Representational dissimilarity component analysis (ReDisCA)

Neuroimage. 2024. No. 301. Article 120868.

Ossadtchi A., Semenkov I., Zhuravleva A., Kozunov V., Serikov O., Voloshina E.

The principle of Representational Similarity Analysis (RSA) posits that neural representations reflect the structure of encoded information, allowing exploration of spatial and temporal organization of brain information processing. Traditional RSA when applied to EEG or MEG data faces challenges in accessing activation time series at the brain source level due to modeling complexities and insufficient geometric/anatomical data.

To address this, we introduce Representational Dissimilarity Component Analysis (ReDisCA), a method for estimating spatial–temporal components in EEG or MEG responses aligned with a target representational dissimilarity matrix (RDM). ReDisCA yields informative spatial filters and associated topographies, offering insights into the location of ”representationally relevant” sources. Applied to evoked response time series, ReDisCA produces temporal source activation profiles with the desired RDM. Importantly, while ReDisCA does not require inverse modeling its output is consistent with EEG and MEG observation equation and can be used as an input to rigorous source localization procedures.

Demonstrating ReDisCA’s efficacy through simulations and comparison with conventional methods, we show superior source localization accuracy and apply the method to real EEG and MEG datasets, revealing physiologically plausible representational structures without inverse modeling. ReDisCA adds to the family of inverse modeling free methods such as independent component analysis (Makeig, 1995), Spatial spectral decomposition (Nikulin, 2011), and Source power comodulation (Dähne, 2014) designed for extraction sources with desired properties from EEG or MEG data. Extending its utility beyond EEG and MEG analysis, ReDisCA is likely to find application in fMRI data analysis and exploration of representational structures emerging in multilayered artificial neural networks.

Keywords: Пространственно-временная активация мозга, ЭЭГ/МЭГ, EEG/MEG, Representational similarity analysis, анализ репрезентативного сходства

Publication based on the results of: A Multidisciplinary Study of the Human Brain: Behavioral, Psychophysiological and Mathematical Approaches to Cognitive Functioning (2024)