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Mathematical and Experimental Model of Oxygen Diffusion for HepaRG Cell Spheroids
Bulletin of Experimental Biology and Medicine . 2016. Vol. 160. No. 6. P. 857–860.
Aleksandrova A., Pulkova N., Gerasimenko T., Anisimov N., Tonevitskaya S., Sakharov D.
Чеботарева О. Е., Пирогов А. А., Antipenko I. et al., Доклады российской академии наук. Науки о жизни 2026 Т. 529 № 1 С. 389–395
Preeclampsia (PE) is a severe obstetric complication caused by chronic placental ischaemia. Genome-wide profiling of microRNA isoforms in two trophoblast hypoxia models (CoCl2 and the oxyquinoline derivative neuradapt, BeWo b30 cells) and clinical PE samples (placental tissue, syncytiotrophoblast vesicles) revealed concordant downregulation of hsa-miR-143-3p isoforms. Under a strict fold-change threshold, the canonical isoform (21 nt) ...
Added: September 16, 2026
Leonid Grinin, Alexander M., Korotayev A., , in: Complexity in Universal Evolution. A Big History Perspective.: Springer, 2026. Ch. 12 P. 283–355.
In the first half of this chapter, Grinin et al. survey general similarities and differences between biological and social macroevolution. They undertake a systematic comparison between biological and social evolution at different levels of analysis and in various aspects, formulating a considerable number of general principles and rules of evolution, and working to develop a ...
Added: August 10, 2026
Kazantseva A. V., A.V. Toropova, Khusnutdinova E. K. et al., ВАВИЛОВСКИЙ ЖУРНАЛ ГЕНЕТИКИ И СЕЛЕКЦИИ, Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (ИЦиГ СО РАН) (Новосибирск) 2025 Vol. 30 No. 3 P. 470–481
The development of musical abilities, including absolute pitch, musical memory, rhythm sense, and musicality, at a high degree is determined by a hereditary component (up to 68 %). The studies implementing a genome-wide linkage and association approach to musical aptitude have revealed more than 100 genetic loci. This spectrum is comprised of the genes encoding ...
Added: May 29, 2026
Silina M., Dzhalilova D., Fokichev N. et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1674608
Humans and laboratory animals differ in their resistance to hypoxia, which affects the severity of inflammatory diseases and the rate of tumor progression. Therefore, it is necessary to search for methods for assessing the initial tolerance to oxygen deficiency and the risks of developing acute mountain sickness without direct hypoxia exposure on the organism. The ...
Added: March 24, 2026
Ок. Е. Колодеева, Ол. Е. Колодеева, Биотехнология 2025 Т. 41 № 6 С. 64–71
A three-dimensional (3D) matrix consisting of collagen fibers can create culture conditions that are more similar to in vivo tissues than 2D cultures in in vitro culture plates. Macrophages are among the most important innate immune cells. They are extremely plastic, allowing them to respond effectively to pro- and anti-inflammatory signals within their microenvironment. There ...
Added: December 24, 2025
Knyazev E., Timur Kulagin, Antipenko I. et al., Placenta 2026 Vol. 176 P. 1–12
Background. Preeclampsia (PE) complicates 2–8% of pregnancies and involves placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Chemical mimetics like cobalt(II) chloride (CoCl2) and oxyquinoline derivatives model trophoblast hypoxia in vitro, yet their fidelity in recapitulating PE gene profiles remains unclear. Integrating patient tissue analyses with experimental models may reveal common markers and ...
Added: December 22, 2025
Antipenko I., Knyazev E., Timur Kulagin et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1731126
Preeclampsia is a leading cause of maternal and perinatal morbidity associated with systemic lipid metabolism disturbances, yet the underlying molecular mechanisms remain incompletely understood. In this study, we integrated single-cell RNA-seq data from preeclamptic placentas with an in vitro hypoxia model to analyze gene expression changes across distinct trophoblast subpopulations. While all trophoblast lineages exhibited ...
Added: December 2, 2025
Leonid Grinin, Markov A., Korotayev A., Journal of Big History 2025 Vol. 8 No. 3 P. 1–51
In this paper, Grinin et al. survey general similarities and differences between biological and social macroevolution and phases of Big History. The comparison of biological and social evolution is an important but (regrettably) understudied subject. The authors have endeavored to make a systematic comparison between biological and social evolution at different levels of analysis and ...
Added: November 1, 2025
Zolotova N., Silina M., Dzhalilova D. et al., - 2025 Vol. 13 No. 8 Article 701
Environmental pollution with microplastics (MPs) can have a negative impact on human health. Certain findings point to the relationship between MP and the development of inflammatory bowel diseases (IBD). We investigated the effect of MP consumption on the severity of chronic colitis in male C57BL/6 mice. The MP effect was modeled by drinking water consumption ...
Added: August 25, 2025
Akhremenko A. S., Philippov I., Sychev V. et al., Политическая наука 2025 № 1 С. 77–102
Modern academic literature has focused on technology adaptation and innovation in politics and public administration. At present, there is a large number of studies, the central object of which is such an actively developing phenomenon as public digital services. Despite the diverse range of theoretical approaches, there is no established methodological tradition of modelling the ...
Added: May 1, 2025
Efremov Y., Ermolaeva A., Vladimirov G. et al., Plos One 2022 Vol. 17 No. 6
Cardiovascular diseases associated with high cholesterol (hypercholesterolemia) and low-density lipoproteins (LDL) levels are significant contributors to total mortality in developing and developed countries. Mathematical modeling of LDL metabolism is an important step in the development of drugs for hypercholesterolemia. The aim of this work was to develop and to analyze an integrated mathematical model of ...
Added: April 9, 2025
Лесин А. В., Исаев А. В., Тонконогов Б. П. et al., Тонкие химические технологии 2023 Т. 19 № 6 С. 485–496
Objectives. A quick cold start of emergency and auxiliary power units based on diesel engines should be possible at any time without
problems and in the shortest possible time. The condition of the engine oil is one of the most important factors influencing the smooth
start-up of power plants. During diesel engine operation, engine oil accumulates soot ...
Added: February 26, 2025
Ekaterina Khakina, Nikovskiy I., Spiridonov K. et al., Dalton Transactions 2025 Vol. 54 No. 9 P. 3667–3678
A low oxygen level in solid tumors is behind the modern concept of selective chemotherapy by hypoxia-activated prodrugs, such as heteroleptic complexes of transition metals (cobalt(III), iron(III) or platinum(IV)) with bi- or tetradentate ligands and an anticancer drug molecule as a co-ligand. A series of new cobalt(III) complexes [Co(LR)2(esc)]ClO4 with esculetin (6,7-dihydroxycoumarin) and 2,2′-bipyridines (2,2′-bipy) ...
Added: February 24, 2025
Ishbulatov Y., Kurbako A., Vahlaeva A. et al., European Physical Journal: Special Topics 2024 Vol. 233 P. 569–577
We propose a mathematical model of the human cardiovascular and respiratory systems. The cardiovascular segment of the model simulates the main heart rate, oscillating blood pressure, peripheral vascular resistance, and nonlinear dynamics of the autonomic control of circulation, namely α- and βsympathetic and parasympathetic control. The respiratory part includes central pattern generator, lungs, and a ...
Added: December 24, 2024
Panchenko S. V., Dli M. I., Chernovalova M. V. et al., CIS Iron and Steel Review 2022 Vol. 23 P. 119–124
Mathematical model for theoretical analysis of thermophysical processes of melt drops solidification is examined during their motion inside cooling gas, applying to granulation task. The heat exchange equations during granulation, taking into account convection, heat conductivity in solid phase and Stefan conditions on the boundary of phase transition, are presented. The relationships characterizing correlation of ...
Added: September 26, 2024
Petrov A., Sergey Zheglov, Akhremenko A. S., , in: 16th International Conference Management of large-scale system development (MLSD).: IEEE, 2023. Ch. 1 P. 1–5.
The paper studies protest campaigns consisting of both days with protest activity and days without activity. A dynamical agent-based model has been constructed. Numerical experiments showed that repression reduces the surviving probability of the campaign, but moderate repression may increase the turnout for the campaigns that survive. ...
Added: March 7, 2024
Vishnyakova P., Gantsova E., Kiseleva V. et al., Placenta 2024 Vol. 145 P. 151–161
Introduction
The role of the TGFβ signaling pathway, an important cascade responsible for the anti-inflammatory polarization of macrophages, in the development of both early- and late-onset preeclampsia (eoPE and loPE), remains poorly understood. In this study, we examined the components of the TGFβ signaling cascade and macrophage markers within placental tissue in normal pregnancy and in ...
Added: December 8, 2023
Poloznikov A., Nikulin S., Hushpulian D. et al., Antioxidants 2022 Vol. 11 No. 2 Article 220
To evaluate the differences in action of commercially available 2-oxoglutarate mimetics and “branched-tail” oxyquinoline inhibitors of hypoxia-inducible factor prolyl hydroxylase (HIF PHD), the inhibitors’ IC50 values in the activation of HIF1 ODD-luciferase reporter were selected for comparative transcriptomics. Structure–activity relationship and computer modeling for the oxyquinoline series of inhibitors led to the identification of novel ...
Added: February 3, 2023
Хушпульян Д. М., Nikulin S., Христиченко А. Ю. et al., Вестник Московского университета. Серия 2: Химия 2021 Т. 62 № 3 С. 213–222
The attempts to elucidate the mechanism of hypoxic activation of erythropoietin synthesis let to the
discovery of hypoxia inducible factor (HIF) and its stability regulation via HIF prolyl hydroxylase, iron
and α-ketoglutarate dependent dioxygenase. Enzyme inhibitors mimic the action of hypoxia, however, are
far more specific. Comparative transcriptomic microanalysis of various types on the enzyme inhibitors
with hypoxia at ...
Added: December 20, 2021
Knyazev E., Maltseva D., Raigorodskaya M. et al., Frontiers in Genetics 2021 Vol. 12 Article 791640
Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium. In contrast, pathological hypoxia is a common feature of some chronic disorders, including inflammatory bowel disease (IBD). This work was aimed at studying HIF-associated changes in the intestinal epithelium in IBD. ...
Added: November 11, 2021
Knyazev E. N., Paul S. Yu., Tonevitsky A. G., Doklady Biochemistry and Biophysics 2021 Vol. 499 No. 1 P. 251–256
Choriocarcinoma cells BeWo b30 are used to model human placental trophoblast hypoxia using cobalt (II) chloride and hydroxyquinoline derivative (HD) as chemical inducers of hypoxia-inducible factor (HIF). In this study, it was shown that both substances activate the hypoxic pathway and the epithelial–mesenchymal transition and inhibit the pathways of cell proliferation. However, CoCl2 caused activation of ...
Added: August 26, 2021
LIUDMILA I. KUZMINA, Osipov Y., International Journal for Computational Civil and Structural Engineering 2020 Vol. 16 No. 4 P. 50–56
Filtration of suspension in a porous medium is actual in the construction of tunnels and underground structures.
A model of deep bed filtration with size-exclusion mechanism of particle capture is considered. The inverse filtration
problem – finding the Langmuir coefficient from a given concentration of suspended particles at the porous medium outlet is solved using the asymptotic solution ...
Added: July 2, 2021