WCN25-1344 GUT MICROBIOTA AND BLOOD METABOLIC PROFILE IN PATIENTS ON PERITONEAL DIALYSIS

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WCN25-1344 GUT MICROBIOTA AND BLOOD METABOLIC PROFILE IN PATIENTS ON PERITONEAL DIALYSIS

Kidney International Reports. 2025. Vol. 10. No. 2. P. S653–S654.

Kozlova A.

In our study we included 60 patients, age 55±16.4 years (32 f/28 m), who received peritoneal dialysis at our nephrology center. Participants were divided into two groups: one group received “Normoflorin” for 1 month (N= 38) and the other group did not (N= 22). We examined standard biochemical analysis in all patients. Fecal samples were collected between June 2023 and March 2024. The intestinal microbiota was analyzed using 16s rRNA sequencing. 1H nuclear magnetic resonance spectroscopy was utilized to analyze the serum samples, focusing on low-molecular-weight metabolites. We used standard statistical methods.

Omics Insights Into the Effects of Highbush Blueberry and Cranberry Crop Agroecosystems on Honey Bee Health and Physiology

Kozlova A., Proteomics 2025 P. e70033–e70033

Honey bees (Apis mellifera) are vital pollinators in fruit-producing agroecosystems like highbush blueberry (HBB) and cranberry (CRA). However, their health is threatened by multiple interacting stressors, including pesticides, pathogens, and nutritional changes. We tested the hypothesis that distinct agricultural ecosystems—with different combinations of agrochemical exposure, pathogen loads, and floral resources—elicit ecosystem-specific, tissue-level molecular responses in ...

Added: September 18, 2025

Современные представления о микробном разнообразии кожи

Шаталова А. Ю., Булыгина Е. С., Гаева Т. Н. et al., Вестник биотехнологии и физико-химической биологии им. Ю.А. Овчинникова 2019 Т. 15 № 3 С. 39–51

В обзоре представлены данные о микробном разнообразии кожи. Одним из важных факторов функционального состояния организма человека выступает его микробиота: относительная стабильность микробного пейзажа для каждой области тела. Поэтому актуальным направлением исследований на сегодняшний день продолжает оставаться изучение характеристики микробных сообществ как отдельных эпитопов (желудочно-кишечного и мочеполового тракта, кожи, дыхательных путей и т.д.), так и организма ...

Added: September 20, 2023

Genomics-Based Reconstruction and Predictive Profiling of Amino Acid Biosynthesis in the Human Gut Microbiome

German A. Ashniev, Petrov S., Iablokov S. et al., Microorganisms 2022 Vol. 10 No. 4 Article 740

The human gut microbiota (HGM) have an impact on host health and disease. Amino acids are building blocks of proteins and peptides, also serving as precursors of many essential metabolites including nucleotides, cofactors, etc. Many HGM community members are unable to synthesize some amino acids (auxotrophs), while other members possess complete biosynthetic pathways for these ...

Added: January 31, 2023

MetaGeneTack: Ab initio detection of frameshifts in metagenomic sequences

Tang S., Antonov I., Borodovsky M., Bioinformatics 2013 Vol. 29 No. 1 P. 114–116

Frameshift (FS) prediction is important for analysis and biological interpretation of metagenomic sequences. Since a genomic context of a short metagenomic sequence is rarely known, there is not enough data available to estimate parameters of species-specific statistical models of protein-coding and non-coding regions. The challenge of ab initio FS detection is, therefore, two fold: (i) ...

Added: March 19, 2021