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Лазерная спайка хрящевой ткани с коллагенсодержащим биоматериалом (исследование in vitro)
Современные технологии в медицине. 2023. Т. 15. № 6. С. 31–39.
Ignatieva N., Захаркина О. Л., Свиридов А. П.
Pogodaeva S., Miletina O., Antipova N. et al., Cancers 2025 Vol. 17 No. 19 Article 3228
Pediatric tumors such as neuroblastoma are characterized by a genome-wide ‘transcriptional burden’, surmising the involvement of multiple alterations of gene expression. Search for master regulators of transcription whose inactivation is lethal for tumor cells identified the non-POU domain-containing octamer-binding protein (NONO), a member of the Drosophila Behavior/Human Splicing family known for the ability to form ...
Added: April 15, 2026
Chernov K. V., Savin A. M., Otvodnikova D. E. et al., Oncology Research 2026 Vol. 34 No. 5 P. 1–40
The formation of drug resistance poses the ultimate threat in modern oncology. Targeted therapy lacks versatility, while conventional therapy is famous for its side effects. However, for the new therapeutics to address the challenge of drug resistance, such compounds should combine properties of both modalities. In this review, we argue that metal-based therapeutics are paramount ...
Added: April 15, 2026
Barskaya E. S., Savin A. M., Chernov K. V. et al., International Journal of Molecular Sciences 2026 Vol. 27 No. 6 Article 2800
Copper–organic compounds are being investigated as antitumor candidates. Besides their efficacy as cytotoxic agents alone, the oxidative potential of electrochemical Cu2+-to-Cu1+ transition emerges as an attractive approach for elimination of tumor cells otherwise resistant to chemotherapy. To minimize side effects of the potent oxidative burst upon Cu(II) reduction, the metal cations should be delivered to the ...
Added: April 15, 2026
S. V. Nikulin, Olkhovik D., A.V. Razumovskaya et al., Doklady Biochemistry and Biophysics 2026
A novel trend in anticancer therapy is based on the combination of cytotoxic and metabolic drugs. Bach1 is a transcription factor activating glycolysis and increasing proliferation and metastatic potential in cancer cells. The cytotoxic effect was evaluated for a combination of rotenone, an inhibitor of mitochondrial respiration, and two different inhibitors of Bach1 transcription factor ...
Added: April 13, 2026
Zolotova N., Kirillova M., Dzhalilova D. et al., International Journal of Molecular Sciences 2025 Vol. 26 No. 23 Article 11511
Recently, evidence indicating that microplastics (MPs) have a hazardous effect on human health is accumulating. The potential of MPs having a role in carcinogenesis was suggested. Therefore, the aim of this study was to evaluate MPs’ effect on colitis-associated colorectal cancer (CAC) development. The AOM/DSS-induced CAC model was reproduced in two groups of adult male ...
Added: March 24, 2026
Silina M., Dzhalilova D., Fokichev N. et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1674608
Humans and laboratory animals differ in their resistance to hypoxia, which affects the severity of inflammatory diseases and the rate of tumor progression. Therefore, it is necessary to search for methods for assessing the initial tolerance to oxygen deficiency and the risks of developing acute mountain sickness without direct hypoxia exposure on the organism. The ...
Added: March 24, 2026
Shchetinin I., Nikolenko P., Nizamov T. et al., Ceramics International 2026 Vol. 52 No. 3 P. 3500–3511
In this work, we comprehensively investigated the influence of Indium doping on the structure, magnetic and functional properties of strontium M-type hexaferrites SrFe12-xInxO19 nanoparticles (where x = 1.7, 1.8, 2.0). Colloidally stable SrFe12-xInxO19 nanoparticles (∼10 nm) were synthesized using a combination of the citrate method and high-energy ball milling. We demonstrate that doping reduces both the specific saturation magnetization and, ...
Added: March 16, 2026
Mungalov R. V., Vand N. S., Chudakov D. M. et al., Биоорганическая химия 2025 Т. 51 № 5 С. 1827–1837
The development of therapeutic antigen-specific T-cell receptors (TCRs) requires comprehensive preclinical validation of their functional activity. One of the approaches in the development of new drugs for cell therapy based on antigen-specific T lymphocytes is the modification of autologous T lymphocytes with endogenous T-cell receptors. The present work reviews modern laboratory platforms used to assess ...
Added: March 4, 2026
Roman V. Mungalov, Mushenkova N., Chudakov D. et al., Frontiers in Immunology 2025 Vol. 16 Article 1551424
T-cell engagers represent a transformative approach to cancer immunotherapy leveraging bispecific and multispecific antibody constructs to redirect T-cell cytotoxicity toward malignant cells. These molecules bridge T cells and tumor cells by simultaneously binding CD3 on T cells and tumor-associated antigens on cancer cells, thereby enabling precise immune targeting even in immunologically “cold” tumors. Recent advancements ...
Added: March 4, 2026
Садовская Я. О., Гусев Д. В., Karimova A. et al., Российский онкологический журнал 2025 Т. 30 № 3 С. 247–258
Обоснование. Активаторы STING с направленной доставкой в опухолевые узлы обладают высоким потенциалом в иммунотерапии рака, особенно в формате иммуноконъюгатов. Известные соединения, такие как MSA-2, не обладают достаточной активностью для их использования в качестве активной составляющей иммуноконъюгата, поэтому требуется разработка новых, более активных соединений.
Цель. Изучение биологической активности нового соединения SAD-2 и оценка его перспективности с целью ...
Added: February 19, 2026
Karimova A., Садовская Я. О., Солопова О. Н., Российский онкологический журнал 2025 Т. 30 № 3 С. 156–169
ABSTRACT Modern oncology needs to develop and implement antineoplastic agents that provide sustained remission without serious side effects. Immunotherapy and targeted therapy agents that activate innate immunity may address this issue. The stimulator of interferon genes (STING), an intracellular protein, mediates the synthesis of type I interferons, which have antiviral, antitumor, and antiproliferative properties. The ...
Added: February 19, 2026
Portnova G., Proskurnina E., Liaukovich K. et al., Journal of Molecular Neuroscience 2026 Vol. 76 Article 19
This study investigates the relationship between stress coping ability, salivary antioxidant capacity (AOC), and trace element concentrations, focusing on zinc (Zn) and potassium (K). A cohort of 73 participants, divided into groups based on stress coping ability (SCA) (“adaptive”, “intermediate”, and “maladaptive”), underwent cognitive tasks while physiological and behavioral data were collected. Saliva samples were ...
Added: February 2, 2026
I. A. Khaustov, Yu. A. Safronova, O. E. Chebotareva et al., Applied Biochemistry and Microbiology 2025 Vol. 61 No. 9 P. 1753–1759
Polydimethylsiloxane (PDMS) remains one of the most popular materials for microfluidic chips, but its high gas permeability can lead to the formation of gas bubbles in microchannels, which hampers the reproducibility of experiments in organ-on-a-chip systems. The dependence of the gas permeability of PDMS on the ratio of base to hardener (2.5 : 1, 5 : 1, and ...
Added: December 22, 2025
David Arteaga, Poptsova M., Computational and Structural Biotechnology Journal 2026 Vol. 31 P. 82–93
Accurate predictions and large-scale identification of protein-protein interactions (PPIs) are crucial for understanding their inherent biological mechanisms and protein functions in virtually all biological processes. Nowadays, graph-based deep learning models have made significant contributions in modeling proteins with physicochemical and geometric features. However, most of these models rely on conventional graph construction methods, such as ...
Added: December 22, 2025
Posnenkova O., Simonyan M., Akimova N., Blood Pressure Monitoring 2025 No. 11
We aimed to evaluate the accuracy of B.Well PRO-33 (B.Well, Widnau, Switzerland) oscillometric device for professional office measurement of blood pressure (BP) on the upper arm in the general population in accordance with the Amendment 2.2024-01 of the Standard 81060-2:2018 by the International Organization for Standardization (ISO 81060-2:2018/AMD 2:2024). Study participants were recruited according to ...
Added: December 11, 2025
Silkina M., Кулагин Т. А., Клычева К. В. et al., Doklady Biochemistry and Biophysics 2026 No. 1
Ferroptosis is considered a promising strategy for inducing the death of tumor cells. However, the effectiveness of known ferroptosis inducers, such as erastin, is in some cases limited, which stimulates the search for new combined application strategies. In this study, the combined effect of erastin and docosahexaenoic acid (DHA) on prostate cancer cells was examined ...
Added: December 11, 2025
Абрамова А. В., Белоусова Е. Н., Ватюков С. Е. et al., Проблемы стандартизации в здравоохранении 2025 № 5-6 С. 3–14
The improvement of artificial intelligence (AI) technologies and their rapid integration into the socially and economically significant medical industry create broad prospects for ensuring accessibility and quality of medical care, while at the same time creating new challenges related to the safety and ethical risks of using innovative solutions. This creates the need to develop ...
Added: December 7, 2025
Antipenko I., Knyazev E., Timur Kulagin et al., Frontiers in Molecular Biosciences 2025 Vol. 12 Article 1731126
Preeclampsia is a leading cause of maternal and perinatal morbidity associated with systemic lipid metabolism disturbances, yet the underlying molecular mechanisms remain incompletely understood. In this study, we integrated single-cell RNA-seq data from preeclamptic placentas with an in vitro hypoxia model to analyze gene expression changes across distinct trophoblast subpopulations. While all trophoblast lineages exhibited ...
Added: December 2, 2025
S. Yu. Paul, Yu. A. Safronova, O. E. Chebotareva et al., Applied Biochemistry and Microbiology 2025 Vol. 61 No. 7 P. 1369–1378
The design and development of a placenta-on-a-chip model is of great importance for various fields of cell biology, especially in studies of the molecular mechanisms of disease pathogenesis and the action of potential drugs. Currently, milling technique is most commonly used to fabricate microfluidic devices from thermoplastics. However, this technology leads to the formation of ...
Added: November 19, 2025
Ugleva A. V., Вопросы философии 2025 № 11 С. 112–123
The article focuses on the phenomenon of reification in digital psychiatry. The author highlights that AI technologies exacerbate the problem of translating complex culturally-conditioned psychiatric constructs into formal mathematical structures, which creates an illusion of objectivity and impedes the development of personalized medical care. The main objective of the article is to minimize negative consequences ...
Added: November 6, 2025
K. V. Klycheva, A. V. Razumovskaya, A. D. Shatsillo et al., Doklady Biochemistry and Biophysics 2025 Vol. 525 P. 532–540
Today, breast cancer (BC) occupies a leading position in prevalence and mortality from oncologi- cal diseases among the female population worldwide. Ferroptosis is a special type of cell death associated with peroxidation of intracellular lipids. It is a promising option for the therapy of BC resistant to traditional meth- ods of treatment. The ELOVL5 gene, ...
Added: October 29, 2025
Ignatieva N., Zakharkina O. L., Sviridov A. P., Journal of Biomedical Photonics and Engineering 2022 Vol. 8 No. 4 Article 040513
The dynamics of temperature fields in whole blood during the action of continuous-wave (CW) laser radiation with wavelengths of 0.97, 1.56, and 1.68 μm for the temperature range up to 600 ºC were studied. On the blood heating thermograms four characteristic stages differing in the heating rate were distinguished. Comparison of the obtained thermograms with ...
Added: January 30, 2023
Ignatieva N., Захаркина О. Л., Свиридов А. П., Современные технологии в медицине 2022 Т. 14 № 6 С. 25–33
The aim of the study was to develop a diagnostic method for the quantitative determination of the main components of cartilage tissue of various types based on multivariate IR spectral analysis and verification of data using classical chemical analysis. Materials and Methods. Cartilages of the nasal septum, knee joint, rib, and nucleus pulposus of the ...
Added: January 29, 2023
N.Yu. Ignat'eva, Zakharkina O. L., Sviridov A. P. et al., Quantum Electronics 2022 Vol. 52 No. 1 P. 78–82
Experiments modelling endovenous laser obliteration (EVLO) are performed. As a result, laser radiation powers Pc at which collagen denaturation, tissue necrosis, and vasa vasorum destruction occur throughout the entire venous-wall thickness and, at the same time, the surrounding tissues are not subjected to unnecessary heating, are found. The main criterion for determining Pc is the ...
Added: October 28, 2022