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МИТОХОНДРИАЛЬНЫЕ МЕХАНИЗМЫ АПОПТОЗА В ОТВЕТ НА ПОВРЕЖДЕНИЕ ДНК
Молекулярная биология. 2008. Т. 42. № 5. С. 765–771.
Глазунова В.А,, Штиль А. А.
Language:
Russian
М.: ООО «Геомодель Развитие», 2024.
Интелшектуальный анализ данных в нефтегазовой отрасли, Калининград, Россия, 2024, ООО «Геомодель Развитие» ...
Added: April 29, 2026
Derkacheva A., Sakirkina M., Kraev G. et al., /. 2026.
Comprehensive data on natural hazards and their consequences are crucial for effective for risk assessment, adaptation planning, and emergency response. However, many countries face challenges with fragmented, inconsistent, and inaccessible data, particularly regarding local-scale events. To address this data gap in Russia, we developed an end-to-end processing pipeline that scrapes news from various online sources, ...
Added: April 28, 2026
Radygina A., Zaripova J., Semenova D. et al., FRONTIERS IN NUTRITION 2026
This paper introduces a novel, open-access dataset designed to advance research into early childhood eating behaviors and their familial determinants. The dataset integrates anthropometric measurements (weight, height, age, BMI, and Estimated Energy Requirement) from 203 children aged 4–14 years alongside rich, granular data on food selection behaviors gathered via Dish-I-Wish—a custom, gamified web application developed ...
Added: April 24, 2026
Кивалов С. Н., Fitzjarrald D., Boundary-Layer Meteorology 2018 Vol. 166 No. 2 P. 165–198
Cloud shadows lead to alternating light and dark periods at the surface, with
the most abrupt changes occurring in the presence of low-level forced cumulus clouds.
We examine multiyear irradiance time series observed at a research tower in a midlatitude
mixed deciduous forest (Harvard Forest, Massachusetts, USA: 42.53◦N, 72.17◦W) and one
made at a similar tower in a tropical ...
Added: April 24, 2026
Кивалов С. Н., Fitzjarrald D., Boundary-Layer Meteorology 2019 Vol. 173 No. 1 P. 1–52
We examine the physical and biological responses of forest canopies to step changes in light
caused by passing low cumulus clouds that intermittently block the direct solar beam. Using
data obtained at a tropical rainforest and at a midlatitude deciduous forest, we estimate the
course of sensible heat flux, net ecosystem exchange, evapotranspiration, and water-use efficiency in response ...
Added: April 24, 2026
Addressing effects of environment on eddy-covariance flux estimates at a temperate sedge-grass marsh
Кивалов С. Н., Dušek J., Czerný R. et al., Boundary-Layer Meteorology 2023 Vol. 186 P. 217–250
We examined the net-ecosystem-exchange (NEE)-based annual carbon-balance estimates
obtained from eddy-covariance (EC) measurements at an unmanaged sedge-grass marsh
ecosystem (Tˇreboˇn, Czech Republic, 49°1′ N, 14°46′ E), seeking methods to improve the EC
measurements in inhomogeneous environment. The data filtering procedure was developed
using three thresholds: (a) a stationarity test; (b) a stability u∗-threshold; and (c) a high relative
humidity RH-threshold. ...
Added: April 24, 2026
Кивалов С. Н., Лопес де Гереню В. О., Хорошаев Д. А. et al., Forests 2023 Vol. 14 No. 8 Article 1568
Soil respiration (SR) is a main component of the carbon cycle in terrestrial ecosystems,
and being strongly affected by changes in the environment, it is a good indicator of the ecosystem’s
ability to cope with climate change. This research aims to find better empirical SR models using
25-year-long SR monitoring in two forest ecosystems formed on sandy Entic ...
Added: April 24, 2026
Касицкий В. А., Кивалов С. Н., Лопес де Гереню В. О. et al., АгроЭкоИнфо 2025 Т. 5 Статья 517
Оценка дыхания почвы - одного из основных источников углекислого газа в атмосферу – необходима для корректного определения углеродного баланса в наземных экосистемах. Сравнение пульсационного и камерного методов измерения дыхания почвы, проведенные в березняке постагрогенном в регионе южного Подмосковья, показывает хорошую сопоставимость этих методов с коэффициентом детерминации R2=0.75 (p-value=7.546e-12). С учетом высокой пространственной и временной неоднородности ...
Added: April 24, 2026
Кивалов С. Н., Ecological Modelling 2024 Vol. 498 Article 110904
On certain kinds of cloudy days, many forested ecosystems exhibit enhanced carbon uptake and water-use efficiency-the cloudy-day forest flux anomaly. Using ensemble methods to analyze eddy-covariance fluxes, we have
diagnosed net ecosystem exchange (NEE) and water-use efficiency (WUE) of a temperate broadleaf forest and a
tropical evergreen forest as they responded to natural fluctuating-light regimes. Here we ...
Added: April 24, 2026
Кивалов С. Н., Курганова И. Н., Быховец С. С. et al., Soil Systems 2025 Vol. 9 No. 1 Article 9010025
Carbon dioxide (CO₂) efflux from soil (or soil respiration, SR) is one of the most important yet variable characteristics of soil. When evaluating large areas, CO₂ efflux modeling serves as a viable alternative to direct measurements. This research aims to identify site-specific differences and their effects on empirical CO₂ efflux modeling. The experimental data from ...
Added: April 24, 2026
Kashevnik A., Glekler E., Artemenko E. et al., Scientific data 2026 Article 7209
We present a multimodal dataset containing electroencephalography (EEG), electrocardiography (ECG), and video recordings from 49 participants. Each participant completed a single session lasting approximately 45 minutes. During each session they performed five tasks: resting state, inward concentration (focusing on the center of the forehead), outward concentration (visual search), and mind-wandering. EEG data were recorded from ...
Added: April 23, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
G.V.Klink, Gulov D. M., Elumeeva T. G. et al., Журнал общей биологии 2024 Т. 85 № 2 С. 83–94
Plant functional traits are important for the formation of plant communities and for the ability of plants to dominate there. The comparison of mean trait values of organisms within community with that for the random samples of the local biota allows estimating the importance of the trait for the formation of the community composition. The ...
Added: April 19, 2026
G.V.Klink, Semenkov I. N., Enchilik P. R., Science of the Total Environment 2025 Vol. 998 Article 180219
Natural regeneration of forest soils affected by agricultural practices is a common phenomenon in many regions worldwide, particularly in boreal ecosystems. Affecting soil quality, the partitioning of extractable fractions of heavy metals and metalloids (HMMs) is not studied during natural regeneration. The following stages of natural regeneration after plowing have been identified in the Smolenskoye ...
Added: April 19, 2026
Гаранкина Е. В., Шоркунов И. Г., Лобков В. А. et al., Геоморфология и палеогеография (ранее - Геоморфология) 2025 Т. 56 № 4 С. 678–700
Late Pleistocene transformation of European glacial landscapes is often narrowed down to the impact of
postglacial linear erosion. Yet in the marginal zone of MIS 6 glaciation extensive watersheds were protractedly
affected by the postglacial flattening in periglacial and interglacial conditions. Local sediment sinks such
as kettle holes and dry valleys infilled throughout the postglacial stage can serve ...
Added: April 18, 2026
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026
Introduction:
While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception).
Methods:
In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 P. 48544–48557
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Shaidulin A.T., Silaev G.O., Vainer Y.G. et al., Biomedical Photonics 2025 Vol. 14 No. 3 P. 14–23
The use of UV-C radiation for the treatment of tumors is a stand-alone therapeutic intervention that can induce cellular apoptosis and is independent of photosensitizer or oxygen concentration in tumor. To explore the potential of using X-ray excited UV-C luminescent nanoparticles as a basis for creating drugs to improve radiation therapy, two colloidal solutions of ...
Added: October 20, 2025
Yanova M., Stepanova E., Maltseva D. et al., Frontiers in Cell and Developmental Biology 2025 Vol. 13 Article 1508577
Cancer chemoresistance presents a challenge in oncology, often leading to treatment failure and disease progression. CD44, a multifunctional cell surface glycoprotein, has garnered attention for its involvement in various aspects of cancer biology. Through alternative splicing, CD44 can form isoforms with the inclusion of only standard exons, typical for normal tissue, or with the addition ...
Added: March 12, 2025
Polukonova N., Baryshnikova M., Khochankov D. et al., Journal of Biomedical Photonics and Engineering 2021 Vol. 7 No. 4 Article 040307
The problem of creating antitumor drugs with new mechanisms of action that predominantly induce apoptosis is still topical. The extract of Gratiola officinalis is a potential antitumor agent containing mainly flavonoids. The aim of this research is to study the effects of Gratiola officinalis extract on activation of apoptosis and autophagy in breast adenocarcinoma SK-BR-3 and kidney carcinoma A-498 lines. ...
Added: October 30, 2024
Antonenko T. A., Gracheva Y. A., Shpakovsky D. B. et al., Journal of Organometallic Chemistry 2022 Vol. 960 Article 122191
Two series of organotin (IV) complexes based on diclofenac L1Na and aspirin L2H of formulae Me3SnL1 (1); Ph3SnL1 (2); Bu2Sn(L1)2 (3); R2Sn(L1)2 (4, R = 3,5-di-tert-butyl-4-hydroxyphenyl); Me3SnL2 (5); Me3Sn(2-hydroxybenzoate) (6) and Me2Sn(L2)2 (7) were synthesized and characterized by 1H, 13C, 119Sn NMR, IR, ESI-MS and elemental analysis. It was found by X-ray diffraction analysis of ...
Added: January 19, 2024
Pavlyuchenkova A., Roman A. Zinovkin, Makievskaya C. et al., Life Sciences 2022 Vol. 288 Article 120174
FcεRI-dependent activation and degranulation of mast cells (MC) play an important role in allergic diseases. We have previously demonstrated that triphenylphosphonium (TPP)-based antioxidant SkQ1 inhibits mast cell degranulation, but the exact mechanism of this inhibition is still unknown. This study focused on investigating the influence of TPP-based compounds SkQ1 and C12TPP on FcεRI-dependent mitochondrial dysfunction and signaling during MC ...
Added: December 10, 2022
Lyamzaev K., Zinovkin R., Chernyak B., Journal of Cellular Physiology 2022 Vol. 237 No. 5 P. 2345–2356
Mitochondria are dynamic organelles that regulate various intracellular signaling pathways, including the mechanisms of programmed cell death, differentiation, inflammation, and so on. Mitochondria may be extruded as membrane enveloped or as free organelles during developmental processes, inflammatory activation, and in the process of “garbage clearance” of damaged mitochondria in postmitotic cells. Extracellular mitochondria can be ...
Added: December 10, 2022
Bogolyubova-Kuznetsova A., Биохимия 2018 Т. 83 № 2
Ультрацентрифугирование в градиенте плотности остается самым надежным способом получения высоко-очищенных препаратов митохондрий. Однако не всегда у исследователя есть необходимое оборудование, кроме того данный метод обладает невысоким выходом, что может иметь критическое значение, когда исходный биологический материал весьма скуден. В данной работе описан комбинированный метод выделения митохондрий для протеомных исследований, объединяющий разрушение клеток ультразвуком, дифференциальное центрифугирование ...
Added: March 4, 2022