Multimodal DTI-TMS assessment of the motor system in patients with chronic ischemic stroke
BioRxiv. http://dx.doi.org/. Cold Spring Harbor Laboratory , 2019. No. 2019.12.24.886754.
Nazarova M., Kulikova S., Piradov M. A., Limonova A., Dobrynina L., Konovalov R. N., Novikov P., Sehm B., Villringer A., Nikulin V.
Background and Purpose Despite the continuing efforts in multimodal assessment of the motor system after stroke, conclusive findings on the complementarity of functional and structural metrics of the corticospinal tract (CST) integrity and the role of the contralesional hemisphere are still missing. The aim of this work was to find the best combination of the motor system parameters, allowing classification of patients into three predefined groups of upper limb motor recovery. Methods 35 chronic ischemic stroke patients (47 [26–66] y.o., 29 [6–58] months post-stroke) with only supratentorial lesion and unilateral upper extremity weakness were enrolled. Patients were divided into three groups depending on the upper limb motor recovery. Non-parametric statistical tests and regression analysis were used to investigate the relationships among structural and functional motor system parameters, probed by diffusion tensor imaging (DTI) and transcranial magnetic stimulation (TMS). In addition, stratification rules were tested, using a decision tree classifier to identify parameters explaining motor recovery. Results Fractional anisotropy (FA) ratio in the internal capsule (IC) and absence/presence of motor evoked potentials (MEPs), were equally discriminative of the worst motor outcome group (96% accuracy). MEP presence diverged for two investigated hand muscles. Concurrently, for the three recovery groups’ classification, the best parameter combination was: IC FA ratio and Fréchet distance between the contralesional and ipsilesional CST FA profiles (91% accuracy). No other metrics had any additional value for patients’ classification. Conclusions This study demonstrates that IC FA ratio and MEPs absence are equally important markers for poor recovery. Importantly, we found that MEPs should be controlled in more than one hand muscle. Finally, we show that better separation between different motor recovery groups may be achieved when considering the whole CST FA profile.
, , et al., Stroke 2021 Vol. 52 No. 1 P. 241-249
Background and Purpose Despite the continuing efforts in multimodal assessment of the motor system after stroke, conclusive findings on the complementarity of functional and structural metrics of the corticospinal tract (CST) integrity and the role of the contralesional hemisphere are still missing. The aim of this work was to find the best combination of the motor ...
Added: December 17, 2020
Диагностические возможности транскраниальной магнитной стимуляции для прогнозирования двигательного восстановления после инсульта
, , et al., Нервно-мышечные болезни 2020 Т. 10 № 1 С. 64-74
Transcranial magnetic stimulation is a method of focal non-invasive brain stimulation, characterized by high spatial and temporal resolution. To date, diagnostic transcranial magnetic stimulation has been used in clinical practice primarily to assess an involvement of the upper motor neurons and to measure the velocity of the neuronal impulse propagation. However, in the last 10 ...
Added: June 4, 2020
Mapping of multiple muscles with transcranial magnetic stimulation: absolute and relative test–retest reliability
, , et al., Human Brain Mapping 2021 Vol. 42 No. 8 P. 2508-2528
The spatial accuracy of transcranial magnetic stimulation (TMS) may be as small as a few millimeters. Despite such great potential, navigated TMS (nTMS) mapping is still underused for the assessment of motor plasticity, particularly in clinical settings. Here, we investigate the within-limb somatotopy gradient as well as absolute and relative reliability of three hand muscle ...
Added: March 1, 2021
, , et al., TMS cortical mapping of multiple muscles: absolute and relative test-retest reliability / Cold Spring Harbor Laboratory. Series http://dx.doi.org/ "BioRxiv". 2020.
The spatial accuracy of TMS may be as small as a few millimeters. Despite such great potential, navigated TMS (nTMS) mapping is still underused for the assessment of motor plasticity, particularly in clinical settings. Here we investigate the within-limb somatotopy gradient as well as absolute and relative reliability of three hand muscle cortical representations (MCRs) ...
Added: November 2, 2020
FEASIBILITY OF PROBING CORTICOSPINAL EXCITABILITY IN SEVERAL UPPER LIMB MUSCLES IN STROKE PATIENTS WITH UPPER LIMB MOTOR DEFICIT
, , et al., European Stroke Journal 2021 Vol. 6 P. 248-248
Background and Aims: The possibility to evoke a motor response (MEP) in a hand muscle by transcranial magnetic stimulation (TMS) is a common proxy of the corticospinal tract integrity after a motor stroke. However, it is still not clear how many muscles should be studied, and which muscles are preferable to probe. Here we aimed to investigate corticospinal excitability in ...
Added: November 1, 2021
Absolute and relative reliability of TMS motor mapping – how much could we trust the results of TMS somatotopy?
, , et al., Brain Stimulation 2019 Vol. 12 No. 2 P. 506-507
In practical medicine, a diagnostic procedure is used only when it can be interpreted at the individual level. The aim of this work was to systematically investigate the relative and absolute reliability of different TMS motor maps parameters. 18 young healthy male right-handed volunteers were enrolled. Two TMS motor mapping sessions of three right-hand muscles ...
Added: October 31, 2019
, , , Frontiers in Human Neuroscience 2018 Vol. 12 No. 239 P. 1-12
The use of the MRI-navigation system ensures accurate targeting of TMS. This, in turn, results in TMS motor mapping becoming a routinely used procedure in neuroscience and neurosurgery. However, currently, there is no standardized methodology for assessment of TMS motor-mapping results. Therefore, we developed TMSmap – free standalone graphical interface software for the quantitative analysis ...
Added: June 15, 2018
Effect of stimulus orientation and intensity on short-interval intracortical inhibition (SICI) and facilitation (SICF): A multi-channel transcranial magnetic stimulation study
, , et al., Plos One 2021 Vol. 16 No. 9 Article e0257554
Besides stimulus intensities and interstimulus intervals (ISI), the electric field (E-field) orientation is known to affect both short-interval intracortical inhibition (SICI) and facilitation (SICF) in paired-pulse transcranial magnetic stimulation (TMS). However, it has yet to be established how distinct orientations of the conditioning (CS) and test stimuli (TS) affect the SICI and SICF generation. With ...
Added: October 31, 2021
HIF-Dependent NFATC1 Activation Upregulates ITGA5 and PLAUR in Intestinal Epithelium in Inflammatory Bowel Disease
, , et al., Frontiers in Genetics 2021 Vol. 12 Article 791640
Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium. In contrast, pathological hypoxia is a common feature of some chronic disorders, including inflammatory bowel disease (IBD). This work was aimed at studying HIF-associated changes in the intestinal epithelium in IBD. ...
Added: November 11, 2021
ESMRMB 2016, 33rd Annual Scientific Meeting, Vienna, AT, September 29–October 1: Abstracts, Thursday
, , et al., Springer, 2016
Adequate assessment of individual functional motor potentials is important for developing appropriate rehabilitation strategies in ischemic stroke . Microstructural changes in corticospinal tract (CST) and corpus callosum (CC) were repeatedly correlated to post-stroke outcome [2, 3]. However, relationship between them and functional recovery remains unclear. Here we investigated relationship between integrity of CST and CC ...
Added: October 14, 2016
A Possible Sensory Interpretation of Alternate Motor Fibers Relating to Structural Reserve during Stroke Recovery
, , et al., Frontiers in Neurology 2017 Vol. 8 P. 1-4
Recovery after stroke relates tightly to the white matter integrity. Currently, the main methodology for non-invasive white matter integrity assessment is diffusion-weighted magnetic resonance imaging (DW-MRI), a state-of-the-art approach which is, however, prone to multiple limitations. Using DW-MRI, it was demonstrated that many pathways including corticospinal tract (CST) and corpus callosum contribute to structural brain ...
Added: July 25, 2017
, , et al., Nature 2014
Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year)1. Minor cervical traumas, infection, migraine and hypertension are putative risk factors1, 2, 3, and inverse associations with obesity and hypercholesterolemia are described3, 4. ...
Added: October 23, 2014
, , et al., Неврология, нейропсихиатрия, психосоматика (Российская Федерация) 2020 Т. 12 № 1 С. 13-21
Patent foramen ovale (PFO) is an important cause of embolic cryptogenic stroke (ECS) in young patients. The main mechanism in this case is paradoxical embolism (PE), the basis for which is a right-to-left (R-L) shunt. Objective: to comparatively characterize patients who have undergone ECS, with and without an R-L shunt, as evidenced by transcranial Doppler ...
Added: February 25, 2020
Neuroplasticity of language in left-hemisphere stroke: evidence linking subsecond electrophysiology and structural connections.
, , et al., Human Brain Mapping 2016
Added: September 22, 2016
P51 Effect of stimulus orientation and intensity on short-interval intracortical inhibition (SICI) and facilitation (SICF)
, , et al., Clinical Neurophysiology 2020 Vol. 131 No. 4 P. e41-e41
Paired-pulse transcranial magnetic stimulation (TMS) allows investigating inhibitory and excitatory interactions in the human motor cortex noninvasively. Short-interval intracortical inhibition (SICI) and facilitation (SICF) are used to measure cortico–cortical excitability in patients with, e.g., stroke, dystonia, and Parkinson’s disease. However, the role of the induced electric field (E-field) orientation remains partly unclear. Posterior–anterior (PA)-oriented E-field elicits ...
Added: June 4, 2020
ОЦЕНКА ФРАКЦИОННОГО РЕЗЕРВА КРОВОТОКА ПО ДАННЫМ КОМПЬЮТЕРНОЙ ТОМОГРАФИИ: СРАВНЕНИЕ РАСЧЕТНЫХ ПОКАЗАТЕЛЕЙ С РЕЗУЛЬТАТАМИ ИНВАЗИВНЫХ ИЗМЕРЕНИЙ
, , et al., Кардиология 2021 Т. 61 № 7 С. 28-35
Цель Создание трехмерной математической модели коронарного кровотока по данным компьютерной томографической ангиографии (КТА) с последующим расчетом фракционного резерва кровотока (ФРККТА). Сопоставление расчетного ФРККТА с результатами инвазивных измерений. Материалы и методы В исследование включено 10 больных с «пограничными» (50-75%) стенозами по данным КТА, выполненной на 640-срезовом компьютерном томографе. На основании данных КТА были построены трехмерные математические модели коронарных ...
Added: August 16, 2021
Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Children and Youth Aged 0-19 Years: Data from the Global and Regional Burden of Stroke 2013
, Neuro-epidemiology 2015 Vol. 45 No. 3 P. 177-189
Background: There is increasing recognition of stroke as an important contributor to childhood morbidity and mortality. Current estimates of global childhood stroke burden and its temporal trends are sparse. Accurate and up-to-date estimates of childhood stroke burden are important for planning research and the resulting evidence-based strategies for stroke prevention and management. Objectives: To estimate ...
Added: October 29, 2015
, , et al., Neuropsychology 2019 Vol. 33(1) P. 77-92
Abstract OBJECTIVE: The Oxford Cognitive Screen (OCS) is a screening tool for the assessment of poststroke deficits in attention, memory, praxis, language, and number processing. The goal of the present study was to develop a Russian version of the OCS (Rus-OCS) via translation of the original battery, its cultural and linguistic adaptations, and reporting preliminary findings on ...
Added: November 1, 2018
, , et al., The Canadian Journal of Psyachaitry 2015 Vol. 60 No. 11 P. 507-514
Functional impairment continues to represent a major challenge in schizophrenia. Surprisingly, patients with schizophrenia report a level of happiness comparable with control subjects, even in the face of the prominent functional deficits, a finding at odds with evidence indicating a positive relation between happiness and level of functioning. In attempting to reconcile these findings, we ...
Added: January 23, 2018
, , et al., Фундаментальная и прикладная математика 2020 Т. 23 № 2 С. 37-56
Рассматривается задача построения триангуляции внутренней поверхности аорты и коронарных артерий. Это необходимо для создания гидродинамической модели крово-снабжения сердца. Исходными данными являются поперечные томографические срезы сердца конкретного пациента толщиной0,5мм. Триангуляцию аорты и коронарных артерий планируется использовать для расчёта кровотока в программном комплексе FlowVision, предназначенном для моделирования трёхмерных течений жидкости и га-за. Результаты моделирования планируется применять в практической медицине для диагностики ишемии ...
Added: August 16, 2021
Endocytosis and Transcytosis of SARS-CoV-2 Across the Intestinal Epithelium and Other Tissue Barriers
, , , Frontiers in Immunology 2021 Vol. 12 Article 636966
Since 2003, the world has been confronted with three new betacoronaviruses that cause human respiratory infections: SARS-CoV, which causes severe acute respiratory syndrome (SARS), MERS-CoV, which causes Middle East respiratory syndrome (MERS), and SARS-CoV-2, which causes Coronavirus Disease 2019 (COVID-19). The mechanisms of coronavirus transmission and dissemination in the human body determine the diagnostic and ...
Added: September 7, 2021
European Stroke Journal -Volume 6 Issue 1_suppl, September 2021 - abstracts from the ESOC 2021 Virtual Conference
European Stroke Organisation, 2021
E-POSTER PRESENTATIONS TOPIC: AS19 BRAIN REORGANISATION AND RECOVERY SOMATOTOPY OF THE INTERHEMISPHERIC INTERACTIONS REFLECTED IN PHYSIOLOGICAL MIRROR ACTIVITY: PRELIMINARY RESULTS M. Nazarova, K. Kozlova , P. Novikov , M. Ivanov , M. Reshetnikov , M. Mitina , E. Nikiforova , M. Baklushev and V. Nikulin Background and Aims: Interhemispheric interaction plays an important role in motor stroke ...
Added: October 28, 2021
‘Moderate global aphasia’: A generalized decline of language processing caused by glioma surgery but not stroke
, , et al., Brain and Language 2022 Vol. 224 Article 105057
Unlike stroke, neurosurgical removal of left-hemisphere gliomas acts upon a reorganized language network and involves brain areas rarely damaged by stroke. We addressed whether this causes the profiles of neurosurgeryand stroke-induced language impairments to be distinct. K-means clustering of language assessment data (neurosurgery cohort: N = 88, stroke cohort: N = 95) identified similar profiles ...
Added: December 8, 2021
Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013: Data from the Global Burden of Disease 2013 Study
, Neuro-epidemiology 2015 Vol. 45 No. 3 P. 190-202
Background: Recent evidence suggests that stroke is increasing as a cause of morbidity and mortality in younger adults, where it carries particular significance for working individuals. Accurate and up-to-date estimates of stroke burden are important for planning stroke prevention and management in younger adults. Objectives: This study aims to estimate prevalence, mortality and disability-adjusted life ...
Added: October 29, 2015