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  • РЕЦЕПТОР VEGF-R1/FLT-1 КАК ХАРАКТЕРИСТИКА АНГИОГЕННОГО ФЕНОТИПА УВЕАЛЬНОЙ МЕЛАНОМЫ
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News
May 25, 2026
HSE Scientists Train Neural Network to 'Hear' Faults in Electric Motors
Researchers at the AI and Digital Science Institute of the HSE Faculty of Computer Science have developed a new method—the Signature-Guided Data Augmentation (SGDA) framework—that achieves 99% accuracy in motor fault detection and 86% accuracy in fault classification. The application of this approach can reduce industrial equipment repair costs, minimise downtime, and improve production safety. The study results have been published in Engineering Applications of Artificial Intelligence.
May 25, 2026
'The Humanities Serve as a Conscience'
Maria Mizernaia studies Soviet literature and the history of book publishing. In this interview for the HSE Young Scientists project, she discusses plans to publish a novel about besieged Leningrad, AI-provoked reflections on what it means to be human, and how novels can help satisfy our dopamine hunger.
May 25, 2026
Is It Possible to Predict a Citys Life Based on the Shape of Its Neighbourhoods?
Is it possible to predict, based on the configuration of streets and buildings, where a café will open or where traffic congestion will occur? Participants in the Spatial Analysis and Modelling of Urban Processes research and study group use open data and machine learning to identify universal patterns. Alexander Sheludkov and Eduard Somov discuss the purpose of comparing cities, the need for new forms of urban statistics, and how open data is transforming approaches to urban studies.

 

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?

РЕЦЕПТОР VEGF-R1/FLT-1 КАК ХАРАКТЕРИСТИКА АНГИОГЕННОГО ФЕНОТИПА УВЕАЛЬНОЙ МЕЛАНОМЫ

Офтальмология. 2021. Т. 18. № 4. С. 866–875.
Лихванцева В. Г., Анурова О. А., Астахова С. Е., Верещагина М. В., Ованесян В. Э., Stepanova E.
Research target: Biology Basic Medicine
Language: Russian
DOI
Text on another site
Keywords: прогнозCancer prognosisangiogenesismelanomaмеланомаангиогенез
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Novelty, Category and Orientation Tuning for Printed Characters: A Magnetoencephalography Study with Fast Periodic Visual Stimulation
Kochetkova Ekaterina, Kostanian D., Martynova O. et al., Brain Topography 2026 Vol. 39 No. 4 Article 51
Letter recognition is assumed to involve several levels of analysis, including coarse tuning for category and novelty and more fine tuning for specific features, related to letter orientation. We employed an oddball fast periodic visual stimulation (FPVS) paradigm with magnetoencephalography (Elekta VectorView, 306 sensors) to study neural discrimination responses in the source space. Using contrasts ...
Added: May 24, 2026
Molecular dynamics simulations refine the pathogenicity of ACVRL1 kinase domain variants by quantifying impacts on ATP binding in pulmonary arterial hypertension
Borovikova I., Okhrimenko G., Zamyatin V. et al., Journal of Structural Biology 2026 Vol. 218 No. 2 Article 108315
Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular diagnosis for pulmonary arterial hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). Since aberrant ATP binding disrupts downstream SMAD1/5/8 phosphorylation, we employed molecular dynamics ...
Added: May 20, 2026
uPAR deficiency triggers TGFβ1-mediated fibrotic remodeling in a cardiac perivascular-like microenvironment
Goltseva Y., Tsokolaeva Z., Beloglazova I. et al., Stem Cell Research and Therapy 2026 Vol. 17 No. 1 Article 112
Background Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling. The urokinase plasminogen activator receptor (uPAR), a critical component of the urokinase system, plays a pivotal role in vascular remodeling and fibrosis. While prior evidence indicates that uPAR deficiency leads to microvascular dysfunction and perivascular fibrosis, ...
Added: May 19, 2026
Motor imagery perspective shapes corticospinal excitability with effector-specific effects
Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Мультимодальные модели в медицинской диагностике как универсальный инструмент
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Multimodal EEG, ECG, and video dataset of yoga practitioners during concentration and mind-wandering tasks
Kashevnik A., Glekler E., Artemenko E. et al., Scientific data 2026 Article 7209
We present a multimodal dataset containing electroencephalography (EEG), electrocardiography (ECG), and video recordings from 49 participants. Each participant completed a single session lasting approximately 45 minutes. During each session they performed five tasks: resting state, inward concentration (focusing on the center of the forehead), outward concentration (visual search), and mind-wandering. EEG data were recorded from ...
Added: April 23, 2026
Rapid synthesis of redox-responsive trithiocyanuric acid-based nanocarriers: in vitro multidrug resistance reversal and In vivo safety assessment
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Функциональные признаки листьев и экологические стратегии важны для формирования растительных сообществ субальпийских болот и высокотравья
Гулов Д. М., Елумеева Т. Г., Федоров Н. И. et al., Журнал общей биологии 2024 Т. 85 № 2 С. 83–94
Plant functional traits are important for the formation of plant communities and for the ability of plants to dominate there. The comparison of mean trait values of organisms within community with that for the random samples of the local biota allows estimating the importance of the trait for the formation of the community composition. The ...
Added: April 19, 2026
The partitioning of mobile fractions of chemical elements in the mineral loamy soils during natural regeneration after plowing in Western Russia
Enchilik P. R., G.V.Klink, Semenkov I. N., Science of the Total Environment 2025 Vol. 998 Article 180219
Natural regeneration of forest soils affected by agricultural practices is a common phenomenon in many regions worldwide, particularly in boreal ecosystems. Affecting soil quality, the partitioning of extractable fractions of heavy metals and metalloids (HMMs) is not studied during natural regeneration. The following stages of natural regeneration after plowing have been identified in the Smolenskoye ...
Added: April 19, 2026
Self-face viewing attenuates cardiac modulation of corticospinal excitability
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807
Introduction:  While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception). Methods:  In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Inactivation of NONO by Auranofin or RNA Interference Triggers Lethal Oxidative Stress in Neuroblastoma Cells
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Discovery of Novel 1,3,5-Triazine Derivative as Potent Anticancer Agent: DNA and HSA Binding, MTT Assay
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Saying “Yes” to NONO: A Therapeutic Target for Neuroblastoma and Beyond
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and Clinical Perspectives
Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Взаимодействие аффективных и когнитивных компонентов рабочей памяти при удержании эмоционально-окрашенной информации. Нейрокогнитивный анализ
Kochetkova E., Мачинская Р. И., Журнал высшей нервной деятельности им. И.П. Павлова 2025 Т. 75 № 2 С. 170–188
The review provides an analysis of modern cognitive psychological theories of emotions and neural basis of mechanisms standing behind retention of emotional information in working memory. The tendency seen in modern neurocognitive theories is characterized by the rejection of localization for any psychological functions in favor of network models, where higher-order processes are supported by distributed neural networks connecting ...
Added: April 15, 2026
Metal-Based Therapeutic Approaches for Overcoming Cancer Drug Resistance: Mechanisms, Drug Delivery Strategies, and Clinical Perspectives
Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Complex (Multi-model) Forecasting of Surface Wind Gusts with Lead Times up to Six Days for the Territory of Russia, Belarus, Kazakhstan, and Central Asia’s States
Bagrov A. N., V. A. Gordin, Svetlova N. A. et al., Russian Meteorology and Hydrology 2026 Vol. 51 No. 1 P. 33–40
A technology for operational complex forecasting (postprocessing)1 of squall wind gusts at the points of weather station location in described. The technology was implemented at the Hydrometeorological Research Center of Russia. It uses the results of forecasts of several forecast models and the complex forecast of average wind. The tests have shown an increase in ...
Added: February 17, 2026
Индо-Тихоокеанская Азия
Kanaev E., Луконин С. А., Куприянов А. В. et al., В кн.: Россия и мир: 2026. Экономика и внешняя политика. Ежегодный прогноз.: М.: ИМЭМО РАН, 2025. С. 177–196.
The chapter forecasts the evolution of the Indo-Pacific Asia in 2026. ...
Added: January 30, 2026
Россия и мир: 2026. Экономика и внешняя политика. Ежегодный прогноз
Kanaev E., Афонцев С. А., Богданов К. В. et al., М.: ИМЭМО РАН, 2025.
The report "Russia and the World: 2026" is the twenty-fourth in a series of annual publications of IMEMO. The report consists of three parts: global trends, economy and foreign policy. The main focus is on issues of key importance for ensuring stable economic and political development of Russia in the immediate (2026) and longer term. ...
Added: January 30, 2026
Современные проблемы науки
Данилевич Т. В., Yasnitsky L., М.: Юрайт, 2025.
This course examines both the historical aspects of science and current philosophical issues related to its contemporary development and impact on society. It describes the emergence of science and its progressive advancement, its adoption by society, and the introduction and dominance of scientific achievements in all areas of human activity. Particular attention is paid to ...
Added: December 19, 2025
О сценариях и количественных параметрах прогноза развития сектора ИКТ в России
Belousov D., Аблаев Э. Ю., Abramova E. et al., Проблемы прогнозирования 2025 № 2 С. 98–117
Статья описывает результаты количественных расчетов в соответствии со сценарными прогнозами мировой и отечественной экономики, а также российского сектора информационнокоммуникационных технологий (ИКТ). На основе сценарных условий определены количественные параметры прогнозов развития отечественного сектора ИКТ в четырех сценариях: «максимальном» (целевой сценарий), «осторожного роста», «умеренной экспансии» и «кризисном» (худший из возможных) с учетом их характерных особенностей. ...
Added: September 19, 2025
Индо-Тихоокеанская Азия
Kanaev E., Куприянов А. В., Леонтьева Е. Л. et al., В кн.: Россия и мир: 2025. Экономика и внешняя политика. Ежегодный прогноз.: М.: ИМЭМО РАН, 2024. С. 185–196.
The chapter presents a forecast on the trends in Indo-Pacific Asia in 2025. ...
Added: December 29, 2024
О сопоставлении структурного и морфологического подходов к сценированию долгосрочных социально-экономических процессов
Belousov D., Проблемы прогнозирования 2024 № 5 С. 59–71
Данная статья является продолжением работы, опубликованной в предыдущем номере журнала. Сопоставляются основные подходы к построению сценариев долгосрочного социально-экономического развития – структурный и морфологический. Производится верификация результатов сценирования традиционным структурным методом на основе морфологического подхода, предлагается система взаимно согласованных сценариев долгосрочного социально-экономического и научно-технологического развития (на основе структурного подхода). ...
Added: November 28, 2024
Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells
Prokofieva A., Ryabaya O., Akasov R. et al., Biomedicine and Pharmacotherapy 2019 Vol. 109 P. 2548–2560
Melanoma is one of the most aggressive and treatment-resistant tumors that responsible for majority of skin-cancer related deaths. Here we propose a combination of MEK inhibitor binimetinib with metformin as a promising therapy against human melanoma cells in vitro, including BRAF -mutated A375, Mel Z, and Mel IL cells, and NRAS-mutated Mel MTP and Mel ...
Added: October 30, 2024
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