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A Mathematical Model of in vitro Hepatocellular Cholesterol and Lipoprotein Metabolism for Hyperlipidemia Therapy
Plos One. 2022. Vol. 17. No. 6.
Cardiovascular diseases associated with high cholesterol (hypercholesterolemia) and low-density lipoproteins (LDL) levels are significant contributors to total mortality in developing and developed countries. Mathematical modeling of LDL metabolism is an important step in the development of drugs for hypercholesterolemia. The aim of this work was to develop and to analyze an integrated mathematical model of cholesterol metabolism in liver cells and its interaction with two types of drugs, statins and PCSK9 inhibitors. The model consisted of 21 ordinary differential equations (ODE) describing cholesterol biosynthesis and lipoprotein endocytosis in liver cells in vitro. The model was tested for its ability to mimic known biochemical effects of familial hypercholesterolemia, statin therapy, and PCSK9 inhibitors. The model qualitatively reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in initial testing of new drugs for cardiology.
Богатырев А. Б., Математический сборник 2023 Т. 214 № 3 С. 106–119
Рассматривается клеточное разбиение пространства модулей вещественных кривых рода 2 с отмеченной точкой на единственном вещественном овале. Клетки перечисляются определенными графами, веса которых описывают комплексную структуру на кривой. Показано, что стягивание ребра графа приводит к корневой особенности естественного отображения из весов графа в пространство модулей кривых. ...
Added: August 14, 2026
Богатырев А. Б., Gendron Q., Успехи математических наук 2023 Т. 78 № 1 С. 209–210
Уравнение Пелля-Абеля — это функциональное уравнение вида P²-DQ² = 1, с заданным многочленом D, свободным от квадратов, и неизвестными многочленами P и Q. Мы показываем, что пространство уравнений Пелля-Абеля с фиксированными степенями D и примитивным решением P является комплексным многообразием. Мы описываем его связные компоненты с помощью эффективно вычислимого инварианта. ...
Added: August 14, 2026
Богатырев А. Б., Transactions of the Moscow Mathematical Society 2024 Vol. 85 No. 2 P. 323–337
The best uniform rational approximation of the Sign function on two intervals separated by zero was explicitly found by E. I. Zolotarëv in 1877. The natural extension of this problem to three bands was solved by E. Stiefel in 1961. We indicate the solutions overlooked by the prominent geometer and study their properties. ...
Added: August 14, 2026
Богатырев А. Б., Успехи математических наук 2026 Т. 81 № 3(489) С. 159–160
Предложена простая и эффективно реализуемая формула для изменения абелевых интегралов (включая их периоды) при вариации образующих классической группы Шоттки, представляющей риманову поврехность. ...
Added: August 14, 2026
Gendron Q., Compositio Mathematica 2025 Vol. 161 No. 7 P. 1483–1511
A Pell–Abel equation is a functional equation of the form P^2-DQ^2=1 , with a given polynomial D free of squares and unknown polynomials P and Q. We show that the space of Pell–Abel equations with the degrees of D and of the primitive solution P fixed is a complex manifold. We describe its connected components ...
Added: August 14, 2026
Yu Z., Wang J., Wang Z. et al., Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 2026 Vol. 384 P. 1–16
The integration of data-driven and knowledge-driven approaches in generative geospatial modelling (GGM) is often hindered by their mathematical incompatibilities. Here, we propose a geometric algebra (GA)-based framework that employs a unified multi-vector representation to fuse heterogeneous data and diverse knowledge. The framework facilitates structured reasoning and hypothesis generation through a task-adaptable, five-stage cycle: representation, reasoning, ...
Added: August 13, 2026
Ratnikov F., European Physical Journal: Special Topics 2026 P. 1–10
EEG recordings are often affected by the loss or corruption of individual channels due to electrode detachment, poor scalp contact, or external interference. Such channels must be accurately reconstructed before further analysis. In this study, we investigate Next-Generation Reservoir Computing (NG-RC) as a data-driven approach for reconstructing corrupted EEG channels and compare its performance with ...
Added: August 12, 2026
Speranski S. O., Математические заметки 2026 Т. 120 № 3 С. 470–483
We show that, in terms of closure ordinals, many infinitary calculi for ‘first-order’ logics of probability (i.e., for languages similar to those in [Abadi & Halpern 1994]) are as hard as possible: the corresponding closure ordinals coincide with the least non-constructive ordinal, denoted by $\omega_1^{\mathrm{CK}}$. ...
Added: August 12, 2026
Ali S., Bocharnikov V., Ratnikov F. et al., Sensors 2026 Vol. 26 No. 16 Article 5024
Large distributed sensor arrays require repeated recalibration as radiation damage, material aging, gain variation, and readout drift alter channel responses. We studied a high-granularity calorimeter as a large sensor array and addressed unsupervised recalibration from two unpaired datasets: a nominal reference response and an aged response with attenuated cell-wise signals. Aging was modeled by a ...
Added: August 11, 2026
Leonid Grinin, Alexander M., Korotayev A., , in: Complexity in Universal Evolution. A Big History Perspective.: Springer, 2026. Ch. 12 P. 283–355.
In the first half of this chapter, Grinin et al. survey general similarities and differences between biological and social macroevolution. They undertake a systematic comparison between biological and social evolution at different levels of analysis and in various aspects, formulating a considerable number of general principles and rules of evolution, and working to develop a ...
Added: August 10, 2026
Lucas J., Hebbar P., Ryabov F. et al., / Series 10.64898/2026.07.21.739710 "10.64898/2026.07.21.739710". 2026.
A pangenome reference overcomes the inherent limitation of any individual reference genome by integrating the variation present in a population. We present the Human Pangenome Reference Consortium’s (HPRC) Release 2 (HPRC2), an openly available, second phase pangenome that is an approximately fivefold expansion in genome number over HPRC Release 1 (HPRC1) and measurable improvement in ...
Added: August 10, 2026
Sandlerskiy R., Elsevier USA, 2026.
Encyclopedia of Ecology, Third Edition, Four Volume Set - with over 300 chapters - once again provides a comprehensive reference work covering the current ideas and practices in ecology.
Ecology is the ideal field for studying complex, adaptive, and self-organizing systems and by observing and understanding ecosystems, it provides valuable insights into creating sustainable systems. This knowledge is ...
Added: August 9, 2026
Kulev Y., Maksaev A., Promyslov V., Linear Algebra and its Applications 2026 Vol. 730 P. 51–72
The notion of λ-th upper scrambling index was introduced by Huang and Liu in 2010, as a generalization of a notion considered by Akelbek and Kirkland in 2009. For a primitive digraph D, it is defined as the smallest positive integer k such that for every λ vertices of D there exist directed paths of lengths k from these vertices to a common vertex. This ...
Added: August 7, 2026
Kanunnikov A., Promyslov V., Vassilieva E., Electronic Journal of Combinatorics 2024 Vol. 31 No. 3 Article P3.6
Introduced by Goulden and Jackson in their 1996 paper, the matchings-Jack conjecture and the hypermap-Jack conjecture (also known as the b-conjecture) are two major open questions relating Jack symmetric functions, the representation theory of the symmetric groups and combinatorial maps. They show that the coefficients in the power sum expansion of some Cauchy sum for ...
Added: August 7, 2026
Dadinova L., Petoukhov M., Mozhaev A. et al., Crystallography Reports 2026 Vol. 71 P. 52–58
Bacterial chromosomes are tightly packed in the cells due to interactions with specific nucleoid-associated proteins. Among them, the IHF protein draws attention due to its presumed influence on intracellular crystallization processes, leading to bacterial resistance to drugs. The crystal structure of the IHF heterodimer is known only in complex with a short DNA fragment, whereas ...
Added: August 6, 2026
Radygina A., Kulikova S., Herald of the Russian Academy of Sciences 2025 Vol. 95 No. 6 P. 963–970
Musical training has a significant impact on brain organization, leading to functional and structural
adaptations that enhance auditory, visual, motor, and cognitive processes. This study investigates how
extensive musical training shapes functional brain connectivity by comparing professional musicians and
non-musicians. Using EEG phase-locking value (PLV) analysis, we examined neural synchronization across
alpha, beta, and gamma frequency ranges during music ...
Added: August 5, 2026
Spiridonov V. P., Belousov N. M., Sarkissian G. A., Analysis and Mathematical Physics 2026 Vol. 16 Article 96
Hyperbolic hypergeometric integrals are defined as Barnes-type integrals of products of hyperbolic gamma functions. Their reduction to ordinary hypergeometric functions is well known. We study in detail their degeneration to complex hypergeometric functions. Namely, using uniform bounds on the integrands, we prove that the univariate hyperbolic beta integral and the conical function degenerate to two-dimensional ...
Added: August 4, 2026
Gayfullin S., Kikteva V., Results in Mathematics 2026 Vol. 81 No. 5 Article 146
In this paper we obtain a criterion of flexibility for an affine complexity-zero horospherical variety. This result generalizes previously known results on flexibility of normal horospherical varieties, horospherical varieties with an action of a semisimple group, and non-normal toric varieties. ...
Added: August 3, 2026
Lunts V., Функциональный анализ и его приложения 2026 Т. 60 № 3 С. 127–129
Доказано, что канонические полуортогональные разложения производной категории диаграммной схемы индуцируют аналогичные разложения подкатегории совершенных комплексов. ...
Added: August 3, 2026
Belomestny D., Gasnikov A., Gladin E. et al., Russian Mathematical Surveys 2026 Vol. 81 No. 4(490) P. 3–90
Reinforcement learning (RL) is increasingly grounded in tools from probability, optimization, and operator theory. This survey organizes the mathematical structures that underpin the design and analysis of modern algorithms in RL. We begin from Markov decision processes (MDPs) and the Bellman operators, emphasizing contraction mappings, monotonicity, and fixed-point theory that yield convergence guarantees and rates ...
Added: August 3, 2026
A. Radomskii, Mathematical notes 2026 Vol. 119 No. 6 P. 1136–1147
We obtain an upper bound for the sum $\sum_{n\leq N} (a_{n}/\varphi (a_{n}))^{s}$, where $\varphi$ is Euler's totient function, $s\in\mathbb{N}$, and $a_{1},\ldots, a_{N}$ are positive integers (not necessarily distinct) with some restrictions. As applications, for any $t>0$, we obtain an upper bound for the number of $n\in [1,N]$ such that $a_{n}/ \varphi (a_{n})> t$. ...
Added: July 31, 2026
Абызов А. Н., Буутай П. Н., Математика и теоретические компьютерные науки 2026 Т. 4 № 2 С. 4–75
This paper is expository and methodological in nature and is devoted to the development of E.I. Zolotarev’s ideas embedded in his approach to the proof of the quadratic reciprocity law (1872). We consider extensions of Zolotarev’s approach to abstract number rings presented in the work of A. Brunyate and P.L. Clark (2015), and to finite ...
Added: July 30, 2026
Kazantseva A. V., A.V. Toropova, Khusnutdinova E. K. et al., ВАВИЛОВСКИЙ ЖУРНАЛ ГЕНЕТИКИ И СЕЛЕКЦИИ, Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (ИЦиГ СО РАН) (Новосибирск) 2025 Vol. 30 No. 3 P. 470–481
The development of musical abilities, including absolute pitch, musical memory, rhythm sense, and musicality, at a high degree is determined by a hereditary component (up to 68 %). The studies implementing a genome-wide linkage and association approach to musical aptitude have revealed more than 100 genetic loci. This spectrum is comprised of the genes encoding ...
Added: May 29, 2026
Leonid Grinin, Markov A., Korotayev A., Journal of Big History 2025 Vol. 8 No. 3 P. 1–51
In this paper, Grinin et al. survey general similarities and differences between biological and social macroevolution and phases of Big History. The comparison of biological and social evolution is an important but (regrettably) understudied subject. The authors have endeavored to make a systematic comparison between biological and social evolution at different levels of analysis and ...
Added: November 1, 2025