• A
  • A
  • A
  • АБВ
  • АБВ
  • АБВ
  • A
  • A
  • A
  • A
  • A
Обычная версия сайта
  • RU
  • EN
  • HSE University
  • Publications
  • Articles
  • Экспрессия генов пероксиредоксинов 1, 2, 3 и 6 при формировании лекарственной устойчивости опухолевых клеток
  • RU
  • EN
Расширенный поиск
Высшая школа экономики
Национальный исследовательский университет
Priority areas
  • business informatics
  • economics
  • engineering science
  • humanitarian
  • IT and mathematics
  • law
  • management
  • mathematics
  • sociology
  • state and public administration
by year
  • 2028
  • 2027
  • 2026
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • 2009
  • 2008
  • 2007
  • 2006
  • 2005
  • 2004
  • 2003
  • 2002
  • 2001
  • 2000
  • 1999
  • 1998
  • 1997
  • 1996
  • 1995
  • 1994
  • 1993
  • 1992
  • 1991
  • 1990
  • 1989
  • 1988
  • 1987
  • 1986
  • 1985
  • 1984
  • 1983
  • 1982
  • 1981
  • 1980
  • 1979
  • 1978
  • 1977
  • 1976
  • 1975
  • 1974
  • 1973
  • 1972
  • 1971
  • 1970
  • 1969
  • 1968
  • 1967
  • 1966
  • 1965
  • 1964
  • 1963
  • 1958
  • More
Subject
News
September 9, 2026
‘Balkan Hospitality Opens Doors: Studying Dialects on the Verge of Extinction
You cannot study spoken dialects from books. Instead, you need to go to a village, seek out its elders, and earn the trust of local residents before you can record hours of spontaneous stories. This is how Natalia Muravleva, Associate Professor at the Faculty of Humanities, conducts her research. Her internship in Serbia continued her long-standing study of dialects spoken by Macedonian settlers. In this interview, she discusses how diaspora cultural centres help researchers reach informants, why native speakers need to be interviewed only in their own language (otherwise, as she puts it, they may 'break'), and how a single field season helped her finalise her monograph. She also shares warm memories of autumn in Belgrade and of colleagues with whom grammar can be discussed in three languages at once.
September 9, 2026
Scientists Train Neural Network to Generate Process Plans from 3D Models
Researchers at the HSE FCS AI and Digital Science Institute have developed CAD2TechSpec, a framework that converts 3D models of mechanical parts into machining process plans—step-by-step instructions for machine tools. The solution aims to reduce the time required for the design and preparation of technical process documentation in mechanical engineering, aircraft manufacturing, and other high-tech industries. The study findings have been published in PeerJ Computer Science.
September 7, 2026
Biologists Discover 'Molecular Fingerprint' of Preeclampsia
Researchers at HSE University employed a new method to model hypoxia in placental cells during pregnancies complicated by preeclampsia and identified molecular markers of tissue hypoxia. Since hypoxia is one of the key mechanisms underlying preeclampsia, these findings are important for a more accurate and timely diagnosis of the disease and for the development of effective treatment methods. The paper has been published in Placenta.

 

Have you spotted a typo?
Highlight it, click Ctrl+Enter and send us a message. Thank you for your help!

Publications
  • Books
  • Articles
  • Chapters of books
  • Working papers
  • Report a publication
  • Research at HSE

?

Экспрессия генов пероксиредоксинов 1, 2, 3 и 6 при формировании лекарственной устойчивости опухолевых клеток

БЮЛЛЕТЕНЬ ЭКСПЕРИМЕНТАЛЬНОЙ БИОЛОГИИ И МЕДИЦИНЫ, Россия. 2012. Т. 153. № 6. С. 861–864.
Калинина Е. В., Березов Т. Т., Штиль А. А., Чернов Н. Н., Глазунова В.А., Новичкова Н. Д., Нумурадов Н. К.

We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells.

Research target: Basic Medicine Health Studies Earth Sciences Biology
Language: Russian
Keywords: экспрессия геновTumor cellsDrug resistanceлекарственная устойчивостьCisplatinPeroxiredoxinGene expressionцисплатинопухолевые клеткипероксиредоксин
Similar publications
DSCA-HLAII: A dual-stream cross-attention model for predicting peptide–HLA class II interaction and presentation
Shaitan A., Ke Y., Hongjun Y. et al., PLoS Computational Biology 2026 Article e1013836
The interaction between peptides and human leukocyte antigen class II (HLA-II) molecules plays a pivotal role in adaptive immune responses, as HLA-II mediates the recognition of exogenous antigens and initiates T cell activation through peptide presentation. Accurate prediction of peptide-HLA-II binding serves as a cornerstone for deciphering cellular immune responses, and is essential for guiding the optimization of antibody therapeutics. ...
Added: September 7, 2026
Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder
Proskurnina E., Liaukovich K., Bychkovskaya L. et al., Metabolites 2023 Vol. 13 No. 1 P. 73
Added: September 7, 2026
Event-Related Potential Study of Recovery of Consciousness during Forced Awakening from Slow-Wave Sleep and Rapid Eye Movement Sleep
Liaukovich K., Sazhin S., Bobrov P. et al., International Journal of Molecular Sciences 2022 Vol. 23 No. 19 P. 11785
Added: September 7, 2026
Implicit auditory perception of local and global irregularities in passive listening condition
Liaukovich K., Ukraintseva Y., Martynova O., Neuropsychologia 2022 Vol. 165 P. 108129
Added: September 7, 2026
Pupillometry and autonomic nervous system responses to cognitive load and false feedback: an unsupervised machine learning approach
Alshanskaia E., Portnova G., Liaukovich K. et al., Frontiers in Neuroscience 2024 Vol. 18
Added: September 7, 2026
Characteristics of the Frequency-Following Response to Changes in the Acoustic Parameters of a Speech Signal (Isolated Syllable)
Oknina L. B., Podlepich V. V., Sieber I. et al., Human Physiology 2026 Vol. 52 No. 3 P. 295–301
The aim of this study was to evaluate the potential use of the frequency-following response (FFR) for assessing preserved perception of simple speech stimuli in humans. To this end, event-related potentials (ERPs) elicited by isolated Russian syllables were recorded and analyzed in 29 healthy subjects in two frequency ranges, the standard range (1—40 Hz) and ...
Added: September 6, 2026
Что такое Свобода? Свобода воли, свободы личности, конституционная модель и законодательное регулирование
Момджян К. Х., Кржевов В. С., Poddiakov A. et al., М.: Новые печатные технологии, 2025.
При всей кажущейся ясности и недвусмысленности понятия «свобода» дать ему исчерпывающую научную дефиницию весьма затруднительно. У каждой отрасли знания свой подход к трактовке этого многоаспектного понятия. В ходе обсуждения, материалы которого вошли в настоящий сборник, свобода рассматривается с позиций философии, социологии, юриспруденции, психологии, нейрофизиологии и т.д. Участники дискуссии рассуждают о границах свободы воли и субъектности человека, о соотношении свободы и ...
Added: September 6, 2026
Event-related potentials and presaccadic activity in response to affective stimuli in participants with obsessive-compulsive disorder
Liaukovich K., Panfilova E., Khayrullina G. et al., International Journal of Psychophysiology 2025 Vol. 207 P. 112475
Added: September 5, 2026
The acoustic features of sincere joyful, sad, and fearful human non-verbal vocalizations and its effect on the emotional valence of cat’s meowing
Portnova G., Liaukovich K., Sharaev M., Cognitive Neurodynamics 2025 Vol. 19 Article 181
Added: September 5, 2026
Validation of the obsessive–compulsive disorder-triggering image set (OCD-TIS)
Liaukovich K., Bainbridge E., Khayrullina G. et al., Neuroscience and Behavioral Physiology 2026 Vol. 56 P. 10–19
Added: September 5, 2026
Commentary: Deep learning in obsessive-compulsive disorder: a narrative review
Kashevarova O., Portnova G., Khayrullina G. et al., Frontiers in Psychiatry 2026 Vol. 17 P. 1776019
Added: September 5, 2026
Does Sound Timing Organization Matter? How Time Interval Influences the Perception of Closely Spaced Frequencies
Liaukovich K., Martynova O., Brain Sciences 2026 Vol. 5 No. 16 P. 439
Highlights What are the main findings? Temporal predictability may enhance auditory frequency discrimination, but only under active listening and when discrimination is difficult; the local irregularity (five-tone bundles) yields higher hit rates and perceptual sensitivity (d’) compared to oddball or two-tone paradigms, accompanied by enhanced P300 amplitude. Participants may show a dissociation between objective performance and subjective awareness: ...
Added: September 4, 2026
HF Heating Effects as Seen From Below and Above: First Results of Joint SURA–Ionosfera-M Experiment
Chernyshov A., Padokhin A. M., Grach S. M. et al., Geophysical Research Letters 2026 Vol. 53 P. 1–11
This paper presents the first results of a coordinated experiment on the ionospheric plasma response to high-frequency (HF) overdense heating, conducted using the SURA heating facility and the Ionosfera-M satellite. The experiment combined ground-based observations with in situ satellite measurements, enabling a comprehensive study of artificial ionospheric disturbances. During the experiment, the SURA facility transmitted ...
Added: August 31, 2026
Hectometric Continuum Radiation Observations on Different Temporal Scales in Near-Earth Space
D. A. Dorofeev, A. A. Chernyshov, Mogilevsky M. M. et al., JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS 2025 Vol. 130 Article e2025JA033900
This study analyzes data from the ERG (Arase) satellite over a period of nearly 7 years (2017–2023). During this time, about 1,000 cases of hectometric continuum (HMC) radiation in near‐Earth space were detected, which made it possible to identify characteristic features on different time scales. On a daily scale, it was established that HMC is ...
Added: August 31, 2026
On the nature of hectometric continuum-type emissions in the near-Earth plasma
Mogilevsky M. M., Shaposhnikov V., Chernyshov A. et al., Physics of Plasmas 2025 Vol. 32 P. 1–10
The ERG (Arase) satellite recently discovered a non-thermal hectometric continuum with a narrowband frequency structure. The mechanism behind the generation of this type of emission in the near-Earth plasma is still unknown. This study examines the potential use of electron cyclotron harmonics instability to explain the line structure of hectometric radio emissions for the first ...
Added: August 31, 2026
Benchmarking Synolitic Graphs for Autism Classification from Multisite Resting-State fMRI
Zaikin A., Vlasenko D., Zakharov D. et al., Diagnostics 2026 Vol. 16 No. 17 P. 1–15
Background/Objectives: Synolitic graphs (SGs) were developed for task-based fMRI, where edge weights encode the discriminative power of pairwise regional features; whether similar information can be recovered from resting-state data was untested. We benchmarked SGs for autism spectrum disorder (ASD) classification using the multisite ABIDE-I dataset (871 subjects: 403 subjects with ASD, 468 typical controls; 17 sites; CC200 atlas). Methods: Using ...
Added: August 27, 2026
Measuring the composition and availability of human resources for health by sex in 204 countries and territories, 1990–2023, and workforce gaps for universal health coverage: a systematic analysis for the Global Burden of Disease Study 2023
Vlassov V., The Lancet Public Health 2026 Vol. 11 No. 9 P. e604–e629
Background Understanding the size, gender composition, and cadre mix of the health workforce and how it has evolved across time and locations can inform policies for planning, recruitment, training, and retention of human resources for health (HRH), and improvement of access to the health-care workforce among populations. Using comparable and standardised data sources, we aim to ...
Added: August 25, 2026
Прогностическое значение полигенного профиля риска при дилатационной кардиомиопатии: анализ краткосрочной выживаемости
Волчкова Е. А., Легкова К. С., Минушкина Л. О. et al., Российский кардиологический журнал 2026 Т. 31 № 8S Статья 6987
Goal. To assess the contribution of polygenic risk scores to the short‑term mortality prediction model in patients with dilated cardiomyopathy (DCM). Materials and methods. The study included 137 patients with DCM. The mean age was 56.8 ± 13.5 years; there were 115 men (83.9 %). The median follow‑up period was 17 [13; 22] months. During the follow‑up period, 26 ...
Added: August 24, 2026
Discovery of Novel 1,3,5-Triazine Derivative as Potent Anticancer Agent: DNA and HSA Binding, MTT Assay
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Unraveling Epistatic Interactions Between Sites Under Drug-Dependent Selection in the Mycobacterium tuberculosis Genome
Anfisa V. Popova, Bykova D., Fedonin G. et al., Molecular Biology and Evolution 2025 Vol. 42 No. 11 Article msaf264
Many Mycobacterium tuberculosis (MTB) genome sites experience different selective forces depending on whether a patient is treated with antibiotics. Here, we searched for pairs of such sites that evolve interdependently. We reconstructed the phylogeny of more than 11,000 MTB clinical isolates with known phenotypes for at least one of 13 antitubercular drugs. By analyzing the ...
Added: November 18, 2025
Усиление цитотоксического действия цисплатина и актиномицина Д пиридиновым производным гидроксиламида янтарной кислоты
Третьяков Б. А., Филатова Н. В., Мумятова В. А. et al., Бюллетень экспериментальной биологии и медицины 2023 Т. 175 № 1 С. 29–33
The principal possibility of inhibition of histone deacetylases (HDACs) in nuclear extract of HeLa cells by N1-hydroxy-N4-(pyridine-4-yl)succinamide (compound 1) has been investigated. Compound 1 inhibits HDAC and exhibits low toxicity to A-172, HepG2, HeLa, MCF-7, and Vero cells. HeLa cells are most sensitive to the compound. With an increase in the interval between the administration ...
Added: September 14, 2025
Синтез, строение и цитотоксические свойства комплексов платины(IV), содержащих аминоксильные и дихлорацетатные лиганды
Сень В. Д., Филатова Н. В., Шилов Г. В. et al., Известия РАН. Серия химическая 2023 Т. 72 № 7 С. 1680–1687
New platinum(IV)-aminoxyl complexes (PAC) 2a,b have been synthesized, containing aminoxyl radical with antioxidant properties in one of equatorial position, and axial ligands are represented by dichloroacetate, capable of inhibiting energy production through glycolysis in tumor cells. Complexes 2a,b are characterized by moderate lipophilicity (lg Pow ~2) and differ in the redox properties of aminoxyls. Cytotoxic ...
Added: September 14, 2025
Polyvinylpyrrolidone–Alginate Film Barriers for Abdominal Surgery: Anti-Adhesion Effect in Murine Model
Forysenkova Anna A., Konovalova M., Fadeeva I. et al., Materials 2023 Vol. 16 No. 16 P. 5532–5549
Surgical operations on the peritoneum are often associated with the formation of adhesions, which can interfere with the normal functioning of the internal organs. The effectiveness of existing barrier materials is relatively low. In this work, the effectiveness of soluble alginate–polyvinylpyrrolidone (PVP-Alg) and non-soluble Ca ion cross-linked (PVP-Alg-Ca) films in preventing these adhesions was evaluated. ...
Added: August 12, 2025
Changes in the Expression of Genes Regulating the Response to Hypoxia, Inflammation, Cell Cycle, Apoptosis, and Epithelial Barrier Functioning during Colitis-Associated Colorectal Cancer Depend on Individual Hypoxia Tolerance
Dzhalilova D., Silina M., Tsvetkov I. et al., International Journal of Molecular Sciences 2024 Vol. 25 No. 14 Article 7801
One of the factors contributing to colorectal cancer (CRC) development is inflammation, which is mostly hypoxia-associated. This study aimed to characterize the morphological and molecular biological features of colon tumors in mice that were tolerant and susceptible to hypoxia based on colitis-associated CRC (CAC). Hypoxia tolerance was assessed through a gasping time evaluation in a ...
Added: March 25, 2025
  • About
  • About
  • Key Figures & Facts
  • Sustainability at HSE University
  • Faculties & Departments
  • International Partnerships
  • Faculty & Staff
  • HSE Buildings
  • HSE University for Persons with Disabilities
  • Public Enquiries
  • Studies
  • Admissions
  • Programme Catalogue
  • Undergraduate
  • Graduate
  • Exchange Programmes
  • Summer University
  • Summer Schools
  • Semester in Moscow
  • Business Internship
  • Research
  • International Laboratories
  • Research Centres
  • Research Projects
  • Monitoring Studies
  • Conferences & Seminars
  • Academic Jobs
  • Yasin (April) International Academic Conference on Economic and Social Development
  • Media & Resources
  • Publications by staff
  • HSE Journals
  • Publishing House
  • iq.hse.ru: commentary by HSE experts
  • Library
  • Economic & Social Data Archive
  • Video
  • HSE Repository of Socio-Economic Information
  • HSE1993–2026
  • Contacts
  • Copyright
  • Privacy Policy
  • Site Map
Edit