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Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution
Aging Cell. 2021. Vol. 20. No. 7. Article 13383.
Ramos-Marques E., García-Mendívil L., Pérez-Zabalza M., Santander-Badules H., Srinivasan S., Oliveiros J. C., Pueyo E.
Aging is the main risk factor for cardiovascular diseases. In humans, cardiac aging remains poorly characterized. Most studies are based on chronological age (CA) and disregard biological age (BA), the actual physiological age (result of the aging rate on the organ structure and function), thus yielding potentially imperfect outcomes. Deciphering the molecular basis of ventricular aging, especially by BA, could lead to major progresses in cardiac research. We aim to describe the transcriptome dynamics of the aging left ventricle (LV) in humans according to both CA and BA and characterize the contribution of microRNAs, key transcriptional regulators. BA is measured using two CA-associated transcriptional markers: CDKN2A expression, a cell senescence marker, and apparent age (AppAge), a highly complex transcriptional index. Bioinformatics analysis of 132 LV samples shows that CDKN2A expression and AppAge represent transcriptomic changes better than CA. Both BA markers are biologically validated in relation to an aging phenotype associated with heart dysfunction, the amount of cardiac fibrosis. BA-based analyses uncover depleted cardiac-specific processes, among other relevant functions, that are undetected by CA. Twenty BA-related microRNAs are identified, and two of them highly heart-enriched that are present in plasma. We describe a microRNA-gene regulatory network related to cardiac processes that are partially validated in vitro and in LV samples from living donors. We prove the higher sensitivity of BA over CA to explain transcriptomic changes in the aging myocardium and report novel molecular insights into human LV biological aging. Our results can find application in future therapeutic and biomarker research.
Gadzhimirzaev S., Хельвас А. В., Компьютерные исследования и моделирование 2022 Т. 14 № 6 С. 1255–1268
This work contains a description of the results of modeling the process of maintaining the readiness of a section of the road network under strikes of with specified parameters. A one-dimensional section of road up to 40 km long with a total number of strikes up to 100 during the work of the brigade is ...
Added: June 26, 2026
Borovikova I., Uporov I., Okhrimenko G. et al., Journal of Structural Biology 2026 Vol. 218 No. 2 Article 108315
Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular diagnosis for pulmonary arterial hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). Since aberrant ATP binding disrupts downstream SMAD1/5/8 phosphorylation, we employed molecular dynamics ...
Added: May 20, 2026
Thangavel B., Kathamuthu T., Srinivasan S., International Journal of Bifurcation and Chaos in Applied Sciences and Engineering 2026 Vol. 36 No. 09 Article 2630019
In this paper, we report, for the first time, that Extreme Events (EEs) can robustly emerge in autonomous, weakly coupled Bonhoeffer–van der Pol oscillators, challenging the prevailing notion that strong interaction and external drive are necessary for such rare, large-amplitude bursts. Our central finding is a novel dynamical route to EEs: a transition from quasi-periodic torus dynamics to ...
Added: May 20, 2026
Kychkin A., Chernitsin I., Прикладная информатика 2026 № 1(121) С. 40–58
The results of the development of a software microservice embedded in atmospheric air quality monitoring systems to support the identification of industrial pollution sources are presented. The emission and subsequent spread of harmful substances in the lower layers of the atmosphere is dynamic and characterized by high uncertainty due to the specific features of technological ...
Added: April 23, 2026
Grebenyuk A. Y., Lobanova P., Саввин Н. В. et al., Медицинские технологии. Оценка и выбор 2026 № 1(47) С. 36–47
Objective: Analysis of the current global agenda in medical science.
Material and methods: The article proposes an approach to building a medical research landscape based on semantic analysis and mapping of medical topics. For this purpose, 2252 topics from English-language articles published in 2024 related to the field of medicine were vectorized, the embeddings were obtained ...
Added: February 20, 2026
М.: Международный центр «Новые научные исследования», 2025.
Сборник содержит статьи участников Международной научно-практической конференции «Научные открытия и инновационные стратегии», состоявшейся 24 мая 2025 г. в г. Москва.
В сборнике научных трудов рассматриваются современные научные проблемы и практики применения результатов научных исследований. Материалы сборника предназначены для научных работников, преподавателей, аспирантов, магистрантов, студентов в целях применения в научной работе и учебной деятельности. Ответственность за аутентичность ...
Added: February 18, 2026
Filippova E., Sukhikh T., Tychinina A. et al., Crystals 2026 Vol. 16 No. 1 Article 12
Reaction of [Zr(η5-Cp’)2Cl2] (Cp’ = tBuC5H4) and Na2Cat36 (Cat36 = 3,6-di-tert-butylcatecholate) leads to the formation of the complexes [Na2Zr(Cat36)3(THF)2(C7H8)] (1) and [Zr(η5-Cp’)2(η1-Cp’)2] (2). Complex 1 along with its congeners [K2Zr(Cat36)3(THF)2] (3), [Li(THF)4][LiZr(Cat36)3] (4) and [Li4Zr(Cat36)4(dme)2] (5) were synthesized by the reaction of [ZrCl4(THF)2] and corresponding alkali metal catecholate M2Cat36. The complexes obtained were characterized by means of single-crystal X-ray diffraction ...
Added: February 18, 2026
Домрачев Д. А., Коннова М. А., Волков А. А., Медико-фармацевтический журнал «Пульс» 2023 Т. 25 № 6 С. 54–57
Medicines based on compounds of iron, copper and zinc occupy a certain place in the pharmaceutical
market. A lack of iron in the body can contribute to the development of iron deficiency anemia, and in the case of
copper and zinc, a deficiency in the immune response and inflammation caused by lipid peroxidation, which ultimately
leads to various ...
Added: February 15, 2026
Стерлитамак: Общество с ограниченной ответственностью "Агентство международных исследований", 2023.
Сборник статей подготовлен на основе докладов Международной научно-практической конференции «ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ РЕАЛИЗАЦИИ МЕЖДИСЦИПЛИНАРНЫХ ИССЛЕДОВАНИЙ», состоявшейся 15 мая 2023 г. в г. Воронеж. Научное издание предназначено для докторов и кандидатов наук различных специальностей, преподавателей вузов, докторантов, аспирантов, магистрантов, практикующих специалистов, студентов учебных заведений, а также всех, проявляющих интерес к рассматриваемой проблематике с целью использования в ...
Added: February 4, 2026
Portnova G., Proskurnina E., Liaukovich K. et al., Journal of Molecular Neuroscience 2026 Vol. 76 Article 19
This study investigates the relationship between stress coping ability, salivary antioxidant capacity (AOC), and trace element concentrations, focusing on zinc (Zn) and potassium (K). A cohort of 73 participants, divided into groups based on stress coping ability (SCA) (“adaptive”, “intermediate”, and “maladaptive”), underwent cognitive tasks while physiological and behavioral data were collected. Saliva samples were ...
Added: February 2, 2026
Anna Melman, Mikhail Alexandrov, Oleg Evsutin, , in: 2025 XIХ International Symposium on Problems of Redundancy in Information and Control Systems (Redundancy), 5-7 Nov. 2025.: IEEE, 2025. P. 1–6.
Digital steganography protects the privacy of data by hiding them in some digital containers, such as images. Protection of confidential messages by hiding them in digital images faces the problem of balancing the main performance indicators, i.e. embedding imperceptibility and capacity. Metaheuristic optimization can be used to flexibly customize embedding options, including parameters and locations ...
Added: January 28, 2026
de Klerk D., de Keijzer M., Franchi L. et al., Biochemical Pharmacology 2026 Vol. 248 Article 117620
The recalcitrance of tumors to photodynamic therapy (PDT) has been linked to PDT-induced activation of survival pathways in sublethally afflicted cancer cells that modulate cellular responses to oxidative stress and damage. Survival signaling manifests in regions of the tumor where the tumor cells are insufficiently photosensitized or subjected to inadequate fluence rates. The survival signaling ...
Added: January 15, 2026
Natalia O. Porozova, Petukhova N., Maxim A. Gureev et al., Frontiers in Immunology 2025 Vol. 16 Article 1729468
Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade has reshaped immuno-oncology, with antibodies establishing benchmarks for survival and durability of response across multiple tumor types. Yet format-related constraints of monoclonal antibodies persist, including incomplete and heterogeneous intratumoral penetration, long half-life with limited real-time toxicity control, immune-related toxicities, and context-dependent resistance within the tumor ...
Added: December 22, 2025
Pikul A. S., Лепендин А. А., Труды молодых ученых Алтайского государственного университета 2023 № 20 С. 190–193
Представлен новый подход для выявления атак презентации на системы распознавания по лицу. Он основан на использовании механизма графового внимания, применяемого к промежуточным картам характеристик изображений лица, вычисленным сверточной сетью ResNet18. Показано, что предложенный подход позволил добиться высокого качества распознавания поддельных изображений при лицевой биометрической верификации, сравнимого с имеющимися в настоящее время альтернативными решениями. ...
Added: December 12, 2025
Pikul A. S., Безопасность информационных технологий 2024 Т. 31 № 4 С. 116–127
This article explores the potential use of modern computer vision architectures for the task of deepfake detection. The following architectures are considered: EfficientNet, Vision Transformer (ViT), VisionLSTM (ViL), Vision KAN, and Mamba Vision. The novelty of the approach lies in the application and comparison of these architectures, as well as their combination into paired ensembles ...
Added: December 12, 2025
Aleksandr S. Pikul, Popov I., Безопасность информационных технологий 2025 Vol. 32 No. 2 P. 73–82
Understanding how artificial intelligence models make decisions is important, especially for difficult tasks like detecting deepfakes, where it's not enough to just get a result – it needs to know why the model made that choice. Many current methods, like Shapley additive explanations (SHAP) and Gradient-weighted Class Activation Mapping (Grad-CAM), help explain these decisions, but ...
Added: December 12, 2025
Ионцев М. А., [б.и.], 2020.
Показано, что системы зарядовых и потоковых кубитов являются математически эквивалентными друг другу, физическое описание различается в том, что параметром порядка в системе с зарядовыми кубитами является обобщенная координата осциллятора (амплитуда фотонного поля), а в системе с потоковыми кубитами таким параметром является обобщенный импульс осциллятора (импульс фотонного поля). Математическая эквивалентность объясняется тем, что уравнения движения (правила ...
Added: November 10, 2025
Dmitriy Demin, Ilya Grebenkin, Alexey Barinov, International Journal of Advanced Manufacturing Technology 2025 Vol. 141 P. 1847–1858
In this paper, a computer simulation of round wire drawing processes with different equations of state for steel A12 has been carried out. In addition, the methods of improving the configuration of neural networks based on a multilayer perceptron (MLP) for estimating the distributions of residual stress tensor components have been investigated. The study demonstrated ...
Added: November 6, 2025
Seralan V., S L. K., Srinivasan S. et al., Scientific Reports 2025 No. 15 P. 1–15
This work explores distinct complex dynamics of simplified two nodes of coupled gene regulatory networks with multiple delays in two self-inhibitory and mutually activated genes. We have identified the emergence of extreme events within a specific range of system parameter values. A detailed analysis of the time delay-induced emergence of extreme events is illustrated using ...
Added: October 15, 2025
Гаевская М. А., СПб.: РГПУ им. А.И. Герцена, 2024.
В сборнике представлены прошедшие отбор редакционной коллегии сборника и рецензирование статьи, которые были подготовлены на основе докладов и сообщений участников 25-й Межвузовской студенческой научной конференции «Студент - Исследователь - Учитель», состоявшейся 3-17 апреля 2023 года в Санкт-Петербурге в Российском государственном педагогическом университете им. А.И. Герцена. Материалы отражают результаты изысканий молодых исследователей - студентов бакалавриата, магистратуры ...
Added: October 5, 2025
Гаевская М. А., СПб.: РГПУ им. А.И. Герцена, 2023.
Сборник включает статьи, подготовленные на основе докладов и сообщений участников 24-й Межвузовской студенческой научной конференции «Студент - Исследователь - Учитель», состоявшейся 4-15 апреля 2022 года в Санкт-Петербурге в Российском государственном педагогическом университете им. А.И. Герцена. Статьи прошли отбор редакционной коллегии сборника и рецензирование. Содержание материалов сборника отражает результаты изысканий молодых исследователей - студентов бакалавриата, магистратуры ...
Added: October 5, 2025
Cham: Springer, 2025.
This book constitutes the refereed proceedings of 34th International Workshops which were held in conjunction with the 34th International Conference on Artificial Neural Networks and Machine Learning, ICANN 2025, held in Kaunas, Lithuania, September 9–12, 2025.
The 20 full papers and 8 abstracts included in this workshop volume were carefully reviewed and selected from 42 submissions. ...
Added: September 29, 2025
Коннова М. А., Волков А. А., Мельникова Н. Б., Медико-фармацевтический журнал «Пульс» 2024 Т. 26 № 7 С. 138–143
Fulvic acids (FA) are natural organic compounds obtained from the peat in the Nizhny Novgorod region
and used in the pharmacy, and require comprehensive studies not only to determine the authenticity, assay of the
main substance and impurities, but also to standardize the product. This is due, first of all, to the fact that
depending on the FA ...
Added: September 8, 2025