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Characteristics of the Frequency-Following Response to Changes in the Acoustic Parameters of a Speech Signal (Isolated Syllable)
Human Physiology. 2026. Vol. 52. No. 3. P. 295–301.
Oknina L. B., Podlepich V. V., Sieber I., Pitskhelauri D. I., Slezkin A. A., Strelnikova E. V., Kantserova A. O.
The aim of this study was to evaluate the potential use of the frequency-following response (FFR) for assessing preserved perception of simple speech stimuli in humans. To this end, event-related potentials (ERPs) elicited by isolated Russian syllables were recorded and analyzed in 29 healthy subjects in two frequency ranges, the standard range (1—40 Hz) and the high-frequency range (70—150 Hz), and the identified peaks were compared with local-field potentials recorded directly from the midbrain in two patients during intraoperative neurophysiological monitoring. In the standard frequency range, a negative peak with a latency of approximately 100 ms from the analyzed event was identified in the ERPs in response to sound onset and to the transition from a consonant to a vowel. In the high-frequency range, FFR components were identified in response to syllable onset and to the transition from a consonant to a vowel; these components were similar to oscillations in local evoked responses from the patients’ midbrain. During syllable presentation, clusters of high-frequency oscillations were identified, and their prominence differed depending on the acoustic characteristics of the component sounds of the syllable. The data obtained suggest that ERP analysis in two frequency ranges, the standard and high-frequency ranges, can be used as an additional method for assessing the ability to perceive speech in humans when verbal contact with a patient is absent. The findings of this study may be used as normative data for evaluating FFRs elicited by isolated Russian syllables.
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324
Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...
Added: September 23, 2026
Hebbar P., Ryabov F., Alexandrov I. et al., Cell 2026 Vol. 189 P. 4891–4908.e12
The common marmoset is a New World monkey widely used to study primate evolution and human disease. We present a telomere-to-telomere (T2T) reference assembly for the species, plus three near-T2T haplotypes. These resolve previously inaccessible regions, including the centromeres, sex chromosomes, subterminal satellites, acrocentric chromosomes, and the major histocompatibility complex (MHC). We find marmoset centromeres ...
Added: September 23, 2026
Shaitan A., Ke Y., Shutao C. et al., 2026 No. 24 Article 181
Background Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues and the contextual dependencies within peptide sequences, which hampers the extraction of deep semantic representations and ...
Added: September 18, 2026
Anton Rogachev, Sysoeva O., Frontiers in Systems Neuroscience 2025 Vol. 19 Article 1658243
Added: September 17, 2026
Anton Rogachev, Sysoeva O., Cognitive Systems Research 2024 Vol. 86 Article 101236
Receptive speech is the ability to understand speech addressed to a person. It is a crucial process for a child’s cognitive development. We examine the relationship between receptive speech and neural tracking of natural speech in 52 children aged 3–8 years to infer the neurophysiological mechanisms underlying speech development. We registered a 32-channel electroencephalogram (EEG) ...
Added: September 17, 2026
Чеботарева О. Е., Пирогов А. А., Antipenko I. et al., Доклады российской академии наук. Науки о жизни 2026 Т. 529 № 1 С. 389–395
Preeclampsia (PE) is a severe obstetric complication caused by chronic placental ischaemia. Genome-wide profiling of microRNA isoforms in two trophoblast hypoxia models (CoCl2 and the oxyquinoline derivative neuradapt, BeWo b30 cells) and clinical PE samples (placental tissue, syncytiotrophoblast vesicles) revealed concordant downregulation of hsa-miR-143-3p isoforms. Under a strict fold-change threshold, the canonical isoform (21 nt) ...
Added: September 16, 2026
Poddiakov A., / Series Social Science Research Network "Social Science Research Network". 2026. No. 7437658.
Clarity of knowledge and reasoning is necessary in many cases. Yet vagueness in scientific thinking related to surprise, curiosity, "ability to engage with not-knowing" (de Freitas) and abductive reasoning is also a crucially important source of scientific creativity which supplements combinatorial logic when dealing with the already known. Starting from studies by C. S. Peirce ...
Added: September 15, 2026
Bug D. S., Kuzovenkova D. A., Tishkov A. V. et al., Biochemical Genetics 2026
Deciphering the evolutionary history of genes is foundational for biomedical research, enabling the identification of compensatory mutations in disease-associated genes and the selection of evolutionarily relevant model organisms. However, challenges of multi-isoform handling, the presence of incomplete genomes/proteomes initial datasets, and problems of evolutionary history representation are still present. To address these issues, we introduce ...
Added: September 14, 2026
Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2024 Т. 13 № 2 С. 33–43
Создание методик диагностики на основе анализа движений глаз является особенно актуальным для оценки когнитивных функций у детей, которые не могут дать речевой или моторный ответ в силу своего возраста или из-за нарушений развития. Для таких детей использование объективных методов оценки когнитивных функций на основе айтрекинга может стать полезным диагностическим инструментом, дополняющим традиционные поведенческие опросники и ...
Added: September 8, 2026
Ребрейкина А. Б., Liaukovich K., Современная зарубежная психология 2023 Т. 12 № 4 С. 51–61
Активное развитие метода видеоокулографии, т. е. регистрации движений глаз, создает возможности для создания новых подходов для развития когнитивных функций и обучения. Методики, основанные на видеоокулографии, могут быть полезны не только для детей с серьезными нарушениями моторных функций, но и детей с нарушениями развития когнитивных функций, прежде всего внимания, так как контроль движений глаз тесно связан ...
Added: September 8, 2026
Портнова Г. В., Liaukovich K., Васильева Л. Н. et al., Журнал высшей нервной деятельности им. И.П. Павлова 2022 Т. 72 № 4 С. 504–519
Когнитивная и эмоциональная нагрузка в ходе увеличения сложности задач приводит к активации различных звеньев вегетативной нервной системы и может сопровождаться как увеличением эффективности решения задач, так и способствовать дестабилизации эмоционального состояния и уменьшению продуктивности. Увеличение когнитивной нагрузки при условии высокой мотивации испытуемых является стрессовым фактором и выражается в различной реакции симпатического и парасимпатического звеньев в ...
Added: September 8, 2026
Shaitan A., Ke Y., Hongjun Y. et al., PLoS Computational Biology 2026 Article e1013836
The interaction between peptides and human leukocyte antigen class II (HLA-II)
molecules plays a pivotal role in adaptive immune responses, as HLA-II mediates
the recognition of exogenous antigens and initiates T cell activation through peptide
presentation. Accurate prediction of peptide-HLA-II binding serves as a cornerstone
for deciphering cellular immune responses, and is essential for guiding the optimization
of antibody therapeutics. ...
Added: September 7, 2026
Окнина Л. Б., Подлепич В. В., Sieber I. et al., Физиология человека 2026 Т. 52 № 3 С. 5–15
The aim of this study was to evaluate the frequency following response (FFR) for the analysis of the intact perception of syllables in humans. For this purpose, event-related potentials (ERPs) in response to isolated Russian syllables were recorded and analyzed in 29 healthy persons in two frequency ranges, standard (1-40 Hz) and high frequency (70-150 ...
Added: June 30, 2026
Zubov V., Осадчая М. А., Риехакайнен Е. И., Вестник Санкт-Петербургского университета. Язык и литература 2026 Т. 23 № 1 С. 99–119
The article is a part of a comprehensive study of the linguistic characteristics of teacher’s speech, which contribute to the success of the pedagogical discourse. Based on a survey of secondary school students and an analysis of previous research in the field, non-syntactic pauses of hesitation were chosen as the object of the study, i. ...
Added: April 29, 2026
Осадчая М. А., Zubov V., Риехакайнен Е. И., Acta Linguistica Petropolitana. Труды института лингвистических исследований 2025 Т. 21 № 3 С. 135–158
This study investigates the role of hesitation pauses in spoken teacher discourse and their duration in the perception and short-term memorization of lexical items. While previous research has suggested that certain disfluencies, including hesitation pauses, can facilitate comprehension and memorization, the specific conditions under which this occurs remain unclear. To address this gap, an experimental ...
Added: April 19, 2026
Пчелинцева М. Е., Lazarev I. E., Lyusin D., В кн.: Когнитивная наука в Москве: новые исследования. Материалы конференции 25 – 26 июня 2025.: М.: Буки Веди, 2025. С. 447–451.
The effects of emotional distraction might differ depending on the valence and arousal of induced affective states. Nevertheless, insufficient complexity of a cognitive task might affect the ability of participants to allocate attention resources for the successful examination of emotional stimuli and task performance. This is why, in previous research, indicators of accuracy and response ...
Added: January 16, 2026
Oknina L. B., Podlepich V. V., Vologdina Y. O. et al., Human Physiology 2025 Vol. 51 No. 2 P. 79–88
In recent years, there has been an increased interest in how a person distinguishes his own name from other stimuli. In large part this interest is determined by the intensive development of a personalized approach in medicine, psychology, and rehabilitation. The purpose of this study was to identify the characteristics of a person’s perception of ...
Added: August 27, 2025
Polyakova A. A., Этнопсихолингвистика 2024 Т. 2 № 17 С. 45–62
The problem of perception and generation of speech by children is in the focus of present-day research. The novelty of the study lies in the consideration of these processes from the viewpoint of the influence on them of the pathology of the nervous system and the musculoskeletal system, namely, infantile cerebral palsy (CP). The review ...
Added: May 11, 2025