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Partial Serotonin Transporter Deficiency Modulates Plasma Metabolome, Arginine-Nitric Oxide Pathway and Emotional Behavior in Mice Exposed to Western Diet
Metabolites. 2026. Vol. 16. No. 2. Article 117.
Cespuglio R., Schmitt-Böhrer A., Deykin A., Kalueff A., Lebedeva K., Nedorubov A., Shulte G., Svirin E., Lyundup A., Lesch K., Strekalova T.
Maltseva D., Tonevitsky A., Frontiers in Molecular Biosciences 2026 Vol. 13 P. 1–28
MicroRNA (miRNA) genes are frequently located in close proximity within the genome, forming so-called clusters. These clusters are transcribed as polycistronic units, suggesting coordinated transcriptional regulation of the miRNAs they contain. However, individual mature miRNAs from the same cluster often accumulate at varying levels and exhibit distinct tissue-specific expression patterns, indicating the presence of regulatory ...
Added: October 23, 2026
Vasilyev A., Svirin EP, Dubynin I. et al., Cortex 2025 Vol. 189 P. 76–96
Added: October 22, 2026
Karina V. Klycheva, Mariia O. Silkina, Dmitry M. Hushpulian et al., Biochemistry. Biokhimiia 2026 Vol. 91 P. 1842–1858
Involvement of the transcription factor Bach1 in various scenarios of cellular regulation is reviewed herein. To date, the most extensively studied role of Bach1 is that of a repressor of the antioxidant genetic program initiated by the Nrf2 factor. This program counteracts oxidative stress, which triggers both ferroptosis and the intrinsic apoptotic pathway. Bach1 functions unrelated ...
Added: October 22, 2026
Svirin E., Бердышев Д. А., Шишкин С. Л., Вестник Российского государственного медицинского университета 2026 № 3 С. 42–50
Quasi-movements (QMs), which are movement attempts minimized to the point of movement extinction, evoke EEG patterns similar to those of real movement. QMs can model attempted movement in healthy subjects and are therefore of interest as an alternative to motor imagery (MI) in rehabilitation brain–computer interfaces (BCIs), in which the attempted movement of the paralyzed ...
Added: October 22, 2026
Sitdikova K., Tsoy A., Chaprov K. et al., Journal of Neuropathology and Experimental Neurology 2026 Article nlag078
Understanding the earliest pathological changes in Alzheimer disease (AD) is critical for improving early intervention strategies. However, the relationship between amyloid plaque characteristics and early behavioral and molecular alterations remains unclear. We used 6-month-old female APPswe/PS1dE9 mice, a model of early amyloid-dominant pathology, to assess cognition and emotionality across a battery of behavioral tests. Amyloid ...
Added: October 22, 2026
Effects of Wheat Malt Extract on Molecular and Behavioral Markers in Aged APP/PS1 and Wild-Type Mice
Kassenova A., Svirin E., Sitdikova K. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 11 Article 4994
Added: October 22, 2026
Logvenkov S. A., Известия РАН. Механика жидкости и газа 2026 № 3 С. 59–75
The problem of the evolution of cell volume fraction in a spherical aggregate composed of cells,
extracellular matrix, and fluid is considered. The aggregate is surrounded by extracellular matrix. The
problem formulation employs a multiphase model of a biological continuum, previously developed by the
author, consisting of two actively interacting solid phases and a fluid. The propagation of ...
Added: October 20, 2026
Liaukovich K., Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova 2026 Vol. 76 No. 5 P. 587–598
Added: October 19, 2026
Nersisyan A., Frontiers in Molecular Biosciences 2026 Vol. 13 Article 1995001
Antiviral activity is commonly summarized using endpoint measures such as EC50 or EC90, yet these quantities emerge from a dynamic biological system and depend on viral replication kinetics, host-cell properties, experimental design, and the assay used to quantify infection. Infectious-virus titers, viral RNA, infected-cell fractions, viability measurements, and immune readouts capture different components of the ...
Added: October 15, 2026
Тукачев Н. В., González-Jiménez M., Ramakrishnan G. et al., Physical Chemistry Chemical Physics 2021 Vol. 23 No. 23 P. 13250–13260
Low-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA–protein recognition. However, understanding the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands ...
Added: October 14, 2026
Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39
Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data
Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity.
Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined
everywhere. In 2015, in Russia experimental ...
Added: October 13, 2026
Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195
Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...
Added: October 11, 2026
Ekaterina D. Riumina, Alekseeva E., Klink G. V. et al., PNAS, США 2026 Vol. 123 No. 35 Article e2619192123
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Lebedev O. B., Beskhielnov M. I., OPTIMIZATION BY THE SWARM OF TRANSFORMING CHROMOSOMES METHOD 2024 Vol. 34 No. 3 P. 652–658
A new strategy for finding effective solutions based on modification and hybridization of the canonical representations of the particle swarm algorithm is proposed. A paradigm of a swarm of transforming chromosomes is described, making it possible to represent solutions in the affine space of chromosomes with integer parameter values. The mechanisms of chromosome transformation in ...
Added: September 12, 2026
Kosmachevskaya O., Nasybullina E., Pokidova O. et al., International Journal of Molecular Sciences 2024 Vol. 25 No. 13 Article 7194
Nitrosyl iron complexes are remarkably multifactorial pharmacological agents. These compounds have been proven to be particularly effective in treating cardiovascular and oncological diseases. We evaluated and compared the antioxidant activity of tetranitrosyl iron complexes (TNICs) Citation: Kosmachevskaya, O.V.; Nasybullina, E.I.; Pokidova, O.V.; Sanina, N.A.; Topunov, A.F. Effects of Nitrosyl Iron Complexes with Thiol, Phosphate, and ...
Added: September 16, 2025
Pokidova О., Novikova V., Emel’yanova N. et al., Journal of Inorganic Biochemistry 2025 Vol. 262 Article 112747
A new promising binuclear tetranitrosyl iron complex with 2-methoxythiophenolyl of the composition [Fe2(C7H7OS)2(NO)4] (complex 1), which acts on the therapeutic targets of cardiovascular diseases, guanylate and adenylate cyclase, has been synthesized. X-ray diffraction data show the presence of two isoforms of complex 1; according to quantum chemical calculations, the structure of only the trans isomer ...
Added: September 16, 2025
Novikova V. O., Emel’yanova N. S., Pokidova O. V. et al., Russian Chemical Bulletin 2024 Vol. 73 No. 4 P. 957–964
The reaction between binuclear nitrosyl iron complex (NIC) with thiosulfate ligands Na2[Fe2(S2O3)2(NO)4]•4H2O (1) and reduced glutathione (GSH) was studied. Using experimental and theoretical methods including UV spectroscopy, Griess test, and quan tum chemical modeling, it was shown that the thiosulfate ligands in complex 1 are replaced by GS– to give a new binuclear nitrosyl iron ...
Added: September 16, 2025
Балакина А. А., Приходченко Т. Р., Якушев И. А. et al., Известия Академии наук. Серия химическая 2023 Т. 72 № 7 С. 1618–1632
The structure of 3-hydroxy-6-methyl-2-ethylpyridinium nitroxysuccinate (2), its cytotoxicity, and its ability to influence the content of intracellular nitrogen monoxide, as well as the formation of reactive oxygen species and lipid peroxidation processes under conditions of induced oxidative stress were studied. It was demonstrated that compound 2 had low cytotoxicity in vitro in both non-cancerous and ...
Added: September 14, 2025
Баянова Л. Ф., Psychology in Russia: State of the Art 2018 Vol. 11 No. 1 P. 61–70
Background. There have been many psychological studies, which show what factors enhance creative thinking in childhood, including studies on the impact of intelligence, personality, self-esteem, and other characteristics. But little is known of the impact of cultural congruence on the enhancement of creative thinking in childhood. In that regard, it would be interesting to explore whether ...
Added: August 25, 2025
Баянова Л. Ф., Современное дошкольное образование. Теория и практика 2017 № 10 С. 14–21
This article presents a review of recent international studies on the problem of the creativity in childhood. The appeal to the problem of children’s creativity is methodologically set forth by the cultural-historical theory of L. Vygotsky. Unlike the works of Russian authors considering the problem of creativity in the context of the imagination, activity and ...
Added: August 25, 2025
Kustova T., Vodneva A., Tcepelevich M. et al., International Journal of Psychophysiology 2025 Vol. 211 Article 112556
This article reviews recent studies of real-time learner-instructor interactions and psychophysiological indicators associated with this process. The initial systematic search of the literature yielded 2,663 articles; 26 peer-reviewed articles in English were included in the final sample. The learner-instructor interpersonal relationships were studied using neuroimaging, eye movements, and peripheral physiological devices. Retrieved articles covered several ...
Added: July 8, 2025
Bakay E., Yusupova E., Antipkina I., Психологическая наука и образование 2024 Т. 29 № 2 С. 32–49
Test-taking behavior in reading comprehension tests is explained, among other things, by meta-cognitive skills, which can be described by indicators of test behavior. These indicators include reading time, respondent-item interaction time, returning to the text, etc. This study is based on the analysis of the test-taking behavior of fourth graders (N=2168) during a reading comprehension ...
Added: October 28, 2024