Synaptamide improves cognitive functions and neuronal plasticity in neuropathic pain

Publications

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Synaptamide improves cognitive functions and neuronal plasticity in neuropathic pain

International Journal of Molecular Sciences. 2021. Vol. 22. No. 23. Article 12779.

Tyrtyshnaia A., Konovalova S., Manzhulo I.

Language: English

Experience-dependent neuroplasticity in the hippocampus of bilingual young adults

Gallo F., Voits T., Rothman J. et al., eNeuro 2025 Vol. 12 No. 6 Article ENEURO.0128-25.2025

Models of experience-dependent neuroplasticity predict that the acquisition and extensive use of a new skill trigger a nonlinear trajectory of neurostructural modifications, where initial expansion of relevant brain areas subsequently (once the skill is acquired) gives way to volumetric renormalization. Such predictions also apply in the domain of language during learning and/or simultaneous management of ...

Added: December 12, 2025

Functional segregation of rostral and caudal hippocampus in associative memory

Vorobyova A., Feurra M., Pavone E. F. et al., Frontiers in Human Neuroscience 2025 Article 1509163

Introduction: The hippocampus plays a crucial role in episodic memory. Given its complexity, the hippocampus participates in multiple aspects of higher cognitive functions, among which are semantics-based encoding and retrieval. However, the “where,” “when” and “how” of distinct aspects of memory processing in the hippocampus are still under debate. Methods: Here, we employed a visual associative memory task that involved ...

Added: February 20, 2025

Traumatic Brain Injury Models in Zebrafish (Danio rerio)

Babchenko V. Y., Belova A. S., A. A. Bashirzade et al., Neuroscience and Behavioral Physiology 2022 Vol. 52 No. 3 P. 405–414

Current medicine has a high level of interest in studies of the pathogenesis of traumatic brain injury (TBI). This comes particularly from high levels of hospitalization of patients with this pathology, its high mortality, and the low level of development of existing treatment methods. Improvements in the understanding of the pathogenesis of TBI require appropriate ...

Added: February 1, 2024

Reduced grey matter volume of amygdala and hippocampus is associated with the severity of autistic symptoms and language abilities in school-aged children with Autism Spectrum Disorder: an exploratory study

Arutiunian V., Davydova E., Pereverzeva D. et al., Brain Structure and Function 2023 Vol. 228 No. 6 P. 1573–1579

The core symptoms of Autism Spectrum Disorder (ASD) are impairments in social interaction/communication and the presence of stereotyped and repetitive behaviour. The amygdala and hippocampus are involved in core functions in the “social brain” and, thus, may be of particular interest in ASD. Previous studies demonstrated inconsistent results, revealing both increased and reduced volume of ...

Added: January 28, 2024

Anti-inflammatory activity of N-docosahexaenoylethanolamine and neicosapentaenoylethanolamine in a mouse model of lipopolysaccharide-inducedneuroinflammation

Konovalova S., Tyrtyshnaia A., Ermolenko E. et al., International Journal of Molecular Sciences 2021 Vol. 22 No. 19 Article 10728

Added: October 11, 2023

Comparative analysis of early neurodegeneration signs in a mouse model of Alzheimer’s disease-like pathology induced by two types of the central (Intracerebroventricular vs. Intrahippocampal) administration of Aβ25–35 oligomers

Belichenko V., Bashirzade A., Tenditnik M. et al., Behavioural Brain Research 2023 Vol. 454 Article 114651

Animal models of Alzheimer’s disease (AD) induced by intracerebroventricular (ICV) or intrahippocampal (IH) administration of amyloid-beta (Aβ) are widely used in current research. It remains unclear whether these models provide similar outcomes or mimic pathological mechanisms of AD equally. The aim of the work was to compare two models induced by ICV or IH administration ...

Added: September 15, 2023

Rapid tuning dynamics of CA1 place codes in one-and two- dimensional free exploration tasks

Sotskov V., Plusnin V., Konstantin S. Sorokin et al., , in: 2022 Fourth International Conference Neurotechnologies and Neurointerfaces (CNN) Kaliningrad, 14-16 Sept. 2022.: IEEE, 2022. P. 168–171.

Added: November 10, 2022

Hippocampal Interneuronal alpha 7 nAChRs Modulate Theta Oscillations in Freely Moving Mice

Gu Z., Smith K., Alexander G. et al., Cell Reports 2020 Vol. 31 No. 10 Article 107740

Muscarinic acetylcholine receptors (mAChRs) are critically involved in hippocampal theta generation, but much less is known about the role of nicotinic AChRs (nAChRs). Here we provide evidence that α7 nAChRs expressed on interneurons, particularly those in oriens lacunosum moleculare (OLM), also regulate hippocampal theta generation. Local hippocampal infusion of a selective α7 nAChR antagonist significantly ...

Added: January 24, 2022

Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord

Tonevitsky A., Kononenko O., Mityakina I. et al., Brain Research 2018 Vol. 1695 P. 78–83

The endogenous opioid system (EOS) controls the processing of nociceptive stimuli and is a pharmacological target for opioids. Alterations in expression of the EOS genes under neuropathic pain condition may account for low efficacy of opioid drugs. We here examined whether EOS expression patterns are altered in the lumbar spinal cord of the rats with ...

Added: October 30, 2018

Commentary: Spatial Olfactory Learning Contributes to Place Field Formation in the Hippocampus

Ossadtchi A., Lebedev M., Frontiers in Systems Neuroscience 2018 Vol. 12 No. 8 P. 1–5

The discovery of place-representing neurons in the hippocampal formation has been recognized by the Nobel Committee as a paradigm shift in Neuroscience (Burgess, 2014). Here we call attention to an innovative paper of particular note (Zhang and Manahan-Vaughan, 2015) that added important findings to this field of study. Zhang and Manahan-Vaughan investigated the contribution of olfactory ...

Added: April 17, 2018