, , , Саратовский научно-медицинский журнал 2022 Т. 18 № 1 С. 112-117
Objective: to study the influence of various kinds of kinesiotherapy on the formation of motor skills in children with ASD, as well as the influence of motor activity on social interaction, communication abilities, stereotypical behavior based on the analysis of published scientific data. A search was made for studies in the scientific databases MEDLINE® (Ovid), ...
Added: December 1, 2022
On the peptide binding affinity changes in population-specific HLA repertoires to the SARS-CoV-2 variants Delta and Omicron
, Tonevitsky A., Journal of Autoimmunity 2022 Vol. 133 Article 102952
Objective To investigate the changes of Spike protein-HLA binding affinity profiles between the Wuhan strain and two dominant variants, the Delta and the Omicron strains, among the Taiwanese, the British and the Russian populations. Methods The HLA frequencies and the HLA-peptide binding affinity profiles in the T-CoV database were combined to conduct the study. We focused on the ...
Added: November 22, 2022
Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2
The ongoing COVID-19 pandemic calls for more effective diagnostic tools. T cell response assessment serves as an independent indicator of prior COVID-19 exposure while also contributing to a more comprehensive characterization of SARS-CoV-2 immunity. In this study, we systematically assessed the immunogenicity of 118 epitopes with immune cells collected from multiple cohorts of vaccinated, convalescent, ...
Added: November 21, 2022
Автоматизация анализа рентгенограмм позвоночника для объективизации оценки степени тяжести сколиотической деформации при идиопатическом сколиозе (предварительное сообщение)
, Ортопедия, травматология и восстановительная хирургия детского возраста 2020 Т. 8 № 3 С. 317-326
Background. A large number of studies have focused on automating the process of measuring the Cobb angle. Although there is no practical tool to assist doctors with estimating the severity of the curvature of the spine and determine the best suitable treatment type.Aim. We aimed to examine the algorithms used for distinguishing vertebral column, vertebrae, ...
Added: November 18, 2022
Кластеризация шумов как способ оценки функции постоянного сосудистого доступа у больных на гемодиализе
Gromov V., , et al., Вестник СурГУ. Медицина 2022 Т. 51 № 1 С. 25-30
Abstract. The study aims to develop an algorithm for assessing spectrographic features of arteriovenous fistula dysfunction for hemodialysis. Materials and methods. Forty-four patients with native radiocephalic fistula formed in the distal third of the forearm participated in the research. Using electronic stethoscope, the noise of arteriovenous fistula was recorded in all patients. 653 spectrograms were analyzed with the ...
Added: November 14, 2022
, , et al., Neuro-Oncology Practice 2022 Vol. 9 No. 4 P. 328-337
Background. People with gliomas need specialized neurosurgical, neuro-oncological, psycho-oncological, and neuropsychological care. The role of language and cognitive recovery and rehabilitation in patients’ well-being and resumption of work is crucial, but there are no clear guidelines for the ideal timing and char- acter of assessments and interventions.The goal of the present work was to describe representative ...
Added: October 25, 2022
Epileptogenic high-frequency oscillations present larger amplitude both in mesial temporal and neocortical regions
Karpychev V., , et al., Frontiers in Human Neuroscience 2022 No. 16 Article 984306
High-frequency oscillations (HFO) are a promising biomarker for the identification of epileptogenic tissue. While HFO rates have been shown to predict seizure outcome, it is not yet clear whether their morphological features might improve this prediction. We validated HFO rates against seizure outcome and delineated the distribution of HFO morphological features. We collected stereo-EEG recordings ...
Added: October 1, 2022
The prevalence of cognitive impairment and their association with socioeconomic, demographic and anthropometric factors and geriatric syndromes in people over 65 years of age: data from the Russian epidemiological study EVKALIPT
, , et al., Nevrologiya, Neiropsikhiatriya, Psikhosomatika 2022 Vol. 14 No. 3 P. 44-53
Cognitive dysfunction is one of the most common disorders in the elderly and senile age. There are currently 57 million people with dementia worldwide. Objective: to assess cognitive functions, to understand the prevalence of cognitive impairment (CI) and to analyze their associations with socioeconomic, demographic and anthropometric factors and geriatric syndromes in people aged ≥65 years. Patients and ...
Added: June 28, 2022
Особенности глазодвигательных реакций как маркеры нарушений когнитивного контроля у пациентов с обсессивно-компульсивным расстройством (обзор)
Multiple studies in patients with obsessive-compulsive disorder (OCD) became the basis for revealing selective attention, inhibitory control, and working memory impairments, which correlates with an imbalance in the activity of the cortico-striatal-thalamic-cortical circuit associated with maintenance of cognitive control functions. Patients with OCD often demonstrate changes in the parameters of target-oriented eye movement reactions being ...
Added: May 31, 2022
Распространенность анемии и ее ассоциации с другими гериатрическими синдромами у лиц старше 65 лет: данные российского эпидемиологического исследования ЭВКАЛИПТ
, , et al., Терапевтический архив 2022 Т. 94 № 1 С. 24-31
Background. A low hemoglobin level in older adults impairs cognitive ability and functional status and associates with risk of falls and fractures, sarcopenia, malnutrition, depression, frailty, and decreased autonomy. Epidemiological data on the anemia prevalence in the geriatric population in our country is not available. Aim. To assess the prevalence of anemia and analyze its associations ...
Added: March 18, 2022
Abstract Objective. Brain–computer interfaces (BCIs) decode information from neural activity and send it to external devices. The use of Deep Learning approaches for decoding allows for automatic feature engineering within the specific decoding task. Physiologically plausible interpretation of the network parameters ensures the robustness of the learned decision rules and opens the exciting opportunity for automatic knowledge ...
Added: January 24, 2022
GATA1 mutation analysis and molecular landscape characterization in acute myeloid leukemia with trisomy 21 in pediatric patients
, , International Journal of Laboratory Hematology 2021 Vol. 43 No. 4
Introduction: Accurate detection of GATA1 mutation is highly significant in patients with acute myeloid leukemia (AML) and trisomy 21 as it allows optimization of clinical protocol. This study was aimed at (a) enhanced search for GATA1 mutations; and (b) characterization of molecular landscapes for such conditions. Methods: The DNA samples from 44 patients with ...
Added: December 21, 2021
Grain-based dietary background impairs restoration of blood flow and skeletal muscle during hindlimb ischemia in comparison with low-fat and high-fat diets
, , et al., FRONTIERS IN NUTRITION 2022 No. 8 Article 809732
Background: Among vascular pathologies associated with obesity peripheral artery disease (PAD) occupies the important position. In clinical practice nutritional interventions are recommended for PAD patients. In this study we investigate how the different dietary backgrounds affect the regeneration rate of ischemic hindlimb in mice. Methods: Male C57BL/6J mice were housed on three types of diet: low-fat ...
Added: December 20, 2021
Обзор психофизиологических и психотерапевтических исследований стресса с помощью технологий виртуальной реальности
Kosonogov V., Efimov K., Rakhmankulova Z. et al., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 4 С. 487-503
Данный обзор посвящён применению технологий виртуальной реальности в психофизиологии и психотерапии стресса. Рассмотрены исследования, применяющие виртуальную реальность, как для введения испытуемых в состояние стресса, так и для помощи в снижении стрессовых реакций. Описаны методики, разработанные для лечения пациентов, страдающих расстройствами, связанными со стрессом (в частности, ПТСР, фобии). Во многих случаях снижение стрессовых реакций с помощью ...
Added: December 14, 2021
Послеоперационная мозговая дисфункция в раннем и отсроченном послеоперационном периоде при каротидной эндартерэктомии
, , et al., Госпитальная медицина: наука и практика 2020 Т. 1 № 4 С. 5-10
Changes in the cognitive status of patients after reconstructive operations in the basin of the carotid arteries are not a rare complication of the course of the early postoperative period, and may also have the character of delayed and persistent changes. Age-dependent neurodegenerative changes, which are essentially a natural sign of brain aging, can trigger ...
Added: December 10, 2021
, , et al., Госпитальная медицина: наука и практика 2020 Т. 1 № 3 С. 5-10
The typical clinical picture of COVID-19 disease is represented by manifestations at the respiratory level, with bilateral atypical pneumonia with significant respiratory impairment due to diffuse alveolar damage, but SARS-CoV-2 can also infect other organs and cell types, including the nervous system. Neurological disorders occur in about a third of COVID-19 patients and are associated ...
Added: December 10, 2021
‘Moderate global aphasia’: A generalized decline of language processing caused by glioma surgery but not stroke
, Stupina E., et al., Brain and Language 2022 Vol. 224 Article 105057
Unlike stroke, neurosurgical removal of left-hemisphere gliomas acts upon a reorganized language network and involves brain areas rarely damaged by stroke. We addressed whether this causes the profiles of neurosurgeryand stroke-induced language impairments to be distinct. K-means clustering of language assessment data (neurosurgery cohort: N = 88, stroke cohort: N = 95) identified similar profiles ...
Added: December 8, 2021
, , et al., Immunity 2020 Vol. 53 P. 1245-1257
Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID-19 patients and healthy donors sampled both prior to and during the pandemic. Healthy donors examined during the pandemic exhibited increased numbers of SARS-CoV-2-specific T cells, but no humoral response. Their ...
Added: December 7, 2021
Yasnitsky L., , et al., Medical News of North Caucasus 2018 Vol. 13 No. 1 P. 259-271
Abstract The first Russian expert consensus on the quantitative evaluation of the treatment adherence: pivotal issues, algorithms and recommendations approved by the XII National Congress of physicians (Moscow, 22-24 November, 2017). © 2018 Stavropol State Medical University. All rights reserved. ...
Added: November 18, 2021
Новые концепции в комплексном лечении пациентов с травмой спинного мозга, включающие реконструктивную микрохирургию и последующую реабилитацию
, , et al., Вестник Российской академии медицинских наук 2008 № 8 С. 29-34
This work is been based upon the experience of performing 100 reconstructive microsurgical operations with transplantation of combined vascular-neural autografts, in 24 cases - with introduction cellular material into zone of transplantation. The complex approach aimed to creating optimal conditions for the functional regeneration of the spinal cord (SC), including neurosurgical methods restoring anatomical integrity ...
Added: November 16, 2021
, Kulikova S., et al., Multimodal DTI-TMS assessment of the motor system in patients with chronic ischemic stroke / Cold Spring Harbor Laboratory. Series http://dx.doi.org/ "BioRxiv". 2019. No. 2019.12.24.886754.
Background and Purpose Despite the continuing efforts in multimodal assessment of the motor system after stroke, conclusive findings on the complementarity of functional and structural metrics of the corticospinal tract (CST) integrity and the role of the contralesional hemisphere are still missing. The aim of this work was to find the best combination of the motor ...
Added: January 29, 2020