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  • РОЛЬ ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМАЛЬНОГО ПЕРЕХОДА И АУТОФАГИИ В ПРОТИВООПУХОЛЕВОМ ОТВЕТЕ КЛЕТОЧНЫХ ЛИНИЙ МЕЛАНОМЫ НА ТАРГЕТНОЕ ИНГИБИРОВАНИЕ MEK и mTOR КИНАЗ
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Subject
News
October 8, 2026
HSE Experts Take Part in 23rd Annual Meeting of Valdai Discussion Club
The 23rd Annual Meeting of the Valdai Discussion Club was held from September 28 to October 1, 2026 under the theme ‘Responsibility for the Future: Limits of the Possible, or Limitless Possibilities?’ The forum brought together 120 experts from 40 countries, including representatives of China, the United States, India, Brazil, the United Kingdom, Germany, Egypt, Iran, and Japan.
October 7, 2026
‘Our Team Consists of True Leaders in Their Respective Academic Disciplines
The HSE International Centre of Decision Choice and Analysis studies a wide range of methods for analysing decision-making and possible scenarios for the development of natural, socio-economic, and political phenomena using various mathematical models. The application of advanced mathematical methods to forecasting helps to prevent negative outcomes and avoid erroneous decisions. The HSE News Service spoke to the centre’s director, Prof. Fuad Aleskerov, about its work.
October 6, 2026
International N5 Symposium ‘Neural Networks and Nonlinearity in Nizhny Novgorod Brings Together Scientists from Russia and Serbia
The International N5 Symposium ‘Neural Networks and Nonlinearity in Nizhny Novgorod’ was held at the Nizhny Novgorod House of Scientists from September 23 to 26. The event was organised by HSE University–Nizhny Novgorod and the Nizhny Novgorod House of Scientists, with the participation of Sberbank and the Institute of Physics Belgrade. The symposium was held for the second time: the first conference took place in 2025 and attracted considerable interest from the academic community.

 

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РОЛЬ ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМАЛЬНОГО ПЕРЕХОДА И АУТОФАГИИ В ПРОТИВООПУХОЛЕВОМ ОТВЕТЕ КЛЕТОЧНЫХ ЛИНИЙ МЕЛАНОМЫ НА ТАРГЕТНОЕ ИНГИБИРОВАНИЕ MEK и mTOR КИНАЗ

Сибирский онкологический журнал. 2019. Т. 18. № 3. С. 54–63.
Рябая О. О., Прокофьева А. А., Хоченков Д. А., Акасов Р. А., Буров С. В., Марквичева Е. А., Stepanova E.
Research target: Biology Basic Medicine
Language: Russian
DOI
Text on another site
Keywords: Autophagyэкспериментальная терапияCancer Spheroidsаутофагияmelanomaмеланомаexperimental therapyсфероиды
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HLA class I escape drives the evolution of SARS-CoV-2 in human populations
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Pericyte-derived cancer-associated fibroblasts correlate with poor survival and are enriched after chemoradiotherapy in glioblastoma
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Профессиональная учебная практика: I курс. Введение в биотехнологию, клеточную и молекулярную биологию : учебно-методическое пособие для студентов и преподавателей
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Анализ in silico вероятных зависимостей «структура-активность» этанола
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
A28-04 Measuring the Polygenic Risk of Thrombosis May Accelerate the Detection of Chronic Thromboembolic Pulmonary Hypertension Among Other Forms of Pulmonary Hypertension
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome
Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324
Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...
Added: September 23, 2026
A complete genome for the common marmoset
Hebbar P., Ryabov F., Alexandrov I. et al., Cell 2026 Vol. 189 P. 4891–4908.e12
The common marmoset is a New World monkey widely used to study primate evolution and human disease. We present a telomere-to-telomere (T2T) reference assembly for the species, plus three near-T2T haplotypes. These resolve previously inaccessible regions, including the centromeres, sex chromosomes, subterminal satellites, acrocentric chromosomes, and the major histocompatibility complex (MHC). We find marmoset centromeres ...
Added: September 23, 2026
Peptide language pragmatic analysis and two-stage hierarchical learning framework for therapeutic peptide prediction
Shaitan A., Ke Y., Shutao C. et al., 2026 No. 24 Article 181
Background Therapeutic peptides exert pivotal effects in diverse biological processes, and have attracted significant interest in the field of biomedicine in recent years. However, most existing methods often fail to adequately capture the intricate interactions among amino acid residues and the contextual dependencies within peptide sequences, which hampers the extraction of deep semantic representations and ...
Added: September 18, 2026
A functional systems view on neural tracking of natural speech
Anton Rogachev, Sysoeva O., Frontiers in Systems Neuroscience 2025 Vol. 19 Article 1658243
Added: September 17, 2026
Neural tracking of natural speech in children in relation to their receptive speech abilities
Anton Rogachev, Sysoeva O., Cognitive Systems Research 2024 Vol. 86 Article 101236
Receptive speech is the ability to understand speech addressed to a person. It is a crucial process for a child’s cognitive development. We examine the relationship between receptive speech and neural tracking of natural speech in 52 children aged 3–8 years to infer the neurophysiological mechanisms underlying speech development. We registered a 32-channel electroencephalogram (EEG) ...
Added: September 17, 2026
Изоформы микроРНК hsa-miR‐143-3p как регуляторы HK2 и SERPINE1 при гипоксии трофобласта и преэклампсии
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Preeclampsia (PE) is a severe obstetric complication caused by chronic placental ischaemia. Genome-wide profiling of microRNA isoforms in two trophoblast hypoxia models (CoCl2 and the oxyquinoline derivative neuradapt, BeWo b30 cells) and clinical PE samples (placental tissue, syncytiotrophoblast vesicles) revealed concordant downregulation of hsa-miR-143-3p isoforms. Under a strict fold-change threshold, the canonical isoform (21 nt) ...
Added: September 16, 2026
Vague stimulating ideas, images and metaphors in scientific thinking: researchers' work with horizons of unclear knowledge
Poddiakov A., / Series Social Science Research Network "Social Science Research Network". 2026. No. 7437658.
Clarity of knowledge and reasoning is necessary in many cases. Yet vagueness in scientific thinking related to surprise, curiosity, "ability to engage with not-knowing" (de Freitas) and abductive reasoning is also a crucially important source of scientific creativity which supplements combinatorial logic when dealing with the already known. Starting from studies by C. S. Peirce ...
Added: September 15, 2026
Discovering New Orthologous Groups with P-COGs
Bug D. S., Kuzovenkova D. A., Tishkov A. V. et al., Biochemical Genetics 2026
Deciphering the evolutionary history of genes is foundational for biomedical research, enabling the identification of compensatory mutations in disease-associated genes and the selection of evolutionarily relevant model organisms. However, challenges of multi-isoform handling, the presence of incomplete genomes/proteomes initial datasets, and problems of evolutionary history representation are still present. To address these issues, we introduce ...
Added: September 14, 2026
CD44 variant exons induce chemoresistance by modulating cell death pathways
Yanova M., Stepanova E., Maltseva D. et al., Frontiers in Cell and Developmental Biology 2025 Vol. 13 Article 1508577
Cancer chemoresistance presents a challenge in oncology, often leading to treatment failure and disease progression. CD44, a multifunctional cell surface glycoprotein, has garnered attention for its involvement in various aspects of cancer biology. Through alternative splicing, CD44 can form isoforms with the inclusion of only standard exons, typical for normal tissue, or with the addition ...
Added: March 12, 2025
Riboflavin photoactivation by upconversion nanoparticles for cancer treatment
Khaydukov E. V., Mironova K. E., Semchishen V. A. et al., Scientific Reports 2016 Vol. 6 No. 1 P. 0
Riboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and irradiated with ultraviolet light, and proved that such Rf ...
Added: October 30, 2024
Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells
Prokofieva A., Ryabaya O., Akasov R. et al., Biomedicine and Pharmacotherapy 2019 Vol. 109 P. 2548–2560
Melanoma is one of the most aggressive and treatment-resistant tumors that responsible for majority of skin-cancer related deaths. Here we propose a combination of MEK inhibitor binimetinib with metformin as a promising therapy against human melanoma cells in vitro, including BRAF -mutated A375, Mel Z, and Mel IL cells, and NRAS-mutated Mel MTP and Mel ...
Added: October 30, 2024
Activation of Apoptosis and Autophagy by Gratiola Officinalis Extract in Human Tumor Cell Lines
Polukonova N., Baryshnikova M., Khochankov D. et al., Journal of Biomedical Photonics and Engineering 2021 Vol. 7 No. 4 Article 040307
The problem of creating antitumor drugs with new mechanisms of action that predominantly induce apoptosis is still topical. The extract of Gratiola officinalis is a potential antitumor agent containing mainly flavonoids. The aim of this research is to study the effects of Gratiola officinalis extract on activation of apoptosis and autophagy in breast adenocarcinoma SK-BR-3 and kidney carcinoma A-498 lines. ...
Added: October 30, 2024
РЕЦЕПТОР VEGF-R1/FLT-1 КАК ХАРАКТЕРИСТИКА АНГИОГЕННОГО ФЕНОТИПА УВЕАЛЬНОЙ МЕЛАНОМЫ
Лихванцева В. Г., Анурова О. А., Астахова С. Е. et al., Офтальмология 2021 Т. 18 № 4 С. 866–875
Благодаря появившимся новым фундаментальным данным наши представления о роли ангиогенеза и его молекулярных участниках изменились. Расшифрованы молекулярно-генетические механизмы активации сигнальных путей пролиферации, малигнизации, подавления апоптоза опухолевых клеток, осуществляемые посредством взаимодействия молекулы VEGF с ее рецепторами. Сменилась доктрина ангиогенеза. Ангиогенез стали рассматривать в аспекте механизма повышения анаплазии, ускорения пролиферации, формирования клона стволовых опухолевых клеток, высокорезистентных к ...
Added: October 30, 2024
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Необходимым условием для роста, прогрессирования и метастазирования злокачественных опухолей любой локализации является развитие собственной сети сосудов. Новообразованные сосуды не только питают первичную опухоль, но и создают условия для распространения опухолевых клеток по кровеносной системе и формирования дистантных метастазов. Ангиогенез способна запустить небольшая популяция из опухолевых 100–300 клеток, накопивших генетические аберрации и начавших экспрессировать проангиогенные молекулы. ...
Added: October 30, 2024
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