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  • Уровень внутриклеточного монофосфата гемцитабина предсказывает эффективность химиотерапии с использованием гемцитабина у больных раком мочевого пузыря
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Subject
News
September 21, 2026
Researchers Develop Methodology to Assess the Quality of Legal Representation in Criminal Proceedings
Having a good defence attorney in criminal proceedings can largely determine whether a defendant retains their freedom, health and good name. Researchers at HSE University propose a method for predicting an attorney’s performance based on the outcomes of their previous cases. The methodology takes into account the severity of the charges, the complexity of the cases, and the most likely outcome, drawing on judicial statistics.
September 21, 2026
Algebra, Geometry, and AI: Russian and Vietnamese Mathematicians Discuss Current Research
A delegation of scientists from Hanoi visited the HSE Faculty of Computer Science and then took part in a Russian-Vietnamese conference in St Petersburg. The events were part of the three-year project ‘Flexibility and Computational Methods.’ Over the course of the project, the researchers have prepared joint publications and obtained new mathematical results.
September 18, 2026
When Pictures Hinder Understanding: Illustrations May Impede Learning of Abstract Ideas
Illustrations can help remember specific actions but do not always make abstract ideas easier to learn. Researchers from HSE University and Humboldt University compared how people learn from texts with different levels of abstractness. They found that participants remembered illustrations better and performed better on related tasks after reading a multimedia text about yoga asanas than after reading an abstract text about the Nash equilibrium. The findings could help improve the selection of illustrations for educational and informational materials. The study has been published in Learning and Instruction.

 

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Уровень внутриклеточного монофосфата гемцитабина предсказывает эффективность химиотерапии с использованием гемцитабина у больных раком мочевого пузыря

Доклады российской академии наук. Науки о жизни. 2023. Т. 513. № 1. С. 581–585.
Yanova M., Zhiyanov A., Antipenko I., Slobodov S., Stepanova E.

Gemcitabine monophosphate (dFdCMP), one of the intracellular forms of phosphorylated gem- citabine, determines its antitumor activity. A pharmaco-molecular model for determining relative gemcit- abine monophosphate level based on the assessment of the activity of ENT1 and ENT2 channels as well as dCK and CDA enzymes in tumor tissue was developed. Relative gemcitabine monophosphate level is a more relevant predictive factor of gemcitabine resistance of bladder cancer as compared with the expression of indi- vidual markers related to dFdCMP formation.

Research target: Biology
Language: Russian
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DOI
Text on another site
Keywords: математическая модельmathematical modelцитотоксичностьcytotoxicitybladder cancergemcitabineрак мочевого пузырягемцитабин
Publication based on the results of:
New tumor organoid models to determine the sensitivity or resistance to anticancer therapy (2023)
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