...
Added: June 20, 2026
Kyrchanova O., Ksenia Kudryashova, Dubrovskaya V. et al., Open Biology 2025 Vol. 15 No. 11 Article 250192
The specification of abdominal segments A5 to A9 depends on the expression of Abdominal-B (Abd-B), which is regulated by four infraabdominal domains: iab-5 through iab-8,9. Each iab domain contains an initiation element that determines its active state, along with enhancers responsible for tissue-specific activation of Abd-B. These iab domains function autonomously due to their flanking boundaries, Fab-6, Fab-7 and Fab-8, which both block crosstalk between adjacent iab domains (insulator function) and facilitate long-range ...
Added: June 20, 2026
Kudryashova K.S., Deriglazova I. O., Osadchiy I. S. et al., Genes 2025 Vol. 16 No. 1 Article 3
Background/Objectives: Transcriptional promoters play an essential role in regulating protein expression. Promoters with weak activity generally lead to low levels of expression, resulting in fewer proteins being produced. At the same time, strong promoters are commonly used in studies using transgenic organisms as model systems. This approach can have various negative consequences for the organism, ...
Added: June 20, 2026
Ksenia Kudryashova, Filippova E., Kryukova E. et al., Archives of Biochemistry and Biophysics 2025 Vol. 769 Article 110437
β-Bungarotoxins (β-BuTx), consisting of covalently bound phospholipase A2 subunit (A-chain), a member of group Ia of secretory phospholipases A2, and non-enzymatic subunit (B-chain) structurally related to Kunitz-type protease inhibitors, block presynaptic neuromuscular transmission via a not completely defined mechanism of action. In vivo physiological studies revealed that the B-chain is targeting voltage-gated potassium channels of not identified subtypes. In our work, six β-BuTx isoforms were ...
Added: June 20, 2026
Cherednichenko O., Herbert A., Poptsova M., Computational and Structural Biotechnology Journal 2025 Vol. 27 P. 992–1000
Large language models (LLMs) in genomics have successfully predicted various functional genomic elements. While their performance is typically evaluated using genomic benchmark datasets, it remains unclear which LLM is best suited for specific downstream tasks, particularly for generating whole-genome annotations. Current LLMs in genomics fall into three main categories: transformer-based models, long convolution-based models, and state-space models ...
Added: June 19, 2026
Cherednichenko O., Poptsova M., Briefings in Bioinformatics 2025 Vol. 26 No. 2 Article bbaf129
Kolmogorov–Arnold networks (KANs) emerged as a promising alternative for multilayer perceptrons (MLPs) in dense fully connected networks. Multiple attempts have been made to integrate KANs into various deep learning architectures in the domains of computer vision and natural language processing. Integrating KANs into deep learning models for genomic tasks has not been explored. Here, we ...
Added: June 19, 2026
Aly Ismailov, Spallone A., Belogurov A. et al., Frontiers in Immunology 2025 Vol. 16 Article 1530305
Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal followed by radio- and chemotherapy, the median survival for glioblastoma patients has remained around 18 months for decades. Glioblastoma is distinguished by its highly complex mechanisms of immune evasion ...
Added: June 17, 2026
Madison A., Plandin F., Kuzmina T. et al., Palaeogeography, Palaeoclimatology, Palaeoecology 2026 Vol. 697 Article 113864
Unlike most other brachiopods, craniiforms lack a prominent pedicle, cement to a hard substrate by their ventral valve, and thereby can be easily distinguished in paleontological materials. In this study, we describe a new genus and species from the Porkuni Regional Stage of Northeastern Estonia (Baltica), corresponding to the lower part of the Hirnantian Stage ...
Added: June 15, 2026
Plandin F., Temereva E., Zoological Journal of the Linnean Society 2025 Vol. 205 No. 2 Article zlaf139
Although Brachiopoda represent a relatively small phylum, they exhibit significant morphological diversity. One of the central issues in understanding the evolution of the ancestral brachiopod body plan pertains to the homologies among body compartments across the different brachiopod subphyla: Craniiformea, Linguliformea, and Rhynchonelliformea. In this context, the pedicle stands out as one of the most ...
Added: June 15, 2026