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Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters
Molecular Biology Reports. 2014. Vol. 41. No. 2. P. 1157–1164.
Živković M., Stanković A., Djurić T., Končar I., Kolaković A., Djurdjević V., Davidović L., Alavantić D.
Glutathione S-transferases (GSTs) carry out a wide range of functions in cells, such as detoxification of endogenous compounds, removal of reactive oxygen species, and even catalysis of reactions in metabolic pathways beyond detoxification. Based on previous research, GSTM1 and GSTT1 might modify the risk of atherosclerosis. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the occurrence of carotid plaque and biochemical parameters of oxidative stress, lipid profile and inflammation in patients with advanced atherosclerosis.
Language:
English
Boldyreva M., Mohammad R., Agareva M. et al., FRONTIERS IN ANIMAL SCIENCE 2026 Vol. 7 Article 1837838
Mammals from arid ecosystems face distinct physiological challenges: water scarcity and unpredictable food availability require the integration of energy storage, maintenance of water balance, and flexible switching between nutrients. Our previous study demonstrated lower fasting blood glucose levels in the desert rodent Acomys cahirinus (African spiny mouse), which also possesses a unique regenerative ability. The aim of ...
Added: June 3, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Медицина 2026 Т. 14 № 2 С. 42–57
A global step in the fight against tobacco was the adoption of the WHO Framework Convention on Tobacco Control in 2003, which includes the organization of monitoring of the prevalence of tobacco consumption. The main condition for monitoring is its organization based on representative surveys of the population and its individual groups, as well as ...
Added: June 3, 2026
Лебедева Д. А., Вестник Воронежского государственного университета. Серия: Право 2026 № 1 С. 66–77
The article is devoted to the study of problems in the fi eld of ensuring the protection and
portability of patient data in medical information and analytical systems (hereinafter – MIAS). The
purpose of the study is a comprehensive analysis of the legal regulation of the MIAS of the constituent
entities of the Russian Federation. The study identifi ...
Added: June 3, 2026
Biryukova A., Zasimova L. S., Вопросы статистики 2026 Т. 33 № 2 С. 40–57
The paper examines changes in the economic affordability of cigarettes in Russian regions in 2011–2023. Using fixed-effects models, it estimates the impact of prices, incomes, and tobacco affordability (the ratio of per capita income to cigarette price), on three indicators: retail sales of cigarettes per capita, adult population spending on tobacco products, and the share of these ...
Added: June 1, 2026
Kazantseva A. V., A.V. Toropova, Khusnutdinova E. K. et al., ВАВИЛОВСКИЙ ЖУРНАЛ ГЕНЕТИКИ И СЕЛЕКЦИИ, Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (ИЦиГ СО РАН) (Новосибирск) 2025 Vol. 30 No. 3 P. 470–481
The development of musical abilities, including absolute pitch, musical memory, rhythm sense, and musicality, at a high degree is determined by a hereditary component (up to 68 %). The studies implementing a genome-wide linkage and association approach to musical aptitude have revealed more than 100 genetic loci. This spectrum is comprised of the genes encoding ...
Added: May 29, 2026
Mokienko O., Zisman M. A., Bobrov P. et al., American Journal of Physical Medicine and Rehabilitation 2026 Vol. 105 No. 6 P. 555–563
Brain-computer interfaces (BCIs) represent a promising technology for restoring lower limb motor functions and gait after stroke. The application of BCIs in this field is supported by a limited number of studies. The objective of the review was to systematically and critically evaluate the current evidence on the use of BCIs for lower limb function ...
Added: May 28, 2026
Давидович А. С., Shestakova A., Arzumanyan N. et al., Frontiers in Psychology 2026 Vol. 17 - 2026 P. 1–18
Background:
Delay discounting refers to the tendency to choose sooner, smaller rewards over larger, later rewards. Many previous studies link this tendency positively to reward sensitivity, yet the specific mechanisms behind this association remain poorly understood. Reward sensitivity may relate to delay discounting through at least three possible pathways: increased sensitivity to reward size, increased sensitivity ...
Added: May 27, 2026
Helen Selorm Wohoyie, Anikin V. A., Tomsk State University Journal of Philosophy, Sociology and Political Science 2026 Vol. 90 P. 204–211
Menstrual health serves as a critical litmus test for state intervention in contexts where women’s bodily experiences are historically shaped by stigma, cultural taboos, and structural violence. Drawing on Joseph Gusfield’s theory of social problems, this review traces the moral passage of menstruation in Ghana (1992–2025) from a privately managed, stigmatized phenomenon to a matter ...
Added: May 26, 2026
Kochetkova E., Kostanian D., Martynova O. et al., Brain Topography 2026 Vol. 39 No. 4 Article 51
Letter recognition is assumed to involve several levels of analysis, including coarse tuning for category and novelty and more fine tuning for specific features, related to letter orientation. We employed an oddball fast periodic visual stimulation (FPVS) paradigm with magnetoencephalography (Elekta VectorView, 306 sensors) to study neural discrimination responses in the source space. Using contrasts ...
Added: May 24, 2026
Borovikova I., Uporov I., Okhrimenko G. et al., Journal of Structural Biology 2026 Vol. 218 No. 2 Article 108315
Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular diagnosis for pulmonary arterial hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). Since aberrant ATP binding disrupts downstream SMAD1/5/8 phosphorylation, we employed molecular dynamics ...
Added: May 20, 2026
Goltseva Y., Tsokolaeva Z., Beloglazova I. et al., Stem Cell Research and Therapy 2026 Vol. 17 No. 1 Article 112
Background Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged
perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling. The urokinase
plasminogen activator receptor (uPAR), a critical component of the urokinase system, plays a pivotal role in vascular
remodeling and fibrosis. While prior evidence indicates that uPAR deficiency leads to microvascular dysfunction and
perivascular fibrosis, ...
Added: May 19, 2026
Карцева М. А., Peresetsky A., / Высшая школа экономики. Серия WP2 "Количественный анализ в экономике". 2026. № WP2/2026/01.
This study examines the association between health status among elderly individuals living alone and pet ownership (cats, dogs). We employ data from the “Time Use Survey” conducted by the Federal State Statistics Service (Rosstat) in 2019, which contains information on more than 10,000 elderly individuals living alone aged 60 or older in Russia, including data ...
Added: May 8, 2026
Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Sosnin E. I., Vasil’ev Y. L., R.A. Solovyev et al., Computer Optics 2025 Vol. 49 No. 6 P. 1129–1137
In this article, we present a new unique dataset for dental research – AlphaDent. This dataset is based on the DSLR camera photographs of the teeth of 295 patients and contains over 1200 images. The dataset is labeled for solving the instance segmentation problem and is divided into 9 classes. The article provides a detailed ...
Added: May 4, 2026
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2026 Т. 6 № 1 С. 17–27
Introduction. The article presents the results of a study on the assessment of the consumption of tobacco and nicotine- containing products by Veterans.
The purpose of the study: to assess the prevalence of tobacco and nicotine among Militaries, impact on health, consumers’ desire to stop using, and the provision of medical care for tobacco/nicotine withdrawal.
Materials and ...
Added: April 30, 2026
Radygina A., Zaripova J., Semenova D. et al., FRONTIERS IN NUTRITION 2026 Vol. 13 Article 1741707
This paper introduces a novel, open-access dataset designed to advance research into early childhood eating behaviors and their familial determinants. The dataset integrates anthropometric measurements (weight, height, age, BMI, and Estimated Energy Requirement) from 203 children aged 4–14 years alongside rich, granular data on food selection behaviors gathered via Dish-I-Wish—a custom, gamified web application developed ...
Added: April 24, 2026
Kashevnik A., Glekler E., Artemenko E. et al., Scientific data 2026 Article 7209
We present a multimodal dataset containing electroencephalography (EEG), electrocardiography (ECG), and video recordings from 49 participants. Each participant completed a single session lasting approximately 45 minutes. During each session they performed five tasks: resting state, inward concentration (focusing on the center of the forehead), outward concentration (visual search), and mind-wandering. EEG data were recorded from ...
Added: April 23, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Zolotova N., Kirillova M., Dzhalilova D. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 23 Article 11511
Recently, evidence indicating that microplastics (MPs) have a hazardous effect on human health is accumulating. The potential of MPs having a role in carcinogenesis was suggested. Therefore, the aim of this study was to evaluate MPs’ effect on colitis-associated colorectal cancer (CAC) development. The AOM/DSS-induced CAC model was reproduced in two groups of adult male ...
Added: March 24, 2026
Egorov E., Kondratenko N., Averina O. et al., Biochemistry. Biokhimiia 2023 Vol. 88 P. 1987–1996
Transcription factor NRF2 is involved in inflammatory reactions, maintenance of redox balance, metabolism of xenobiotics, and is of particular interest for studying aging. In the present work, the CRISPR/Cas9 genome editing technology was used to generate the NRF2ΔNeh2 mice containing a substitution of eight amino acid residues at the N-terminus of the NRF2 protein, upstream of ...
Added: March 20, 2026
Urban dust nanoparticles drive inflammatory activation of human neutrophils and macrophages in vitro
Pavlyuchenkova A., Vorobjeva N., Ivaneev A. et al., Environmental Science and Pollution Research 2025 Vol. 32 P. 26541–26553
Today, the majority of the world’s population lives in urban environments, where they are constantly exposed to dust particles of varying sizes, including urban dust nanoparticles (NPs). The minute size of NPs ensures their quick and efficient penetration into inner body parts, where they can interact with many cell types, including epithelial, endothelial, and immune ...
Added: March 20, 2026
Балакина А. А., Приходченко Т. Р., Якушев И. А. et al., Известия Академии наук. Серия химическая 2023 Т. 72 № 7 С. 1618–1632
The structure of 3-hydroxy-6-methyl-2-ethylpyridinium nitroxysuccinate (2), its cytotoxicity, and its ability to influence the content of intracellular nitrogen monoxide, as well as the formation of reactive oxygen species and lipid peroxidation processes under conditions of induced oxidative stress were studied. It was demonstrated that compound 2 had low cytotoxicity in vitro in both non-cancerous and ...
Added: September 14, 2025