, , Ryskina H., М. : Литрес, 2023
The collection contains brief information about a theoretical course in biochemistry, including basic terms, formulas of bioorganic compounds and their metabolites, questions for self-control, tasks and exercises for students’ independent work, tasks for the current and final certification, and a guide to writing an essay. The manual meets the requirements of the Federal State Educational ...
Added: September 11, 2023
Imidazole-4-N-acetamide Derivatives as a Novel Scaffold for Selective Targeting of Cyclin Dependent Kinases
, , et al., Cancers 2023 Vol. 15 No. 15 Article 3766
General toxicity for the organism is a major drawback of anticancer drugs. Development of new generation chemotherapeutics requires the knowledge about macromolecules critical for tumor cell viability. Among these species (called therapeutic targets), the protein kinases are the established enzymes. However, the parts of protein kinases that are supposed to be targeted by drugs can ...
Added: November 1, 2023
Response-adaptive randomization for multiarm clinical trials using context-dependent information measures
Theoretical-information approach applied to the clinical trial designs appeared to bring several advantages when tackling a problem of finding a balance between power and expected number of successes (ENS). In particular, it was shown that the built-in parameter of the weight function allows finding the desired trade-off between the statistical power and number of treated ...
Added: October 13, 2023
Anti-inflammatory activity of N-docosahexaenoylethanolamine and neicosapentaenoylethanolamine in a mouse model of lipopolysaccharide-inducedneuroinflammation
, , et al., International Journal of Molecular Sciences 2021 Vol. 22 No. 19 Article 10728
Added: October 11, 2023
Date-Driven Approach for Identifying State of Hemodialysis Fistulas: Entropy-Complexity and Formal Concept Analysis
Gromov V., , et al., Working papers by Cornell University. Series math "arxiv.org" 2023 Article 14399
The paper explores mathematical methods that differentiate regular and chaotic time series, specifically for identifying pathological fistulas. It proposes a noise-resistant method for classifying responding rows of normally and pathologically functioning fistulas. This approach is grounded in the hypothesis that laminar blood flow signifies normal function, while turbulent flow indicates pathology. The study explores two ...
Added: September 27, 2023
The Role of the Midbrain in the Perception of Tone Sequences and Speech: An Analysis of Individual Studies
, , et al., Human Physiology 2023 Vol. 49 No. 4 P. 347-356
Human speech is a complex combination of sounds and auditory events. To date, there is no consensus on how speech perception occurs. Does the brain react to each sound in the flow of speech separately, or are discrete units distinguished in the sound series and analyzed by the brain as one sound event. The pilot ...
Added: September 3, 2023
Increased error rate and delayed response to negative emotional stimuli in antisaccade task in obsessive-compulsive disorder
, Martynova O., , International Journal of Psychophysiology 2023 No. 192 P. 62-71
Ample evidence links impaired inhibitory control, attentional distortions, emotional dysregulation, and obsessive-compulsive disorder (OCD). However, it remains unclear what underlies the deficit that triggers the OCD cycle. The present study used an antisaccade paradigm with emotional valences to compare eye movement patterns reflecting inhibitory control and attention switching in OCD and healthy control groups. Thirty-two patients with OCD and ...
Added: August 23, 2023
What Do Nurses Think About the Immunization Campaign in Russia and the Prospects for the COVID-19 Pandemic Development?
, Aleksandr A. Maksimenko, Клиническая и специальная психология 2023 Vol. 12 No. 2 P. 118-137
Prevention and vaccination against COVID-19 are not unanimously accepted in international practice. The effectiveness of the COVID-19 vaccination campaign depends on both population and medical staff attitudes towards immunoprophylaxis. We carried out an empirical study of nurses' opinions about the COVID-19 vaccination campaign in Russia and compared the results with those obtained from surveys of ...
Added: July 12, 2023
, , Pavlova I. et al., Успехи геронтологии 2022 Т. 35 № 6 С. 900-910
Satisfaction with the quality of life of the older generation in the regions of Russia was analyzed in the following aspects: satisfaction with the financial situation, conditions of labour and salary, the ability to travel, satisfaction with legal security, the level of respect and trust in society, satisfaction with one’s health and life in general. ...
Added: July 5, 2023
Using an Artificial Neural Network to Predict Coronary Microvascular Obstruction (No-Reflow Phenomenon) during Percutaneous Coronary Interventions in Patients with Myocardial Infarction
, , et al., Sovremennye Tehnologii v Medicine 2021 Vol. 13 No. 6 P. 6-13
The aim of the study was to develop, evaluate, and validate an artificial neural network to predict coronary microvascular obstruction (CMVO) during percutaneous coronary interventions (PCI) in patients with myocardial infarctions (MI) based on the parameters, which are routinely available in an operating room when choosing a surgical approach. Materials and Methods 5621 patients with MI and emergency ...
Added: June 21, 2023
, Khudyakova M., et al., Социальная и клиническая психиатрия 2023 Т. 33 № 1 С. 56-67
This article discusses the place of thought disorders in contemporary psychiatric classification, as well as the approaches to their conceptualization and assessment, not just with the use of clinical methods, but also linguistics and behavioral psychology, including the possibility of automatization. We submit data pertaining to the standardized methods of studying thought disorders, which have ...
Added: June 6, 2023
, , et al., Metabolites 2023 Vol. 13 No. 1 Article 73
Abstract: Generalized anxiety disorder (GAD) is a prevalent disorder. The search for biomarkers may contribute to new knowledge about molecular pathogenesis and treatment. Since oxidative stress and micronutrient imbalance play a key role in the development of mental disorders, we aimed to study salivary antioxidant capacity and magnesium in patients with GAD in an anxiety ...
Added: May 15, 2023
, Maksimenko A., et al., Психологический журнал 2023 Т. 44 № 1 С. 101-112
In recent years, our country and the whole world have faced a situation of a large-scale epidemic caused by the COVID‑19 virus, which created favorable conditions for the development of cyberchondria. The aim of the study is to theoretically substantiate the attention of researchers to the phenomenon of cyberchondria and to adapt the methodology for studying the severity ...
Added: March 13, 2023
The association of osteoporosis and geriatric syndromes in the elderly: data from the Russian epidemiological study EVKALIPT
, , et al., Archives of Osteoporosis 2023 Vol. 18 No. 1 Article 40
Summary. Osteoporosis is associated with almost all geriatric syndromes (GSs), and the occurrence of osteoporosis in patients over 65 years of age increases by 1.2–2.5 times. Early diagnosis of osteoporosis and GSs is very important. Additional programs should be adopted by the state to introduce information about the possibilities of working with elderly patients. Purpose. To analyze associations ...
Added: March 12, 2023
, , et al., BMC Genomics 2022 Vol. 23 Article 558
The histidine metabolism and transport (his) genes are controlled by a variety of RNA-dependent regulatory systems among diverse taxonomic groups of bacteria including T-box riboswitches in Firmicutes and Actinobacteria and RNA attenuators in Proteobacteria. Using a comparative genomic approach, we previously identified a novel DNA-binding transcription factor (named HisR) that controls the histidine metabolism genes ...
Added: January 31, 2023
Genomics-Based Reconstruction and Predictive Profiling of Amino Acid Biosynthesis in the Human Gut Microbiome
, , et al., Microorganisms 2022 Vol. 10 No. 4 Article 740
The human gut microbiota (HGM) have an impact on host health and disease. Amino acids are building blocks of proteins and peptides, also serving as precursors of many essential metabolites including nucleotides, cofactors, etc. Many HGM community members are unable to synthesize some amino acids (auxotrophs), while other members possess complete biosynthetic pathways for these ...
Added: January 31, 2023
Speech decoding from a small set of spatially segregated minimally invasive intracranial EEG electrodes with a compact and interpretable neural network
, Voskoboynikov A., et al., Journal of Neural Engineering 2022 Vol. 19 No. 6 Article 066016
Objective. Speech decoding, one of the most intriguing brain-computer interface applications, opens up plentiful opportunities from rehabilitation of patients to direct and seamless communication between human species. Typical solutions rely on invasive recordings with a large number of distributed electrodes implanted through craniotomy. Here we explored the possibility of creating speech prosthesis in a minimally ...
Added: December 9, 2022
, , et al., Кардиоваскулярная терапия и профилактика 2022 Т. 21 № 10 С. 80-91
The use of a systematic approach to the study of the etiology of a certain pathology makes it possible to improve the understanding of its patho-genesis, as well as to develop more effective diagnostic and therapeutic approaches, including improving the prediction of its risk. Within this review, we will consider such an area of interdisciplinary ...
Added: December 6, 2022
, , , Саратовский научно-медицинский журнал 2022 Т. 18 № 1 С. 112-117
Objective: to study the influence of various kinds of kinesiotherapy on the formation of motor skills in children with ASD, as well as the influence of motor activity on social interaction, communication abilities, stereotypical behavior based on the analysis of published scientific data. A search was made for studies in the scientific databases MEDLINE® (Ovid), ...
Added: December 1, 2022
HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire
In mid-2021, the SARS-CoV-2 Delta variant caused the third wave of the COVID-19 pandemic in several countries worldwide. The pivotal studies were aimed at studying changes in the efficiency of neutralizing antibodies to the spike protein. However, much less attention was paid to the T-cell response and the presentation of virus peptides by MHC-I molecules. ...
Added: November 23, 2022
On the peptide binding affinity changes in population-specific HLA repertoires to the SARS-CoV-2 variants Delta and Omicron
, , et al., Journal of Autoimmunity 2022 Vol. 133 Article 102952
Objective To investigate the changes of Spike protein-HLA binding affinity profiles between the Wuhan strain and two dominant variants, the Delta and the Omicron strains, among the Taiwanese, the British and the Russian populations. Methods The HLA frequencies and the HLA-peptide binding affinity profiles in the T-CoV database were combined to conduct the study. We focused on the ...
Added: November 22, 2022
, Kulikova S., et al., / Cold Spring Harbor Laboratory. Series http://dx.doi.org/ "BioRxiv". 2019. No. 2019.12.24.886754.
Background and Purpose Despite the continuing efforts in multimodal assessment of the motor system after stroke, conclusive findings on the complementarity of functional and structural metrics of the corticospinal tract (CST) integrity and the role of the contralesional hemisphere are still missing. The aim of this work was to find the best combination of the motor ...
Added: January 29, 2020