Reductive coupling of nitroarenes with carboxylic acids

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Reductive coupling of nitroarenes with carboxylic acids – a direct route to amide synthesis

Organic and Biomolecular Chemistry. 2023. Vol. 21. No. 42. P. 8477–8481.

Лосев М. А., Козлов А. С., Kliuev F., Chusov D.

A simple and atom-efficient way to prepare amides directly from carboxylic acids and nitroarenes was developed. Carbon monoxide as a sole reducing agent provides the ultimate selectivity of the protocol. A straightforward and selective way for the preparation of amides from nitroarenes and carboxylic acids using carbon monoxide as a reductant was developed. This protocol does not require any non-gaseous additives, thus simplifying product isolation. Aliphatic carboxylic acid was modified in the presence of aromatic ones, and reducible functional groups such as C–C, Ar–Br, and R–NO2 were saved.

Research target: Chemistry

Language: English

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