Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters

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Effects of glutathione S-transferase T1 and M1 deletions on advanced carotid atherosclerosis, oxidative, lipid and inflammatory parameters

Molecular Biology Reports. 2014. Vol. 41. No. 2. P. 1157–1164.

Živković M., Stanković A., Djurić T., Končar I., Kolaković A., Djurdjević V., Davidović L., Alavantić D.

Glutathione S-transferases (GSTs) carry out a wide range of functions in cells, such as detoxification of endogenous compounds, removal of reactive oxygen species, and even catalysis of reactions in metabolic pathways beyond detoxification. Based on previous research, GSTM1 and GSTT1 might modify the risk of atherosclerosis. The aim of our study was to analyze the possible association of GSTM1 and GSTT1 gene polymorphisms with the occurrence of carotid plaque and biochemical parameters of oxidative stress, lipid profile and inflammation in patients with advanced atherosclerosis.

Research target: Health Studies Clinical Medicine Biology

Global, regional, and national burden of road injuries 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Vlassov V., The Lancet Public Health 2026 P. 1–6

Background Road injuries are a leading cause of mortality and morbidity worldwide. Years of international efforts have aimed to strengthen policy engagement, including the 2020 UN General Assembly's proclamation of the Second Decade of Action for Road Safety (2021–30), targeting a 50% reduction in road traffic deaths and serious injuries by 2030. The aim of this ...

Added: July 25, 2026

Система здравоохранения России: что можно изменить уже сегодня. Идеи и предложения. 2-е издание, переработанное и дополненное

Авксентьева М. В., Ашихмин Я. И., Ашихмина О. В. et al., М.: ФГБУ "Издательство "Наука", 2023.

Предложены основные направления совершенствования планирования, организации и оплаты медицинской помощи, лекарственного обеспечения, информатизации и оценки технологий здравоохранения. Рекомендованы такие мероприятия, как конкретизация программы государственных гарантий бесплатного оказания гражданам медицинской помощи, создание системы общедоступного лекарственного обеспечения, использование клинико-статистических групп для оплаты медицинской помощи при ряде хронических неинфекционных заболеваний в амбулаторных условиях, формирование механизма привлечения соплатежей при ...

Added: July 16, 2026

Клиническая и экономическая оценка эффективности современных стратегий скрининга и ранней диагностики рака шейки матки в Российской Федерации

Михайлов И. А., Опухоли женской репродуктивной системы 2025 Т. 21 № 1 С. 86–105

Цель исследования – определить наиболее целесообразную стратегию скрининга и ранней диагностики рака шейки матки (РШМ) в Российской Федерации с точки зрения клинической (диагностической) и экономической эффективности. Материалы и методы. Для оценки клинической (диагностической) эффективности различных стратегий скрининга проведен систематический обзор публикаций об исследованиях, оценивающих эффективность применения цитологического исследования и тестирования на вирус папилломы человека (ВПЧ) с целью диагностики ...

Added: July 16, 2026

Телемедицинские консультации в детской онкологии – гематологии: современный взгляд на актуальность, проблемы и их решения при оказании профильной медицинской помощи

Иванова А. А., Коган С. А., Горбунова Т. В. et al., Менеджер здравоохранения 2026 № 3 С. 96–105

The research r elev anc e is determined by the demand for telemedicine consultations (TMC) as one of health care digitalization pathways in Russian Federation. Telemedicine, regardless of the field, continues to prove its significant role, saving health resources without losing medical care quality. The TMC is regulated by federal level framework. Each year the ...

Added: July 16, 2026

WSI-GT: Pseudo-Label Guided Graph Transformer for Whole-Slide Histology

Михайлов И. А., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8

Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...

Added: July 16, 2026

Оценка социальных эффектов от внедрения системы организационных мероприятий для совершенствования оказания медицинской помощи при онкологических заболеваниях на региональном уровне в субъектах Центрального федерального округа

Хайлова Ж. В., Омельяновский В. В., Михайлов И. А. et al., Менеджер здравоохранения 2026 № 4 С. 41–52

The urgency of the problem of organizing effective medical care for cancer patients is determined by the steady trend of increasing incidence of malignant neoplasms, the high proportion of this pathology in the structure of overall mortality, as well as significant medical, demographic and socio-economic losses for society.Purpose of the st udy is to conduct ...

Added: July 16, 2026

Социологическое исследование влияния комплекса организационных мероприятий по внедрению инновационных медицинских технологий в многопрофильном стационаре на качество жизни пациентов

Михайлов И. А., Здоровье мегаполиса 2026 Т. 7 № 2 С. 7–16

Objective. To evaluate the impact of a series of organizational measures for implementing innovative medical technology in a multidisciplinary hospital on patient quality of life based on patient self-assessments. Results. Patients who received care using innovative medical technology within a systemic organizational approach demonstrated a significantly higher level of overall satisfaction with the quality of care. ...

Added: July 16, 2026

Международные подходы к оценке сложности труда специалистов с высшим медицинским образованием (врачей) разных специальностей

Ахапкина Е. С., Омельяновский В. В., Тулупова О. Н. et al., Медицинские технологии. Оценка и выбор 2026 Т. 48 № 2 С. 70–77

OBJECTIVE To analyze international approaches to assessing the labor complexity for different specialists with higher medical education (physicians). MATERIAL AND METHODS We performed a systematic searching and content analysis of foreign and national studies and documents devoted to labor complexity of different specialists with higher medical education (doctors). A group of experts among the authors of this study discussed and identified significant factors in assessing complexity. RESULTS There are 2 main systems to assess physician workload complexity in foreign countries. The first approach is based ...

Added: July 16, 2026

Phase-1 study of vamotinib (PF-114), a 3rd generation BCR::ABL1 tyrosine kinase-inhibitor, in chronic myeloid leukaemia

Михайлов И. А., Annals of Hematology 2025 Vol. 104 P. 2707–2715

Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...

Added: July 16, 2026

Shared environment, shared mechanisms: comparing pathways to mental health outcomes among indigenous youth and youth with other ethnic backgrounds

Arina Bukina, Eritsyan K., Antonova N. et al., Frontiers in Psychology 2026 Vol. 17 Article 1824428

Background: Numerous studies have shown that indigenous populations experience poorer health outcomes compared to people with other backgrounds. However, the interpretation of these disparities remains challenging due to differences in living conditions and social environments, as well as by potential measurement-related biases. Little is known about whether the underlying mechanisms of mental health outcomes differ between ...

Added: July 15, 2026

Global, regional, and national burden of tuberculosis and multidrug-resistant tuberculosis by HIV status, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Ledesma J. R., Zhang M., Liew M. F. et al., The Lancet Infectious Diseases 2026 P. 1–12

Background Tuberculosis (TB) is the leading global cause of death from a single infectious agent. Recent reductions in global health funding have threatened TB control, making comprehensive assessment of TB, HIV-related TB, and drug-resistant TB burdens before these disruptions essential for shaping effective responses. The WHO End TB Strategy sets targets of a 95% reduction in ...

Added: July 7, 2026

Особенности потенциала, следующего за частотой, зарегистрированного в ответ на изменения в параметрах звучания речевого сигнала (изолированного слога)

Окнина Л. Б., Подлепич В. В., Sieber I. et al., Физиология человека 2026 Т. 52 № 3 С. 5–15

The aim of this study was to evaluate the frequency following response (FFR) for the analysis of the intact perception of syllables in humans. For this purpose, event-related potentials (ERPs) in response to isolated Russian syllables were recorded and analyzed in 29 healthy persons in two frequency ranges, standard (1-40 Hz) and high frequency (70-150 ...

Added: June 30, 2026

Socioeconomic development, longevity and prevalence of obesity and overweight: The retrospective longitudinal analysis of international data

Liapin G., Vlassov V., DIALOGUES IN HEALTH 2026 Vol. 8 Article 100317

Objectives Due to the economic growth at the end of the 20th century, people in low-income countries live longer but still spend most of their income on food. These countries, as well as affluent countries, demonstrate a rising prevalence of obesity. The interplay of longevity and obesity at different levels of economic development is not clear. Methods We ...

Added: June 29, 2026

Эволюция, экология, генетика человека, медицинская паразитология. Практикум.

Ryskina H., Лобаева Т. А., Ануркина А. И., Ваш формат, 2025.

Я Эволюция, экология, генетика человека, медицинская паразитология. Практикум. Аннотация Аннотация к практикуму «Эволюция, экология, генетика человека, медицинская паразитология» Учебное пособие «Эволюция, экология, генетика человека, медицинская паразитология. Практикум» (авторы: Лобаева Т. А., Рыскина Е. А., Ануркина А. И.; издательство «Ваш формат», 2025 год, 194 страницы) предназначено для студентов высших учебных заведений. Цель практикума — обеспечить комплексное освоение ключевых разделов биологии с акцентом на их прикладное значение в медицине. ...

Added: June 23, 2026

Zα and Zβ Localize ADAR1 to Flipons That Modulate Innate Immunity, Alternative Splicing, and Nonsynonymous RNA Editing

Herbert A., Cherednichenko O., Lybrand T. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 6 Article 2422

The double-stranded RNA editing enzyme ADAR1 connects two forms of genetic programming, one based on codons and the other on flipons. ADAR1 recodes codons in pre-mRNA by deaminating adenosine to form inosine, which is translated as guanosine. ADAR1 also plays essential roles in the immune defense against viruses and cancers by recognizing left-handed Z-DNA and ...

Added: June 22, 2026

Embryonic enhancers help transmit positional information to the initiator cores that control Drosophila Abd-B regulatory domains

Kyrchanova O., Kudryashova K., Ibragimov A. et al., Development 2025 Vol. 152 No. 19 P. 1–12

Drosophila homeotic gene Abdominal-B (Abd-B) is controlled throughout development by four infraabdominal (iab) regulatory domains, the active or repressed state of which is determined by initiators that have parasegment-specific enhancer activity at an early stage of embryonic development. For this reason, it has long been assumed that the enhancer activity and initiation function of these elements are synonymous. ...

Added: June 20, 2026

Initiators counteract Polycomb repression and stimulate long-range contacts between enhancers and the Abdominal-B promoter in Drosophila

Kyrchanova O., Ksenia Kudryashova, Dubrovskaya V. et al., Open Biology 2025 Vol. 15 No. 11 Article 250192

The specification of abdominal segments A5 to A9 depends on the expression of Abdominal-B (Abd-B), which is regulated by four infraabdominal domains: iab-5 through iab-8,9. Each iab domain contains an initiation element that determines its active state, along with enhancers responsible for tissue-specific activation of Abd-B. These iab domains function autonomously due to their flanking boundaries, Fab-6, Fab-7 and Fab-8, which both block crosstalk between adjacent iab domains (insulator function) and facilitate long-range ...

Added: June 20, 2026

Construction of Promoter Elements for Strong, Moderate, and Weak Gene Expression in Drosophila melanogaster

Kudryashova K.S., Deriglazova I. O., Osadchiy I. S. et al., Genes 2025 Vol. 16 No. 1 Article 3

Background/Objectives: Transcriptional promoters play an essential role in regulating protein expression. Promoters with weak activity generally lead to low levels of expression, resulting in fewer proteins being produced. At the same time, strong promoters are commonly used in studies using transgenic organisms as model systems. This approach can have various negative consequences for the organism, ...

Added: June 20, 2026

Diverse β-bungarotoxin isoforms manifest different affinities to voltage-gated potassium channels of Kv1.x subfamily

Ksenia Kudryashova, Filippova E., Kryukova E. et al., Archives of Biochemistry and Biophysics 2025 Vol. 769 Article 110437

β-Bungarotoxins (β-BuTx), consisting of covalently bound phospholipase A2 subunit (A-chain), a member of group Ia of secretory phospholipases A2, and non-enzymatic subunit (B-chain) structurally related to Kunitz-type protease inhibitors, block presynaptic neuromuscular transmission via a not completely defined mechanism of action. In vivo physiological studies revealed that the B-chain is targeting voltage-gated potassium channels of not identified subtypes. In our work, six β-BuTx isoforms were ...

Added: June 20, 2026

Inactivation of NONO by Auranofin or RNA Interference Triggers Lethal Oxidative Stress in Neuroblastoma Cells

Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544

Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...

Added: April 15, 2026

Microplastics’ Impact on the Development of AOM/DSS-Induced Colitis-Associated Colorectal Cancer in Mice

Zolotova N., Kirillova M., Dzhalilova D. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 23 Article 11511

Recently, evidence indicating that microplastics (MPs) have a hazardous effect on human health is accumulating. The potential of MPs having a role in carcinogenesis was suggested. Therefore, the aim of this study was to evaluate MPs’ effect on colitis-associated colorectal cancer (CAC) development. The AOM/DSS-induced CAC model was reproduced in two groups of adult male ...

Added: March 24, 2026

A New Mouse Strain with a Mutation in the NFE2L2 (NRF2) Gene

Egorov E., Kondratenko N., Averina O. et al., Biochemistry. Biokhimiia 2023 Vol. 88 P. 1987–1996

Transcription factor NRF2 is involved in inflammatory reactions, maintenance of redox balance, metabolism of xenobiotics, and is of particular interest for studying aging. In the present work, the CRISPR/Cas9 genome editing technology was used to generate the NRF2ΔNeh2 mice containing a substitution of eight amino acid residues at the N-terminus of the NRF2 protein, upstream of ...

Added: March 20, 2026

Urban dust nanoparticles drive inflammatory activation of human neutrophils and macrophages in vitro

Pavlyuchenkova A., Vorobjeva N., Ivaneev A. et al., Environmental Science and Pollution Research 2025 Vol. 32 P. 26541–26553

Today, the majority of the world’s population lives in urban environments, where they are constantly exposed to dust particles of varying sizes, including urban dust nanoparticles (NPs). The minute size of NPs ensures their quick and efficient penetration into inner body parts, where they can interact with many cell types, including epithelial, endothelial, and immune ...

Added: March 20, 2026

Структура и биологическая активность нитроксисукцината 3-гидрокси-6-метил-2-этилпиридиния

Балакина А. А., Приходченко Т. Р., Якушев И. А. et al., Известия Академии наук. Серия химическая 2023 Т. 72 № 7 С. 1618–1632

The structure of 3-hydroxy-6-methyl-2-ethylpyridinium nitroxysuccinate (2), its cytotoxicity, and its ability to influence the content of intracellular nitrogen monoxide, as well as the formation of reactive oxygen species and lipid peroxidation processes under conditions of induced oxidative stress were studied. It was demonstrated that compound 2 had low cytotoxicity in vitro in both non-cancerous and ...

Added: September 14, 2025