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July 13, 2026
Biologists Discover Unique Properties of MiR-93-5p MicroRNA in Prostate Cancer
Researchers at the International Laboratory of Microphysiological Systems of the HSE Faculty of Biology and Biotechnology investigated how different isoforms of the same microRNA influence gene function in prostate adenocarcinoma. The study found that in some cases, microRNAs can reinforce each other’s effects by targeting and suppressing the same genes. This finding offers a fresh perspective on the molecular mechanisms underlying tumour development and on the search for disease biomarkers. The results have been published in PeerJ.
July 13, 2026
'My Goal Is to Become a Tenured Professor'
Mikhail Samatov focuses on the theoretical study of perovskite solar cells. In this interview for the HSE Young Scientists project, he talks about working on HSE University’s supercomputer, collaborating with Peking University, and making furniture.
July 9, 2026
HSE Economists Use Search Queries to Forecast Birth Rates
Researchers from the HSE Faculty of Economic Sciences have shown that the accuracy of birth rate forecasts for Russia can be improved by almost 50% by incorporating the dynamics of online search queries related to pregnancy and childbirth into forecasting models. In the best-performing models, the forecasting error fell from 4.6% to 3.2%. The findings have been published in Populations and Economics.

 

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New Working Memory Paradigm for Neuroimaging Testing of Visual and Verbal Modality under Different Attentional Involvement

Psychology. Journal of the Higher School of Economics. 2024. No. 3. P. 456–471.
Nikita Otstavnov, Ekaterina Voevodina, Semyon Mening, Urazaeva R., Tommaso Fedele

Working memory (WM) is a cognitive function essential for short-term maintenance of information in a highly accessible state to support goal-directed behavior. The classical behavioral model of WM includes a visuospatial sketchpad, a phonological loop and the central executive. Neuroimaging studies selectively targeted the activity associated with maintenance and processing of modality specific information. However, an experimental design is still missing that would enable the assessment of all components of WM drawing a holistic neuroimaging model. In this study, we propose a modified paradigm based on the classical retro-cue task, which allows disentangling the activity of all WM components, and in particular of the central executive. This paradigm consists of five conditions: passive perception, simple verbal storage, simple visual storage, alphabetical reordering (complex verbal) and mental rotation (complex visual). Testing on a cohort of 35 healthy adults, we obtained a similar workload for simple storage conditions with a low engagement of the central executive. A different workload was verified between the simple and complex conditions in both verbal and visual modalities. This experimental design provides the framework to assess the neural activity associated with the central executive components in different modalities and to address the question of a unitary or modality-specific central executive nature. Therefore, the paradigm is suitable for utilization in neuroimaging to potentially advance our comprehension of the WM organization.

Research target: Psychology Biology Medical Biotechnologies
Language: English
DOI
Text on another site
Keywords: working memoryрабочая памятьобработка информациицентральный процессорinformation processingобработка информации в мозге человекаmodified retro-cue taskcentral executiveмодифициро- ванная задача с ретро-подсказкой
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