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Regular version of the site

Article

Statistical model of intra-chromosome contact maps

Soft Matter. 2015. Vol. 11. No. 5. P. 1019-1025.
Nechaev S., Tamm M., Nazarov L., Avetisov V. A.

A statistical model describing a fine structure of the intra-chromosome maps obtained by a genome-wide chromosome conformation capture method (Hi-C) is proposed. It combines hierarchical chain folding with quenched heteropolymer structure of primary chromatin sequences. It is conjectured that the observed Hi-C maps are statistical averages over many different ways of hierarchical genome folding. It is shown that the existence of quenched primary structure coupled with hierarchical folding induces full range of features observed in experimental Hi-C maps: hierarchical elements, chess-board intermittency and large-scale compartmentalization