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News
September 18, 2026
When Pictures Hinder Understanding: Illustrations May Impede Learning of Abstract Ideas
Illustrations can help remember specific actions but do not always make abstract ideas easier to learn. Researchers from HSE University and Humboldt University compared how people learn from texts with different levels of abstractness. They found that participants remembered illustrations better and performed better on related tasks after reading a multimedia text about yoga asanas than after reading an abstract text about the Nash equilibrium. The findings could help improve the selection of illustrations for educational and informational materials. The study has been published in Learning and Instruction.
September 17, 2026
'I Wish That People Would Place Greater Trust in Science'
When Tatiana Eremicheva chose Fundamental and Computational Linguistics as her field of study, she thought it would be about learning languages. Instead, she discovered it was about helping people. In this interview for the HSE Young Scientists project, she discusses science as a way of understanding the world, billiards as a team-building activity, and why learning to read is not always as easy as it seems.
September 15, 2026
Immunity to Chaos: How Personal Resources Help Us Cope with the Challenges of a Turbulent World
International conflicts, crises and digital overload—the modern world puts our minds to the test every day. Traditional psychology often focuses on the consequences: anxiety, depression, and psychosomatic disorders. But what if we looked at the problem differently—through the lens of the resources that prevent us from breaking down? Psychological immunity is precisely this set of resources. Alena Zolotareva and her group, Psychological Immunity as a Resource for Positive Functioning, are developing an integrative model of this phenomenon, adapting diagnostic tools and preparing for large-scale empirical research. Why do psychologists need to collaborate with medical professionals, and how could their research transform preventive care in clinics and corporations?

 

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Pharmacological targeting of nuclear factor (erythroid-derived 2)-like 2 (NRF2): a potential strategy to improve the efficacy of oncological photodynamic therapy

Biochemical Pharmacology. 2026. Vol. 248. Article 117620.
de Klerk D., de Keijzer M., Franchi L., Tian J., Maxim A. Gureev, Porozov Y.

The recalcitrance of tumors to photodynamic therapy (PDT) has been linked to PDT-induced activation of survival pathways in sublethally afflicted cancer cells that modulate cellular responses to oxidative stress and damage. Survival signaling manifests in regions of the tumor where the tumor cells are insufficiently photosensitized or subjected to inadequate fluence rates. The survival signaling in these tumor regions is believed to account for tumor recurrence. Accordingly, PDT efficacy can be improved by intervening in these pathways using molecular inhibitors of key modulators of survival signaling, thereby reducing the number of sublethality afflicted cancer cells whilst increasing therapeutic efficacy. A promising target for pharmacological intervention is the nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway, which induces the antioxidant and xenobiotic stress response that helps cells cope with prolonged periods of hyperoxidative stress after PDT. This review outlines our current understanding of this pathway, how it is activated, and how it confers cytoprotective effects and ensures cell survival. Additional distinguishing features of the review are that (1) studies are addressed in which PDT activation of the NRF2 pathway has been demonstrated; (2) an exhaustive overview of NRF2 pathway inhibitors is presented that could serve as potential adjuvants in PDT regimens to augment therapeutic efficacy in treatment-resistant tumors and cancers that recur after PDT; (3) molecular docking analyses are included that show potential interactions between the NRF2 inhibitors and the redox sensor KEAP1; and (4) an elaborate account is provided on the potential bottlenecks and caveats that can be encountered when using NRF2 inhibitors in the development of fourth-generation photosensitizers for oncological PDT.

Research target: Natural Sciences Chemistry Biology
Language: English
DOI
Text on another site
Keywords: Keap1Redox homeostasisOxidantsPhotochemotherapy
Publication based on the results of:
Металлизированные фталоцианины как высокоэффективные фотосенсибилизаторы в фототерапии рака (2027)
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Added: September 14, 2026
The discovery of AKT inhibitor (4-(purin-6-yl)piperazin-1-yl)(benzofuran-2-yl)methanone for treatment of myeloid neoplasms: computer modelling, synthesis and biological activity
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The recalcitrance of tumors to photodynamic therapy (PDT) has been linked to PDT-induced activation of survival pathways in sublethally afflicted cancer cells that modulate cellular responses to oxidative stress and damage. Survival signaling manifests in regions of the tumor where the tumor cells are insufficiently photosensitized or subjected to inadequate fluence rates. The survival signaling ...
Added: March 5, 2026
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