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Возможности индивидуального фМРТ-картирования мозговых основ рабочей памяти с помощью задачи «N шагов назад»
Вестник рентгенологии и радиологии. 2025. Т. 106. № 6. С. 192–206.
Pechenkova E., Паникратова Я. Р., Королькова О. А., Пчелинцева М. Е., Смирнова А. В., Mening S., Маковская Л. А., Синицын В. Е.
Background. Individual activation maps based on brain functional magnetic resonance imaging (fMRI) data cannot yet be applied to refine a patient's diagnosis and prognosis. However, tracking activation dynamics in the same patient during the course of treatment or rehabilitation can be useful for assessing their efficacy. Population-based studies often fail to identify clinically significant activation parameters and to aid interpretation. To address this gap, we propose the examination of individual differences in activation in correspondence with the state of the mental process of interest.
Objective: to analyze individual differences in brain activation evoked by the n-back task (working memory updating) in young and elderly healthy participants related to accuracy and response times in this task.
Material and methods. fMRI was recorded in 16 young (18–35 years) and 16 elderly (60–75 years) healthy right-handed participants while they performed the n-back task. Group-level activation was assessed in the 2-back versus 0-back conditions. The effects of age (young/elderly), material type (verbal/nonverbal), accuracy and response times were assessed.
Results. In all participants, regardless of age, less effective performance in the 2-back task was accompanied by more pronounced activation. Lower accuracy was coupled with higher activation in the visual cortex bilaterally and in the right inferior frontal gyrus, while a higher response time was associated with greater activation in the right frontal components of the frontoparietal network and the right frontal pole.
Conclusion. Our findings explain a very small portion of the variance in activation patterns in the working memory tasks, so they cannot yet be used to interpret individual activation maps. However, they could pave the way for assessing dynamics of individual patterns over time if successfully replicated in a longitudinal study.
Keywords: пожилой возрастрабочая памятьindividual differencesиндивидуальные различияfunctional magnetic resonance imagingфункциональная магнитно-резонансная томографияelderly agen-back taskвербальный материалневербальный материал working memoryздоровое старениеverbal material nonverbal materialyoung agehealthy agingзадача «N шагов назад»молодой возраст
Boldyreva M., Mohammad R., Agareva M. et al., FRONTIERS IN ANIMAL SCIENCE 2026 Vol. 7 Article 1837838
Mammals from arid ecosystems face distinct physiological challenges: water scarcity and unpredictable food availability require the integration of energy storage, maintenance of water balance, and flexible switching between nutrients. Our previous study demonstrated lower fasting blood glucose levels in the desert rodent Acomys cahirinus (African spiny mouse), which also possesses a unique regenerative ability. The aim of ...
Added: June 3, 2026
Obukhov A., Маерле М. А., Минаева Е. И., Исследователь/Researcher 2025 № 3-4 С. 282–299
The article presents a preliminary synthesis of materials from an expedition conducted in the Ulyunkhan ulus, an Evenk
settlement in the Kurumkansky District of the Republic of Buryatia, in 2025, comparing them with materials from a 2005 expedition. The study focuses on the changes over the past twenty years as perceived by the local residents themselves (Buryats and Evenks). It compares ...
Added: June 2, 2026
Obukhov A., Кириллова К. Б., Исследователь/Researcher 2025 № 3-4 С. 26–48
This article investigates the phenomenon of enduring informal multi-age communities contributing to adolescent upbringing. The conditions for the establishment and the factors ensuring the endurance of such communities are identified through the example of three organizations: the “Nadezhda” unit, the Children and Youth Organization “Ostrov Sokrovishch” (Treasure Island), and the “Karavella” (Caravel) unit. As for ...
Added: June 2, 2026
Kudriavtseva E., / РЦИС. Серия № 0148-756-286. 2026.
The content of the work is the system is a system for identifying four types of written speech structures. A set of 11 calculated parameters, statistical standards, and semantic characteristics allows for the identification of a text's structure as the result of a specific cognitive schema (scene, event, story, evaluation). The method has been verified ...
Added: June 2, 2026
СПб.: Международный институт развития когнитивно-поведенческой терапии, 2026.
This collection of scientific articles addresses current issues and modern developments in cognitive-behavioral therapy in clinical psychology, psychotherapy, coaching, and related fields. ...
Added: May 31, 2026
Vorchik A., / SSRN. Серия Social Science Research Network "Social Science Research Network". 2026.
This work is devoted to a theoretical explanation of the Easterlin paradox, according to which long-term economic growth does not make average level of people's happiness increasing. By happiness, we mean the intensity of emotions people experience while comparing their new income with its expected value, or the target income with its original value. In the first case, ...
Added: May 31, 2026
Ван Г., Торопова А. В., Музыкальное искусство и образование 2025 Т. 13 № 4 С. 73–91
Contemporary vocal pedagogy faces a complex set of methodological challenges that encompass not only the search for ways to improve technical vocal skills for the realization of artistic vision, but also the development of self-control and self-regulation in future singers, as well as the entire creative process. A successful artist cannot function without the ability ...
Added: May 29, 2026
Kazantseva A. V., A.V. Toropova, Khusnutdinova E. K. et al., ВАВИЛОВСКИЙ ЖУРНАЛ ГЕНЕТИКИ И СЕЛЕКЦИИ, Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (ИЦиГ СО РАН) (Новосибирск) 2025 Vol. 30 No. 3 P. 470–481
The development of musical abilities, including absolute pitch, musical memory, rhythm sense, and musicality, at a high degree is determined by a hereditary component (up to 68 %). The studies implementing a genome-wide linkage and association approach to musical aptitude have revealed more than 100 genetic loci. This spectrum is comprised of the genes encoding ...
Added: May 29, 2026
Давидович А. С., Shestakova A., Arzumanyan N. et al., Frontiers in Psychology 2026 Vol. 17 - 2026 P. 1–18
Background:
Delay discounting refers to the tendency to choose sooner, smaller rewards over larger, later rewards. Many previous studies link this tendency positively to reward sensitivity, yet the specific mechanisms behind this association remain poorly understood. Reward sensitivity may relate to delay discounting through at least three possible pathways: increased sensitivity to reward size, increased sensitivity ...
Added: May 27, 2026
Kolachev N., Kovaleva G., Behavior Genetics 2026
Functional literacy—the ability to apply reading, mathematical, and scientific knowledge in authentic contexts as operationalized by the PISA framework—is a key predictor of educational attainment, labour-market outcomes, and economic growth. Despite extensive behavioral-genetic research on cognitive ability, the heritability of competency-based literacy measures remains largely unexamined, particularly outside Western populations. The present study addresses this ...
Added: May 26, 2026
Dorri Sedeh S., Kosonogov V., Kerimova N. et al., Frontiers in Psychology 2026 Vol. 17 Article 1710257
Introduction:
As cities continue to grow, access to natural environments is becoming more limited, contributing to increased stress levels in urban populations. Panoramic 360° videos provide a creative and scalable means of simulating natural environments, potentially reducing stress in city residents under controlled settings. Here, we examined whether short immersive experiences in different urban environments support ...
Added: May 25, 2026
Kochetkova E., Kostanian D., Martynova O. et al., Brain Topography 2026 Vol. 39 No. 4 Article 51
Letter recognition is assumed to involve several levels of analysis, including coarse tuning for category and novelty and more fine tuning for specific features, related to letter orientation. We employed an oddball fast periodic visual stimulation (FPVS) paradigm with magnetoencephalography (Elekta VectorView, 306 sensors) to study neural discrimination responses in the source space. Using contrasts ...
Added: May 24, 2026
Zaikin A., Sviridov I., Sosedka A. et al., Technologies 2026 Vol. 14 No. 2 Article 84
High-dimensional tabular data are common in biomedical and clinical research, yet conventional machine learning methods often struggle in such settings due to data scarcity, feature redundancy, and limited generalization. In this study, we systematically evaluate Synolitic Graph Neural Networks (SGNNs), a framework that transforms high-dimensional samples into sample-specific graphs by training ensembles of low-dimensional pairwise ...
Added: May 23, 2026
Samoilov O., Tatarko A., Вопросы теоретической экономики 2026 № 2 С. 209–228
The article presents a theoretical review of literature from the last ten years devoted to the analysis of socio-psychological factors of trust in artificial intelligence. The widespread adoption of automated artificial intelligence systems, which is associated with expected economic growth, reduced resource costs, and the optimization of various work processes, often faces user distrust in ...
Added: May 21, 2026
Kadieva D., Blagoveshchensky E., Agranovich O. et al., Frontiers in Psychology 2026 Vol. 17 Article 1832623
Embodied and embedded cognition (EEC) theory proposes that language and cognitive development emerge from bodily interactions with the environment, yet empirical tests of this claim in clinical developmental populations remain rare. This mini-review synthesizes behavioral, electrophysiological, and structural neuroimaging evidence from children with serious early motor disorders—obstetric brachial plexus palsy and arthrogryposis multiplex congenita—which restrict ...
Added: May 20, 2026
Borovikova I., Uporov I., Okhrimenko G. et al., Journal of Structural Biology 2026 Vol. 218 No. 2 Article 108315
Single amino acid substitutions in the ATP-binding domain of ACVRL1, a key receptor in the bone morphogenetic protein (BMP) signaling pathway, are frequently classified as variants of uncertain significance (VUS), complicating molecular diagnosis for pulmonary arterial hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). Since aberrant ATP binding disrupts downstream SMAD1/5/8 phosphorylation, we employed molecular dynamics ...
Added: May 20, 2026
Кияненко И. К., Клиническая и специальная психология 2026 Т. 15 № 1 С. 7–19
Context and relevance. The problem of the impact of urban stress factors on mental health is becoming increasingly relevant in the context of urbanization. Living in cities is accompanied by increased psychophysiological stress, which leads to an increase in the prevalence of mental disorders among urban residents. Objective. The purpose of the article is to ...
Added: May 19, 2026
Goltseva Y., Tsokolaeva Z., Beloglazova I. et al., Stem Cell Research and Therapy 2026 Vol. 17 No. 1 Article 112
Background Cardiac fibrosis represents a significant health burden, with endothelial dysfunction and damaged
perivascular microenvironment increasingly recognized as key contributors to fibrotic remodeling. The urokinase
plasminogen activator receptor (uPAR), a critical component of the urokinase system, plays a pivotal role in vascular
remodeling and fibrosis. While prior evidence indicates that uPAR deficiency leads to microvascular dysfunction and
perivascular fibrosis, ...
Added: May 19, 2026
Kochetkova E., Machinskaya R., Human Physiology 2025 Vol. 51 No. 6 P. 580–590
Growing evidence suggests the specific systems for emotional information maintenance and processing in working memory, highlighting the role of cognitive domains in emotional awareness. The question of neural basis of social-emotional processing in working memory remains open. We hypothesized that the neural systems supporting working memory for emotional processing may rely on shared ‘core’ networks ...
Added: April 15, 2026
Паникратова Я. Р., Королькова О. А., Пчелинцева М. Е. et al., Национальный психологический журнал 2026 Т. 21 № 2 С. 144–158
Background.
Working memory (WM) declines with ageing. Despite a large body of relevant studies, changes in verbal and nonverbal WM, relevant specifically for healthy aging, and their brain correlates, remain understudied.Objectives. Our study aimed to analyse changes in maintenance and updating of verbal and nonverbal material in WM in healthy ageing (i.e., the absence of cognitive ...
Added: April 2, 2026
Komyaginskaya E., Gallyamova A., Grigoryev D., В кн.: Способности и ресурсы человека в изменяющемся мире: материалы Международной научной конференции, посвященной 70‑летию со дня рождения В. Н. Дружинина.: Институт психологии РАН, 2026. С. 556– 562.
Психометрические методики оценки стратегии истории жизни (СИЖ) обычно основываются на оценке т. н. K-фактора, высокое значение которого свидетельствует о более медленной СИЖ, и наоборот — о более быстрой СИЖ. В нашем исследовании мы адаптировали и валидизировали самую популярную однофакторную методику Mini-K для российского контекста. ...
Added: March 17, 2026
Паникратова Я. Р., Пчелинцева М. Е., Егорова М. В. et al., Психиатрия, психотерапия и клиническая психология 2025 Т. 16 № 4 С. 528–543
Working memory (WM) may largely determine human cognitive capabilities and, consequently, daily functioning and performance in leading activity for diverse ages. Therefore, WM training seems to be relevant for both healthy individuals and patients with neurological or mental conditions of a broad age range. The kinds of WM training described in the literature are highly ...
Added: March 15, 2026
Pechenkova E., Королькова О. А., Паникратова Я. Р. et al., В кн.: Когнитивная наука в Москве: новые исследования. Материалы конференции 25 – 26 июня 2025.: М.: Буки Веди, 2025. С. 394–399.
Working memory (WM) is a system for the short-term storage and processing of a limited amount of information required for a current cognitive activity. WM largely determines a person's cognitive abilities throughout life and has been shown to decline with aging. This decline affects WM updating to a greater degree than maintenance and is more ...
Added: December 29, 2025
Del Maschio N., Bellini C., Giannachi M. et al., Brain Structure and Function 2025 Vol. 230 Article 55
Reading is a core feature of human communication that develops throughout intensive academic training. Recently, a group of studies examined whether neuroanatomical variants that predate literacy acquisition may influence reading abilities at later stages of life, yielding mixed results. To complement and expand previous knowledge, we used multimodal magnetic resonance imaging (MRI) to investigate whether ...
Added: December 12, 2025