АКАДЕЗИН ВЫЗЫВАЕТ НЕАПОПТОТИЧЕСКУЮ ГИБЕЛЬ ОПУХОЛЕВЫХ КЛЕТОК

Глазунова В.А.; Лобанов К. В.; Шакулов Р. С.; Миронов А. С.; Штиль А. А.

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АКАДЕЗИН ВЫЗЫВАЕТ НЕАПОПТОТИЧЕСКУЮ ГИБЕЛЬ ОПУХОЛЕВЫХ КЛЕТОК

Acta Naturae. 2013. Т. 5. № 3. С. 78–82.

Глазунова В.А., Лобанов К. В., Шакулов Р. С., Миронов А. С., Штиль А. А.

We studied the cytotoxicity of acadesine (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) for tumor and normal cells of various species and tissue origin. In tumor cells, acadesine triggered non-apoptotic death; the potency of the compound to normal cells was substantially lower. Acadesine was toxic for tumor cells with multidrug resistant phenotypes caused by the transmembrane transporter P-glycoprotein or lack of proapoptotic p53. Activity of adenosine receptors was required for acadesine-induced cell death, whereas functioning of AMP-dependent protein kinase was not required. A more pronounced cytotoxicity for tumor cells, as well as the non-canonical death mechanism(s), makes acadesine a promising candidate for antitumor therapy.

Research target: Basic Medicine Health Studies Earth Sciences Biology

Language: Russian

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Keywords: Tumor cells гибель клеток опухолевые клетки acadesine cell death акадезин

Field survey of the 2025 Kamchatsk Tsunami on coasts of the Northern Kurilis, Russia (2d Kuril Strait).

Kotenko M., Zaytsev A. I., Pelinovsky E., Pure and Applied Geophysics 2026 Vol. 183 No. 6 P. 2681–2695

On July 29, 2025, a strong earthquake near Kamchatka (Russia) generated a tsunami that spread across the entire Pacific Ocean. The tsunami had its strongest impact on the coast of the North Kuril Islands (Paramushir and Shumshu), causing significant destruction. During the first days after the earthquake, a field survey of tsunami traces on these islands was conducted in the area ...

Added: August 3, 2026

Reach: Recognising episodes of acute complexity in health: a predictive older patient prioritisation machine learning model.

Maghsoohi A., Pavlov V., Rouse P. et al., Health Care Management Science 2026 Vol. 29 No. 37

As the numbers of older people (65 +) rise globally, the pressure on acute hospitals to provide efficient and effective care while addressing resource inequities increases. In this study we introduce Recognising Episodes of Acute Complexity in Health (REACH), a novel Automatic Machine Learning (AutoML)-based predictive model that prioritises older patients and assigns them to complex ...

Added: July 30, 2026

EEG evidence for reproducible neural states during Buddhist Highest Yoga Tantra meditation

Mikhaylets E. V., Razorenova A. М., Chernyshev V. L. et al., Scientific Reports 2026 Vol. 16 Article 23560

Meditation offers a naturalistic paradigm for studying introspection, yet the neural dynamics of advanced tantric practices remain largely unexplored. Buddhist Highest Yoga Tantra (BHYT) comprises a sequence of eight dissolution stages culminating in the “clear light” state. We recorded EEG during eyes-closed BHYT meditation performed in monasteries and hermitages (51 sessions from 36 male practitioners; ...

Added: July 29, 2026

Global, regional, and national burden of road injuries 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Vlassov V., van der Lubbe S. C., Moberg M. E. et al., The Lancet Public Health 2026 P. 1–6

Background Road injuries are a leading cause of mortality and morbidity worldwide. Years of international efforts have aimed to strengthen policy engagement, including the 2020 UN General Assembly's proclamation of the Second Decade of Action for Road Safety (2021–30), targeting a 50% reduction in road traffic deaths and serious injuries by 2030. The aim of this ...

Added: July 25, 2026

Whole-canopy net ecosystem exchange and water use efficiency in an intermittent-light environment -- dynamic approach

Kivalov S., Legacy Theses & Dissertations (2009 - 2024), 2024.

An observed 20-30% increase in forest net ecosystem exchange (NEE) on partly cloudy days is often attributed to there being more uniform canopy illumination by diffuse radiation when clouds are present. However, the sky on such days is typically populated by fair-weather cumulus clouds, bringing dynamically changing shadow-to-light conditions on the order of minutes to ...

Added: July 24, 2026

Система здравоохранения России: что можно изменить уже сегодня. Идеи и предложения. 2-е издание, переработанное и дополненное

Авксентьева М. В., Ашихмин Я. И., Ашихмина О. В. et al., М.: ФГБУ "Издательство "Наука", 2023.

Предложены основные направления совершенствования планирования, организации и оплаты медицинской помощи, лекарственного обеспечения, информатизации и оценки технологий здравоохранения. Рекомендованы такие мероприятия, как конкретизация программы государственных гарантий бесплатного оказания гражданам медицинской помощи, создание системы общедоступного лекарственного обеспечения, использование клинико-статистических групп для оплаты медицинской помощи при ряде хронических неинфекционных заболеваний в амбулаторных условиях, формирование механизма привлечения соплатежей при ...

Added: July 16, 2026

Клиническая и экономическая оценка эффективности современных стратегий скрининга и ранней диагностики рака шейки матки в Российской Федерации

Михайлов И. А., Опухоли женской репродуктивной системы 2025 Т. 21 № 1 С. 86–105

Цель исследования – определить наиболее целесообразную стратегию скрининга и ранней диагностики рака шейки матки (РШМ) в Российской Федерации с точки зрения клинической (диагностической) и экономической эффективности. Материалы и методы. Для оценки клинической (диагностической) эффективности различных стратегий скрининга проведен систематический обзор публикаций об исследованиях, оценивающих эффективность применения цитологического исследования и тестирования на вирус папилломы человека (ВПЧ) с целью диагностики ...

Added: July 16, 2026

Телемедицинские консультации в детской онкологии – гематологии: современный взгляд на актуальность, проблемы и их решения при оказании профильной медицинской помощи

Иванова А. А., Коган С. А., Горбунова Т. В. et al., Менеджер здравоохранения 2026 № 3 С. 96–105

The research r elev anc e is determined by the demand for telemedicine consultations (TMC) as one of health care digitalization pathways in Russian Federation. Telemedicine, regardless of the field, continues to prove its significant role, saving health resources without losing medical care quality. The TMC is regulated by federal level framework. Each year the ...

Added: July 16, 2026

WSI-GT: Pseudo-Label Guided Graph Transformer for Whole-Slide Histology

Михайлов И. А., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8

Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...

Added: July 16, 2026

Оценка социальных эффектов от внедрения системы организационных мероприятий для совершенствования оказания медицинской помощи при онкологических заболеваниях на региональном уровне в субъектах Центрального федерального округа

Хайлова Ж. В., Омельяновский В. В., Михайлов И. А. et al., Менеджер здравоохранения 2026 № 4 С. 41–52

The urgency of the problem of organizing effective medical care for cancer patients is determined by the steady trend of increasing incidence of malignant neoplasms, the high proportion of this pathology in the structure of overall mortality, as well as significant medical, demographic and socio-economic losses for society.Purpose of the st udy is to conduct ...

Added: July 16, 2026

Социологическое исследование влияния комплекса организационных мероприятий по внедрению инновационных медицинских технологий в многопрофильном стационаре на качество жизни пациентов

Михайлов И. А., Здоровье мегаполиса 2026 Т. 7 № 2 С. 7–16

Objective. To evaluate the impact of a series of organizational measures for implementing innovative medical technology in a multidisciplinary hospital on patient quality of life based on patient self-assessments. Results. Patients who received care using innovative medical technology within a systemic organizational approach demonstrated a significantly higher level of overall satisfaction with the quality of care. ...

Added: July 16, 2026

Международные подходы к оценке сложности труда специалистов с высшим медицинским образованием (врачей) разных специальностей

Ахапкина Е. С., Омельяновский В. В., Тулупова О. Н. et al., Медицинские технологии. Оценка и выбор 2026 Т. 48 № 2 С. 70–77

OBJECTIVE To analyze international approaches to assessing the labor complexity for different specialists with higher medical education (physicians). MATERIAL AND METHODS We performed a systematic searching and content analysis of foreign and national studies and documents devoted to labor complexity of different specialists with higher medical education (doctors). A group of experts among the authors of this study discussed and identified significant factors in assessing complexity. RESULTS There are 2 main systems to assess physician workload complexity in foreign countries. The first approach is based ...

Added: July 16, 2026

Phase-1 study of vamotinib (PF-114), a 3rd generation BCR::ABL1 tyrosine kinase-inhibitor, in chronic myeloid leukaemia

Михайлов И. А., Annals of Hematology 2025 Vol. 104 P. 2707–2715

Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...

Added: July 16, 2026

Shared environment, shared mechanisms: comparing pathways to mental health outcomes among indigenous youth and youth with other ethnic backgrounds

Arina Bukina, Eritsyan K., Antonova N. et al., Frontiers in Psychology 2026 Vol. 17 Article 1824428

Background: Numerous studies have shown that indigenous populations experience poorer health outcomes compared to people with other backgrounds. However, the interpretation of these disparities remains challenging due to differences in living conditions and social environments, as well as by potential measurement-related biases. Little is known about whether the underlying mechanisms of mental health outcomes differ between ...

Added: July 15, 2026

Ecological Assessment of Temperature's Influence on CO2 Efflux from Lawn Soils in Case of Its Pronounced Dynamics

Stepanov A., Kivalov Sergey N., Vasenev I., Sustainability 2026 Vol. 18 No. 13 Article 6879

The carried-out microfield model research was aimed at identifying patterns in the dynamics of soil CO2 effluxes depending on the locally occurring hydrothermal regimes of regenerated lawn ecosystems on peat-sand substrates with different peat contents. Monitoring was carried out every ten days from 21 April 2019 to 30 October 2019 and included measurements of soil ...

Added: July 8, 2026

Global, regional, and national burden of tuberculosis and multidrug-resistant tuberculosis by HIV status, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Ledesma J. R., Zhang M., Liew M. F. et al., The Lancet Infectious Diseases 2026 P. 1–12

Background Tuberculosis (TB) is the leading global cause of death from a single infectious agent. Recent reductions in global health funding have threatened TB control, making comprehensive assessment of TB, HIV-related TB, and drug-resistant TB burdens before these disruptions essential for shaping effective responses. The WHO End TB Strategy sets targets of a 95% reduction in ...

Added: July 7, 2026

Особенности потенциала, следующего за частотой, зарегистрированного в ответ на изменения в параметрах звучания речевого сигнала (изолированного слога)

Окнина Л. Б., Подлепич В. В., Sieber I. et al., Физиология человека 2026 Т. 52 № 3 С. 5–15

The aim of this study was to evaluate the frequency following response (FFR) for the analysis of the intact perception of syllables in humans. For this purpose, event-related potentials (ERPs) in response to isolated Russian syllables were recorded and analyzed in 29 healthy persons in two frequency ranges, standard (1-40 Hz) and high frequency (70-150 ...

Added: June 30, 2026

Socioeconomic development, longevity and prevalence of obesity and overweight: The retrospective longitudinal analysis of international data

Liapin G., Vlassov V., DIALOGUES IN HEALTH 2026 Vol. 8 Article 100317

Objectives Due to the economic growth at the end of the 20th century, people in low-income countries live longer but still spend most of their income on food. These countries, as well as affluent countries, demonstrate a rising prevalence of obesity. The interplay of longevity and obesity at different levels of economic development is not clear. Methods We ...

Added: June 29, 2026

Rapid synthesis of redox-responsive trithiocyanuric acid-based nanocarriers: in vitro multidrug resistance reversal and In vivo safety assessment

Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16

Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...

Added: April 20, 2026

Discovery of Novel 1,3,5-Triazine Derivative as Potent Anticancer Agent: DNA and HSA Binding, MTT Assay

Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287

This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...

Added: April 15, 2026

The Complex of Copper (II) and Zoledronic Acid: Relevance to Oxidative Death of Leukemia Cells in the Bone Marrow

Barskaya E. S., Savin A. M., Chernov K. V. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 6 Article 2800

Copper–organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the ...

Added: April 15, 2026

Z-RNA and the Flipside of the SARS Nsp13 Helicase: Is There a Role for Flipons in Coronavirus-Induced Pathology?

Herbert A., Poptsova M., Frontiers in Immunology 2022 Vol. 13 Article 912717

We present evidence suggesting that the severe acute respiratory syndrome (SARS) coronavirus non-structural protein 13 (Nsp13) modulates the Z-RNA dependent regulated cell death pathways. We show that Z-prone sequences [called flipons] exist in coronavirus and provide a signature (Z-sig) that enables identification of the animal viruses from which the human pathogens arose. We also identify ...

Added: October 31, 2022

Effect of low molecular weight chitosan on cells of epidermis from pea leaves

Kiselevsky D. B., Shagdarova B. T., Varlamov V. P. et al., Moscow University Biological Sciences Bulletin 2021 Vol. 76 No. 1 P. 14–19

The effect of low molecular weight chitosans with a molecular weight (MW) of 5, 6, 10, 25, and 45 kDa and a deacetylation degree (DD) of 85–99% obtained by chemical depolymerization and enzymatic hydrolysis on the cells of the epidermis of pea leaves was analyzed. Low molecular weight chitosans induced damage to guard cells' plasma membrane, ...

Added: October 14, 2022

Synthesis and cytotoxic potency of novel tris(1-alkylindol-3-yl)methylium salts: Role of N-alkyl substituents

Lavrenov S. N., Luzikov Y. N., Bykov E. E. et al., Bioorganic and Medicinal Chemistry 2010 Vol. 18 No. 18 P. 6905–6913

Novel derivatives of tris(indol-3-yl)methane and tris(indol-3-yl)methylium salts with the alkyl substituents at the N-atoms of the indole rings were synthesized. An easy substitution of indole rings in trisindolylmethanes for other indoles under the action of acids is demonstrated, and the mechanism of substitution is discussed. To obtain trisindolylmethylium salts, the environmentally safe method of oxidation ...

Added: July 14, 2015