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Генетические аспекты нейропсихиатрической симптоматики при болезни Паркинсона
Кремлевская медицина. Клинический вестник. 2019. № 1. С. 58–68.
Самушия М. А., Ragimova A.
The review presents the data on the effects of the COMT, MAO-A, MAO-B, DAT, DRD2, VMAT2, TPH2 and SNCA genes on Parkinson's disease, the effectiveness of therapy and theiraffinity to a number of mental disorders. A systematic review was conducted with 77 articles and monographs devoted to the problems of genetics, neurology and psychiatry, published in the period from 1972 to 2018. Early recognition of the disease genetic features will optimize drug therapy, predict early complications of the disease, such as: cognitive decline, affective, obsessive-compulsive, psychotic disorders, and impulse control disorder. Genetic perdition of clinical features of Parkinson's disease can be also helping in selecting and preparing patients for deep brain stimulation
Wang R., He Y., Myachykov A. et al., Neuroimage 2026 Vol. 332 Article 121926
Insomnia disorder (ID) exhibits considerable heterogeneity in neuroimaging findings across studies, and whether functional brain alterations are consistent across resting and task states remains unclear. This study aimed to identify neural dysfunction across states in ID and explore its transcriptomic correlates. ...
Added: July 13, 2026
Shestoperov A. I., Ivchenko A., Fomina E. V., Microgravity Science and Technology 2025 Vol. 37 Article 19
The paper is dedicated to the analysis of medico-biological data obtained during locomotor testing of astronauts. Accurate data interpretation plays a crucial role in locomotion system monitoring, prophylaxis of long-duration spaceflight negative effects and thus in the development of an autonomous medical support system for deep space expeditions. During the locomotor testing the astronaut changes ...
Added: June 26, 2026
Kyrchanova O., Ksenia Kudryashova, Dubrovskaya V. et al., Open Biology 2025 Vol. 15 No. 11 Article 250192
The specification of abdominal segments A5 to A9 depends on the expression of Abdominal-B (Abd-B), which is regulated by four infraabdominal domains: iab-5 through iab-8,9. Each iab domain contains an initiation element that determines its active state, along with enhancers responsible for tissue-specific activation of Abd-B. These iab domains function autonomously due to their flanking boundaries, Fab-6, Fab-7 and Fab-8, which both block crosstalk between adjacent iab domains (insulator function) and facilitate long-range ...
Added: June 20, 2026
Vasilev R., Savchenko A., Blinov P. et al., Frontiers in Medicine 2026 Vol. 13 Article 1778404
Automated disease screening systems face challenges when applied to multi-class medical image analysis, particularly under severe class imbalance inherent in clinical datasets. Retinal fundus imaging enables non-invasive screening for multiple ocular and systemic diseases simultaneously, yet current automated systems typically assess risk for only a single pathology or a limited disease range. We developed a ...
Added: June 16, 2026
Zaikin A., Sviridov I., Sosedka A. et al., Technologies 2026 Vol. 14 No. 2 Article 84
High-dimensional tabular data are common in biomedical and clinical research, yet conventional machine learning methods often struggle in such settings due to data scarcity, feature redundancy, and limited generalization. In this study, we systematically evaluate Synolitic Graph Neural Networks (SGNNs), a framework that transforms high-dimensional samples into sample-specific graphs by training ensembles of low-dimensional pairwise ...
Added: May 23, 2026
ЯКУБЕНКО Т. В., Plotnikov S., Ratio et Natura 2024 № 3 (11) Статья 10
The article presents the results of our own research aimed at studying the prospects of using genetic sequencing technologies to identify the risk of having children with genetic abnormalities. ...
Added: May 21, 2026
Андрушкевич О. М., Калиновский А. В., Гаврюшин А. В. et al., Нейрохирургия 2026 Т. 28 № 1 С. 33–42
Background. The application of cortical and subcortical stimulation during awake craniotomy mitigates the risk of persistent postoperative speech deficits. However, the functions of some white matter pathways remain inadequately understood, particularly the frontal aslant tract (FAT) of the dominant hemisphere.
Aim. To evaluate the efficacy of cortical and subcortical stimulation techniques in the localization of glial tumors near ...
Added: May 18, 2026
Garmonova A., Shcheglova D., Камалова Г. Р. et al., Кубанский научный медицинский вестник 2026 Т. 33 № 2 С. 92–110
Introduction. The study analyzes the structure and volume of workload for faculty at Russian medical universities amidst increasing student numbers, rising demands for students' clinical training, scientific output, and continuous professional education. The relevance of the topic stems from the contradiction between official regulatory requirements and the actual excessive workload of medical educators. The aim is to provide ...
Added: April 29, 2026
Krasnov L., Malikov D., Kiseleva M. et al., Journal of Medicinal Chemistry 2026 Vol. 69 No. 8 P. 8838–8851
In this work, we developed a straightforward data-driven approach to predict the cytotoxicity of metal complexes based entirely on their (metal + ligands) composition. To this end, we have manually curated MetalCytoToxDB─a comprehensive experimental database comprising 26,500 IC50 values for 7050 metal complexes against 754 cell lines from 1921 articles. Based on these, machine learning ...
Added: April 23, 2026
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Nosachev P., М.: Новое литературное обозрение, 2026.
Что такое мистический опыт и как его изучают? Где заканчивается религиозное переживание и начинается психиатрический диагноз? Могут ли нейронауки объяснить, что такое медитация и молитва? Подходя к теме с позиций критической культурологии, Павел Носачев в этой книге ставит под сомнение общепринятый инструментарий изучения религиозных переживаний. Он предлагает читателю три масштабных экскурса: историю становления научной категории ...
Added: March 21, 2026
Данилова Н. В., Олейникова Н. А., Михайлов И. А. et al., М.: КДУ, Университетская книга, 2025.
This textbook contains all the lectures from the pathological anatomy course at the Faculty of Fundamental Medicine of Lomonosov Moscow State University. The total duration of video recordings is over 50 hours. Each lecture has a brief summary. The accessible presentation of the material will allow you to effectively use your knowledge in preparation for ...
Added: March 3, 2026
Екатеринбург: ФГБОУ ВО УГМУ Минздрава России, 2025.
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Федеральное государственное бюджетное образовательное учреждение
высшего образования
«Уральский государственный медицинский университет»
Министерства здравоохранения Российской Федерации
Научное общество молодых ученых и студентов
Медицинское образование, наука,
практика
Сборник статей X Международной научно-практической конференции
молодых ученых и студентов
Medical education, science, practice
22-23 апреля 2025 г. ...
Added: March 2, 2026
Пермский государственный национальный исследовательский университет, 2025.
Представлены материалы Десятой всероссийской научно-практической конференции с международным участием «Искусственный интеллект в решении
актуальных социальных и экономических проблем ХХI века», которая проводилась 9–10 октября 2025 г. в Перми, ПГНИУ.
Сборник предназначен для научных и педагогических работников, преподавателей, аспирантов, магистрантов, студентов и всех, кто интересуется и занимается проблемами развития и применения методов искусственного интеллекта. ...
Added: February 15, 2026
М.: Эксмо, 2025.
"Сердечная недостаточность"— это современное и всестороннее практическое руководство для врачей, посвященное одной из ключевых проблем кардиологии. В основе книги лежат принципы доказательной медицины, актуальные клинические рекомендации и последние научные достижения в области диагностики и лечения хронической сердечной недостаточности (ХСН).
В руководстве подробно рассмотрены:
- этиология и патофизиологические механизмы развития ХСН;
- современные классификации и критерии диагностики;
- дифференциальная диагностика ...
Added: February 7, 2026
Ларина Е. В., М.: Юрайт, 2026.
-В курсе представлены сведения, необходимые для совершенствования теоретических и практических навыков диагностики, лечения и профилактики хронических неинфекционных заболеваний у мультиморбидных пациентов пожилого и старческого возраста. Информационный материал систематизирован, нагляден, соответствует последним достижениям науки и клинической практики в области внутренних болезней, сопровождается ссылками на современную литературу для самостоятельного изучения. Курс подготовлен в соответствии с действующим Федеральным ...
Added: February 6, 2026
Ларина В. Н., Матвейчук Т. А., Ларина Е. В., Клиницист 2026 Т. 19 № 4 С. 34–42
In response to the global increase in chronic noncommunicable diseases, the World Health Organization and the United Nations have adopted strategies to reduce premature mortality. Improving the health literacy of the population which is defined as a combination of knowledge, motivation and practical skills to maintain health is recognized as a key task for achieving ...
Added: February 6, 2026
Miske O., Abatayo A. L., Daley M. et al., Nature 2026 Vol. 652 P. 126–134
Published claims should be reproducible, yielding the same result when applying the same analysis to the same data. ...
Added: January 19, 2026
Pothi.com, 2025.
Материалы XXXVIII международной научно-практической конференции ...
Added: January 15, 2026
Махачкала: ИПЦ ДГМУ, 2025.
В сборнике опубликованы доклады научной конференции, посвященные 80-летию Победы в Великой Отечественной войне. ...
Added: December 28, 2025
Sokolov B., Социология: методология, методы, математическое моделирование 2025 № 61 С. 7–76
This article reviews a set of estimands commonly used in modern applied research to operationalize causal inquiries within the Rubin Causal Model (RCM). I first introduce the basic average treatment effects (ATE, ATT, ATC) and then describe their main extensions, including local and conditional treatment effects, causal interactions, causal mediation, multivalued or continuous treatments, and ...
Added: December 19, 2025
Yanova M., Maltseva D., Tonevitsky A., Frontiers in Cell and Developmental Biology 2025 Vol. 13 Article 1720996
Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide. Tumor sidedness, distinguishing left- (LCRC) and right-sided (RCRC) cancers, has emerged as a critical clinical determinant, influencing patient prognosis and therapeutic response. However, the cellular and molecular mechanisms underlying these differences remain poorly understood. Recent advances in single-cell RNA sequencing ...
Added: December 12, 2025
Muscarà G., Vergallito A., Letorio V. et al., Brain Sciences 2025 Vol. 15 No. 3 Article 246
Stuttering is a speech disorder involving fluency disruptions like repetitions, prolongations, and blockages, often leading to emotional distress and social withdrawal. Here, we present Augmented Multisensory Feedback Stimulation (AMFS), a novel personalized intervention to improve speech fluency in people who stutter (PWS). AMFS includes a five-day intensive phase aiming at acquiring new skills, plus a ...
Added: December 12, 2025
Gallo F., Voits T., Rothman J. et al., eNeuro 2025 Vol. 12 No. 6 Article ENEURO.0128-25.2025
Models of experience-dependent neuroplasticity predict that the acquisition and extensive use of a new skill trigger a nonlinear trajectory of neurostructural modifications, where initial expansion of relevant brain areas subsequently (once the skill is acquired) gives way to volumetric renormalization. Such predictions also apply in the domain of language during learning and/or simultaneous management of ...
Added: December 12, 2025