Saccadic responses to consecutive visual stimuli in healthy people and patients with schizophrenia
We investigated cognitive functions of attention and decision-making in 18 healthy subjects and 15 schizophrenia patients using an experimental design with consecutive presentation of two short visual stimuli (double-step). In patients with schizophrenia, an increase in the number of errors and change in the pattern of saccadic responses have been found: an increase of the number of two-saccade responses to each stimulus and a decrease in the number of single-saccade responses to the second stimulus. In schizophrenia patients, the latent period of the first of a pair of saccades has been shorter; and the latent period of single saccade has been increased in comparison with healthy subjects. Opposite lateral differences in latent periods of saccades in healthy subjects and schizophrenia patients have been found. Our results show the deficit of cognitive oculomotor control and a decrease in prognostic processes of saccade programming in schizophrenia patients. © 2015, Pleiades Publishing, Inc.