Взаимосвязь изменения экспрессии микроРНК и мРНК в клетках линии НТ-29 в условиях гипоксии

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Взаимосвязь изменения экспрессии микроРНК и мРНК в клетках линии НТ-29 в условиях гипоксии

Вестник Российского государственного медицинского университета. 2020. № 6. С. 48–54.

Nersisyan S., Galatenko A. V., Maltseva D., Ushkarev Y., Tonevitsky A.

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Gureev M., Advanced Science 2026 P. 1–13

Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...

Added: September 26, 2026

A28-04 Measuring the Polygenic Risk of Thrombosis May Accelerate the Detection of Chronic Thromboembolic Pulmonary Hypertension Among Other Forms of Pulmonary Hypertension

Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212

Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...

Added: September 23, 2026

Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome

Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324

Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...

Added: September 23, 2026

A complete genome for the common marmoset

Hebbar P., Ryabov F., Alexandrov I. et al., Cell 2026 Vol. 189 P. 4891–4908.e12

The common marmoset is a New World monkey widely used to study primate evolution and human disease. We present a telomere-to-telomere (T2T) reference assembly for the species, plus three near-T2T haplotypes. These resolve previously inaccessible regions, including the centromeres, sex chromosomes, subterminal satellites, acrocentric chromosomes, and the major histocompatibility complex (MHC). We find marmoset centromeres ...

Added: September 23, 2026

Peptide language pragmatic analysis and two-stage hierarchical learning framework for therapeutic peptide prediction

Shaitan A., Ke Y., Shutao C. et al., 2026 No. 24 Article 181

Background Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues and the contextual dependencies within peptide sequences, which hampers the extraction of deep semantic representations and ...

Added: September 18, 2026

A functional systems view on neural tracking of natural speech

Anton Rogachev, Sysoeva O., Frontiers in Systems Neuroscience 2025 Vol. 19 Article 1658243

Added: September 17, 2026

Neural tracking of natural speech in children in relation to their receptive speech abilities

Rogachev A.O., Sysoeva O. V., Cognitive Systems Research 2024 Vol. 86 Article 101236

Receptive speech is the ability to understand speech addressed to a person. It is a crucial process for a child’s cognitive development. We examine the relationship between receptive speech and neural tracking of natural speech in 52 children aged 3–8 years to infer the neurophysiological mechanisms underlying speech development. We registered a 32-channel electroencephalogram (EEG) ...

Added: September 17, 2026

Vague stimulating ideas, images and metaphors in scientific thinking: researchers' work with horizons of unclear knowledge

Poddiakov A., / Series Social Science Research Network "Social Science Research Network". 2026. No. 7437658.

Clarity of knowledge and reasoning is necessary in many cases. Yet vagueness in scientific thinking related to surprise, curiosity, "ability to engage with not-knowing" (de Freitas) and abductive reasoning is also a crucially important source of scientific creativity which supplements combinatorial logic when dealing with the already known. Starting from studies by C. S. Peirce ...

Added: September 15, 2026

Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Kang J., Kim H. J., Kim M. S. et al., Nature Medicine 2026 No. 32 P. 527–544

Drug use disorders (DUDs) are emerging global public health challenges. Here we investigated the global and regional estimates of the prevalence and burden of DUDs, including amphetamine, cannabis, cocaine and opioid use disorders, from 1990 to 2023 for 204 countries and territories by using the Global Burden of Disease Study 2023. Overall, trends in global ...

Added: September 9, 2026

Разработка методик на основе айтрекинга для диагностики когнитивных функций у детей

Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2024 Т. 13 № 2 С. 33–43

Создание методик диагностики на основе анализа движений глаз является особенно актуальным для оценки когнитивных функций у детей, которые не могут дать речевой или моторный ответ в силу своего возраста или из-за нарушений развития. Для таких детей использование объективных методов оценки когнитивных функций на основе айтрекинга может стать полезным диагностическим инструментом, дополняющим традиционные поведенческие опросники и ...

Added: September 8, 2026

Развитие когнитивных функций детей с помощью методик, использующих видеоокулографию

Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2023 Т. 12 № 4 С. 51–61

Активное развитие метода видеоокулографии, т. е. регистрации движений глаз, создает возможности для создания новых подходов для развития когнитивных функций и обучения. Методики, основанные на видеоокулографии, могут быть полезны не только для детей с серьезными нарушениями моторных функций, но и детей с нарушениями развития когнитивных функций, прежде всего внимания, так как контроль движений глаз тесно связан ...

Added: September 8, 2026

Вегетативные и поведенческие показатели при увеличении когнитивной нагрузки у здоровых добровольцев

Портнова Г. В., Liaukovich K., Васильева Л. Н. et al., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 4 С. 504–519

Когнитивная и эмоциональная нагрузка в ходе увеличения сложности задач приводит к активации различных звеньев вегетативной нервной системы и может сопровождаться как увеличением эффективности решения задач, так и способствовать дестабилизации эмоционального состояния и уменьшению продуктивности. Увеличение когнитивной нагрузки при условии высокой мотивации испытуемых является стрессовым фактором и выражается в различной реакции симпатического и парасимпатического звеньев в ...

Added: September 8, 2026

DSCA-HLAII: A dual-stream cross-attention model for predicting peptide–HLA class II interaction and presentation

Shaitan A., Ke Y., Hongjun Y. et al., PLoS Computational Biology 2026 Article e1013836

The interaction between peptides and human leukocyte antigen class II (HLA-II) molecules plays a pivotal role in adaptive immune responses, as HLA-II mediates the recognition of exogenous antigens and initiates T cell activation through peptide presentation. Accurate prediction of peptide-HLA-II binding serves as a cornerstone for deciphering cellular immune responses, and is essential for guiding the optimization of antibody therapeutics. ...

Added: September 7, 2026

Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder

Proskurnina E., Liaukovich K., Bychkovskaya L. et al., Metabolites 2023 Vol. 13 No. 1 P. 73

Added: September 7, 2026

Liaukovich K., Sazhin S., Bobrov P. et al., International Journal of Molecular Sciences 2022 Vol. 23 No. 19 P. 11785

Added: September 7, 2026

Implicit auditory perception of local and global irregularities in passive listening condition

Liaukovich K., Ukraintseva Y., Martynova O., Neuropsychologia 2022 Vol. 165 P. 108129

Added: September 7, 2026

Pupillometry and autonomic nervous system responses to cognitive load and false feedback: an unsupervised machine learning approach

Alshanskaia E., Portnova G., Liaukovich K. et al., Frontiers in Neuroscience 2024 Vol. 18

Added: September 7, 2026

Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers

Silina M., Dzhalilova D., Fokichev N. et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1674608

Humans and laboratory animals differ in their resistance to hypoxia, which affects the severity of inflammatory diseases and the rate of tumor progression. Therefore, it is necessary to search for methods for assessing the initial tolerance to oxygen deficiency and the risks of developing acute mountain sickness without direct hypoxia exposure on the organism. The ...

Added: March 24, 2026

Длительное культивирование макрофагов в коллагеновом геле на мембране (Transwell) индуцирует гипоксию

Ок. Е. Колодеева, Ол. Е. Колодеева, Биотехнология 2025 Т. 41 № 6 С. 64–71

A three-dimensional (3D) matrix consisting of collagen fibers can create culture conditions that are more similar to in vivo tissues than 2D cultures in in vitro culture plates. Macrophages are among the most important innate immune cells. They are extremely plastic, allowing them to respond effectively to pro- and anti-inflammatory signals within their microenvironment. There ...

Added: December 24, 2025

scRNA-seq of preeclamptic trophoblasts identifies EBI3, COL17A1, miR-27a-5p, and miR-193b-5p as hypoxia markers: validation of neuradapt as a superior mimetic to cobalt chloride

Knyazev E., Timur Kulagin, Antipenko I. et al., Placenta 2026 Vol. 176 P. 1–12

Background. Preeclampsia (PE) complicates 2–8% of pregnancies and involves placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Chemical mimetics like cobalt(II) chloride (CoCl2) and oxyquinoline derivatives model trophoblast hypoxia in vitro, yet their fidelity in recapitulating PE gene profiles remains unclear. Integrating patient tissue analyses with experimental models may reveal common markers and ...

Added: December 22, 2025

Comparative Analysis of Lipid Metabolism in Trophoblast Subpopulations in Preeclampsia and In Vitro Hypoxia Model

Antipenko I., Knyazev E., Timur Kulagin et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1731126

Preeclampsia is a leading cause of maternal and perinatal morbidity associated with systemic lipid metabolism disturbances, yet the underlying molecular mechanisms remain incompletely understood. In this study, we integrated single-cell RNA-seq data from preeclamptic placentas with an in vitro hypoxia model to analyze gene expression changes across distinct trophoblast subpopulations. While all trophoblast lineages exhibited ...

Added: December 2, 2025

Профиль микроРНК у женщин с инсомнией в менопаузе: пилотное исследование

Семенова Н. В., Райгородская М. П., Averinskaya D. et al., Бюллетень экспериментальной биологии и медицины 2025 Т. 180 № 7 С. 114–118

The microRNA profile in the blood plasma of menopausal women with insomnia (according to the Pittsburgh Sleep Quality Index questionnaire) was studied in two stages with 15 participants in each and an interval of 12 months. Both stages involved 12 women, and no transition from one group to another was detected in the second stage ...

Added: September 5, 2025

Influence of Microplastics on Manifestations of Experimental Chronic Colitis

Zolotova N., Silina M., Dzhalilova D. et al., - 2025 Vol. 13 No. 8 Article 701

Environmental pollution with microplastics (MPs) can have a negative impact on human health. Certain findings point to the relationship between MP and the development of inflammatory bowel diseases (IBD). We investigated the effect of MP consumption on the severity of chronic colitis in male C57BL/6 mice. The MP effect was modeled by drinking water consumption ...

Added: August 25, 2025

Hypoxia-activated dissociation of heteroleptic cobalt(III) complexes with functionalized 2,2′-bipyridines and a model anticancer drug esculetin

Ekaterina Khakina, Nikovskiy I., Spiridonov K. et al., Dalton Transactions 2025 Vol. 54 No. 9 P. 3667–3678

A low oxygen level in solid tumors is behind the modern concept of selective chemotherapy by hypoxia-activated prodrugs, such as heteroleptic complexes of transition metals (cobalt(III), iron(III) or platinum(IV)) with bi- or tetradentate ligands and an anticancer drug molecule as a co-ligand. A series of new cobalt(III) complexes [Co(LR)2(esc)]ClO4 with esculetin (6,7-dihydroxycoumarin) and 2,2′-bipyridines (2,2′-bipy) ...

Added: February 24, 2025