Полиморфизм гена рецептора витамина D (VDR) в выборках населения европейской России и Приуралья

Пермский медицинский журнал. 2016. Т. 33. № 5. С. 60–66.

Kozlov A., Вершубская Г. Г., Негашева М. А.

Aim. To assess the genotype frequencies of VDR BsmI (rs1544410) and FokI (rs10735810) in ethnic Russian
population and in different groups of the population of Volgo(Kamsky region and Priuraliye.
 

Materials and methods. Samplings of Russians of the European part of RF (n = 96) and Eastern Finns including Komi(Permyaks (n = 71), Komis (n = 190) and Udmurts (n = 86) were examined. Genotype frequencies were determined using the method of PCR(amplification.

Results. Russians differ for the inhabitants of Moscow (without taking into account ethnic origin) by the 
distribution of VDR FokI (p = 0,09001), but not BsmI. Eastern Finns in the regions of their historical residence
do not differ by VDR FokI and BsmI, but they differ from Russians by BsmI frequencies (p = 0,0856).

Conclusions. The obtained results agree with the assumption about the specificity of VDR allel frequencies in different ethnic groups.

 

Keywords: vitamin D, VDR, VDR, витамин D, FokI, BsmI, Vitamin D receptor, bone tissue, рецептор витамина D, FokI, BsmI, костная ткань