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МИТОХОНДРИАЛЬНЫЕ МЕХАНИЗМЫ АПОПТОЗА В ОТВЕТ НА ПОВРЕЖДЕНИЕ ДНК
Молекулярная биология. 2008. Т. 42. № 5. С. 765–771.
Глазунова В.А,, Штиль А. А.
Language:
Russian
Li A., Agriculture, Ecosystems and Environment 2026 Vol. 412 Article 110676
Rangeland degradation is a global environmental challenge; however, intense debate persists between equilibrium (focused on the negative effects of grazing intensity) and non-equilibrium (emphasizing livestock mobility for adapting to climate variability) theories in rangeland ecology. In recent years, an integrative theory advocating the “coexistence of equilibrium and non-equilibrium” has emerged to reconcile this debate. However, ...
Added: September 28, 2026
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324
Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...
Added: September 23, 2026
Hebbar P., Ryabov F., Alexandrov I. et al., Cell 2026 Vol. 189 P. 4891–4908.e12
The common marmoset is a New World monkey widely used to study primate evolution and human disease. We present a telomere-to-telomere (T2T) reference assembly for the species, plus three near-T2T haplotypes. These resolve previously inaccessible regions, including the centromeres, sex chromosomes, subterminal satellites, acrocentric chromosomes, and the major histocompatibility complex (MHC). We find marmoset centromeres ...
Added: September 23, 2026
Karachurina L. B., Mkrtchyan N. V., Региональные исследования 2026 Т. 91 № 1 С. 34–47
Migration for higher education is one of the largest and most intense migration flows in most developed countries, and Russia is no exception. The direction of educational migration flows is determined by many factors. Among these, traditionally significant determinants of the basic gravity model include the population size of the centers participating in migration exchange ...
Added: September 19, 2026
Shaitan A., Ke Y., Shutao C. et al., 2026 No. 24 Article 181
Background Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues and the contextual dependencies within peptide sequences, which hampers the extraction of deep semantic representations and ...
Added: September 18, 2026
Anton Rogachev, Sysoeva O., Frontiers in Systems Neuroscience 2025 Vol. 19 Article 1658243
Added: September 17, 2026
Rogachev A.O., Sysoeva O. V., Cognitive Systems Research 2024 Vol. 86 Article 101236
Receptive speech is the ability to understand speech addressed to a person. It is a crucial process for a child’s cognitive development. We examine the relationship between receptive speech and neural tracking of natural speech in 52 children aged 3–8 years to infer the neurophysiological mechanisms underlying speech development. We registered a 32-channel electroencephalogram (EEG) ...
Added: September 17, 2026
Koriakina M., Ntoumanis I., Blagoveshchensky E. et al., Frontiers in Human Neuroscience 2026 Vol. 20 Article 1754368
Introduction:
Understanding how we perceive and interpret the movements of other living beings is fundamental to social interaction, survival, and navigating our dynamic environment. Traditional studies of biological motion perception have predominantly employed simplified stimuli, such as point-light displays, which sacrifice ecological validity for experimental control.
Methods:
To overcome this limitation, we created a novel stimulus set featuring ...
Added: September 15, 2026
Poddiakov A., / Series Social Science Research Network "Social Science Research Network". 2026. No. 7437658.
Clarity of knowledge and reasoning is necessary in many cases. Yet vagueness in scientific thinking related to surprise, curiosity, "ability to engage with not-knowing" (de Freitas) and abductive reasoning is also a crucially important source of scientific creativity which supplements combinatorial logic when dealing with the already known. Starting from studies by C. S. Peirce ...
Added: September 15, 2026
Medvedev A., Dronin N., Telnova N., Земля и Вселенная 2026 № 3(369) С. 48–65
Взрывной рост объема данных несколько последних десятилетий ставит вопрос перехода от количества к качеству их использования, ведь не всегда они доходят до конечного пользователя и используются на региональном и локальном уровне. Данные дистанционного зондирования Земли из космоса (ДЗЗ), основанные на длинных временных сериях, и результаты их обработки уже давно стали глобальными цифровыми продуктами. Когда речь ...
Added: September 11, 2026
Kang J., Kim H. J., Kim M. S. et al., Nature Medicine 2026 No. 32 P. 527–544
Drug use disorders (DUDs) are emerging global public health challenges. Here we investigated the global and regional estimates of the prevalence and burden of DUDs, including amphetamine, cannabis, cocaine and opioid use disorders, from 1990 to 2023 for 204 countries and territories by using the Global Burden of Disease Study 2023. Overall, trends in global ...
Added: September 9, 2026
Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2024 Т. 13 № 2 С. 33–43
Создание методик диагностики на основе анализа движений глаз является особенно актуальным для оценки когнитивных функций у детей, которые не могут дать речевой или моторный ответ в силу своего возраста или из-за нарушений развития. Для таких детей использование объективных методов оценки когнитивных функций на основе айтрекинга может стать полезным диагностическим инструментом, дополняющим традиционные поведенческие опросники и ...
Added: September 8, 2026
Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2023 Т. 12 № 4 С. 51–61
Активное развитие метода видеоокулографии, т. е. регистрации движений глаз, создает возможности для создания новых подходов для развития когнитивных функций и обучения. Методики, основанные на видеоокулографии, могут быть полезны не только для детей с серьезными нарушениями моторных функций, но и детей с нарушениями развития когнитивных функций, прежде всего внимания, так как контроль движений глаз тесно связан ...
Added: September 8, 2026
Портнова Г. В., Liaukovich K., Васильева Л. Н. et al., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 4 С. 504–519
Когнитивная и эмоциональная нагрузка в ходе увеличения сложности задач приводит к активации различных звеньев вегетативной нервной системы и может сопровождаться как увеличением эффективности решения задач, так и способствовать дестабилизации эмоционального состояния и уменьшению продуктивности. Увеличение когнитивной нагрузки при условии высокой мотивации испытуемых является стрессовым фактором и выражается в различной реакции симпатического и парасимпатического звеньев в ...
Added: September 8, 2026
Shaidulin A.T., Silaev G.O., Vainer Y.G. et al., Biomedical Photonics 2025 Vol. 14 No. 3 P. 14–23
The use of UV-C radiation for the treatment of tumors is a stand-alone therapeutic intervention that can induce cellular apoptosis and is independent of photosensitizer or oxygen concentration in tumor. To explore the potential of using X-ray excited UV-C luminescent nanoparticles as a basis for creating drugs to improve radiation therapy, two colloidal solutions of ...
Added: October 20, 2025
Yanova M., Stepanova E., Maltseva D. et al., Frontiers in Cell and Developmental Biology 2025 Vol. 13 Article 1508577
Cancer chemoresistance presents a challenge in oncology, often leading to treatment failure and disease progression. CD44, a multifunctional cell surface glycoprotein, has garnered attention for its involvement in various aspects of cancer biology. Through alternative splicing, CD44 can form isoforms with the inclusion of only standard exons, typical for normal tissue, or with the addition ...
Added: March 12, 2025
Polukonova N., Baryshnikova M., Khochankov D. et al., Journal of Biomedical Photonics and Engineering 2021 Vol. 7 No. 4 Article 040307
The problem of creating antitumor drugs with new mechanisms of action that predominantly induce apoptosis is still topical. The extract of Gratiola officinalis is a potential antitumor agent containing mainly flavonoids. The aim of this research is to study the effects of Gratiola officinalis extract on activation of apoptosis and autophagy in breast adenocarcinoma SK-BR-3 and kidney carcinoma A-498 lines. ...
Added: October 30, 2024
Antonenko T. A., Gracheva Y. A., Shpakovsky D. B. et al., Journal of Organometallic Chemistry 2022 Vol. 960 Article 122191
Two series of organotin (IV) complexes based on diclofenac L1Na and aspirin L2H of formulae Me3SnL1 (1); Ph3SnL1 (2); Bu2Sn(L1)2 (3); R2Sn(L1)2 (4, R = 3,5-di-tert-butyl-4-hydroxyphenyl); Me3SnL2 (5); Me3Sn(2-hydroxybenzoate) (6) and Me2Sn(L2)2 (7) were synthesized and characterized by 1H, 13C, 119Sn NMR, IR, ESI-MS and elemental analysis. It was found by X-ray diffraction analysis of ...
Added: January 19, 2024
Pavlyuchenkova A., Roman A. Zinovkin, Makievskaya C. et al., Life Sciences 2022 Vol. 288 Article 120174
FcεRI-dependent activation and degranulation of mast cells (MC) play an important role in allergic diseases. We have previously demonstrated that triphenylphosphonium (TPP)-based antioxidant SkQ1 inhibits mast cell degranulation, but the exact mechanism of this inhibition is still unknown. This study focused on investigating the influence of TPP-based compounds SkQ1 and C12TPP on FcεRI-dependent mitochondrial dysfunction and signaling during MC ...
Added: December 10, 2022
Lyamzaev K., Zinovkin R., Chernyak B., Journal of Cellular Physiology 2022 Vol. 237 No. 5 P. 2345–2356
Mitochondria are dynamic organelles that regulate various intracellular signaling pathways, including the mechanisms of programmed cell death, differentiation, inflammation, and so on. Mitochondria may be extruded as membrane enveloped or as free organelles during developmental processes, inflammatory activation, and in the process of “garbage clearance” of damaged mitochondria in postmitotic cells. Extracellular mitochondria can be ...
Added: December 10, 2022
Bogolyubova-Kuznetsova A., Биохимия 2018 Т. 83 № 2
Ультрацентрифугирование в градиенте плотности остается самым надежным способом получения высоко-очищенных препаратов митохондрий. Однако не всегда у исследователя есть необходимое оборудование, кроме того данный метод обладает невысоким выходом, что может иметь критическое значение, когда исходный биологический материал весьма скуден. В данной работе описан комбинированный метод выделения митохондрий для протеомных исследований, объединяющий разрушение клеток ультразвуком, дифференциальное центрифугирование ...
Added: March 4, 2022
Khashchenko E., Vysokikh M., Uvarova E. et al., Journal of Clinical Medicine 2020 Vol. 9 No. 5 P. 1399
Relevance: Mitochondrial dysfunction and systemic inflammation are believed to play pivotal role in the pathogenesis of polycystic ovary syndrome (PCOS) and related complications of metabolic disorders in adult patients. Though such researches are limited or almost absent in adolescents. The aim of the study is to evaluate the impact of mitochondrial dysfunction and systemic inflammation ...
Added: May 12, 2020