Molecular basis of COVID-19 pathogenesis
The review summarizes studies of chemical and biological processes occurring in human body
upon exposure to coronaviruses, in particular SARS-CoV-2. The mechanisms of viral particles
penetration into the cell and their replication, impact on the immune system and oxygen transport
systems are considered. The mechanisms of complications occurring as a consequence of viral
infection - vasculitis, thrombosis, cytokine storm and lung fibrosis are discussed. The review
also includes data on the latest research in the field of small molecule medication to counteract
the virus. Molecular targets and possible vectors of exploiting them are considered.
The review is written primarily for specialists who want to understand the chains of activation,
replication, actions and methods of protection/inhibition of SARS-CoV-2. Due to the short
period of such studies, the data on complexes of small molecule compounds and possible protein
targets are not numerous, but they will be useful in search and synthesis of new potentially
The global economy passes the COVID-19 related crises. For various projections, the output fall in Russia in 2020 will vary from 2 to 8 percent. So, in comparison with the crises of 1998 and 2008, the current shock can be more severe. In the upcoming years the Russian economy will pass the recovery stage, approaching the new balanced growth path. What proximate sources would push this growth?
With the neoclassical industry growth accounting and the Russia KLEMS dataset the present report aims to shed light on this, considering the growth patterns and sources of growth after the crises of 1998 and 2008. The report unveils the most important sources of the after-2008 stagnation in Russia, which are the decreasing efficiency of the extended oil and gas sector and the suspension of technology convergence. Since the recovery in Russia will be, most probably, caused by the increasing demand on energy and raw materials, driven by the recovery of global markets, policy implications for Russia should include efforts to improve efficiency in such export-oriented sectors, as oil and gas, and efforts, which aim to boost technology convergence such as backing export-oriented firms, which have been integrated to global value chains.
This work contains an express answer to four questions about what happened in the higher education system at the very beginning of the introduction of quarantine measures: (1) how have universities and the states reacted worldwide? (2) what are the reaction of Russian universities? (3) how do students and teachers perceive the situation? (4) Is there enough infrastructure to implement quarantine measures of remote work and training?
Most of the analytics were collected on an initiative basis, but the most important sections were written on the basis of data collected within the working group of the Russian Ministry of Education and Science to organize educational activities in the context of preventing the spread of COVID-19 infection in the Russian Federation under the leadership of the Department of Youth Policy (in terms of sociological student survey) and the Department of Information Technology in the field of science and higher education (in terms of monitoring infrastructure and opportunities Translation courses in distance learning). Data collection and analysis would not have been possible without cooperation with MIREA, as well as representatives of ITMO University, Ural Federal University, Tomsk State University and support from Mail.ru Group and the Association of Volunteer Centers.
The publication, prepared by experts from the Institute of Education at the Higher School of Economics and the World Bank, provides a comprehensive assessment of possible losses for school education and human capital in connection with the COVID-19 pandemic, as well as possible ways to minimize and compensate them.
The publication includes three sections. The first section, based on data (quasi-experimental studies of the effects of school closures due to cataclysms, non-attendance by individual students of schools, studies of losses during the summer break), discusses the hypotheses about the extent of possible losses in student knowledge in the conditions of termination of full-time education. The second section is devoted to the analysis of three scenarios in connection with a pandemic and the forecasting of changes in the learning curve of schoolchildren. The third section examines the longer-term effects of the current crisis on the future earnings of current students and the overall economic situation.
The publication includes practical recommendations and suggestions on educational policy measures that can be implemented to minimize and compensate for the negative impact of the pandemic.
This work is of interest, both for researchers in the field of school education, and for leaders of the educational system at different levels, principals and teachers of schools.
The Arctic Council is well-positioned to play a leadership role in better understanding the impact of Covid-19 in the Arctic and spearheading activities to respond to the pandemic in the short-, medium- and longer-term. This briefing document was prepared to inform initial discussions regarding the coronavirus pandemic in the Arctic at the Senior Arctic Officials’ executive meeting (SAOX) on 24-25 June 2020. It draws together available information – to date (June 2020) – about the impact of Covid-19 in the Arctic: Briefing Document for SAOs June 2020 For public release Page 10 of 83 Covid-19 and the actions taken to respond in the Arctic region. The document draws from a wide spectrum of sources, reflecting the complex and intricate nature of how Covid-19 affects Arctic peoples and communities, including national and subnational statistical databases and tools, peer-reviewed articles, policy statements, technical guidelines, field surveys, and local observations from Arctic communities.
All world upward trends and cycles have a lot in common while crises significantly differ. In the case of this research the recession was sparked not by the shock of financial sector but by the restrictions imposed on consumption that previously was not inclined to fluctuate that much. Oil price shock has increased negative influence on the world energy market and economy overall. The decline in employment and personal consumption has struck more on most vulnerable social classes but the decreased volume of demand can be also attributed to the wealth (catering, tourism and others). Once began, the recession develops by its own rules — a sharp fall in the world trade, fixed capital formation, growth of budget deficits, and particularly strong impact on developing countries most dependent on tourism and financial assistance.
Keywords: pandemic, coronavirus, COVID-19, business cycle, social inequality, personal consumption, capital formation, finance.
JEL: A14, D11, F02, T32.
On April 21, 2020, the Presidium of the Supreme Court of the Russian Federation issued an “Overview of selected issues of judicial practice, related to the application of legislation and measures to stop the spread of the coronavirus infection (COVID-19) on the territory of the Russian Federation No. 1” (the “Overview”).
This Overview sets out a number of important clarifications on the practical application of recent legislative developments as well as recent COVID-19 related measures to dispute resolution, contract performance, creditors’ rights, the imposition of criminal liability for spreading fake news on COVID-19 and on administrative liability for the violation of sanitary rules and protective measures. We set forth herein a number of clarifications affecting contract performance and dispute resolution.
Data management and analysis is one of the fastest growing and most challenging areas of research and development in both academia and industry. Numerous types of applications and services have been studied and re-examined in this field resulting in this edited volume which includes chapters on effective approaches for dealing with the inherent complexity within data management and analysis. This edited volume contains practical case studies, and will appeal to students, researchers and professionals working in data management and analysis in the business, education, healthcare, and bioinformatics areas.
This prototype development explains the challenges encountered during the ISO/IEEE 11073 standard implementation process. The complexity of the standard and the consequent heavy requirements, which have not encouraged software engineers to adopt the standard. The developing complexity evaluation drives us to propose two possible implementation strategies that cover almost all possible use cases and eases handling the standard by non-expert users. The first one is focused on medical devices (MD) and proposes a low-memory and low-processor usage technique. It is based on message patterns that allow simple functions to generate ISO/IEEE 11073 messages and to process them easily. MD act as X73 agent. Second one is focused on more powerful device X73 manager, which do not have the MDs' memory and processor usage constraints. The protocol between Agent and Manager is point-to-point and we can distribute the functionality between devices.
Developed both implementation X73 Agent and Manager will cut developing time for applications based on ISO/EEE 11073.
In the internal medicine wide spectrum the gastroenterology is one of the chapters, less enlightened by the scientific evidence. It does not mean that the practice of the grasntroenterology may ot be improved by the systematic use of the approaches of the evidence based medicine