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Изотермическая петлевая амплификация - перспективный метод массовой диагностики COVID-19
Биотехнология. 2020. Т. 36. № 5. С. 6–12.
Makarova J., Фомичева К. А., Осипьянц А. И., Шкурников М. Ю., Покрыщенко А. А., Тоневицкий Е. А., Вечорко В. И.
Real-time RT-PCR currently remains a gold standard for early COVID-19 diagnostics. However
Loop-mediated isothermal amplification (LAMP) method outperform real-time RT-PCR in simplicity
because it doesn't require expensive lab equipment and trained personnel, and in speed. LAMP-based
diagnostic kits for COVID-19 testing are already exist, but LAMP-based tests have not been widely
accepted yet. The method has great potential for massive diagnostics. Here we discuss technical and
methodological aspects of its wide implementation.
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Артёменко В. Г., Проблемы прогнозирования 2026 № 1 С. 144–156
The article analyzes the adaptation of the ICT specialist labor market in Russia in the context of technological development and external shocks in the first half of the 2020s. Against the backdrop of a general increase in the number of ICT specialists in Russia, external shocks changed the balance of supply and demand in the labor market. In ...
Added: September 29, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
ARUTYUNOV G. P., TARLOVSKAYA E. I., POLYAKOV D. S. et al., Heliyon 2024 Vol. 10 No. 7 Article e28892
The aim of this study is to investigate the course of the acute period of COVID-19 and devise a prognostic scale for patients hospitalized.
Materials and methods
The ACTIV registry encompassed both male and female patients aged 18 years and above, who were diagnosed with COVID-19 and subsequently hospitalized. Between June 2020 and March 2021, a total ...
Added: September 28, 2026
АРУТЮНОВ Г. П., ТАРЛОВСКАЯ Е. И., БАТЛУК Т. И. et al., Российский кардиологический журнал 2025 Т. 30 № 10 С. 111–120
The use of beta-blockers (BB) plays a crucial role in the treatment of cardiovascular diseases. However, there are significant discrepancies with current guidelines in real-world practice. The main issues related to suboptimal dosing regimens and poor medication adherence reduce the effectiveness of therapy and worsen the prognosis of patients. Under the auspices of the Eurasian ...
Added: September 28, 2026
АРУТЮНОВ Г. П., БАТЛУК Т. И., БАШКИНОВ Р. А. et al., Клиническая медицина 2025 Т. 103 № 4 С. 309–313
Recurrent Pericarditis (RP) is a significant medical issue despite advancements in modern cardiology. The management of patients with this condition is associated with several challenges due to the variety of clinical manifestations, difficulties in differential diagnosis, lack of standardized treatment protocols, and a high likelihood of recurrences. Furthermore, there is insufficient data in the literature ...
Added: September 28, 2026
Новосибирск: ИПЦ НГУ, 2025.
This edition represents the publications of the 63rd International Scientific Student Conference 2025 (ISSC-2025) theses in in oriental studies and ethnography.
These Conference materials can be of interest for students, Ph.D. candidates, professors, scientists, and members of educational institutions. ...
Added: September 26, 2026
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Burkova V., Butovskaya M., , in: Principles and Forms of Sociocultural Organization: Historical Contexts of Interaction.: L., NY: Anthem Press, 2026. Ch. 12 P. 237–250.
Cross-cultural psychology and anthropology have many ways of studying human cultures in all their diversity. There are multiple theories of cultural dimensions which provide a foundation for understanding how a culture of a given society influences individual values within it and how these values shape individual behavior. The chapter presents several examples of such classifications ...
Added: September 24, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324
Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...
Added: September 23, 2026
Hebbar P., Ryabov F., Alexandrov I. et al., Cell 2026 Vol. 189 P. 4891–4908.e12
The common marmoset is a New World monkey widely used to study primate evolution and human disease. We present a telomere-to-telomere (T2T) reference assembly for the species, plus three near-T2T haplotypes. These resolve previously inaccessible regions, including the centromeres, sex chromosomes, subterminal satellites, acrocentric chromosomes, and the major histocompatibility complex (MHC). We find marmoset centromeres ...
Added: September 23, 2026
Shaitan A., Ke Y., Shutao C. et al., 2026 No. 24 Article 181
Background Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues and the contextual dependencies within peptide sequences, which hampers the extraction of deep semantic representations and ...
Added: September 18, 2026
Anton Rogachev, Sysoeva O., Frontiers in Systems Neuroscience 2025 Vol. 19 Article 1658243
Added: September 17, 2026
Anton Rogachev, Sysoeva O., Cognitive Systems Research 2024 Vol. 86 Article 101236
Receptive speech is the ability to understand speech addressed to a person. It is a crucial process for a child’s cognitive development. We examine the relationship between receptive speech and neural tracking of natural speech in 52 children aged 3–8 years to infer the neurophysiological mechanisms underlying speech development. We registered a 32-channel electroencephalogram (EEG) ...
Added: September 17, 2026
Чеботарева О. Е., Пирогов А. А., Antipenko I. et al., Доклады российской академии наук. Науки о жизни 2026 Т. 529 № 1 С. 389–395
Preeclampsia (PE) is a severe obstetric complication caused by chronic placental ischaemia. Genome-wide profiling of microRNA isoforms in two trophoblast hypoxia models (CoCl2 and the oxyquinoline derivative neuradapt, BeWo b30 cells) and clinical PE samples (placental tissue, syncytiotrophoblast vesicles) revealed concordant downregulation of hsa-miR-143-3p isoforms. Under a strict fold-change threshold, the canonical isoform (21 nt) ...
Added: September 16, 2026
Poddiakov A., / Series Social Science Research Network "Social Science Research Network". 2026. No. 7437658.
Clarity of knowledge and reasoning is necessary in many cases. Yet vagueness in scientific thinking related to surprise, curiosity, "ability to engage with not-knowing" (de Freitas) and abductive reasoning is also a crucially important source of scientific creativity which supplements combinatorial logic when dealing with the already known. Starting from studies by C. S. Peirce ...
Added: September 15, 2026
Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2024 Т. 13 № 2 С. 33–43
Создание методик диагностики на основе анализа движений глаз является особенно актуальным для оценки когнитивных функций у детей, которые не могут дать речевой или моторный ответ в силу своего возраста или из-за нарушений развития. Для таких детей использование объективных методов оценки когнитивных функций на основе айтрекинга может стать полезным диагностическим инструментом, дополняющим традиционные поведенческие опросники и ...
Added: September 8, 2026
Rakhlin N., Li N., Momotenko D. et al., American Journal of Speech-Language Pathology 2026 Vol. 35 No. 5 P. 1998–2015
Purpose:
We (a) investigated whether children of lower socioeconomic status (SES) are at a greater risk of developmental language disorder (DLD) than children of higher SES, based on standardized assessment; (b) identified the language skills most strongly affected by SES; and (c) examined which standardized and naturalistic measures best differentiate DLD in children from lower SES ...
Added: August 10, 2026
Васильчук М. С., Шаньков Ф. М., Chumakova M. et al., Psychology. Journal of the Higher School of Economics 2021 Vol. 18 No. 2 P. 247–258
The 2019 Coronavirus disease outbreak leads to negative psychological outcomes not only for healthcare workers and patients, but also for the general public. S. Hobfoll’s Conservation of Resources theory is one of the most applicable models for conceptualizing and evaluating natural and social catastrophes and their impact. A web-based screening has been conducted at the ...
Added: June 30, 2026
Levin J., Oprea T. I., Davidovich S. et al., Nature Biotechnology 2020 P. 1127–1131
The COVID-19 pandemic has transformed the way scientific and clinical results are shared and disseminated. According to a recent analysis, an average of 367 COVID-19 papers are being published every week, with a median time from submission to acceptance of just 6 days (compared with 84 days for non-COVID-19 content)1. These unprecedented peer review turnaround ...
Added: June 1, 2026
Dvoynikova A., Маркитантов М. В., Рюмина Е. В. et al., Информатика и автоматизация (Труды СПИИРАН) 2021 Т. 20 № 5 С. 1116–1152
Начиная с 2019 года все страны мира столкнулись со стремительным распространением пандемии, вызванной коронавирусной инфекцией COVID-19, борьба с которой продолжается мировым сообществом и по настоящее время. Несмотря на очевидную эффективность средств индивидуальной защиты органов дыхания от заражения коронавирусной инфекцией, многие люди пренебрегают использованием защитных масок для лица в общественных местах. Поэтому для контроля и своевременного ...
Added: April 24, 2026