?
A Mathematical Model of in vitro Hepatocellular Cholesterol and Lipoprotein Metabolism for Hyperlipidemia Therapy
Plos One. 2022. Vol. 17. No. 6. Article e0264903.
Cardiovascular diseases associated with high cholesterol (hypercholesterolemia) and low-density lipoproteins (LDL) levels are significant contributors to total mortality in developing and developed countries. Mathematical modeling of LDL metabolism is an important step in the development of drugs for hypercholesterolemia. The aim of this work was to develop and to analyze an integrated mathematical model of cholesterol metabolism in liver cells and its interaction with two types of drugs, statins and PCSK9 inhibitors. The model consisted of 21 ordinary differential equations (ODE) describing cholesterol biosynthesis and lipoprotein endocytosis in liver cells in vitro. The model was tested for its ability to mimic known biochemical effects of familial hypercholesterolemia, statin therapy, and PCSK9 inhibitors. The model qualitatively reproduced the well-known biology of cholesterol regulation, which confirms its potential for minimizing cellular research in initial testing of new drugs for cardiology.
Keywords: mathematical model
Panov V., Ryabchenko A., / Series arXiv "stat.ME". 2026. No. 2607.05048.
This paper investigates the problem of statistical inference for a mixture distribution consisting of a discrete and a continuous component, with a particular focus on the class of rational-infinitely divisible distributions. We consider non-parametric estimation of both components of the mixture as well as the quasi-L{é}vy measure, assuming that the mixture belongs to the class ...
Added: July 9, 2026
Springer, 2027.
The series Lecture Notes in Computer Science (LNCS), including its subseries Lecture Notes in Artificial Intelligence (LNAI) and Lecture Notes in Bioinformatics (LNBI), has established itself as a medium for the publication of new developments in computer science and information technology research, teaching, and education. LNCS enjoys close cooperation with the computer science R & ...
Added: July 8, 2026
Маликов М. А., Монахова Э. А., Rzaev E. et al., Ученые записки Казанского университета. Серия: Физико-математические науки 2026 Т. 168 № 2 С. 269–286
This article examines series of families of two-dimensional circulant networks with rectangular
L -shapes, optimal in diameter, as network-on-chip topologies with a minimal number of crossings
between the links and a bounded length of the maximum link that does not depend on the network
size. New network-on-chip routing algorithms, which use the coordinates of three adjacent zeros in
the ...
Added: July 8, 2026
Pilé I., Shchur L., Deng Y., Physical Review B: Condensed Matter and Materials Physics 2026 Vol. 114 Article 014101
We investigate the spatial overlap of successive spin configurations in Markov chain Monte Carlo simulations using the local Metropolis algorithm and the Swendsen-Wang and Wolff cluster algorithms. We examine the dynamics of these algorithms for models in different universality classes: Ising model, Potts model with three components, and four-state Potts model. The overlap of two ...
Added: July 6, 2026
Irkutsk: ISDCT SB RAS, 2026.
We study a model problem on the filtration of a conducting fluid through a
porous layer. A porous medium is presented as an assemblage of identical spherical
cells. Each cell consists of a porous core and liquid shell. We derive apriori estimates
for flow characteristics which show the specific behavior of the fluid. Our estimates
are validated numerically. ...
Added: July 5, 2026
М.: Наука и технологии, 2026.
«Телекоммуникации» ежемесячный рецензируемый производственный, информационно-аналитический и учебно-методический журнал выходит в свет с июля 2000 г.
Для руководителей и работников промышленности, научно-исследовательских и проектно-конструкторских институтов, высших учебных заведений, аспирантов и студентов, а также для специалистов, разрабатывающих, выпускающих и эксплуатирующих средства телекоммуникаций.
Новости разработок и производства, прогнозы развития, защита информации, Нормативные, справочные, аналитические и учебно-методические материалы.
Переход к глобальному информационному ...
Added: July 4, 2026
МФТИ, 2025.
абота редакции научного журнала «Труды Московского физико-технического института» (кратко «Труды МФТИ»), редакционной коллегии и редакционного совета осуществляется в соответствии с Положением, утвержденным ректором института. В состав редакционной коллегии входят руководители института, факультетов, институтских и факультетских кафедр. Главный редактор журнала —президент МФТИ, член-корр. РАН Кудрявцев Н.Н.
Журнал «Труды МФТИ» входит в базу данных РИНЦ (Российский Индекс Научного Цитирования) и доступен в электронной ...
Added: July 4, 2026
Springer, 2026.
This book presents established and new research on the close connections between graph games and systems of logic, particularly existing and newly designed modal logics. The volume utilizes two graph games – the sabotage game and the hide-and-seek game – to demonstrate the natural interplay between designing new graph games and exploring new kinds of ...
Added: June 30, 2026
Pochinka O., Barinova M., Journal of Geometry and Physics 2026 Vol. 228 P. 1–8
In the present paper we consider an Ω-stable 3-diffeomorphism with a solid or thickened surfaced non-trivial basic set. Such basic sets include, for instance, all one-dimensional expanding attractors and those two-dimensional basic sets that are not expanding. We prove that the chain recurrent set of every such a diffeomorphism necessarily contains at least two non-trivial ...
Added: June 30, 2026
German O., Illarionov A., Известия РАН. Серия математическая 2026 Т. 90 № 3 С. 3–18
Пусть симплекс с целочисленными вершинами - содержащий ровно одну целочисленную точку, отличную от своих вершин. В работе доказывается, что если точка находится во внутренности симплекса или в относительной внутренности некоторой гиперграни симплекса, то объем симплекса ограничен величиной, зависящей только от размерности, в противном случае объем симплекса может быть сколь угодно большим. Этот результат применяется для вывода асимптотической формулы для среднего числа вершин полиэдров ...
Added: June 29, 2026
Romanova T. V., Khomenko A., Legal Issues in the Digital Age 2022 Vol. 3 No. 2 P. 90–115
The article deals with validation of an integrative attribution algorithm based on the analysis of the author’s idiostyle using methods of interpretative linguistics with ob jectification of the available data with the help of mathematical statistics. The algo rithm addresses the identification problem of the attribution. The choice of parameters describing the individual style of ...
Added: March 12, 2025
M. R. Yanova, A. P. Zhiyanov, I. D. Antipenko et al., Doklady Biochemistry and Biophysics 2023 Vol. 513 P. 324–327
Gemcitabine monophosphate (dFdCMP), one of the intracellular forms of phosphorylated gemcitabine, determines its antitumor activity. A pharmaco-molecular model for determining relative gemcitabine monophosphate level based on the assessment of the activity of ENT1 and ENT2 channels as well as dCK and CDA enzymes in tumor tissue was developed. Relative gemcitabine monophosphate level is a more ...
Added: January 23, 2025
Yanova M., Zhiyanov A., Antipenko I. et al., Доклады российской академии наук. Науки о жизни 2023 Т. 513 № 1 С. 581–585
Gemcitabine monophosphate (dFdCMP), one of the intracellular forms of phosphorylated gem- citabine, determines its antitumor activity. A pharmaco-molecular model for determining relative gemcit- abine monophosphate level based on the assessment of the activity of ENT1 and ENT2 channels as well as dCK and CDA enzymes in tumor tissue was developed. Relative gemcitabine monophosphate level is ...
Added: November 17, 2023
Aleksandr Belov, Monina M., Rakhmetullina Z., , in: 2022 IEEE International IOT, Electronics and Mechatronics Conference (IEMTRONICS 2022).: IEEE, 2022. P. 1–6.
Added: July 20, 2022
Серебрякова Ю. О., Polesskiy S., Korolev P., Известия высших учебных заведений. Приборостроение 2022 Т. 65 № 8 С. 597–611
It is shown in the article that not all mathematical models used to solve the problems of estimating the time of telecommunication equipment technological run take into account design and technological features. The existing statistics of failures of telecommunication equipment is given, proving the need to take into account design and technological features. It is ...
Added: June 5, 2022
Khomenko A., Baranova Y., Romanov A. et al., , in: Компьютерная лингвистика и интеллектуальные технологииВып. 20 (27): Дополнительный том.: Изд-во РГГУ, 2021. P. 1063–1074.
This paper discusses approbation of an integrative attribution method for texts in the Russian language. The methodology goes after (Koppel, Schler 2003): computer program tries to imitate human expert work. So, it is based on interpretative language study with its objectification through mathematical statistics. The choice of parameters describing the author’s individual style is rooted ...
Added: August 11, 2021
L I Kuzmina, Osipov Y. V., Astakhov M. D., , in: Journal of Physics: Conference Series 1926 (2021)Vol. 1926: Innovations and Technologies in Construction (BUILDINTECH BIT 2021) 9 th - 10th March 2021, Belgorod, Russia.: IOP Publishing, 2021. Ch. 012001 P. 1–7.
During the construction of underground storage of hazardous waste, it is necessary to create waterproof walls in the ground. The grout is filtered in the rock, fills the pores and, when hardened, creates a reliable barrier to groundwater. A one-dimensional model of the flow of inhomogeneous particles in a porous medium is considered. The retained ...
Added: July 3, 2021
The system of predictive analysis of Bank investments using technologies of supercomputer simulation
Belov A. V., Kurmanova K., Journal of Physics: Conference Series 2021 Vol. 1740 P. 1–6
The article discusses an approach to building a system for generating a bank investment prediction with the technology of parallel computing. We develop a predictive model of the price of securities for the banking business on the stock market. For predictive analysis of investments, the choice of a mathematical model was justified using the Monte ...
Added: January 27, 2021
Liudmila I. Kuzmina, Osipov Y., Zheglova Y., , in: Journal of Physics: Conference Series, Volume 1425, Modelling and Methods of Structural Analysis 13–15 November 2019, Moscow, Russian FederationVol. 1425.: IOP Publishing, 2020. Ch. 1425 P. 1–8.
Particle transport in a porous medium occurs in environmental, chemical and industrial technologies. The transport of suspended concrete grains in a liquid grout through porous soil is used in construction industry to strengthen foundations. When particles are transported by a fluid flow in a porous medium, some particles are retained in the pores and form ...
Added: July 2, 2020
Liudmila Kuzmina, Osipov Y., Zheglova Y., , in: E3S Web of Conferences Volume 97 (2019) XXII International Scientific Conference “Construction the Formation of Living Environment” (FORM-2019)Vol. 97: XXII International Scientific Conference “Construction the Formation of Living Environment” (FORM-2019).: EDP Sciences, 2019. Ch. 05002 P. 1–8.
Filtration problems are actual for the design of underground structures and foundations, strengthening of loose soil and construction of watertight walls in the porous rock. A liquid grout pumped under pressure penetrates deep into the porous rock. Solid particles of the suspension retained in the pores, strengthen the loose soil and create watertight partitions. The ...
Added: July 7, 2019
Петренко А. А., Suvorov A., Plotnikova E. G., Безопасность в техносфере 2018 Т. 7 № 2 С. 22–28
Some theoretical aspects for determining the required number of mobile groups involved in objects security assurance from the impact of various negative factors have been considered. A mathematical model, that allow substantiate the required number of groups for timely response to negative factors has been developed. The total number of response teams has been determined ...
Added: January 23, 2019
L I Kuzmina, Osipov Y., Zheglova Y., , in: VII International Symposium Actual Problems of Computational Simulation in Civil EngineeringVol. 456.: IOP Publishing, 2018. Ch. 012051 P. 1–6.
The solution of the filtration problem allows calculating the injection of the grout
into a loose ground to create a solid foundation. The basic deep bed filtration model of a
monodisperse suspension in a porous medium is considered. Based on the synthesis of the
standard asymptotic solution for a short time and the asymptotics of the filtration problem ...
Added: January 18, 2019
Aleksander V. Belov, Загуменнов Ф. Д., , in: Proceedings of the 2018 IEEE International Conference "Quality Management, Transport and Information Security, Information Technologies" (IT&QM&IS).: IEEE, 2018. P. 308–311.
The objective of this research is to develop a software algorithm for evaluating the effectiveness of using the Financial Message Transfer System for Remote Banking Systems. The study considers hardware system that provide two types of interactions between the legal entity and the bank: ≪Direct Banking≫ and ≪Internet Banking≫. During the work were identified and ...
Added: November 27, 2018
Liudmila Kuzmina, Osipov Y., , in: IOP Conference Series: Materials Science and Engineering, Volume 365, Safety in Construction XXI International Scientific Conference on Advanced in Civil Engineering "Construction - The Formation of Living Environment" (FORM 2018)Vol. 365.: IOP Publishing, 2018. Ch. 042003 P. 1–7.
Modelling of the suspended particles transport in a porous medium is used in the analysis of methods for strengthening foundations. To strengthen the porous soil, a low concentration cement-based grout is pumped into it under pressure. The suspension is filtered in a porous medium and fills the cavity of the soil. Grains of the grout ...
Added: November 2, 2018