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Систематический обзор оригинальных исследований прогностических свойств белка YB-1 в отношении общей и безрецидивной выживаемости больных раком молочной железы
Value and Outcomes Spotlight. 2015. Т. 20. № 1. С. 1-12.
Генс Г. П., Федяева В. К., Rebrova O.
Shkurnikov M. Y., V. V. Galatenko, Lebedev A. E. et al., Bulletin of Experimental Biology and Medicine 2014 Vol. 157 No. 4 P. 454-458
The search for novel parameters to predict the risk of relapse in breast cancer was conducted. Significant correlation between the risk of relapse and α-2A adrenergic receptor (ADRA2A) expression was revealed using public microarray datasets. This relationship was confirmed by validation on independent microarray dataset. It was found that when assessing the risk of BC ...
Added: October 28, 2015
Ella Y Tyuryumina, Alexey A Neznanov, Plos One 2018 Vol. 13 No. 7 P. 1-16
The goal of this research is to improve the accuracy of predicting the breast cancer (BC) pro- cess using the original mathematical model referred to as CoMPaS. The CoMPaS is the original mathematical model and the corresponding software built by modelling the natural history of the primary tumor (PT) and secondary distant metastases (MTS), it ...
Added: July 7, 2018
Ernst A. -., Putscher A., Samatov T. R. et al., Plos One 2018 Vol. 13 No. 2 Article e0192525
Finding additional functional targets for combination therapy could improve the outcome for melanoma patients. In a spontaneous metastasis xenograft model of human melanoma a shRNA mediated knockdown of L1CAM more than sevenfold reduced the number of lung metastases after the induction of subcutaneous tumors for two human melanoma cell lines (MeWo, MV3). Whole genome expression ...
Added: February 1, 2021
Ella Y Tyuryumina, Neznanov A., , in : The Breast. : Elsevier, 2017. P. S106-S106.
PRIMARY THERAPY OF EARLY BREAST CANCER
Evidence, Controversies, Consensus
15th St.Gallen International Breast Cancer Conference
Vienna, Austria, 15–18 March 2017 ...
Added: March 22, 2017
Rebrova O., Федяева В. К., Медицинские технологии. Оценка и выбор 2016 № 1 С. 10-16
Meta-analysis is often considered as the highest level evidence on the effectiveness and safety of drugs and other medical technologies; however, the methodological quality of meta-analyses and systematic reviews varies considerably, which leads to the differences of effect values and the levels of evidence of the results. In 2007, validated tool to assess the methodological ...
Added: October 15, 2016
Nersisyan S., Zhiyanov A., Еngibaryan N. et al., Frontiers in Genetics 2022 Vol. 13 Article 1070528
A widely used procedure for selecting significant miRNA-mRNA or isomiR-mRNA pairs out of predicted interactions involves calculating the correlation between expression levels of miRNAs/isomiRs and mRNAs in a series of samples. In this manuscript, we aimed to assess the validity of this procedure by comparing isomiR-mRNA correlation profiles in sets of sequence-based predicted target mRNAs ...
Added: December 1, 2022
Knyazev E. N., Nikulin S. V., Khristichenko A. Y. et al., Russian Chemical Bulletin 2019 Vol. 68 No. 12 P. 2344-2349
An in vitro placental barrier model based on human choriocarcinoma BeWo b30 cell line was considered as a method of preclinical study of the transport and toxicity of antitumor agents and other organic compounds. Low permeabilities were found for 5-fluorouracil as an example of hydrophilic compound and for doxorubicin as an example of a lipophilic compound with ...
Added: February 1, 2021
Arnold S., Cortland J., Maltseva D. et al., Journal of Cancer Research and Clinical Oncology 2021 Vol. 148 No. 6 P. 1525-1542
Purpose:
The transcription factor Fra-2 affects the invasive potential of breast cancer cells by dysregulating adhesion molecules in vitro. Previous results suggested that it upregulates the expression of E- and P-selectin ligands. Such selectin ligands are important members of the leukocyte adhesion cascade, which govern the adhesion and transmigration of cancer cells into the stroma of ...
Added: October 23, 2021
Maltseva D. V., Khaustova N. A., Fedotov N. N. et al., Journal of Clinical Bioinformatics 2013 Vol. 3 No. 1
Background
Quantification and normalization of RT-qPCR data critically depends on the expression of so called reference genes. Our goal was to develop a strategy for the selection of reference genes that utilizes microarray data analysis and combines known approaches for gene stability evaluation and to select a set of appropriate reference genes for research and clinical ...
Added: October 30, 2015
Tyuryumina E., Neznanov A., Turumin J. L., Cancers 2020 Vol. 12 No. 9 P. 1-20
Previously, a consolidated mathematical model of primary tumor (PT) growth and secondary distant metastasis (sdMTS) growth in breast cancer (BC) (CoMPaS) was presented. The aim was to detect the diagnostic periods for visible sdMTS via CoMPaS in patients with different subtypes ER/PR/HER2/Ki-67 (Estrogen Receptor/Progesterone Receptor/Human Epidermal growth factor Receptor 2/Ki-67 marker) of breast cancer. CoMPaS ...
Added: August 19, 2020
Nikulin S., Razumovskaya A., Poloznikov A. et al., Frontiers in Molecular Biosciences 2023 Vol. 10 Article 1075704
Relapse of breast cancer is one of the key obstacles to successful treatment. Previously we have shown that low expression of ELOVL5 and IGFBP6 genes in breast cancer tissue corresponded to poor prognosis. ELOVL5 participates directly in the elongation of polyunsaturated fatty acids (PUFAs) that are considered to play an important role in cancer cell metabolism. Thus, in this work we ...
Added: February 22, 2023
V. V. Galatenko, Shkurnikov M. Y., Samatov T. R. et al., Scientific Reports 2015 Vol. 5
Genes with significant differential expression are traditionally used to reveal the genetic background underlying phenotypic differences between cancer cells. We hypothesized that informative marker sets can be obtained by combining genes with a relatively low degree of individual differential expression. We developed a method for construction of highly informative gene combinations aimed at the maximization ...
Added: October 27, 2015
Avxentyev N., Журавлева М. В., Пазухина Е. М. et al., Опухоли женской репродуктивной системы 2018 Т. 14 № 2 С. 21-35
Breast cancer is the most common malignant tumor and accounts for the most number of cancer-related deaths among Russian women. Combination of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor ribociclib and aromatase inhibitor is approved for the first-line treatment of postmenopausal women with HR-positive HER2-negative advanced breast cancer.
Objective: to conduct pharmacoeconomic evaluation of using ribociclib + ...
Added: November 9, 2018
Tyuryumina E., В кн. : Сборник тезисов участников форума «Наука будущего — наука молодых». Т. 1.: М. : Инконсалт К, 2016. С. 281-283.
This study is an attempt to obtain reliable data on the natural history of breast cancer growth. The opportunities for using classical mathematical models (exponential and logistic tumor growth models, Gompertz and von Bertalanffy tumor growth models) were analysed in order to describe growth of the primary tumor and the secondary distant metastases of human ...
Added: October 2, 2016
Cardoso F., Elsevier, 2017
PRIMARY THERAPY OF EARLY BREAST CANCER
Evidence, Controversies, Consensus ...
Added: March 22, 2017
Baban S. M., Vasilyeva O. G., М. : МИИТ, 2012
Added: January 25, 2013
Ikryannikov V., Барыкин А. Н., Научные исследования и разработки. Российский журнал управления проектами 2018 Т. 7 № 3 С. 13-21
В статье приведены результаты исследования фонда стандартов и нормативных документов, которые применялись при составлении описаний объектов государственных закупок на федеральном уровне. Исследование проводилось на основе контент-анализа 2089 закупок, осуществленных в течение 2017 г. 15 федеральными органами исполнительной власти. В составе рассмотренной закупочной документации было идентифицировано 22 052 ссылки на 2657 документов по стандартизации и иных ...
Added: November 27, 2019
Устинова О. Е., Карпова С. В., Kazakov S. P., Экономика и управление в машиностроении 2019 Т. 66 № 6 С. 37-43
The article discusses the features and problematic issues that arise in brand management, taking into account the research conducted on differences in the emotional connections types among consumers. The article reveals the motivation factors of various consumers segments, primarily through the regular customers motivation analysis. The authors discuss the question of how to estimate the ...
Added: July 21, 2020
Уварина Ю. А., Fiyaksel E., Инновации 2013 Т. июль № 177 С. 30-38
In the modern world one of the most effective tools of management can be - development of business-models. Thanks to the innovative principles and procedures laid down in this methodology, enterprises can gain sustainable competitive advantage and intensify their positions on the market. The using of business-modeling technologies in the conditions of Russian business today ...
Added: May 29, 2013
Lavrenchuk E. N., Экономические науки 2011 № 74 С. 257-260
В статье автор рассматривает вопросы необходимости планирования, прогнозирования и бюджетирования в налогообложении, а также предлагаемые методики оценки налогового потенциала. ...
Added: November 28, 2012
Sirotin V., Arkhipova M., Dubrova T. A. et al., Bielsko-Biala : University of Bielsko-Biala Press, 2016
The main attributes of modern enterprises should be the flexibility and the ability of forecasting the future. Constant adaptation to the changing environment and the rapidity of undertaking certain actions which are conditioned by specific situations determine the rules for the future position of market competition. Effective and efficient adjustment of the company in line ...
Added: November 2, 2016
Tishchenko O., Волков О. С., Камышева С. А., Научные исследования и разработки. Российский журнал управления проектами 2017 Т. 6 № 1 С. 37-52
The article is devoted to a problem of resistance to organizational changes. An objective of this research is to detect interdependence between personal characteristics of organizational change projects participants, psychological readiness of staff of the divisions involved in the project of organizational transformations, ways of conflict permission and efficiency of the realized projects. The results ...
Added: October 20, 2017
Rozhdestvensky V. G., Shubnyakova N. G., Кадровик 2012 № 2
Формирование инновационной модели экономики в России требует развития системы управления инновационной деятельностью, повышения ее эффективности. Квалифицированно подготовленные управленческие кадры для инновационной среды, понимающие свою роль и задачи, являются одним из необходимых условий успешной реализации данной модели. В статье рассматривается специфика деятельности инновационных менеджеров, а также авторами предложена типология инновационных менеджеров, разработанная с учетом запросов инновационных ...
Added: December 1, 2012
Osin E. N., Организационная психология 2013 Т. 3 № 3 С. 42-60
В статье представлены результаты анализа факторной структуры краткой версии теста жизнестойкости (Леонтьев, Рассказова, 2006; Осин, Рассказова, 2013) из 24 утверждений. Анализ проводился параллельно на студенческой выборке (N=1285) и на выборке сотрудников производственного предприятия (N=4647). По итогам структурного моделирования с учётом систематической ошибки, связанной с направлением пунктов, наилучшее соответствие исходным данным показала модель из 3 субшкал, ...
Added: January 30, 2014