SEARCHING FOR NON-B-DNA STRUCTURES AS NUCLEOSOME BARRIERS WITH MACHINE LEARNING METHODS
Tevanyan E., Poptsova M.
We trained Random Forest model to recognize patterns of nucleosome and non-B DNA structures, considered as potential nucleosome barriers in the mouse genome. We showed that among four types of structures – Z-DNA, H-DNA, G-Quadruplexes and SIDD regions – recognition of G-Quadruplexes and H-DNA showed the best performance.
The proceedings of International congress «Biotechnology: state of the art and perspectives» FEBRUARY 25 - 27, 2019.
LLC “RED GROUP”, 2019
, , , in : Proceedings 2018 IEEE International Conference on Bioinformatics and Biomedicine. : Madrid : IEEE, 2018. P. 2808-2809.
Non-B DNA structures have a great potential to form and influence various genomic processes including transcription. One of the mechanisms of transcription regulation is nucleosome positioning. Even though only B-DNA can be wrapped around a nucleosome, non-B DNA structures can compete with a nucleosome for a genomic location. Here we used permanganate/S1 nuclease footprinting data ...
Added: February 3, 2019
, , , in : Сборник трудов 42-й междисциплинарной школы-конференции ИППИ РАН "Информационные технологии и системы 2018". : Институт проблем передачи информации им. А.А. Харкевича РАН, 2018. P. 1-10.
Non-B DNA structures have a great potential to form and influence various genomic processes including transcription. One of the mechanisms of transcription regulation is nucleo- some positioning. Even though only B-DNA can be wrapped around a nucleosome, non-B DNA structures can compete with a nucleosome for a genomic location. Here we used perman- ganate/S1 nuclease ...
Added: January 15, 2019
, PROCEEDINGS OF THE VLDB ENDOWMENT 2021 Vol. 14 No. 12 P. 3186-3189
Array DBMSs strive to be the best systems for managing, processing, and even visualizing big N-d arrays. The last decade blossomed with R&D in array DBMS, making it a young and fast-evolving area. We present the first comprehensive tutorial on array DBMS R&D. We start from past impactful results that are still relevant today, then ...
Added: June 4, 2021
, , , , in : Smart Education and e-Learning 2016. Issue 59.: Switzerland : Springer, 2016. P. 631-639.
Added: September 19, 2016
, , , in : Proceedings of the MACSPro Workshop 2019. Vol. 2478: CEUR Workshop Proceedings.: CEUR-WS.org, 2019. P. 139-148.
DNAsecondary structures are important functional elements thatmay influence cellular processes. One of theirpossible functions is regulation of nucleosome positioning. Here MNAse-seq and ssDNA-seq data were used to define patterns of positional relationship of DNA structures such as Z-DNA, H-DNA and G-quadruplexes with nucleosomes. Three types of patterns werefound: a structure is surrounded by nucleosomes from ...
Added: January 15, 2020
SEQUENCE-BASED AND STRUCTURE-BASED MACHINE-LEARNING MODELS FOR RECOGNITION OF 3’-END L1 AND ALU STEM-LOOPS IN HUMAN GENOME
, , , , in : The proceedings of International congress «Biotechnology: state of the art and perspectives» FEBRUARY 25 - 27, 2019. : LLC “RED GROUP”, 2019. P. 356-356.
We built and evaluated two types of models: sequence-based and structure-based for recognition of 3’-end stem- loops of human L1s and Alus and found most important parameters contributing to recognition: Shift, Tilt and Rise, and aslo hydrophilicity. ...
Added: November 12, 2019
, , Мониторинг общественного мнения: Экономические и социальные перемены 2021 № 1 С. 304-328
The article discusses the opportunities and limitations of using new data sources and methods of its collection, processing and analysis, namely, digital traces and machine learning in Sociology. At first, we examine the disadvantages of traditional data sources (surveys) and then, based on relevant and recent empirical studies, we discuss how these disadvantages can be ...
Added: March 9, 2021
Chelyabinsk : IEEE, 2018
The 2018 Global Smart Industry Conference is organized in order to exchange experience, promote discussion and presentation of research papers, and summarize results in development of innovative models, methods and technologies for the digital industry in universities, scientific and industrial associations of the Russian Federation as well as in foreign companies, and the experience of ...
Added: November 25, 2019
, , et al., Big Data 2017 Vol. 5 No. 4 P. 310-324
Automated and semiautomated Twitter accounts, bots, have recently gained significant public attention due to their potential interference in the political realm. In this study, we develop a methodology for detecting bots on Twitter using an ensemble of classifiers and apply it to study bot activity within political discussions in the Russian Twittersphere. We focus on ...
Added: October 1, 2020
Sampling terabytes of Landsat data with Google Earth Engine for 30 meters/pixel empirical estimates of ground-level PM10 in mg/m3
, , Remote Sensing of Environment 2017
Exposures to particulate matter (PM) cause severe health effects including heart attacks and lung cancer. Big cities require increased attention due to large population and complex spatial patterns of PM pollution. Satellite data are actively used to estimate PM ground concentrations. However, the estimates have too coarse spatial resolution (usually 250 meters and above) to ...
Added: October 5, 2016
Intelligent Data Processing 11th International Conference, IDP 2016, Barcelona, Spain, October 10–14, 2016, Revised Selected Papers
Switzerland : Springer, 2019
This book constitutes the refereed proceedings of the 11th International Conference on Intelligent Data Processing, IDP 2016, held in Barcelona, Spain, in October 2016. The 11 revised full papers were carefully reviewed and selected from 52 submissions. The papers of this volume are organized in topical sections on machine learning theory with applications; intelligent data processing in life ...
Added: February 8, 2020
CEUR Workshop Proceedings, 2019
Added: October 31, 2019
Труды ХVIII международной конференции DAMDID / RSDL’2016, 11-14 октября 2016, Ершово, Московская область, Россия
НИЯУ МИФИ, 2016
In 2016 the International Conference “Data Analytics and Management in Data Intensive Domains” (DAMDID/RCDL’2016) was held on October 11 – 14 in the Holiday Center, Ershovo (Moscow region). By tradition the “Data Analytics and Management in Data Intensive Domains” conference (DAMDID) is planned as a multidisciplinary forum of researchers and practitioners from various domains of science and research, promoting ...
Added: January 26, 2017
, , et al., Journal of Cheminformatics 2022 Vol. 14 Article 49
Polypharmacy refers to the administration of multiple drugs on a daily basis. It has demonstrated effectiveness in treating many complex diseases , but it has a higher risk of adverse drug reactions. Hence, the prediction of polypharmacy side effects is an essential step in drug testing, especially for new drugs. This paper shows that the ...
Added: October 11, 2022
, Логистика и управление цепями поставок 2018 № 4 (87) С. 27-33
One of the options for a more flexible approach to analyzing the reliability of supply chains is the principal component analysis (PCA). With a large number of variables describing supply chain, it is a difficult task to analyze the structure of variables in two-dimensional space. Within the analysis of the variables dependencies PCA allows to ...
Added: November 29, 2018
Learning and Intelligent Optimization. 8th International Conference, Lion 8, Gainesville, FL, USA, February 16-21, 2014. Revised Selected Papers
This book constitutes the thoroughly refereed post-conference proceedings of the 8th International Conference on Learning and Optimization, LION 8, which was held in Gainesville, FL, USA, in February 2014. The 33 contributions presented were carefully reviewed and selected for inclusion in this book. A large variety of topics are covered, such as algorithm configuration; multiobjective ...
Added: September 15, 2014
, , in : Software Quality: Future Perspectives on Software Engineering Quality: 13th International Conference, SWQD 2021, Vienna, Austria, January 19–21, 2021, Proceedings. : Springer, 2021. P. 54-65.
In this concept paper, we explore some of the aspects of quality of continuous learning artificial intelligence systems as they interact with and influence their environment. We study an important problem of implicit feedback loops that occurs in recommendation systems, web bulletins and price estimation systems. We demonstrate how feedback loops intervene with user behavior ...
Added: September 23, 2021
Proceedings of the International Workshop "What can FCA do for Artificial Intelligence?" (FCA4AI at ECAI 2014)
Prague : CEUR Workshop Proceedings, 2014
The first and the second edition of the FCA4AI Workshop showed that many researchers working in Artificial Intelligence are indeed interested by a well-founded method for classi- fication and mining such as Formal Concept Analysis (see http://www.fca4ai.hse.ru/). The first edition of FCA4AI was co-located with ECAI 2012 in Montpellier and published as http://ceur-ws.org/Vol-939/ while the ...
Added: September 12, 2014
, , et al., Plos One 2022 Vol. 17 No. 10 Article e0275814
Artificial intelligence and machine learning have demonstrated remarkable results in science and applied work. However, present AI models, developed to be run on computers but used in human-driven applications, create a visible disconnect between AI forms of processing and human ways of discovering and using knowledge. In this work, we introduce a new concept of ...
Added: October 29, 2022
, , et al., , in : 2021 International Conference Engineering and Telecommunication (En&T). : IEEE, 2022. P. 1-6.
Style transfer is an important and a rapidly developing of Natural Language Processing. This days more and more methods and models are proposed which allow us to generate text in predefined style. In this paper we propose a framework for style transfer of “Friends” TV series. The trained models are able to mimic one of ...
Added: May 21, 2022
Berlin, Heidelberg : Springer, 2013
The proceedings of the 11th International Conference on Service-Oriented Computing (ICSOC 2013), held in Berlin, Germany, December 2–5, 2013, contain high-quality research papers that represent the latest results, ideas, and positions in the field of service-oriented computing. Since the first meeting more than ten years ago, ICSOC has grown to become the premier international forum ...
Added: March 21, 2014
, В кн. : МАШИННОЕ ОБУЧЕНИЕ В ИССЛЕДОВАНИЯХ МЕДИКО-БИОЛОГИЧЕСКИХ И СОЦИАЛЬНО-ЭКОНОМИЧЕСКИХ ДАННЫХ. : СПб. : Федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский политехнический университет Петра Великого", 2020. С. 284-333.
In many practical tasks it is needed to estimate an effect of treatment on individual level. For example, in medicine it is essential to determine the patients that would benefit from a certain medicament. In marketing, knowing the persons that are likely to buy a new product would reduce the amount of spam. In this ...
Added: December 7, 2021
Formal Concept Analysis: 16th International Conference, ICFCA 2021, Strasbourg, France, June 29 – July 2, 2021, Proceedings
This book constitutes the proceedings of the 16th International Conference on Formal Concept Analysis, ICFCA 2021, held in Strasbourg, France, in June/July 2021. The 14 full papers and 5 short papers presented in this volume were carefully reviewed and selected from 32 submissions. The book also contains four invited contributions in full paper length. The research part ...
Added: July 10, 2021