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Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria
BMC Genomics. 2022. Vol. 23. Article 558.
German A. Ashniev, Sernova N., Shevkoplias A., Rodionov I., Rodionova I., Vitreschak A., Gelfand M., Rodionov D.
The histidine metabolism and transport (his) genes are controlled by a variety of RNA-dependent regulatory systems among diverse taxonomic groups of bacteria including T-box riboswitches in Firmicutes and Actinobacteria and RNA attenuators in Proteobacteria. Using a comparative genomic approach, we previously identified a novel DNA-binding transcription factor (named HisR) that controls the histidine metabolism genes in diverse Gram-positive bacteria from the Firmicutes phylum.
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Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39
Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data
Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity.
Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined
everywhere. In 2015, in Russia experimental ...
Added: October 13, 2026
Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195
Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...
Added: October 11, 2026
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Shishkin S., Almazov A., Vlassov V. et al., Электронный научный журнал "Социальные аспекты здоровья населения" 2026 Т. 72 № 4 Статья 4
Abstract
Significance. The epidemiological, clinical, and socioeconomic effects of healthcare digitalization are actively discussed in the scientific literature. Less attention has been paid to changes in the organization of healthcare resulting from the introduction of digital technologies. These changes have not been the subject of specific research. However, digital technologies is becoming a driver for the ...
Added: September 29, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
ARUTYUNOV G. P., TARLOVSKAYA E. I., POLYAKOV D. S. et al., Heliyon 2024 Vol. 10 No. 7 Article e28892
The aim of this study is to investigate the course of the acute period of COVID-19 and devise a prognostic scale for patients hospitalized.
Materials and methods
The ACTIV registry encompassed both male and female patients aged 18 years and above, who were diagnosed with COVID-19 and subsequently hospitalized. Between June 2020 and March 2021, a total ...
Added: September 28, 2026
АРУТЮНОВ Г. П., ТАРЛОВСКАЯ Е. И., БАТЛУК Т. И. et al., Российский кардиологический журнал 2025 Т. 30 № 10 С. 111–120
The use of beta-blockers (BB) plays a crucial role in the treatment of cardiovascular diseases. However, there are significant discrepancies with current guidelines in real-world practice. The main issues related to suboptimal dosing regimens and poor medication adherence reduce the effectiveness of therapy and worsen the prognosis of patients. Under the auspices of the Eurasian ...
Added: September 28, 2026
АРУТЮНОВ Г. П., БАТЛУК Т. И., БАШКИНОВ Р. А. et al., Клиническая медицина 2025 Т. 103 № 4 С. 309–313
Recurrent Pericarditis (RP) is a significant medical issue despite advancements in modern cardiology. The management of patients with this condition is associated with several challenges due to the variety of clinical manifestations, difficulties in differential diagnosis, lack of standardized treatment protocols, and a high likelihood of recurrences. Furthermore, there is insufficient data in the literature ...
Added: September 28, 2026
Ugleva A. V., Социологическое обозрение 2026 Т. 25 № 3 С. 268–293
This article undertakes a socio-philosophical analysis of a situation in which the place of the Other within the structure of subjective experience is occupied by an algorithmic agent – an entity that simulates understanding yet remains devoid of genuine subjectivity. To investigate this configuration, the author turns to psychiatric practice as a representative case study: ...
Added: September 26, 2026
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324
Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...
Added: September 23, 2026
Hebbar P., Ryabov F., Alexandrov I. et al., Cell 2026 Vol. 189 P. 4891–4908.e12
The common marmoset is a New World monkey widely used to study primate evolution and human disease. We present a telomere-to-telomere (T2T) reference assembly for the species, plus three near-T2T haplotypes. These resolve previously inaccessible regions, including the centromeres, sex chromosomes, subterminal satellites, acrocentric chromosomes, and the major histocompatibility complex (MHC). We find marmoset centromeres ...
Added: September 23, 2026
Sharko F., Mazloum A., Krotova A. et al., Frontiers in Veterinary Science 2024 Vol. 11 Article 1321202
It has been recognized that capripoxvirus infections have a strong cutaneous tropism with the manifestation of skin lesions in the form of nodules and scabs in the respective hosts, followed by necrosis and sloughing off. Considering that the skin microbiota is a complex community of commensal bacteria, fungi and viruses that are influenced by infections ...
Added: August 25, 2025
Fishman V., Kuratov Y., Shmelev A. et al., Nucleic Acids Research 2025 Vol. 53 No. 2 Article gkae1310
Recent advancements in genomics, propelled by artificial intelligence, have unlocked unprecedented capabilities in interpreting genomic sequences, mitigating the need for exhaustive experimental analysis of complex, intertwined molecular processes inherent in DNA function. A significant challenge, however, resides in accurately decoding genomic sequences, which inherently involves comprehending rich contextual information dispersed across thousands of nucleotides. To ...
Added: August 1, 2025
German A. Ashniev, Petrov S., Iablokov S. et al., Microorganisms 2022 Vol. 10 No. 4 Article 740
The human gut microbiota (HGM) have an impact on host health and disease. Amino acids are building blocks of proteins and peptides, also serving as precursors of many essential metabolites including nucleotides, cofactors, etc. Many HGM community members are unable to synthesize some amino acids (auxotrophs), while other members possess complete biosynthetic pathways for these ...
Added: January 31, 2023
Garushyants S., Beliavskaia A., Malko D. et al., Frontiers in Microbiology 2018 Vol. 9 Article 738
While most endosymbiotic bacteria are transmitted only vertically, Holospora spp., an alphaproteobacterium from the Rickettsiales order, can desert its host and invade a new one. All bacteria from the genus Holospora are intranuclear symbionts of ciliates Paramecium spp. with strict species and nuclear specificity. Comparative metabolic reconstruction based on the newly sequenced genome of Holospora ...
Added: December 16, 2021
Granata I., Manzo M., Kusumastuti A. et al., Current Medicinal Chemistry 2021 Vol. 28 No. 32 P. 6619–6653
Purpose: Systems biology and network modeling represent, nowadays, the hallmark approaches for the development of predictive and targeted-treatment based precision medicine. The study of health and disease as properties of the human body system allows the understanding of the genotype-phenotype relationship through the definition of molecular interactions and dependencies. In this scenario, metabolism plays a ...
Added: August 25, 2021
Manipur I., Granata I., Maddalena L. et al., BMC Bioinformatics 2020 Vol. 21 No. 10 P. 349
Background: Biological networks are representative of the diverse molecular interactions that occur within cells. Some of the commonly studied biological networks are modeled through protein-protein interactions, gene regulatory, and metabolic pathways. Among these, metabolic networks are probably the most studied, as they directly influence all physiological processes. Exploration of biochemical pathways using multigraph representation is ...
Added: November 22, 2020
Granata I., Guarracino M., Kalyagin V. A. et al., , in: Proceedings 2018 IEEE International Conference on Bioinformatics and Biomedicine.: Madrid: IEEE, 2018. P. 2688–2693.
Networks represent a convenient model for many scientific and technological problems. From power grids to biological processes and functions, from financial networks to chemical compounds, the representation of case studies with graphs enables the possibility to highlight both topological and qualitative characteristics. In this work, we are interested in the supervised classification models for data ...
Added: November 24, 2019
Granata I., Guarracino M., Kalyagin V. A. et al., Annals of Mathematics and Artificial Intelligence 2020 Vol. 88 P. 91–104
Many real applications require the representation of complex entities and their relations. Frequently, networks are the chosen data structures, due to their ability to highlight topological and qualitative characteristics. In this work, we are interested in supervised classification models for data in the form of networks. Given two or more classes whose members are networks, ...
Added: November 24, 2019
Gelfand M. S., Scientific Reports 2018 Vol. 8 No. 1 P. 1–12
Comparative genomics analysis of conserved gene cassettes demonstrated resemblance between a recently described cassette of genes involved in sulphoquinovose degradation in Escherichia coli K-12 MG1655 and a Bacilli cassette linked with lactose degradation. Six genes from both cassettes had similar functions related to carbohydrate metabolism, namely, hydrolase, aldolase, kinase, isomerase, transporter, and transcription factor. The ...
Added: March 17, 2019