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Неврологические нежелательные явления антипсихотической терапии
Психиатрия. 2019. Т. 17. № 3. С. 75–86.
Language:
Russian
Андрушкевич О. М., Калиновский А. В., Гаврюшин А. В. et al., Нейрохирургия 2026 Т. 28 № 1 С. 33–42
Background. The application of cortical and subcortical stimulation during awake craniotomy mitigates the risk of persistent postoperative speech deficits. However, the functions of some white matter pathways remain inadequately understood, particularly the frontal aslant tract (FAT) of the dominant hemisphere.
Aim. To evaluate the efficacy of cortical and subcortical stimulation techniques in the localization of glial tumors near ...
Added: May 18, 2026
Gerges M., Kosonogov V., OBM Neurobiology 2025 Vol. 9 No. 4 Article 310
Emotion regulation (ER) involves processes by which individuals modulate the intensity, duration, and expression of emotional responses, and its dysregulation is associated with a broad spectrum of psychological disorders. While traditionally conceptualized within psychological frameworks, ER is increasingly recognized as biologically grounded, involving intricate interactions between neurochemical, hormonal, and metabolic systems. This narrative review aims ...
Added: May 12, 2026
Perevoznyuk G., Batov A., Pleskovskaya A. et al., Scientific Reports 2026 Vol. 16 Article 13098
Motor imagery (MI) allows individuals to mentally simulate movements without execution, engaging neural pathways that overlap with those used during real actions. However, how imagery perspective influences corticospinal excitability across different effectors remains unclear. Using neuronavigated transcranial magnetic stimulation (TMS), we compared kinesthetic (KMI), first-person visual (VMI-1PP), and third-person visual (VMI-3PP) imagery of elbow flexion-extension ...
Added: May 5, 2026
Sosnin E. I., Vasil’ev Y. L., R.A. Solovyev et al., Computer Optics 2025 Vol. 49 No. 6 P. 1129–1137
In this article, we present a new unique dataset for dental research – AlphaDent. This dataset is based on the DSLR camera photographs of the teeth of 295 patients and contains over 1200 images. The dataset is labeled for solving the instance segmentation problem and is divided into 9 classes. The article provides a detailed ...
Added: May 4, 2026
Назаренко А. Г., Федоров М. В., Moshkin A. et al., Вестник Росздравнадзора 2026 № 1 С. 14–29
Multimodal foundation models and medical multimodal large language models are establishing a new class of diagnostic clinical decision support systems capable of operating on heterogeneous data sources, including medical imaging (X-ray, CT, MRI, ultrasound, histopathology), physiological signals (ECG, EEG), clinical text (electronic health records, reports, discharge summaries), laboratory measurements, molecular profiling data, and related modalities. ...
Added: May 4, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Общественное здоровье 2026 Т. 6 № 1 С. 17–27
Introduction. The article presents the results of a study on the assessment of the consumption of tobacco and nicotine- containing products by Veterans.
The purpose of the study: to assess the prevalence of tobacco and nicotine among Militaries, impact on health, consumers’ desire to stop using, and the provision of medical care for tobacco/nicotine withdrawal.
Materials and ...
Added: April 30, 2026
Garmonova A., Shcheglova D., Камалова Г. Р. et al., Кубанский научный медицинский вестник 2026 Т. 33 № 2 С. 92–110
Introduction. The study analyzes the structure and volume of workload for faculty at Russian medical universities amidst increasing student numbers, rising demands for students' clinical training, scientific output, and continuous professional education. The relevance of the topic stems from the contradiction between official regulatory requirements and the actual excessive workload of medical educators. The aim is to provide ...
Added: April 29, 2026
Krasnov L., Malikov D., Kiseleva M. et al., Journal of Medicinal Chemistry 2026 Vol. 69 No. 8 P. 8838–8851
In this work, we developed a straightforward data-driven approach to predict the cytotoxicity of metal complexes based entirely on their (metal + ligands) composition. To this end, we have manually curated MetalCytoToxDB─a comprehensive experimental database comprising 26,500 IC50 values for 7050 metal complexes against 754 cell lines from 1921 articles. Based on these, machine learning ...
Added: April 23, 2026
Kopoleva E., Sergey A. Tsymbal, Kuchur O. et al., Drug Delivery and Translational Research 2026 P. 1–16
Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. ...
Added: April 20, 2026
Makarova M., Fedosov N., Mikhailova I. et al., FRONTIERS IN SIGNAL PROCESSING 2026 Vol. 6 Article 1776807
Introduction:
While self-referential attention is thought to enhance interoceptive sensitivity, its effect on cardiac modulation of corticospinal excitability remains unexplored. This pilot study investigated how viewing one’s own face (self-face processing) modulates the cardiac-phase coupling of motor output and whether this heart-brain coupling depends on interoceptive accuracy (heartbeat perception).
Methods:
In 15 healthy adults, motor-evoked potentials (MEPs) were ...
Added: April 17, 2026
Pogodaeva S. S., Miletina O. O., Mammadova L. V. et al., Frontiers in Bioscience - Landmark 2026 Vol. 31 No. 4 Article 48544
Background: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity. Two major subtypes, adrenergic and mesenchymal, are differentially governed by distinct subsets of transcription factors that constitute the core regulatory circuitry (CRC). The adrenergic subtype is often associated with MYCN amplification and is particularly aggressive and therapy-resistant, underscoring the need ...
Added: April 15, 2026
Chernov I., Protas A., Popova E. et al., Biochemistry. Biokhimiia 2025 Vol. 19 No. 3 P. 279–287
This article reports the synthesis, characterization, cytotoxic activity, DNA binding study and antioxidant activity of N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4,6-di(aziridin-1-yl)-1,3,5-triazin-2-amine. The synthesized compound was found to possess cytotoxic effects against six various cancer cell lines including HeLa, HCT116, T96G, A549, MCF7, and PANC-1 and non-cancer ECV cell line. Additionally, the capacity for DNA binding was assessed. The addition of 1,3,5-triazine ...
Added: April 15, 2026
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Chernov K., Savin A., Otvodnikova D. et al., Oncology Research 2026 Vol. - No. -
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Barskaya E. S., Savin A. M., Chernov K. V. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 6 Article 2800
Copper–organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the ...
Added: April 15, 2026
Сахарова Г. М., Антонов Н. С., Stadnik N., Здравоохранение стран СНГ 2025 Т. 1 № 1 С. 42–49
Introduction. Self-rated health is the most widely used indicator of health, taking into account all its components - physical and mental health, emotional, social and financial well-being. Although individuals rate their health based on their own perceptions, when aggregated, the indicator accurately represents the health of the entire population. The purpose of the study: based ...
Added: April 10, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Вопросы наркологии 2025 Т. 37 № 1 С. 27–43
In order to study the prevalence of signs of nicotine dependence among tobacco/nicotine users and the level of medical care for tobacco/nicotine use in addiction treatment organizations in the Russian Federation in 2013-2023, we have analyzed microdata from a sample observation of the health status of the population conducted in 2023. The analysis of the ...
Added: April 10, 2026
Антонов Н. С., Сахарова Г. М., Stadnik N., Электронный научный журнал "Социальные аспекты здоровья населения" 2025 Т. 71 № S3 Статья 13
Significance. A sedentary lifestyle is one of the four most important risk factors for developing non-communicable diseases. Regular physical activity can prevent from 4 million to 5 million deaths annually worldwide.
Purpose. To study the prevalence of a sufficient level of daily physical activity and its three components among the adult population, men and women, in ...
Added: April 9, 2026
Stadnik N., Антонов Н. С., Сахарова Г. М. et al., Профилактическая медицина 2025 Т. 28 № 6 С. 11–20
Studies on alcohol use generally analyze the age-related behavior associated with this factor but do not consider the attitude of people of different ages to the socio-economic situation, the absence or implementation of anti-alcohol policies, or the attitude change over time in people of different generations.
Objective. To analyze the features and changes over time of ...
Added: April 9, 2026
Салагай О. О., Сахарова Г. М., Антонов Н. С. et al., Современные проблемы здравоохранения и медицинской статистики 2025 № 2 С. 50–69
In order to achieve global goals to reduce tobacco/nicotine use, the package of effective tobacco control measures must include the provision of medical assistance to stop tobacco and nicotine use.
Purpose. To analyze the organization of medical care for tobacco/nicotine quitting in the Russian Federation (RF) in accordance with established regulatory legal acts in the field ...
Added: April 9, 2026
Stadnik N., Никитина С. Ю., Сахарова Г. М. et al., Демографическое обозрение 2025 Т. 12 № 2 С. 132–156
The study assesses the dynamics of the prevalence and structure of alcohol consumption in Russia by age, gender and regions. The data source is the microdata databases of the Sample Survey of the Health Condition of the Population conducted by Rosstat in 2019-2023. The assessment of the dynamics of alcohol consumption is based on the ...
Added: April 9, 2026
Олейчик И. В., Баранов П. А., Shishkovskaya T. et al., Современная терапия психических расстройств 2021 № 2 С. 28–35
Актуальность. По данным целого ряда исследований, депрессии при шизофрении регистрируются в среднем у 25 % больных и по показате5 лям распространенности в структуре данного заболевания уступают лишь галлюцинаторно5параноидной и негативной симптоматике. При этом данные состояния вообще не указываются в качестве отдельного показания к назначению психофармакологических средств, хотя в условиях реальной клинической практики они, несомненно, требуют ...
Added: March 12, 2024