Применение транскраниальной магнитной стимуляции в психиатрической и психоневрологической практике
This training manual contains information about the features of the use of transcranial magnetic stimulation (TMS) in the main mental and neuropsychiatric disorders. The manual discusses in detail the main mechanisms of action of TMS, legal, organizational and sanitary norms of this procedure, indications and contraindications for its implementation, the peculiarities of combining TMS with psychopharmacotherapy and psychotherapy. In separate sections, the features of the use of TMS for affective diseases, anxiety disorders, obsessive-compulsive disorder, schizophrenia, chronic pain, neuropsychiatric diseases, and addictions are highlighted. The textbook "Application of transcranial magnetic stimulation in psychiatric and neuropsychiatric practice" was prepared in the discipline "Psychiatry" in accordance with the Federal State Educational Standard of Higher Professional Education for students of postgraduate and additional professional education of doctors studying in the specialty "Psychiatry" (14.01.06)
The development of the rational medicine, based on scientific evidence (evidence based medicine, EBM) in the late 21 century lead to the opening of the Pandora box of doubt in the evidence base of medicine. Paradoxically part of the specialists and the public, who are inconvenient with the critical assessment of the evidence, start to criticize the EBM for the corrupted evidence base. In the real world the only way out from the situation with the weak evidence base is the work to support the free access to the research evidence and hard work to improve the quality of evidence
Special issue of Epilepsia dedicated to the 31stInternational Epilepsy Congress Istanbul, Turkey 5th–9th September, 2015
The article examines the plethora of ideas regarding norms and deviations in late imperial Russia. Adapting criminal anthropology to the imperial situation, doctors and scientists examined the “natural-born criminal” as a collective category and created a comparative scale of imperial human diversity that allowed them to stigmatize entire groups. In the period between revolutions, the discourse on criminality underwent a semiotic shift from the signifier to the signified, conditioning a new image of the “internal savage,” one that was, however, hybrid and unstable. The following generation of psychiatrists was tasked with overcoming this duality, but this was only achieved in the early Soviet period, when the concept of the “natural-born criminal” was replaced by that of the “counterrevolutionary” and acquired an unambiguous, purely sociological sense.
Background: In this review we survey medical treatments and research strategies, and we discuss why they have failed to cure degenerative disc diseases or even slow down the degenerative process.
Objective: We seek to stimulate discussion with respect to changing the medical paradigm associated with treatments and research applied to degenerative disc diseases.
Method Proposal: We summarize a Biological Transformation therapy for curing chronic inflammations and degenerative disc diseases, as was previously described in the book Biological Transformations controlled by the Mind Volume 1.
Preliminary Studies: A single-patient case study is presented that documents complete recovery from an advanced lumbar bilateral discopathy and long-term hypertrophic chronic rhinitis by application of the method proposed.
Conclusion: Biological transformations controlled by the mind can be applied by men and women in order to improve their quality of life and cure degenerative disc diseases and chronic inflammations illnesses.
Conversion disorder is defined by one or more physical symptoms that are not under voluntary control and are not thought to be caused by neurological or medical conditions. The key feature of this disorder is thus the incongruence between presented symptomology and medical conceptualizations of organic diseases. The most commonly observed conversion symptoms include blindness, psychogenic non-epileptic seizures, paralyses, unresponsiveness, anesthesia, aphonia, and abnormal gait. There is no unified model for conversion disorder and its conceptualization relies on psychological, social, and biological factors. The onset of the symptoms is sudden, and is often preceded by either psychological or physical trauma. The diagnosis of conversion disorder is often problematic. Since the presenting symptoms of this psychiatric disorder are neurological, a full diagnosis often requires collaboration between a psychiatrist and a neurologist. Once the diagnosis has been made several treatment options may be considered. While there are no specific pharmacological or psychological treatments for conversion disorder, case reports suggest that a multidisciplinary approach in rehabilitation settings with an emphasis on maximizing physical function appear to be most beneficial.
he 19th Annual Meeting of the Organization for Human Brain Mapping was held June 16-20, 2013 at the Washington State Convention Center in Seattle, WA, USA. OHBM draws attendance between 2500-3000 attendees each year. Membership in the organization is growing and the meeting continues to be one of the most significant neuroimaging conferences for those in the field. The OHBM meeting boasts a combination of exciting scientific programs and social events, all tailored to the city the meeting is being held. Unique, innovative and full of surprises, Seattle is a diverse city with a laid-back approach to life. To experience Seattle is to experience the quiet confidence and balanced urban and natural lifestyles. Seattle is a world-class metropolis with a fast-paced city life within wild, beautiful natural surroundings.
Materials of the all-Russian scientific-practical conference with international participation
Objective: Glioblastoma is a highly aggressive and invasive brain and Central Nervous System (CNS) tumor. Current treatment options do not prolong overall survival significantly because the disease is highly prone to relapse. Therefore, research to find new therapies is of paramount importance. It has been discovered that glioblastomas contain a population of cells with stem-like properties and that these cells are may be responsible for tumor recurrence.
Methods: A review of relevant papers and clinical trials in the field was conducted. A PubMed search with related keywords was used to gather the data. For example, “glioblastoma stem cells AND WNT signaling” is an example used to find information on clinical trials using the database ClinicalTrials.gov.
Results: Cancer stem cell research has several fundamental issues and uncertainties that should be taken into consideration. Theoretically, a number of treatment options that target glioblastoma stem cells are available for patients. However, only a few of them have obtained promising results in clinical trials. Several strategies are still under investigation.
Conclusion: The majority of treatments to target cancer stem cells have failed during clinical trials. Taking into account a number of biases in the field and the number of unsuccessful investigations, the application of the cancer stem cells concept is questionable in clinical settings, at least with respect to glioblastoma.
Data management and analysis is one of the fastest growing and most challenging areas of research and development in both academia and industry. Numerous types of applications and services have been studied and re-examined in this field resulting in this edited volume which includes chapters on effective approaches for dealing with the inherent complexity within data management and analysis. This edited volume contains practical case studies, and will appeal to students, researchers and professionals working in data management and analysis in the business, education, healthcare, and bioinformatics areas.
Little is known about the burden of common mental disorders in Russia despite high levels of suicide and alcohol-related mortality. Here we investigated levels of symptoms, self-reports of ever having received a diagnosis and treatment of anxiety and depression in two Russian cities.
The study population was men and women aged 35–69 years old participating in cross-sectional population-based studies in the cities of Arkhangelsk and Novosibirsk (2015–18). Participants completed an interview which included the PHQ-9 and GAD-7 scales, questions on whether participants had ever received a diagnosis of depression or anxiety, and health service use in the past year. Participants also reported current medication use and medications were coded in line with the WHO anatomical therapeutic classification (ATC). Depression was defined as PHQ-9 ≥ 10 and Anxiety as GAD-7 ≥ 10.
Age-standardised prevalence of PHQ-9 ≥ 10 was 10.7% in women and 5.4% in men (GAD-7 ≥ 10 6.2% in women; 3.0% in men). Among those with PHQ-9 ≥ 10 17% reported ever having been diagnosed with depression (equivalent finding for anxiety 29%). Only 1.5% of those with PHQ-9 ≥ 10 reported using anti-depressants and 0.6% of those with GAD-7 ≥ 10 reported using anxiolytics. No men with PHQ-9 ≥ 10 and/or GAD-7 ≥ 10 reported use of anti-depressants or anxiolytics. Use of health services increased with increasing severity of both depression and anxiety.
There was a large gap between symptoms and reporting of past diagnosis and treatment of common mental disorders in two Russian cities. Interventions aimed at improving mental health literacy and reducing stigma could be of benefit in closing this substantial treatment gap.
Given many developing economies depend on primary commodities, the fluctuations of commodity prices may imply significant effects for the wellbeing of children. To investigate, this paper examines the relationship between child mortality and commodity price movements as reflected by country-specific commodity terms-of-trade. Employing a panel of 69 low and lower-middle income countries over the period 1970-2010, we show that commodity terms-of-trade volatility increases child mortality in highly commodity-dependent importers suggesting a type of ‘scarce’ resource curse. Strikingly however, good institutions appear able to mitigate the negative impact of volatility. The paper concludes by highlighting this tripartite relationship between child mortality, volatility and good institutions and posits that an effective approach to improving child wellbeing in low to lower-middle income countries will combine hedging, import diversification and improvement of institutional quality.