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Conservation, evolution, and regulation of splicing during prefrontal cortex development in humans, chimpanzees and macaques
RNA. 2018. P. 585–596.
Mazin P., Jiang X., Fu N., Han D., Guo M., Gelfand M. S., Khaitovich P.
Changes in splicing are known to affect the function and regulation of genes. We analyzed splicing events that take place during the postnatal development of the prefrontal cortex in humans, chimpanzees, and rhesus macaques based on data obtained from 168 individuals. Our study revealed that among the 38,822 quantified alternative exons, 15% are differentially spliced among species, and more than 6% splice differently at different age. Mutations in splicing acceptor and/or donor sites might explain more than 14% of all splicing differences among species and up to 64% of high-amplitude differences. A reconstructed trans- regulatory network containing 21 RNA-binding proteins explain a further 4% of splicing variations within species. While most age-dependent splicing patterns are conserved among the three species, developmental changes in intron retention are substantially more pronounced in humans.
Батова О. Н., Савинецкая Л. Е., Проявка С. В. et al., Nature Conservation Research. Заповедная наука 2026 Т. 11 № 4 С. 25–39
Spermophilus suslicus is a threatened species listed in Red Data Books at all levels (from regional Red Data
Books to the IUCN Red List of Threatened Species), and it currently requires special conservation activity.
Over the past 30–50 years, its range has changed from continuous to mosaic, and its population has declined
everywhere. In 2015, in Russia experimental ...
Added: October 13, 2026
Ari G., Liu X., Jiang L. et al., Ecological Indicators 2026 Vol. 191 Article 115592
Snow drought has become a research hotspot due to its widespread impacts on ecosystems and water resources, yet its effects on vegetation phenology remain relatively understudied. Focusing on the Mongolian Plateau, this study used the Snow Water Equivalent Index and the start of growing season (SOS) to assess the associations between snow drought and vegetation ...
Added: October 12, 2026
Temereva E., Zoologischer Anzeiger 2026 Vol. 325 P. 182–195
Brachiopoda is a group of animals, that is still insufficiently studied at the ultrastructural level, despite the significance of ultrastructure of tissues and organs for analysing the functional morphology, reconstructing the organisation and biology of numerous extinct brachiopods, and establishing relationships among major taxa. In the present study, we provide a revised reconstruction of the ...
Added: October 11, 2026
Didenkulova E., Chugunov V., Didenkulova I., Wave Motion 2026 Vol. 147 Article 103787
This work presents a new analytical solution of the shallow water theory for cylindrical propagation of long tsunami-like waves in the basin of variable depth. Considered model cases are related to tsunami wave propagation from an asteroid fallen into the sea, or from underwater volcanic eruptions. The corresponding bottom geometries represent radially symmetric obstacles such ...
Added: October 8, 2026
Flamarion M., Didenkulova E., Pelinovsky E., Physics Letters A 2026 Vol. 598 Article 132218
In this letter, bipolar solitary wave interactions in the Schamel equation are revisited numerically. Two simulation settings are considered: repeated collisions in a periodic domain, and the interaction of a positive solitary wave with a train of negative polarity solitary waves of equal amplitude. In the first case, when the amplitudes are comparable, the larger ...
Added: October 8, 2026
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Le M. T., Шукуров И. С., Курск: Закрытое акционерное общество "Университетская книга", 2026.
This monograph studies the thermal characteristics of urban habitats and analyzes the impact of urban morphology on the emergence of urban heat island effects (UHI), particularly in the context of high-density urban development, modern high-rise buildings and related sanitary standards. It presents comprehensive findings from theoretical and empirical research focused on minimizing the urban heat ...
Added: September 30, 2026
Dolgov A., МЕТОД: Московский ежегодник трудов из обществоведческих дисциплин 2025 Т. 5 № 4 С. 120–133
В обзоре интеллектуальное наследие В.И. Вернадского (1863-1945) рассматривается в контексте зарубежных инвайронментальных исследований (преимущественно на материале англоязычных публикаций двух последних десятилетий). Реконструируются ключевые идейные истоки мировоззрения Вернадского: влияние В.В. Докучаева, русского космизма и концепции ноосферы П. Тейяра де Шардена. Анализируются понятия научной системы Вернадского - «живое вещество», «биосфера» и «ноосфера»; прослеживается их рецепция в современных ...
Added: September 30, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
Dregulo A., СПб.: Издательство Санкт-Петербургского государственного экономического университета, 2026.
В монографии представлен междисциплинарный анализ современных вызовов перехода городских агломераций к климатически нейтральному и энергоэффективному развитию. В работе рассмотрены теоретические подходы к определению городских агломераций, международных стратегий устойчивого развития, проведен анализ климатических рисков, энергопотребления и секторальных выбросов парниковых газов в Российской Федерации, стран Европейского союза и др. В России, несмотря на рост энергопотребления и выбросов ...
Added: September 29, 2026
Li A., Agriculture, Ecosystems and Environment 2026 Vol. 412 Article 110676
Rangeland degradation is a global environmental challenge; however, intense debate persists between equilibrium (focused on the negative effects of grazing intensity) and non-equilibrium (emphasizing livestock mobility for adapting to climate variability) theories in rangeland ecology. In recent years, an integrative theory advocating the “coexistence of equilibrium and non-equilibrium” has emerged to reconcile this debate. However, ...
Added: September 28, 2026
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Xu Y., Ryabov F., Alexandrov I. et al., USA 2026 Vol. 6 No. 8 Article 101324
Центромеры обеспечивают расхождение хромосом, однако организацию их хроматина в пределах повторяющейся альфа-сателлитной ДНК долгое время было трудно изучать. Для решения этой задачи мы создали гаплотип-разрешённые аннотации сателлитной ДНК для полной диплоидной сборки генома человека T2T-HG002. Затем с помощью метода направленного метилирования с секвенированием длинных прочтений (DiMeLo-seq) мы картировали центромерный белок A (CENP-A), модификацию H3K9me3 и ...
Added: September 23, 2026
Shaitan A., Sergeeva A. M., Gribkova A. K. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 1 P. 98–108
Multiple myeloma (MM) is a malignant lymphoproliferative disorder associated with accumulation of terminally differentiated B lymphocytes (plasma cells) in the bone marrow, monoclonal expression of pathologic immunoglobulin, anemia, renal damage, hypercalcemia, and bone lesions. Despite considerable attention to the study of ММ pathogenesis and the development of new drugs, this disease remains incurable. Omics technologies ...
Added: September 18, 2025
Novosad V., Doklady Biochemistry and Biophysics 2023 Vol. 510 No. 1 P. 99 – 103
The expression of RNA-binding proteins and their interaction with the spliced pre-mRNA are the key factors in determining the final isoform profile. Transmembrane protein CD44 is involved in differentiation, invasion, motility, growth and survival of tumor cells, and is also a commonly accepted marker of cancer stem cells and epithelial-mesenchymal transition. However, the functions of ...
Added: September 1, 2025
Maddalena L., Granata I., Giordano M. et al., SN Computer Science 2023 Vol. 4 Article 249
Alzheimer’s disease (AD) is the most common form of dementia with physical, psychological, social, and economic impacts on patients, their carers, and society. Its early diagnosis allows clinicians to initiate the treatment as early as possible to arrest or slow down the disease progression more effectively. We consider the problem of classifying AD patients through ...
Added: September 13, 2023
Miheecheva N., Ramachandran A., Lyu Y. et al., Cancer Research 2021 Vol. 81 No. 13_Supplement P. 2742–2742
Although genomic analyses of clear cell renal cell carcinoma (ccRCC) patients have revealed targetable pathways that have led to FDA-approved therapies, the responses to these therapies remain limited. The significant success of immune checkpoint inhibitors and anti-angiogenic agents suggest that ccRCC has a unique tumor microenvironment composition and tumor behavior that influences therapeutic response. Here, ...
Added: September 10, 2022
Knyazev E., Maltseva D., Raigorodskaya M. et al., Frontiers in Genetics 2021 Vol. 12 Article 791640
Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium. In contrast, pathological hypoxia is a common feature of some chronic disorders, including inflammatory bowel disease (IBD). This work was aimed at studying HIF-associated changes in the intestinal epithelium in IBD. ...
Added: November 11, 2021
Mironov A., Denisov S., Gress A. et al., PLoS Computational Biology 2021 Vol. 17 No. 4 Article e1008329
Tandem alternative splice sites (TASS) is a special class of alternative splicing events that are characterized by a close tandem arrangement of splice sites. Most TASS lack functional characterization and are believed to arise from splicing noise. Based on the RNA-seq data from the Genotype Tissue Expression project, we present an extended catalogue of TASS ...
Added: July 7, 2021
Yaple Z. A., Yu R., Arsalidou M., Human Brain Mapping 2020 Vol. 41 No. 14 P. 3993–4009
Functional magnetic resonance imaging (fMRI) studies have shown notable agedependent differences in reward processing. We analyzed data from a total of 554 children, 1,059 adolescents, and 1,831 adults from 70 articles. Quantitative meta-analyses results show that adults engage an extended set of regions that include anterior and posterior cingulate gyri, insula, basal ganglia, and thalamus. ...
Added: September 4, 2020
Mazin P., Gelfand M. S., Proceedings of the National Academy of Sciences of the United States of America 2018 P. E2477–E2486
Polypedilum vanderplanki is a striking and unique example of an insect that can survive almost complete desiccation. Its genome and a set of dehydration-rehydration transcriptomes, together with the genome of Polypedilum nubifer (a congeneric desiccation-sensitive midge), were recently released. Here, using published and newly generated datasets reflecting detailed transcriptome changes during anhydrobiosis, as well as a developmental series, ...
Added: March 5, 2018