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АКАДЕЗИН ВЫЗЫВАЕТ НЕАПОПТОТИЧЕСКУЮ ГИБЕЛЬ ОПУХОЛЕВЫХ КЛЕТОК
Acta Naturae. 2013. Т. 5. № 3. С. 78–82.
Глазунова В.А., Лобанов К. В., Шакулов Р. С., Миронов А. С., Штиль А. А.
We studied the cytotoxicity of acadesine (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) for tumor and normal cells of various species and tissue origin. In tumor cells, acadesine triggered non-apoptotic death; the potency of the compound to normal cells was substantially lower. Acadesine was toxic for tumor cells with multidrug resistant phenotypes caused by the transmembrane transporter P-glycoprotein or lack of proapoptotic p53. Activity of adenosine receptors was required for acadesine-induced cell death, whereas functioning of AMP-dependent protein kinase was not required. A more pronounced cytotoxicity for tumor cells, as well as the non-canonical death mechanism(s), makes acadesine a promising candidate for antitumor therapy.
Language:
Russian
Didenkulova E., Chugunov V., Didenkulova I., Wave Motion 2026 Vol. 147 Article 103787
This work presents a new analytical solution of the shallow water theory for cylindrical propagation of long tsunami-like waves in the basin of variable depth. Considered model cases are related to tsunami wave propagation from an asteroid fallen into the sea, or from underwater volcanic eruptions. The corresponding bottom geometries represent radially symmetric obstacles such ...
Added: October 8, 2026
Flamarion M., Didenkulova E., Pelinovsky E., Physics Letters A 2026 Vol. 598 Article 132218
In this letter, bipolar solitary wave interactions in the Schamel equation are revisited numerically. Two simulation settings are considered: repeated collisions in a periodic domain, and the interaction of a positive solitary wave with a train of negative polarity solitary waves of equal amplitude. In the first case, when the amplitudes are comparable, the larger ...
Added: October 8, 2026
Ekaterina D. Riumina, Klink G. V., Alekseeva E. et al., PNAS, США 2026 Vol. 123 No. 35 P. 1–20
The role of escape from the cytotoxic T cell (CTL) response in SARS-CoV-2 evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the HLA class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and ...
Added: October 2, 2026
Aly Ismailov, Poptsova M., Plos One 2026 Vol. 21 No. 9 Article e0355902
Added: October 2, 2026
Le M. T., Шукуров И. С., Курск: Закрытое акционерное общество "Университетская книга", 2026.
This monograph studies the thermal characteristics of urban habitats and analyzes the impact of urban morphology on the emergence of urban heat island effects (UHI), particularly in the context of high-density urban development, modern high-rise buildings and related sanitary standards. It presents comprehensive findings from theoretical and empirical research focused on minimizing the urban heat ...
Added: September 30, 2026
Dolgov A., МЕТОД: Московский ежегодник трудов из обществоведческих дисциплин 2025 Т. 5 № 4 С. 120–133
В обзоре интеллектуальное наследие В.И. Вернадского (1863-1945) рассматривается в контексте зарубежных инвайронментальных исследований (преимущественно на материале англоязычных публикаций двух последних десятилетий). Реконструируются ключевые идейные истоки мировоззрения Вернадского: влияние В.В. Докучаева, русского космизма и концепции ноосферы П. Тейяра де Шардена. Анализируются понятия научной системы Вернадского - «живое вещество», «биосфера» и «ноосфера»; прослеживается их рецепция в современных ...
Added: September 30, 2026
Knyazev E., Чеботарева О. Е., М.: Издательский дом НИУ ВШЭ, 2026.
This teaching and learning guide provides a concise overview of the theoretical and practical aspects of the basic skills required to work in a biological laboratory. It also includes protocols for practical classes conducted as part of the introductory professional training placement for first-year students in the Bachelor’s programme in Cell and Molecular Biotechnology at ...
Added: September 30, 2026
Shishkin S., Almazov A., Vlassov V. et al., Электронный научный журнал "Социальные аспекты здоровья населения" 2026 Т. 72 № 4 Статья 4
Abstract
Significance. The epidemiological, clinical, and socioeconomic effects of healthcare digitalization are actively discussed in the scientific literature. Less attention has been paid to changes in the organization of healthcare resulting from the introduction of digital technologies. These changes have not been the subject of specific research. However, digital technologies is becoming a driver for the ...
Added: September 29, 2026
Ryskina H., Knyazev E., Вопросы биологической, медицинской и фармацевтической химии 2026 Т. 29 № 9 С. 84–91
Introduction. The active integration of rapidly developing omics and computer technologies in the 21st century has led to a breakthrough in understanding the principles of the functioning of living systems. One of the dynamically developing integrative areas in biology is biological modeling. The fundamental paradigm has been the methodology that allows for the prediction of ...
Added: September 29, 2026
Dregulo A., СПб.: Издательство Санкт-Петербургского государственного экономического университета, 2026.
В монографии представлен междисциплинарный анализ современных вызовов перехода городских агломераций к климатически нейтральному и энергоэффективному развитию. В работе рассмотрены теоретические подходы к определению городских агломераций, международных стратегий устойчивого развития, проведен анализ климатических рисков, энергопотребления и секторальных выбросов парниковых газов в Российской Федерации, стран Европейского союза и др. В России, несмотря на рост энергопотребления и выбросов ...
Added: September 29, 2026
Li A., Agriculture, Ecosystems and Environment 2026 Vol. 412 Article 110676
Rangeland degradation is a global environmental challenge; however, intense debate persists between equilibrium (focused on the negative effects of grazing intensity) and non-equilibrium (emphasizing livestock mobility for adapting to climate variability) theories in rangeland ecology. In recent years, an integrative theory advocating the “coexistence of equilibrium and non-equilibrium” has emerged to reconcile this debate. However, ...
Added: September 28, 2026
Ugleva A. V., Социологическое обозрение 2026 Т. 25 № 3 С. 268–293
This article undertakes a socio-philosophical analysis of a situation in which the place of the Other within the structure of subjective experience is occupied by an algorithmic agent – an entity that simulates understanding yet remains devoid of genuine subjectivity. To investigate this configuration, the author turns to psychiatric practice as a representative case study: ...
Added: September 26, 2026
Gureev M., Advanced Science 2026 P. 1–13
Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small‐molecule GPX4 degraders that incorporate ...
Added: September 26, 2026
Diachkova E., Nikulin D., Кубкин Я. В. et al., American Journal of Respiratory and Critical Care Medicine 2026 Vol. 212
Accurate classification of a patient with pulmonary hypertension (PH) into one of five groups is fundamental for appropriate disease management strategies. The time from disease onset to correct diagnosis is unacceptably long in many cases. Chronic thromboembolic pulmonary hypertension (CTEPH) develops as a consequence of venous thromboemboli, resulting in a more pronounced hereditary predisposition to ...
Added: September 23, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Barskaya E. S., Savin A. M., Chernov K. V. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 6 Article 2800
Copper–organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the ...
Added: April 15, 2026
Herbert A., Poptsova M., Frontiers in Immunology 2022 Vol. 13 Article 912717
We present evidence suggesting that the severe acute respiratory syndrome (SARS) coronavirus non-structural protein 13 (Nsp13) modulates the Z-RNA dependent regulated cell death pathways. We show that Z-prone sequences [called flipons] exist in coronavirus and provide a signature (Z-sig) that enables identification of the animal viruses from which the human pathogens arose. We also identify ...
Added: October 31, 2022
Kiselevsky D. B., Shagdarova B. T., Varlamov V. P. et al., Moscow University Biological Sciences Bulletin 2021 Vol. 76 No. 1 P. 14–19
The effect of low molecular weight chitosans with a molecular weight (MW) of 5, 6, 10, 25, and 45 kDa and a deacetylation degree (DD) of 85–99% obtained by chemical depolymerization and enzymatic hydrolysis on the cells of the epidermis of pea leaves was analyzed. Low molecular weight chitosans induced damage to guard cells' plasma membrane, ...
Added: October 14, 2022
Lavrenov S. N., Luzikov Y. N., Bykov E. E. et al., Bioorganic and Medicinal Chemistry 2010 Vol. 18 No. 18 P. 6905–6913
Novel derivatives of tris(indol-3-yl)methane and tris(indol-3-yl)methylium salts with the alkyl substituents at the N-atoms of the indole rings were synthesized. An easy substitution of indole rings in trisindolylmethanes for other indoles under the action of acids is demonstrated, and the mechanism of substitution is discussed. To obtain trisindolylmethylium salts, the environmentally safe method of oxidation ...
Added: July 14, 2015
Shchekotikhin A. E., Glazunova V.A., Dezhenkova L. G. et al., European Journal of Medicinal Chemistry, France 2011 Vol. 46 No. 1 P. 423–428
We developed the synthesis of a series of furan-fused tetracyclic analogues of the antitumor agent ametantrone. The reactions included nucleophilic substitution of propoxy groups in 4,11-dipropoxyanthra[2,3-b]furan-5,10-diones with ethylenediamines, producing the derivatives of 4,11-diaminoanthra[2,3-b] furan-5,10-dione in good yields. Studies of anti-proliferative activity on a panel of mammalian tumor cell lines demonstrated that anthra[2,3-b]furan-5,10- diones were the ...
Added: July 14, 2015
Калинина Е. В., Березов Т. Т., Чернов Н. Н. et al., ВОПРОСЫ БИОЛОГИЧЕСКОЙ, МЕДИЦИНСКОЙ И ФАРМАЦЕВТИЧЕСКОЙ ХИМИИ, Россия 2012 Т. 10 № 8 С. 27–33
Исследованы характер экспрессии генов Prx 1, 2 и 6 при формировании лекарственной устойчивости опухолевых клеток к доксорубицину (DOX), цитотоксический эффект которого помимо интеркалирующего действия связан с активацией образования активных форм кислорода. Полученные данные свидетельствуют в пользу важной роли редокс-зависимого механизма формирования устойчивости опухолевых клеток к DOX. ...
Added: July 14, 2015
Калинина Е. В., Березов Т. Т., Чернов Н. Н. et al., ВОПРОСЫ БИОЛОГИЧЕСКОЙ, МЕДИЦИНСКОЙ И ФАРМАЦЕВТИЧЕСКОЙ ХИМИИ, Россия 2012 Т. 10 № 5 С. 51–57
Проведена оценка экспрессии генов изоформ тиоредоксина и тиоредоксинредуктазы при формировании лекарственной устойчивости опухолевых клеток к доксорубицину. Показано, что у резистентных к DOX опухолевых клеток K562/DOX, MCF-7/DOX, SKVLB обнаружен рост экспрессии генов TRX2 и TRXRD1, тогда как повышение экспрессии гена TRX1 установлено только в клетках SKVLB. Во всех трех типах резистентных клеток обнаружен рост активности как ...
Added: July 14, 2015
Калинина Е. В., Березов Т. Т., Штиль А. А. et al., БЮЛЛЕТЕНЬ ЭКСПЕРИМЕНТАЛЬНОЙ БИОЛОГИИ И МЕДИЦИНЫ, Россия 2012 Т. 153 № 6 С. 861–864
We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer ...
Added: July 14, 2015