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Regular version of the site

Article

Naphthoquinone-derived polyol macrolides from natural sources

Russian Chemical Bulletin. 2019. Vol. 68. No. 5. P. 955-966.
В.А. Коршун.

New biologically active substances isolated from natural sources provide valuable information
on structural motifs that are important for a specifi c type of activity and can also be used
as drugs or serve as raw materials for chemical modifi cation in order to develop new pharmaceuticals.
This review considers natural antibiotics combining two pharmacophores in their
structure: a redox-active naphthoquinone moiety and a membrane-active polyol macrolide.
Data on their structures and the spectrum of biological activity are summarized.