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July 13, 2026
Biologists Discover Unique Properties of MiR-93-5p MicroRNA in Prostate Cancer
Researchers at the International Laboratory of Microphysiological Systems of the HSE Faculty of Biology and Biotechnology investigated how different isoforms of the same microRNA influence gene function in prostate adenocarcinoma. The study found that in some cases, microRNAs can reinforce each other’s effects by targeting and suppressing the same genes. This finding offers a fresh perspective on the molecular mechanisms underlying tumour development and on the search for disease biomarkers. The results have been published in PeerJ.
July 13, 2026
'My Goal Is to Become a Tenured Professor'
Mikhail Samatov focuses on the theoretical study of perovskite solar cells. In this interview for the HSE Young Scientists project, he talks about working on HSE University’s supercomputer, collaborating with Peking University, and making furniture.
July 9, 2026
HSE Economists Use Search Queries to Forecast Birth Rates
Researchers from the HSE Faculty of Economic Sciences have shown that the accuracy of birth rate forecasts for Russia can be improved by almost 50% by incorporating the dynamics of online search queries related to pregnancy and childbirth into forecasting models. In the best-performing models, the forecasting error fell from 4.6% to 3.2%. The findings have been published in Populations and Economics.

 

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2024 17th International Conference on Management of Large-Scale System Development (MLSD)

IEEE, 2024.
Compiler: Anatoly Tsvirkun

Topics of the conference • Management problems of large-scale system development, including multinational corporations, state holdings, and state corporations • Methods and tools for managing investment projects and programs • Management of development of a digital economy. Design offices both situational and expected analytical centers, institutes of development of large-scale systems • Simulation and optimization in the problems of development management of large-scale systems • Nonlinear processes and computing methods in the problems of management of large-scale systems • Management of development of banking and financial systems • Management of fuel, power, infrastructure and other systems • Management of transport systems • Managing the development of aerospace and other large-scale organizational-technical complexes • Managing the development of regional, urban and municipal systems • Management of objects of nuclear power and other objects of increased danger • Information support and software management systems for large-scale production • Methodology, methods, software and algorithmic support of Intellectual processing of large volumes of information • Monitoring in the management of large-scale systems • Management of large scales systems advancement in healthcare, medico-biological systems, and technologies • Managing the development of social systemsTopics of the conference • Management problems of large-scale system development, including multinational corporations, state holdings, and state corporations • Methods and tools for managing investment projects and programs • Management of development of a digital economy. Design offices both situational and expected analytical centers, institutes of development of large-scale systems • Simulation and optimization in the problems of development management of large-scale systems • Nonlinear processes and computing methods in the problems of management of large-scale systems • Management of development of banking and financial systems • Management of fuel, power, infrastructure and other systems • Management of transport systems • Managing the development of aerospace and other large-scale organizational-technical complexes • Managing the development of regional, urban and municipal systems • Management of objects of nuclear power and other objects of increased danger • Information support and software management systems for large-scale production • Methodology, methods, software and algorithmic support of Intellectual processing of large volumes of information • Monitoring in the management of large-scale systems • Management of large scales systems advancement in healthcare, medico-biological systems, and technologies • Managing the development of social systems

Chapters
Assessment of Digital Connectivity in Russian Regions
Arkhipova M., Sirotin V., , in: 2024 17th International Conference on Management of Large-Scale System Development (MLSD).: IEEE, 2024. Ch. 12 P. 1–4.
Added: October 14, 2024
Can the Effects of Internet Shutdowns be Estimated Separately from Their Causes? Simulation-Based Inference in the Context of Difference-in-Differences Models
Vadim Belenkov, Koncha V., Sedashov E., , in: 2024 17th International Conference on Management of Large-Scale System Development (MLSD).: IEEE, 2024. P. 1–3.
We propose a simulation-based approach based on the difference-in-differences model for estimating the causal effects of Internet shutdowns. Using synthetic data, we show that researchers can be largely agnostic about the underlying factors that led to Internet shutdowns when estimating their effects. ...
Added: November 29, 2024
Construction of a Nonlinear Model of an Enterprise Based on its Structure and Business Processes Description
Nekrasov I., Nikolay Pravdivets, , in: 2024 17th International Conference on Management of Large-Scale System Development (MLSD).: IEEE, 2024. Ch. 998976798 P. 1–5.
Added: December 20, 2024
Comparative Analysis of the Quality of Linear Regression on Principal Components Constructed by Robust and Classical Methods
Goryainov V. B., Goryainova E. R., , in: 2024 17th International Conference on Management of Large-Scale System Development (MLSD).: IEEE, 2024. P. 1–5.
Added: December 29, 2024
Model for Assessing the Liquidity of a Stock Market Trading Instrument
Sizykh D., Tregub K., Belyakov B. et al., , in: 2024 17th International Conference on Management of Large-Scale System Development (MLSD).: IEEE, 2024. P. 1–5.
Currently, a large number of studies are being conducted to improve the accuracy of the developed forecasting methods for the stock market. At the same time, multivariate models based on machine learning methods are increasingly used. Since liquidity indicators have a significant impact on asset pricing, taking them into account can improve the accuracy of ...
Added: January 15, 2025
Improving the Credit Risk Assessment Model using Forecasting and Monte Carlo Methods
Sizykh D., Kovalev R., Sizykh N., , in: 2024 17th International Conference on Management of Large-Scale System Development (MLSD).: IEEE, 2024. P. 1–5.
To improve the assessment model of credit risk by Merton for Russian financial market using the Monte Carlo simulation method and the SARIMA model for data forecasting. Nowadays, there are many methods of the assessment use in European countries. However, the applications of these methods may lead to inaccurate forecasts. In this work, modern methods ...
Added: January 15, 2025
Simulation and Optimization in the Tasks of Organizing Labor Resources in the Context of Digitalization
Aristova N., Chadeev V., Iakimova O., , in: 2024 17th International Conference on Management of Large-Scale System Development (MLSD).: IEEE, 2024. P. 1–4.
Added: February 3, 2025
Agent-Based Model of Protest Campaign with Dynamic Network
Petrov A., Sergey Zheglov, Akhremenko A. S., , in: 2024 17th International Conference on Management of Large-Scale System Development (MLSD).: IEEE, 2024. Ch. 1 P. 1–4.
Agent-based models on networks most often assume static networks. However, in some contexts political science provides arguments that the dynamical character of the network should be taken into account. Specifically, during a protest campaign, new social ties between the participants may occur. Here we present an agent-based model of protest campaign and some numerical experiments with it. It is shown that ...
Added: May 1, 2025
Research target: Economics and Management Engineering and Technology
Language: English
DOI
Keywords: investment projectsinformation supportLarge-scale systems digital economy
2024 17th International Conference on Management of Large-Scale System Development (MLSD)
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