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IsomiRs of hsa-miR-143-3p as regulators of HK2 and SERPINE1 in trophoblast hypoxia and preeclampsia

Doklady Biochemistry and Biophysics. 2026. Vol. 529. No. 1.
O. E. Chebotareva, A. A. Pirogov, I. D. Antipenko, A. T. Magkaev, E. N. Knyazev
In press

Preeclampsia (PE) is a severe obstetric complication caused by chronic placental ischaemia. Genome-wide profiling of microRNA isoforms in two trophoblast hypoxia models (CoCl2 and the oxyquinoline derivative neuradapt, BeWo b30 cells) and clinical PE samples (placental tissue, syncytiotrophoblast vesicles) revealed concordant downregulation of hsa-miR-143-3p isoforms. Under a strict fold-change threshold, the canonical isoform (21 nt) and uridylated miR-143-3p|0|−1(+1U) (21 nt) were downregulated across all conditions, and applying padj < 0.05 alone additionally identified miR-143-3p|0|+1 (22 nt) and miR-143-3p|0|0(+1U) (22 nt). Upregulation of direct targets SERPINE1 and HK2 and glycolytic genes LDHA, GAPDH, and PKM was observed in all conditions. TUT4 overexpression combined with DICER1 downregulation indicates systemic dysregulation of microRNA biogenesis. Downregulation of miR-143-3p isoforms represents a universal hypoxic signal in trophoblasts driving glycolytic reprogramming in PE.

Research target: Biology Medical Biotechnologies Basic Medicine
Language: English
Keywords: микроРНКгипоксияПреэклампсияhypoxiamicroRNAspre-eclampsiahsa-miR-143-3pSERPINE1hexokinase-2hsa-miR‐143-3pSERPINE1гексокиназа‐2
Publication based on the results of:
Microfluidic models (2025)
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