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The inconsistent effects of tDCS in rehabilitation and cognitive enhancement: sources of variability and paths to personalization
Frontiers in Human Neuroscience. 2026. Vol. 20. No. 0. P. 1–10.
Background/aims:
Transcranial direct current stimulation (tDCS) has emerged as a promising intervention in both rehabilitation and cognitive enhancement, yet its effects remain inconsistent across studies. This variability has raised questions about the underlying mechanisms influencing tDCS efficacy.
Methods:
In this review, we address the issue of the inconsistent effect of tDCS on motor and cognitive domains across studies in healthy individuals and those with neurodegenerative disorders. A review of literature in the field was conducted using PubMed and Google Scholar.
Results:
Research indicates that individual anatomical differences among subjects may contribute to the inconsistent outcomes observed, as variations in current density at targeted brain regions and genetic variations responsible for the stimulation effect. Understanding the factors that contribute to the inconsistent effects of tDCS will be essential for enhancing its application in clinical settings and maximizing its potential benefits in cognitive rehabilitation and enhancement.
Conclusion:
Future research should focus on optimizing tDCS parameters and exploring individualized approaches to treatment, taking into account the diverse responses observed in different populations.
Chebotareva E., Гончарова М. Э., Дубинина Т. С., М.: Российский университет дружбы народов им. Патриса Лумумбы, 2024.
В сборнике представлены материалы Международной научно-практической конференции, посвящённой 85-летию доктора психологических наук, профессора, заслуженного работника высшей школы РФ, заслуженного профессора РУДН им. Патриса Лумумбы Александра Ивановича Крупнова, которая состоялась 26 апреля 2024 г. на кафедре психологии и педагогики филологического факультета Российского университета дружбы народов им. Патриса Лумумбы. В работе конференции приняли участие более 500 ученых ...
Added: June 26, 2026
Chebotareva E., Routledge, 2025.
The Routledge International Handbook of Interracial and Intercultural Relationships and Mental Health presents critical, theoretical, empirical, and psychological accounts of intercultural intimacies.
It challenges pervasive Eurocentric discourse and ideas and offers current, scholarly, practical, equitable, global, and intercultural responsive philosophies, theories, clinical frameworks, and practices. The chapters in this text offer critical perspectives on the mental ...
Added: June 25, 2026
Chebotareva E., Hill C. T., Springer, 2025.
The second revised and expanded edition of this successful handbook extensively explores the idea and practice of love from diverse cultural, psychological, and biological perspectives. It provides a comprehensive understanding of love by examining its various manifestations, cultural interpretations, and the underlying psychological and biological mechanisms that shape it. Notably, the book won the William ...
Added: June 25, 2026
Chebotareva E., Психология и психотерапия семьи 2025 № 4 С. 100–101
This review of experience of the EFT adapting to work with adult sibling dyads. The specifics of
the therapeutic process are highlighted and the main focus of influence is indicated. ...
Added: June 25, 2026
Худова В. А., Glebko N., Новые психологические исследования 2026 № 2 С. 13–37
Digitalization and the widespread use of the Internet have changed the way people interact with information. The Internet and digital devices are becoming a kind of “external memory storage,” functioning as a form of transactive memory: instead of relying on their own cognitive resources, people increasingly trust search engines and cloud services. In this regard, ...
Added: June 24, 2026
Shmelev I., Новые психологические исследования 2026 № 2 С. 57–78
Statement of the Problem. In the context of information overload, the develop
ment of digital resilience has become critically important. Coaching is considered
a practice-oriented approach capable of enhancing cognitive, emotional, behavior
al, and value-motivational resources, thereby supporting adaptive and productive
functioning in a digital environment. Existing research remains fragmented, high
lighting the need for a systemic approach and the ...
Added: June 24, 2026
Maklasova E., Tatarko A., Boehnke K., Psychology in Russia: State of the Art 2026 Vol. 19 No. 2
Background. Corruption severely threatens societal stability and well-being, with various factors contributing to its prevalence. This study, relying on theory and empirical research on the relationship between suffering and fraud, offers a new explanation, that worries may be an essential factor in the acceptability of corruption. People’s worries are the consequences of suffering they experience throughout ...
Added: June 24, 2026
Осипова В. В., Kosova E., New psychological research 2026 No. 2 P. 228–250
Statement of the Problem. In the age of pervasive digitalization, online news consumption is growing steadily. Simultaneously, tools for creating and spreading fake news are expanding. Previous research highlights the impact of structural usability elements on trust across domains, yet their specific effect on trust in news web interfaces remains inadequately explored. The Purpose of ...
Added: June 23, 2026
Ryskina H., Лобаева Т. А., Ануркина А. И., Ваш формат, 2025.
Я
Эволюция, экология, генетика человека, медицинская паразитология. Практикум. Аннотация
Аннотация к практикуму «Эволюция, экология, генетика человека, медицинская паразитология»
Учебное пособие «Эволюция, экология, генетика человека, медицинская паразитология. Практикум» (авторы: Лобаева Т. А., Рыскина Е. А., Ануркина А. И.; издательство «Ваш формат», 2025 год, 194 страницы) предназначено для студентов высших учебных заведений. Цель практикума — обеспечить комплексное освоение ключевых разделов биологии с акцентом на их прикладное значение в медицине. ...
Added: June 23, 2026
Poddiakov A., Klarina E., New psychological research 2026 No. 2 P. 207–227
In the initial stage of our study, participants were shown Polunin’s pantomime 10,000-Meter Race (1981), in which he portrayed a runner growing increasingly exhausted through different stages of the race. In individual interviews, participants were asked about their impressions of the pantomime. Then an emergent turn in the research occurred. One of the participants found and sent ...
Added: June 22, 2026
Signayevskaya K., Gorbunova E. S., Сибирский психологический журнал 2026 № 100 С. 76–91
Эффект контекстной подсказки, заключающийся в постепенном сокращении времени поиска цели при многократном повторении контекста, традиционно считается формой имплицитного научения, однако его зависимость от ресурсов рабочей памяти остается предметом активных научных дискуссий. Результаты исследований влияния загрузки рабочей памяти на данный эффект неоднозначны, что обусловлено отсутствием учета многокомпонентной структуры зрительной рабочей памяти и индивидуальных различий в ее ...
Added: June 22, 2026
Фонина В. В., Lvova E., Chumakova M., Сибирский психологический журнал 2026 № 100 С. 20–38
Context and relevance. According to statistics from the Lens.org database, interest in the topic of proactivity is growing every year. However, it is worth noting that a unified understanding of this phenomenon has not yet emerged, which complicates its study. Objective. To develop a semantic field and its content for the concept of "proactivity." Hypothesis. ...
Added: June 22, 2026
Herbert A., Cherednichenko O., Lybrand T. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 6 Article 2422
The double-stranded RNA editing enzyme ADAR1 connects two forms of genetic programming, one based on codons and the other on flipons. ADAR1 recodes codons in pre-mRNA by deaminating adenosine to form inosine, which is translated as guanosine. ADAR1 also plays essential roles in the immune defense against viruses and cancers by recognizing left-handed Z-DNA and ...
Added: June 22, 2026
Kyrchanova O., Kudryashova K., Ibragimov A. et al., Development 2025 Vol. 152 No. 19 Article 205051
Drosophila homeotic gene Abdominal-B (Abd-B) is controlled throughout development by four infraabdominal (iab) regulatory domains, the active or repressed state of which is determined by initiators that have parasegment-specific enhancer activity at an early stage of embryonic development. For this reason, it has long been assumed that the enhancer activity and initiation function of these elements are synonymous. ...
Added: June 20, 2026
Kyrchanova O., Ksenia Kudryashova, Dubrovskaya V. et al., Open Biology 2025 Vol. 15 No. 11 Article 250192
The specification of abdominal segments A5 to A9 depends on the expression of Abdominal-B (Abd-B), which is regulated by four infraabdominal domains: iab-5 through iab-8,9. Each iab domain contains an initiation element that determines its active state, along with enhancers responsible for tissue-specific activation of Abd-B. These iab domains function autonomously due to their flanking boundaries, Fab-6, Fab-7 and Fab-8, which both block crosstalk between adjacent iab domains (insulator function) and facilitate long-range ...
Added: June 20, 2026
Kudryashova K.S., Deriglazova I. O., Osadchiy I. S. et al., Genes 2025 Vol. 16 No. 1 Article 3
Background/Objectives: Transcriptional promoters play an essential role in regulating protein expression. Promoters with weak activity generally lead to low levels of expression, resulting in fewer proteins being produced. At the same time, strong promoters are commonly used in studies using transgenic organisms as model systems. This approach can have various negative consequences for the organism, ...
Added: June 20, 2026
Ksenia Kudryashova, Filippova E., Kryukova E. et al., Archives of Biochemistry and Biophysics 2025 Vol. 769 Article 110437
β-Bungarotoxins (β-BuTx), consisting of covalently bound phospholipase A2 subunit (A-chain), a member of group Ia of secretory phospholipases A2, and non-enzymatic subunit (B-chain) structurally related to Kunitz-type protease inhibitors, block presynaptic neuromuscular transmission via a not completely defined mechanism of action. In vivo physiological studies revealed that the B-chain is targeting voltage-gated potassium channels of not identified subtypes. In our work, six β-BuTx isoforms were ...
Added: June 20, 2026
Cherednichenko O., Herbert A., Poptsova M., Computational and Structural Biotechnology Journal 2025 Vol. 27 P. 992–1000
Large language models (LLMs) in genomics have successfully predicted various functional genomic elements. While their performance is typically evaluated using genomic benchmark datasets, it remains unclear which LLM is best suited for specific downstream tasks, particularly for generating whole-genome annotations. Current LLMs in genomics fall into three main categories: transformer-based models, long convolution-based models, and state-space models ...
Added: June 19, 2026
Poptsova M., Briefings in Bioinformatics 2025 Vol. 26 No. 2 P. 1–11
Kolmogorov–Arnold networks (KANs) emerged as a promising alternative for multilayer perceptrons (MLPs) in dense fully connected networks. Multiple attempts have been made to integrate KANs into various deep learning architectures in the domains of computer vision and natural language processing. Integrating KANs into deep learning models for genomic tasks has not been explored. Here, we ...
Added: June 19, 2026
Zirko A., Ребенок Д. С., Ежегодник по клиентоцентрированной психотерапии и человекоцентрированному подходу, Россия 2026 Т. 6 С. 113–120
The article considers the problem of panic disorders in adulthood. While the number of people with panic disorders is growing, the short-term person-centered encounter group psychotherapy form is suggested. It’s peculiarities and facilitator’s role are described. The preliminary recommendations for such group facilitators are given. The probable group and individual dynamics of the participants is ...
Added: June 19, 2026
Viktor Timokhov, Andrey Timashkov, Oksana Zinchenko, Scientific Reports 2025 Vol. 15 No. 1 Article 38153
This study investigated the causal role of the human frontopolar cortex (FPC) in managing counterfactual strategies during decision-making under uncertainty. Using a combination of cathodal high-definition transcranial direct current stimulation (HD-tDCS) and computational modeling, we examined how cathodal stimulation, preliminarily simulated with SimNIBS, affects the retrieval of alternative strategies in the task that constantly provokes ...
Added: October 1, 2025
Alexandra Bernadotte, Zinchenko O., Frontiers in Systems Neuroscience 2025 Vol. 19 Article 1444283
Attention deficit hyperactivity disorder (ADHD) stands as one of the most prevalent neurodevelopmental disorders, affecting millions worldwide. While traditional pharmacological interventions have been the cornerstone of ADHD treatment, emerging novel methods such as transcranial Direct Current Stimulation (tDCS) and neurofeedback offer promising avenues for addressing the multifaceted challenges of ADHD management. This review paper critically ...
Added: October 1, 2025
Перикова Е. И., Филиппова М. Г., Blagoveshchensky E. et al., International Journal of Psychophysiology 2021 Vol. 168 P. S89
Effects of transcranial direct current stimulation (tDCS) on acquisition of novel vocabulary remain controversial, which could be related to specific neural mechanisms underpinning different language learning strategies. To comprehensively assess tDCS effects on fast mapping (FM) and explicit encoding (EE) of novel words, we modulated tDCS stimulation regime (anodal/cathodal/sham), stimulated hemisphere (left/right), site (Broca/Wernicke/their right-hemispheric ...
Added: April 2, 2025
Sherbakova O., Блинова Е. Н., Новиковская Н. А. et al., В кн.: От слова - к репрезентации: нейрокогнитивные основы вербального научения.: СПб.: Скифия-принт, 2022. Гл. 5 С. 294–350.
Added: April 1, 2025