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Экспрессия генов пероксиредоксинов 1, 2, 3 и 6 при формировании лекарственной устойчивости опухолевых клеток
БЮЛЛЕТЕНЬ ЭКСПЕРИМЕНТАЛЬНОЙ БИОЛОГИИ И МЕДИЦИНЫ, Россия. 2012. Т. 153. № 6. С. 861–864.
Калинина Е. В., Березов Т. Т., Штиль А. А., Чернов Н. Н., Глазунова В.А., Новичкова Н. Д., Нумурадов Н. К.
We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells.
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Le M. T., Шукуров И. С., Курск: Закрытое акционерное общество "Университетская книга", 2026.
This monograph studies the thermal characteristics of urban habitats and analyzes the impact of urban morphology on the emergence of urban heat island effects (UHI), particularly in the context of high-density urban development, modern high-rise buildings and related sanitary standards. It presents comprehensive findings from theoretical and empirical research focused on minimizing the urban heat ...
Added: September 30, 2026
Dolgov A., МЕТОД: Московский ежегодник трудов из обществоведческих дисциплин 2025 Т. 5 № 4 С. 120–133
В обзоре интеллектуальное наследие В.И. Вернадского (1863-1945) рассматривается в контексте зарубежных инвайронментальных исследований (преимущественно на материале англоязычных публикаций двух последних десятилетий). Реконструируются ключевые идейные истоки мировоззрения Вернадского: влияние В.В. Докучаева, русского космизма и концепции ноосферы П. Тейяра де Шардена. Анализируются понятия научной системы Вернадского - «живое вещество», «биосфера» и «ноосфера»; прослеживается их рецепция в современных ...
Added: September 30, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Shishkin S., Almazov A., Vlassov V. et al., Электронный научный журнал "Социальные аспекты здоровья населения" 2026 Т. 4 № 72
Abstract
Significance. The epidemiological, clinical, and socioeconomic effects of healthcare digitalization are actively discussed in the scientific literature. Less attention has been paid to changes in the organization of healthcare resulting from the introduction of digital technologies. These changes have not been the subject of specific research. However, digital technologies is becoming a driver for the ...
Added: September 29, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
Dregulo A., СПб.: Издательство Санкт-Петербургского государственного экономического университета, 2026.
В монографии представлен междисциплинарный анализ современных вызовов перехода городских агломераций к климатически нейтральному и энергоэффективному развитию. В работе рассмотрены теоретические подходы к определению городских агломераций, международных стратегий устойчивого развития, проведен анализ климатических рисков, энергопотребления и секторальных выбросов парниковых газов в Российской Федерации, стран Европейского союза и др. В России, несмотря на рост энергопотребления и выбросов ...
Added: September 29, 2026
Li A., Agriculture, Ecosystems and Environment 2026 Vol. 412 Article 110676
Rangeland degradation is a global environmental challenge; however, intense debate persists between equilibrium (focused on the negative effects of grazing intensity) and non-equilibrium (emphasizing livestock mobility for adapting to climate variability) theories in rangeland ecology. In recent years, an integrative theory advocating the “coexistence of equilibrium and non-equilibrium” has emerged to reconcile this debate. However, ...
Added: September 28, 2026
Ugleva A. V., Социологическое обозрение 2026 Т. 25 № 3 С. 268–293
This article undertakes a socio-philosophical analysis of a situation in which the place of the Other within the structure of subjective experience is occupied by an algorithmic agent – an entity that simulates understanding yet remains devoid of genuine subjectivity. To investigate this configuration, the author turns to psychiatric practice as a representative case study: ...
Added: September 26, 2026
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324
Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...
Added: September 23, 2026
Hebbar P., Ryabov F., Alexandrov I. et al., Cell 2026 Vol. 189 P. 4891–4908.e12
The common marmoset is a New World monkey widely used to study primate evolution and human disease. We present a telomere-to-telomere (T2T) reference assembly for the species, plus three near-T2T haplotypes. These resolve previously inaccessible regions, including the centromeres, sex chromosomes, subterminal satellites, acrocentric chromosomes, and the major histocompatibility complex (MHC). We find marmoset centromeres ...
Added: September 23, 2026
Тыров И. А., Васильев Ю. А., Владзимирский А. В. et al., Труды Института системного анализа Российской академии наук 2026 Т. 76 № 3 С. 79–89
Large language models (LLMs) in healthcare currently attract significant interest. This study compared GigaChat and YandexGPT by evaluating 1,200 LLM-generated responses to physician queries from outpatient and inpatient settings across 7 topics. Thirteen expert physicians assessed the responses using a 5-point scale across five criteria: relevance, correctness, safety, completeness, and language literacy. We performed paired ...
Added: September 22, 2026
Karachurina L. B., Mkrtchyan N. V., Региональные исследования 2026 № 1(91) С. 34–47
Migration for higher education is one of the largest and most intense migration flows in most developed countries, and Russia is no exception. The direction of educational migration flows is determined by many factors. Among these, traditionally significant determinants of the basic gravity model include the population size of the centers participating in migration exchange ...
Added: September 19, 2026
Shaitan A., Ke Y., Shutao C. et al., 2026 No. 24 Article 181
Background Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues and the contextual dependencies within peptide sequences, which hampers the extraction of deep semantic representations and ...
Added: September 18, 2026
Anton Rogachev, Sysoeva O., Frontiers in Systems Neuroscience 2025 Vol. 19 Article 1658243
Added: September 17, 2026
Anton Rogachev, Sysoeva O., Cognitive Systems Research 2024 Vol. 86 Article 101236
Receptive speech is the ability to understand speech addressed to a person. It is a crucial process for a child’s cognitive development. We examine the relationship between receptive speech and neural tracking of natural speech in 52 children aged 3–8 years to infer the neurophysiological mechanisms underlying speech development. We registered a 32-channel electroencephalogram (EEG) ...
Added: September 17, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Anfisa V. Popova, Bykova D., Fedonin G. et al., Molecular Biology and Evolution 2025 Vol. 42 No. 11 Article msaf264
Many Mycobacterium tuberculosis (MTB) genome sites experience different selective forces depending on whether a patient is treated with antibiotics. Here, we searched for pairs of such sites that evolve interdependently. We reconstructed the phylogeny of more than 11,000 MTB clinical isolates with known phenotypes for at least one of 13 antitubercular drugs. By analyzing the ...
Added: November 18, 2025
Третьяков Б. А., Филатова Н. В., Мумятова В. А. et al., Бюллетень экспериментальной биологии и медицины 2023 Т. 175 № 1 С. 29–33
The principal possibility of inhibition of histone deacetylases (HDACs) in nuclear extract of HeLa cells by N1-hydroxy-N4-(pyridine-4-yl)succinamide (compound 1) has been investigated. Compound 1 inhibits HDAC and exhibits low toxicity to A-172, HepG2, HeLa, MCF-7, and Vero cells. HeLa cells are most sensitive to the compound. With an increase in the interval between the administration ...
Added: September 14, 2025
Сень В. Д., Филатова Н. В., Шилов Г. В. et al., Известия РАН. Серия химическая 2023 Т. 72 № 7 С. 1680–1687
New platinum(IV)-aminoxyl complexes (PAC) 2a,b have been synthesized, containing aminoxyl radical with antioxidant properties in one of equatorial position, and axial ligands are represented by dichloroacetate, capable of inhibiting energy production through glycolysis in tumor cells. Complexes 2a,b are characterized by moderate lipophilicity (lg Pow ~2) and differ in the redox properties of aminoxyls. Cytotoxic ...
Added: September 14, 2025
Forysenkova Anna A., Konovalova M., Fadeeva I. et al., Materials 2023 Vol. 16 No. 16 P. 5532–5549
Surgical operations on the peritoneum are often associated with the formation of adhesions, which can interfere with the normal functioning of the internal organs. The effectiveness of existing barrier materials is relatively low. In this work, the effectiveness of soluble alginate–polyvinylpyrrolidone (PVP-Alg) and non-soluble Ca ion cross-linked (PVP-Alg-Ca) films in preventing these adhesions was evaluated. ...
Added: August 12, 2025