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Synaptamide improves cognitive functions and neuronal plasticity in neuropathic pain
International Journal of Molecular Sciences. 2021. Vol. 22. No. 23. Article 12779.
Tyrtyshnaia A., Konovalova S., Manzhulo I.
Gallo F., Voits T., Rothman J. et al., eNeuro 2025 Vol. 12 No. 6 Article ENEURO.0128-25.2025
Models of experience-dependent neuroplasticity predict that the acquisition and extensive use of a new skill trigger a nonlinear trajectory of neurostructural modifications, where initial expansion of relevant brain areas subsequently (once the skill is acquired) gives way to volumetric renormalization. Such predictions also apply in the domain of language during learning and/or simultaneous management of ...
Added: December 12, 2025
Vorobyova A., Feurra M., Pavone E. F. et al., Frontiers in Human Neuroscience 2025 Article 1509163
Introduction: The hippocampus plays a crucial role in episodic memory. Given its complexity, the hippocampus participates in multiple aspects of higher cognitive functions, among which are semantics-based encoding and retrieval. However, the “where,” “when” and “how” of distinct aspects of memory processing in the
hippocampus are still under debate.
Methods: Here, we employed a visual associative memory task that involved ...
Added: February 20, 2025
Babchenko V. Y., Belova A. S., A. A. Bashirzade et al., Neuroscience and Behavioral Physiology 2022 Vol. 52 No. 3 P. 405–414
Current medicine has a high level of interest in studies of the pathogenesis of traumatic brain injury (TBI). This comes particularly from high levels of hospitalization of patients with this pathology, its high mortality, and the low level of development of existing treatment methods. Improvements in the understanding of the pathogenesis of TBI require appropriate ...
Added: February 1, 2024
Arutiunian V., Davydova E., Pereverzeva D. et al., Brain Structure and Function 2023 Vol. 228 No. 6 P. 1573–1579
The core symptoms of Autism Spectrum Disorder (ASD) are impairments in social interaction/communication and the presence of stereotyped and repetitive behaviour. The amygdala and hippocampus are involved in core functions in the “social brain” and, thus, may be of particular interest in ASD. Previous studies demonstrated inconsistent results, revealing both increased and reduced volume of ...
Added: January 28, 2024
Konovalova S., Tyrtyshnaia A., Ermolenko E. et al., International Journal of Molecular Sciences 2021 Vol. 22 No. 19 Article 10728
Added: October 11, 2023
Belichenko V., Bashirzade A., Tenditnik M. et al., Behavioural Brain Research 2023 Vol. 454 Article 114651
Animal models of Alzheimer’s disease (AD) induced by intracerebroventricular (ICV) or intrahippocampal (IH) administration of amyloid-beta (Aβ) are widely used in current research. It remains unclear whether these models provide similar outcomes or mimic pathological mechanisms of AD equally. The aim of the work was to compare two models induced by ICV or IH administration ...
Added: September 15, 2023
Sotskov V., Plusnin V., Konstantin S. Sorokin et al., , in: 2022 Fourth International Conference Neurotechnologies and Neurointerfaces (CNN) Kaliningrad, 14-16 Sept. 2022.: IEEE, 2022. P. 168–171.
Added: November 10, 2022
Gu Z., Smith K., Alexander G. et al., Cell Reports 2020 Vol. 31 No. 10 Article 107740
Muscarinic acetylcholine receptors (mAChRs) are critically involved in hippocampal theta generation, but much less is known about the role of nicotinic AChRs (nAChRs). Here we provide evidence that α7 nAChRs expressed on interneurons, particularly those in oriens lacunosum moleculare (OLM), also regulate hippocampal theta generation. Local hippocampal infusion of a selective α7 nAChR antagonist significantly ...
Added: January 24, 2022
Tonevitsky A., Kononenko O., Mityakina I. et al., Brain Research 2018 Vol. 1695 P. 78–83
The endogenous opioid system (EOS) controls the processing of nociceptive stimuli and is a pharmacological target for opioids. Alterations in expression of the EOS genes under neuropathic pain condition may account for low efficacy of opioid drugs. We here examined whether EOS expression patterns are altered in the lumbar spinal cord of the rats with ...
Added: October 30, 2018
Ossadtchi A., Lebedev M., Frontiers in Systems Neuroscience 2018 Vol. 12 No. 8 P. 1–5
The discovery of place-representing neurons in the hippocampal formation has been recognized by the Nobel Committee as a paradigm shift in Neuroscience (Burgess, 2014). Here we call attention to an innovative paper of particular note (Zhang and Manahan-Vaughan, 2015) that added important findings to this field of study.
Zhang and Manahan-Vaughan investigated the contribution of olfactory ...
Added: April 17, 2018