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The Size of the Human Proteome: The Width and Depth
International Journal of Analytical Chemistry. 2016. P. 1–6.
Ponomarenko E., Poverennaya E., Ilgisonis E., Pyatnitskiy M., Kopylov A., Zgoda V., Lisitsa A., Archakov A.
This work discusses bioinformatics and experimental approaches to explore the human proteome, a constellation of proteins expressed in different tissues and organs. As the human proteome is not a static entity, it seems necessary to estimate the number of different protein species (proteoforms) and measure the number of copies of the same protein in a specific tissue. Here, meta-analysis of neXtProt knowledge base is proposed for theoretical prediction of the number of different proteoforms that arise from alternative splicing (AS), single amino acid polymorphisms (SAPs), and posttranslational modifications (PTMs). Three possible cases are considered: (1) PTMs and SAPs appear exclusively in the canonical sequences of proteins, but not in splice variants; (2) PTMs and SAPs can occur in both proteins encoded by canonical sequences and in splice variants; (3) all modification types (AS, SAP, and PTM) occur as independent events. Experimental validation of proteoforms is limited by the analytical sensitivity of proteomic technology. A bell-shaped distribution histogram was generated for proteins encoded by a single chromosome, with the estimation of copy numbers in plasma, liver, and HepG2 cell line. The proposed metabioinformatics approaches can be used for estimation of the number of different proteoforms for any group of protein-coding genes.
Окнина Л. Б., Подлепич В. В., Sieber I. et al., Физиология человека 2026 Т. 52 № 3 С. 5–15
The aim of this study was to evaluate the frequency following response (FFR) for the analysis of the intact perception of syllables in humans. For this purpose, event-related potentials (ERPs) in response to isolated Russian syllables were recorded and analyzed in 29 healthy persons in two frequency ranges, standard (1-40 Hz) and high frequency (70-150 ...
Added: June 30, 2026
Podolskaia E., Вопросы лесной науки 2022 Т. 5 № 4 С. 1–21
Paper presents an overview of history and current research state on the use of remote sensing data from
space to recognize roads for the regional projects. We have characterized principles of road detection on the imagery. A group of direct deciphering signs used in combinations such as brightness and texture, geometry and
brightness. Three research directions with ...
Added: June 25, 2026
Князева С. В., Ершов Д. В., Никитина А. Д. et al., Современные проблемы дистанционного зондирования Земли из космоса 2025 Т. 22 № 6 С. 383–386
This brief report summarizes the key outcomes of the IX All-Russia (with International Participation)
Scientific Conference “Aerospace Methods and Geoinformation Technologies in Forest Science,
Forestry and Ecology”. The conference was held April 15–17, 2025, in Moscow at Isaev Center for
Forest Ecology and Productivity RAS with organizational support from Space Research Institute RAS.
The conference was attended about 130 ...
Added: June 24, 2026
Ekaterina S. Podolskaia, Sinitsina A., European Journal of Forest Engineering 2026 Vol. 12 No. 1 P. 7–22
Machine learning in transport modeling has become a trend in science and industry. In this paper, we observe its main directions and focus on a dataset of seasonal road creation. Seasonality as a parameter in transport modeling has a significant impact on transport scenarios but is underestimated worldwide and in Russia, despite modern data challenges. ...
Added: June 24, 2026
Ryskina H., Лобаева Т. А., Ануркина А. И., Ваш формат, 2025.
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Эволюция, экология, генетика человека, медицинская паразитология. Практикум. Аннотация
Аннотация к практикуму «Эволюция, экология, генетика человека, медицинская паразитология»
Учебное пособие «Эволюция, экология, генетика человека, медицинская паразитология. Практикум» (авторы: Лобаева Т. А., Рыскина Е. А., Ануркина А. И.; издательство «Ваш формат», 2025 год, 194 страницы) предназначено для студентов высших учебных заведений. Цель практикума — обеспечить комплексное освоение ключевых разделов биологии с акцентом на их прикладное значение в медицине. ...
Added: June 23, 2026
Herbert A., Cherednichenko O., Lybrand T. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 6 Article 2422
The double-stranded RNA editing enzyme ADAR1 connects two forms of genetic programming, one based on codons and the other on flipons. ADAR1 recodes codons in pre-mRNA by deaminating adenosine to form inosine, which is translated as guanosine. ADAR1 also plays essential roles in the immune defense against viruses and cancers by recognizing left-handed Z-DNA and ...
Added: June 22, 2026
Kyrchanova O., Kudryashova K., Ibragimov A. et al., Development 2025 Vol. 152 No. 19 Article 205051
Drosophila homeotic gene Abdominal-B (Abd-B) is controlled throughout development by four infraabdominal (iab) regulatory domains, the active or repressed state of which is determined by initiators that have parasegment-specific enhancer activity at an early stage of embryonic development. For this reason, it has long been assumed that the enhancer activity and initiation function of these elements are synonymous. ...
Added: June 20, 2026
Kyrchanova O., Ksenia Kudryashova, Dubrovskaya V. et al., Open Biology 2025 Vol. 15 No. 11 Article 250192
The specification of abdominal segments A5 to A9 depends on the expression of Abdominal-B (Abd-B), which is regulated by four infraabdominal domains: iab-5 through iab-8,9. Each iab domain contains an initiation element that determines its active state, along with enhancers responsible for tissue-specific activation of Abd-B. These iab domains function autonomously due to their flanking boundaries, Fab-6, Fab-7 and Fab-8, which both block crosstalk between adjacent iab domains (insulator function) and facilitate long-range ...
Added: June 20, 2026
Kudryashova K.S., Deriglazova I. O., Osadchiy I. S. et al., Genes 2025 Vol. 16 No. 1 Article 3
Background/Objectives: Transcriptional promoters play an essential role in regulating protein expression. Promoters with weak activity generally lead to low levels of expression, resulting in fewer proteins being produced. At the same time, strong promoters are commonly used in studies using transgenic organisms as model systems. This approach can have various negative consequences for the organism, ...
Added: June 20, 2026
Ksenia Kudryashova, Filippova E., Kryukova E. et al., Archives of Biochemistry and Biophysics 2025 Vol. 769 Article 110437
β-Bungarotoxins (β-BuTx), consisting of covalently bound phospholipase A2 subunit (A-chain), a member of group Ia of secretory phospholipases A2, and non-enzymatic subunit (B-chain) structurally related to Kunitz-type protease inhibitors, block presynaptic neuromuscular transmission via a not completely defined mechanism of action. In vivo physiological studies revealed that the B-chain is targeting voltage-gated potassium channels of not identified subtypes. In our work, six β-BuTx isoforms were ...
Added: June 20, 2026
Cherednichenko O., Herbert A., Poptsova M., Computational and Structural Biotechnology Journal 2025 Vol. 27 P. 992–1000
Large language models (LLMs) in genomics have successfully predicted various functional genomic elements. While their performance is typically evaluated using genomic benchmark datasets, it remains unclear which LLM is best suited for specific downstream tasks, particularly for generating whole-genome annotations. Current LLMs in genomics fall into three main categories: transformer-based models, long convolution-based models, and state-space models ...
Added: June 19, 2026
Cherednichenko O., Poptsova M., Briefings in Bioinformatics 2025 Vol. 26 No. 2 Article bbaf129
Kolmogorov–Arnold networks (KANs) emerged as a promising alternative for multilayer perceptrons (MLPs) in dense fully connected networks. Multiple attempts have been made to integrate KANs into various deep learning architectures in the domains of computer vision and natural language processing. Integrating KANs into deep learning models for genomic tasks has not been explored. Here, we ...
Added: June 19, 2026
Aly Ismailov, Spallone A., Belogurov A. et al., Frontiers in Immunology 2025 Vol. 16 Article 1530305
Glioblastomas are the most prevalent primary brain tumors and are associated with a dramatically poor prognosis. Despite an intensive treatment approach, including maximal surgical tumor removal followed by radio- and chemotherapy, the median survival for glioblastoma patients has remained around 18 months for decades. Glioblastoma is distinguished by its highly complex mechanisms of immune evasion ...
Added: June 17, 2026
Lifshits A., Святохина Е. В., Одиссей: Человек в истории 2026 № 1 С. 156–173
This article introduces a new source for scholarly discussion on the history of Russian language, science, and culture in the late 17th century. Numerous Russian captions for engravings were discovered in a copy of the "Travnik" (Herbal) by the great Renaissance botanist and pharmacist Pietro Andrea Mattioli, published in Prague in German in 1563. In ...
Added: June 15, 2026
Madison A., Plandin F., Kuzmina T. et al., Palaeogeography, Palaeoclimatology, Palaeoecology 2026 Vol. 697 Article 113864
Unlike most other brachiopods, craniiforms lack a prominent pedicle, cement to a hard substrate by their ventral valve, and thereby can be easily distinguished in paleontological materials. In this study, we describe a new genus and species from the Porkuni Regional Stage of Northeastern Estonia (Baltica), corresponding to the lower part of the Hirnantian Stage ...
Added: June 15, 2026
Plandin F., Temereva E., Zoological Journal of the Linnean Society 2025 Vol. 205 No. 2 Article zlaf139
Although Brachiopoda represent a relatively small phylum, they exhibit significant morphological diversity. One of the central issues in understanding the evolution of the ancestral brachiopod body plan pertains to the homologies among body compartments across the different brachiopod subphyla: Craniiformea, Linguliformea, and Rhynchonelliformea. In this context, the pedicle stands out as one of the most ...
Added: June 15, 2026
Namsaraev Z., Nanzatov B., Kozlova A. et al., Scientific Reports 2026 Vol. 16 No. 1 Article 17769
Distilled fermented milk beverages are rare in food technology, despite the global prevalence of plant-based spirits. Currently, the production of distilled strong alcoholic beverages from fermented milk using traditional technologies is known only among Mongolic-speaking peoples and their Siberian neighbors. This study provides the first interdisciplinary analysis of darasun, a traditional Buryat spirit made from fermented ...
Added: June 10, 2026
Yin X., Wu Y., Kivalov S. et al., Journal of Hydrology 2026 Vol. 677 No. A Article 135843
As a frequent extreme event under global climate change, drought significantly threatens the net primary productivity (NPP) of terrestrial ecosystems. Although numerous studies have reported drought-induced declines in NPP, the hydroclimatic mechanisms behind remain insufficiently understood. The strong interdependence among temperature, precipitation, and water availability has made it challenging to quantify their independent effects on ...
Added: June 8, 2026
An S., Wu Y., Luo X. et al., Catena 2026 Vol. 263 Article 109767
Vegetation restoration represents a highly effective strategy for offsetting carbon emissions, mitigating climate change, and enhancing the quality of the eco-environment. Despite the ecological benefits, the large-scale ‘Grain-for-Green’ program in China has caused unintended hydrological consequences, threatening the sustainability of regional water resources in this arid and semi-arid region. Therefore, it is crucial to understand ...
Added: June 8, 2026
Zhang G., Wu Y., Lu X. et al., Journal of Environmental Management 2026 Vol. 401 Article 128981
The ‘Grain for Green’ (GFG) project is a key ecological restoration initiative in the Loess Plateau. The land use changes induced by GFG project have the potential to alter the spatial distribution of soil organic carbon (SOC), yet its impact on the lateral loss of SOC was not well understood or insufficiently quantified. This study ...
Added: June 8, 2026
Tararushkin E., Glushak A., Rudmin M. et al., Applied Clay Science 2026 Vol. 291 Article 108288
Phengite is one of the important hydrous phyllosilicate minerals capable of transporting water and potassium in subducting slabs down to the Earth’s upper mantle. Being able to incorporate significant amounts of ammonium in its structure, phengite is also a major contributor to the nitrogen cycle in subduction zones. Employing classical molecular dynamic simulations with the ...
Added: June 6, 2026
Kazakova E., Solovyeva E., Levitsky L. et al., Proteomics 2023 Vol. 53 No. 5 Article 2200275
Omics technologies focus on uncovering the complex nature of molecular mechanisms in cells and organisms, including biomarkers and drug targets discovery. Aiming at these tasks, we see that information extracted from omics data is still underused. In particular, characteristics of differentially regulated molecules can be combined in a single score to quantify the signaling pathway ...
Added: September 14, 2023
Sabatier P., Beusch C., Maltseva D. et al., Nature Communications 2021 No. 12 Article 6558
Detailed characterization of cell type transitions is essential for cell biology in general and particularly for the development of stem cell-based therapies in regenerative medicine. To systematically study such transitions, we introduce a method that simultaneously measures protein expression and thermal stability changes in cells and provide the web-based visualization tool ProteoTracker. We apply our ...
Added: November 12, 2021
Kopylov A., Ponomarenko E., Ilgisonis E. et al., Journal of Proteome Research 2019 Vol. 18 No. 1 P. 120–129
This work continues the series of the quantitative measurements of the proteins encoded by different chromosomes in the blood plasma of a healthy person. Selected Reaction Monitoring with Stable Isotope-labeled peptide Standards (SRM SIS) and a gene-centric approach, which is the basis for the implementation of the international Chromosome-centric Human Proteome Project (C-HPP), were applied ...
Added: October 7, 2019