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Evolution of transcriptional regulation of histidine metabolism in Gram-positive bacteria
BMC Genomics. 2022. Vol. 23. Article 558.
German A. Ashniev, Sernova N., Shevkoplias A., Rodionov I., Rodionova I., Vitreschak A., Gelfand M., Rodionov D.
The histidine metabolism and transport (his) genes are controlled by a variety of RNA-dependent regulatory systems among diverse taxonomic groups of bacteria including T-box riboswitches in Firmicutes and Actinobacteria and RNA attenuators in Proteobacteria. Using a comparative genomic approach, we previously identified a novel DNA-binding transcription factor (named HisR) that controls the histidine metabolism genes in diverse Gram-positive bacteria from the Firmicutes phylum.
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English
Radygina A., Kulikova S., Herald of the Russian Academy of Sciences 2025 Vol. 95 No. 6 P. 963–970
Musical training has a significant impact on brain organization, leading to functional and structural
adaptations that enhance auditory, visual, motor, and cognitive processes. This study investigates how
extensive musical training shapes functional brain connectivity by comparing professional musicians and
non-musicians. Using EEG phase-locking value (PLV) analysis, we examined neural synchronization across
alpha, beta, and gamma frequency ranges during music ...
Added: August 5, 2026
Vlassov V., JAMA - Journal of the American Medical Association 2026 P. 1–6
Importance Elevated low-density lipoprotein cholesterol (LDL-C) is a modifiable risk factor for cardiovascular disease, the leading cause of premature death worldwide. Assessing the LDL-C–related burden is critical for guiding prevention and treatment strategies.
Objectives To estimate the global, regional, and national burden of ischemic heart disease and ischemic stroke attributable to elevated LDL-C (relative to 35-54 mg/dL) from ...
Added: August 4, 2026
Provlotskaya I., Minnigulova A., Gordeyeva E. et al., Brain Structure and Function 2026 Vol. 231 Article 113
The Wada test is an invasive procedure used to assess language and memory lateralization. Despite the widespread use of the Wada test in the population of people with epilepsy, the two existing standardized protocols for conducting the procedure are methodologically different and do not fully account for language comprehension as a separate domain. In this ...
Added: August 4, 2026
Maghsoohi A., Pavlov V., Rouse P. et al., Health Care Management Science 2026 Vol. 29 No. 37
As the numbers of older people (65 +) rise globally, the pressure on acute hospitals to provide efficient and effective care while addressing resource inequities increases. In this study we introduce Recognising Episodes of Acute Complexity in Health (REACH), a novel Automatic Machine Learning (AutoML)-based predictive model that prioritises older patients and assigns them to complex ...
Added: July 30, 2026
Mikhaylets E. V., Razorenova A. М., Chernyshev V. L. et al., Scientific Reports 2026 Vol. 16 Article 23560
Meditation offers a naturalistic paradigm for studying introspection, yet the neural dynamics of advanced tantric practices remain largely unexplored. Buddhist Highest Yoga Tantra (BHYT) comprises a sequence of eight dissolution stages culminating in the “clear light” state. We recorded EEG during eyes-closed BHYT meditation performed in monasteries and hermitages (51 sessions from 36 male practitioners; ...
Added: July 29, 2026
Vlassov V., van der Lubbe S. C., Moberg M. E. et al., The Lancet Public Health 2026 P. 1–6
Background
Road injuries are a leading cause of mortality and morbidity worldwide. Years of international efforts have aimed to strengthen policy engagement, including the 2020 UN General Assembly's proclamation of the Second Decade of Action for Road Safety (2021–30), targeting a 50% reduction in road traffic deaths and serious injuries by 2030. The aim of this ...
Added: July 25, 2026
Авксентьева М. В., Ашихмин Я. И., Ашихмина О. В. et al., М.: ФГБУ "Издательство "Наука", 2023.
Предложены основные направления совершенствования планирования, организации и оплаты медицинской помощи, лекарственного обеспечения, информатизации и оценки технологий здравоохранения. Рекомендованы такие мероприятия, как конкретизация программы государственных гарантий бесплатного оказания гражданам медицинской помощи, создание системы общедоступного лекарственного обеспечения, использование клинико-статистических групп для оплаты медицинской помощи при ряде хронических неинфекционных заболеваний в амбулаторных условиях, формирование механизма привлечения соплатежей при ...
Added: July 16, 2026
Михайлов И. А., Опухоли женской репродуктивной системы 2025 Т. 21 № 1 С. 86–105
Цель исследования – определить наиболее целесообразную стратегию скрининга и ранней диагностики рака шейки матки (РШМ) в Российской Федерации с точки зрения клинической (диагностической) и экономической эффективности.
Материалы и методы. Для оценки клинической (диагностической) эффективности различных стратегий скрининга проведен систематический обзор публикаций об исследованиях, оценивающих эффективность применения цитологического исследования и тестирования на вирус папилломы человека (ВПЧ) с целью диагностики ...
Added: July 16, 2026
Иванова А. А., Коган С. А., Горбунова Т. В. et al., Менеджер здравоохранения 2026 № 3 С. 96–105
The research r elev anc e is determined by the demand for telemedicine consultations (TMC) as one of health care digitalization pathways in Russian Federation. Telemedicine, regardless of the field, continues to prove its significant role, saving health resources without losing medical care quality. The TMC is regulated by federal level framework. Each year the ...
Added: July 16, 2026
Михайлов И. А., Machine Learning and Knowledge Extraction 2026 Vol. 8 No. 1 Article 8
Whole-slide histology images (WSIs) can exceed 100 k × 100 k pixels, making direct pixel-level segmentation infeasible and requiring patch-level classification as a practical alternative for downstream WSI segmentation. However, most approaches either treat patches independently, ignoring spatial and biological context, or rely on deep graph models prone to oversmoothing and loss of local tissue ...
Added: July 16, 2026
Хайлова Ж. В., Омельяновский В. В., Михайлов И. А. et al., Менеджер здравоохранения 2026 № 4 С. 41–52
The urgency of the problem of organizing effective medical care for cancer patients is determined by the steady trend of increasing incidence of malignant neoplasms, the high proportion of this pathology in the structure of overall mortality, as well as significant medical, demographic and socio-economic losses for society.Purpose of the st udy is to conduct ...
Added: July 16, 2026
Михайлов И. А., Здоровье мегаполиса 2026 Т. 7 № 2 С. 7–16
Objective. To evaluate the impact of a series of organizational measures for implementing innovative medical technology in a multidisciplinary hospital on patient quality of life based on patient self-assessments. Results. Patients who received care using innovative medical technology within a systemic organizational approach demonstrated a significantly higher level of overall satisfaction with the quality of care. ...
Added: July 16, 2026
Ахапкина Е. С., Омельяновский В. В., Тулупова О. Н. et al., Медицинские технологии. Оценка и выбор 2026 Т. 48 № 2 С. 70–77
OBJECTIVE
To analyze international approaches to assessing the labor complexity for different specialists with higher medical education (physicians).
MATERIAL AND METHODS
We performed a systematic searching and content analysis of foreign and national studies and documents devoted to labor complexity of different specialists with higher medical education (doctors). A group of experts among the authors of this study discussed and identified significant factors in assessing complexity.
RESULTS
There are 2 main systems to assess physician workload complexity in foreign countries. The first approach is based ...
Added: July 16, 2026
Михайлов И. А., Annals of Hematology 2025 Vol. 104 P. 2707–2715
Vamotinib (PF-114) is a 3rd -generation, ATP-competitive oral tyrosine kinase inhibitor (TKI) active against wild-type and mutated BCR::ABL1 isoforms including BCR::ABL1T315I. We present final results of a phase-1 vamotinib dose-escalation study to identify maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) followed by expansion cohorts. 51 subjects with chronic myeloid leukaemia (CML) failing ≥ 1 2nd generation TKI or with BCR::ABL1T315I were ...
Added: July 16, 2026
Arina Bukina, Eritsyan K., Antonova N. et al., Frontiers in Psychology 2026 Vol. 17 Article 1824428
Background:
Numerous studies have shown that indigenous populations experience poorer health outcomes compared to people with other backgrounds. However, the interpretation of these disparities remains challenging due to differences in living conditions and social environments, as well as by potential measurement-related biases. Little is known about whether the underlying mechanisms of mental health outcomes differ between ...
Added: July 15, 2026
IEEE, 2026.
The purpose of the 2026 IEEE Ural-Siberian Conference on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT) is to bring together researchers and practitioners from multiple areas of radio science, including biomedical engineering, radioelectronics, microelectronics, information technology, smart energy, information security and others. ...
Added: July 8, 2026
Ledesma J. R., Zhang M., Liew M. F. et al., The Lancet Infectious Diseases 2026 P. 1–12
Background
Tuberculosis (TB) is the leading global cause of death from a single infectious agent. Recent reductions in global health funding have threatened TB control, making comprehensive assessment of TB, HIV-related TB, and drug-resistant TB burdens before these disruptions essential for shaping effective responses. The WHO End TB Strategy sets targets of a 95% reduction in ...
Added: July 7, 2026
Окнина Л. Б., Подлепич В. В., Sieber I. et al., Физиология человека 2026 Т. 52 № 3 С. 5–15
The aim of this study was to evaluate the frequency following response (FFR) for the analysis of the intact perception of syllables in humans. For this purpose, event-related potentials (ERPs) in response to isolated Russian syllables were recorded and analyzed in 29 healthy persons in two frequency ranges, standard (1-40 Hz) and high frequency (70-150 ...
Added: June 30, 2026
Sharko F., Mazloum A., Krotova A. et al., Frontiers in Veterinary Science 2024 Vol. 11 Article 1321202
It has been recognized that capripoxvirus infections have a strong cutaneous tropism with the manifestation of skin lesions in the form of nodules and scabs in the respective hosts, followed by necrosis and sloughing off. Considering that the skin microbiota is a complex community of commensal bacteria, fungi and viruses that are influenced by infections ...
Added: August 25, 2025
Fishman V., Kuratov Y., Shmelev A. et al., Nucleic Acids Research 2025 Vol. 53 No. 2 Article gkae1310
Recent advancements in genomics, propelled by artificial intelligence, have unlocked unprecedented capabilities in interpreting genomic sequences, mitigating the need for exhaustive experimental analysis of complex, intertwined molecular processes inherent in DNA function. A significant challenge, however, resides in accurately decoding genomic sequences, which inherently involves comprehending rich contextual information dispersed across thousands of nucleotides. To ...
Added: August 1, 2025
German A. Ashniev, Petrov S., Iablokov S. et al., Microorganisms 2022 Vol. 10 No. 4 Article 740
The human gut microbiota (HGM) have an impact on host health and disease. Amino acids are building blocks of proteins and peptides, also serving as precursors of many essential metabolites including nucleotides, cofactors, etc. Many HGM community members are unable to synthesize some amino acids (auxotrophs), while other members possess complete biosynthetic pathways for these ...
Added: January 31, 2023
Garushyants S., Beliavskaia A., Malko D. et al., Frontiers in Microbiology 2018 Vol. 9 Article 738
While most endosymbiotic bacteria are transmitted only vertically, Holospora spp., an alphaproteobacterium from the Rickettsiales order, can desert its host and invade a new one. All bacteria from the genus Holospora are intranuclear symbionts of ciliates Paramecium spp. with strict species and nuclear specificity. Comparative metabolic reconstruction based on the newly sequenced genome of Holospora ...
Added: December 16, 2021
Granata I., Manzo M., Kusumastuti A. et al., Current Medicinal Chemistry 2021 Vol. 28 No. 32 P. 6619–6653
Purpose: Systems biology and network modeling represent, nowadays, the hallmark approaches for the development of predictive and targeted-treatment based precision medicine. The study of health and disease as properties of the human body system allows the understanding of the genotype-phenotype relationship through the definition of molecular interactions and dependencies. In this scenario, metabolism plays a ...
Added: August 25, 2021
Manipur I., Granata I., Maddalena L. et al., BMC Bioinformatics 2020 Vol. 21 No. 10 P. 349
Background: Biological networks are representative of the diverse molecular interactions that occur within cells. Some of the commonly studied biological networks are modeled through protein-protein interactions, gene regulatory, and metabolic pathways. Among these, metabolic networks are probably the most studied, as they directly influence all physiological processes. Exploration of biochemical pathways using multigraph representation is ...
Added: November 22, 2020